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Mutational signatures of synchronous and metachronous brain metastases from lung adenocarcinoma

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Article Oncology

Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)

Meichen Li et al.

Summary: Analysis of the immune phenotypes of primary lung tumors and brain metastases revealed that brain metastatic tumors are more immunosuppressed than primary lung tumors. Additionally, significant differences were observed in gene expression and immune microenvironment between the synchronous group and the metachronous group.

ONCOIMMUNOLOGY (2022)