Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID

Article Biology

Infrared image method for possible COVID-19 detection through febrile and subfebrile people screening

Marcos Leal Brioschi et al.

Summary: This study proposed an infrared image-based method for febrile and subfebrile people screening to comply with the society need for alternative, quick response, and effective methods for COVID-19 contagious people screening.

JOURNAL OF THERMAL BIOLOGY (2023)

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Article Immunology

Persistent Autoimmune Activation and Proinflammatory State in Post-Coronavirus Disease 2019 Syndrome

Yeny Acosta-Ampudia et al.

Summary: Post-COVID syndrome is characterized by the persistence of latent autoimmunity up to 11 months after recovery, accompanied by a persistent proinflammatory state and altered effector phenotype. The need to evaluate the role of immunomodulation in the treatment of PCS is suggested.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Review Immunology

Pathological sequelae of long-haul COVID

Saurabh Mehandru et al.

Summary: This review examines the underlying pathophysiological mechanisms of post-COVID-19 syndromes, including persistent inflammation, induced autoimmunity, and putative viral reservoirs. The disease is called 'long-haul COVID' or 'post-COVID-19 syndrome', and clinical symptoms include fatigue, dyspnea, and neuropsychiatric syndromes.

NATURE IMMUNOLOGY (2022)

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Article Clinical Neurology

Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study

Alex Buoite Stella et al.

Summary: The study revealed that dysautonomia may be a possible complication in post-COVID individuals, presenting symptoms such as orthostatic intolerance, sudomotor dysfunction, gastrointestinal issues, and pupillomotor dysfunction. Patients with neurological symptoms had a higher COMPASS-31 score due to more severe orthostatic intolerance symptoms compared to those without neurological symptoms.

JOURNAL OF NEUROLOGY (2022)

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Review Biochemistry & Molecular Biology

Dissecting the Molecular Mechanisms Surrounding Post-COVID-19 Syndrome and Neurological Features

Mohamed S. Mohamed et al.

Summary: Many survivors of COVID-19 are experiencing persistent symptoms, known as post-COVID-19 syndrome or long COVID, which significantly impact their quality of life. Understanding the mechanisms behind this syndrome is crucial for diagnosis, biomarker development, and potential treatments. This article discusses the prevalence and manifestations of post-COVID-19 syndrome, as well as the molecular mechanisms underlying its neurological features, highlighting potential targets for pharmacological intervention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, General & Internal

Impaired Endothelial Function in Convalescent Phase of COVID-19: A 3 Month Follow Up Observational Prospective Study

Luca Santoro et al.

Summary: This study evaluated the impact of COVID-19 severity on endothelial function three months after the acute phase. The findings showed that hospitalized COVID-19 patients had impaired endothelial function after three months, which was correlated with pulmonary function impairment.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Endocrinology & Metabolism

Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19)

Yue Zhou et al.

Summary: The Covid-19 outbreak has evolved into a global health crisis, with the increasing prevalence of obesity and diabetes exacerbating the risks of infectious diseases. This study provides a synthesis of recent advances in understanding the relationships between obesity, diabetes, and Covid-19, offering special treatment guidance for these at-risk populations.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2021)

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Article Medicine, General & Internal

Assessment and characterisation of post-COVID-19 manifestations

Marwa Kamal et al.

Summary: The study found that the majority of COVID-19 survivors experience post-viral symptoms, with fatigue being the most common, and some experiencing severe complications such as stroke and myocarditis. The presence of comorbidities prior to COVID-19 infection is related to the severity of post-COVID-19 manifestations.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

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Article Medicine, General & Internal

Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies

Melanie Dani et al.

Summary: The COVID-19 pandemic has caused unprecedented morbidity, mortality, and disruption, with a new syndrome known as 'long COVID' emerging among survivors. This syndrome, characterized by debilitating symptoms like breathlessness and palpitations, may be related to autonomic nervous system disruption post-infection. Physicians should recognize and support individuals with 'long COVID' symptoms, with a focus on managing the underlying impaired autonomic physiology.

CLINICAL MEDICINE (2021)

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Review Medical Laboratory Technology

COVID-19: from3 an acute to chronic disease? Potential long-term health consequences

Victoria Higgins et al.

Summary: COVID-19, caused by SARS-CoV-2, has resulted in over 57.8 million confirmed cases worldwide with potential long-term health consequences for recovered patients. While multi-organ manifestations are well-documented, the long-term implications remain to be fully uncovered, necessitating large cohort studies to better understand the breadth and severity of long-term effects.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Article Geriatrics & Gerontology

Long Covid and menopause - the important role of hormones in Long Covid must be considered

Louise Newson et al.

MATURITAS (2021)

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Article Cell Biology

Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations

Bing Sun et al.

Summary: A study showed increased levels of plasma cytokines and nEV proteins in individuals recovering from COVID-19, potentially leading to neuronal dysfunction, especially in patients with neurological issues and those recovering from the infection. Longitudinal studies are needed to monitor these biomarkers to assess neural damage and systemic effects.

CELLS (2021)

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Letter Medicine, General & Internal

Sequelae in Adults at 6 Months After COVID-19 Infection

Jennifer K. Logue et al.

JAMA NETWORK OPEN (2021)

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Article Cardiac & Cardiovascular Systems

Evaluation of Endothelial Dysfunction and Inflammatory Vasculopathy After SARS-CoV-2 Infection-A Cross-Sectional Study

Philipp Jud et al.

Summary: The study found that post-COVID-19 patients have higher arterial stiffness, endothelial dysfunction, and inflammatory vasculopathy compared to healthy controls.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Virology

COVID-19 and Neurological Impairment: Hypothalamic Circuits and Beyond

Bashair M. Mussa et al.

Summary: The emergence of SARS-CoV-2 in Wuhan, China in December 2019 led to the global concern of COVID-19. Clinical reports have shown neurological manifestations in COVID-19 patients, indicating involvement of the CNS and PNS. This article reviews the routes and mechanisms of neuroinvasion of SARS-CoV-2, focusing on the role of hypothalamic circuits in mediating neurological symptoms during COVID-19 infection.

VIRUSES-BASEL (2021)

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News Item Medicine, General & Internal

Covid-19: Middle aged women face greater risk of debilitating long term symptoms

Ingrid Torjesen

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Environmental Sciences

Post-COVID-19 Syndrome and the Potential Benefits of Exercise

Amaya Jimeno-Almazan et al.

Summary: Post-COVID-19 syndrome poses a serious challenge, with patients potentially experiencing effects of the disease beyond 12 weeks. While there are concerns about diagnostic identification, regular exercise can help improve many symptoms and reduce the long-term effects of COVID-19.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Physiology

Alteration of Autonomic Nervous System Is Associated With Severity and Outcomes in Patients With COVID-19

Yuchen Pan et al.

Summary: Assessing autonomic function in COVID-19 patients, it was found that HRV was associated with disease severity. Severe patients showed consistent trends between HRV parameters and laboratory indices, and those without improved HRV parameters required longer recovery time.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Neurosciences

COVID-19 is getting on our nerves: sympathetic neural activity and haemodynamics in young adults recovering from SARS-CoV-2

Nina L. Stute et al.

Summary: SARS-CoV-2 infection may lead to increased resting sympathetic activity, decreased pain perception, and altered physiological stress responses in young adults. If similar autonomic dysregulation is present in older adults, there may be significant adverse implications for cardiovascular health.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Hematology

Persistent endotheliopathy in the pathogenesis of long COVID syndrome

Helen Fogarty et al.

Summary: The study found that endothelial cell activation may persist in convalescent COVID-19 patients and may contribute to the pathogenesis of long COVID. This sustained endotheliopathy was more common in older, comorbid patients, and those requiring hospitalization, indicating a potential link between endothelial dysfunction and long-term COVID symptoms.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Neurosciences

Emerging COVID-19 Neurological Manifestations: Present Outlook and Potential Neurological Challenges in COVID-19 Pandemic

Saikat Dewanjee et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to a year-long phase of public health adversaries and compromised healthcare globally. Understanding of neurological complications in COVID-19 patients is still limited, and factors such as age, sex, comorbidity, and disease severity play a role in exacerbating neurological manifestations in these patients.

MOLECULAR NEUROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Clinical Assessment of Endothelial Function in Convalescent COVID-19 Patients Undergoing Multidisciplinary Pulmonary Rehabilitation

Pasquale Ambrosino et al.

Summary: This study found that endothelial function improved in convalescent COVID-19 patients after pulmonary rehabilitation, with a direct correlation between pulmonary function and endothelial health. Endothelial function testing may be useful for follow-up care in these patients.

BIOMEDICINES (2021)

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Article Health Care Sciences & Services

Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study

Max Augustin et al.

Summary: The study observed long-term symptoms in non-hospitalised patients post SARS-CoV-2 infection for four and seven months, identifying persistent symptoms such as shortness of breath, anosmia, ageusia, and fatigue, summarised as post-COVID syndrome (PCS).

LANCET REGIONAL HEALTH-EUROPE (2021)

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Article Psychology, Multidisciplinary

Neuropsychiatric and Cognitive Sequelae of COVID-19

Sanjay Kumar et al.

Summary: COVID-19 may have long-term mental health effects on patients, necessitating global recognition and planning to address mental health issues. Research indicates that patients may develop neurological symptoms and the virus could potentially cause damage to the nervous system, leading to long-term neuropsychiatric sequelae.

FRONTIERS IN PSYCHOLOGY (2021)

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Article Respiratory System

'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

Swapna Mandal et al.

Summary: Following discharge from hospital, a significant number of COVID-19 patients continue to experience persistent symptoms such as breathlessness, cough, fatigue, and depression. Some patients also show elevated levels of biomarkers indicating ongoing health issues. Chest radiographs reveal abnormalities in a considerable portion of patients, with a small percentage showing deterioration.

THORAX (2021)

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Review Neurosciences

Neuroinflammation in heart failure: new insights for an old disease

Hugo S. Diaz et al.

JOURNAL OF PHYSIOLOGY-LONDON (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Editorial Material Biochemistry & Molecular Biology

Neurological Insights of COVID-19 Pandemic

Gaurav Das et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Review Infectious Diseases

Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis

Zhaohai Zheng et al.

JOURNAL OF INFECTION (2020)

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Article Geriatrics & Gerontology

Autonomic Nervous System and Cognitive Impairment in Older Patients: Evidence From Long-Term Heart Rate Variability in Real-Life Setting

Anna Maria Dalise et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Clinical Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Ling Mao et al.

JAMA NEUROLOGY (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Review Oncology

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain

Zhengqian Li et al.

FRONTIERS OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

Yingxia Liu et al.

NATIONAL SCIENCE REVIEW (2020)

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Review Medicine, General & Internal

Impact of COVID-19 on the Cardiovascular System: A Review

Kensuke Matsushita et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Biochemistry & Molecular Biology

SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms

Manuela Pennisi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Health Care Sciences & Services

Planning for the Post-COVID Syndrome: How Payers Can Mitigate Long-Term Complications of the Pandemic

David H. Jiang et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2020)

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Editorial Material Medicine, General & Internal

Long-term Health Consequences of COVID-19

Carlos del Rio et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Editorial Material Physiology

Potential Role of Autonomic Dysfunction in Covid-19 Morbidity and Mortality

Rodrigo Del Rio et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Editorial Material Biochemistry & Molecular Biology

Deleterious Outcomes in Long-Hauler COVID-19: The Effects of SARS-CoV-2 on the CNS in Chronic COVID Syndrome

Abdul Mannan Baig

ACS CHEMICAL NEUROSCIENCE (2020)

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Review Critical Care Medicine

Heart rate variability: Measurement and emerging use in critical care medicine

Brian W. Johnston et al.

JOURNAL OF THE INTENSIVE CARE SOCIETY (2020)

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Article Cardiac & Cardiovascular Systems

Autonomic Nervous System Dysfunction JACC Focus Seminar

Jeffrey J. Goldberger et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Evaluation of the autonomic nervous system by analysis of heart rate variability in the preterm infants

Luiz Fernando Martins de Souza Filho et al.

BMC CARDIOVASCULAR DISORDERS (2019)

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Review Urology & Nephrology

The neural basis of homeostatic and anticipatory thirst

Claire Gizowski et al.

NATURE REVIEWS NEPHROLOGY (2018)

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Article Biology

Ultra-short-term heart rate variability during resistance exercise in the elderly

G.P.T. Arêas et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2018)

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Article Biophysics

Thermography-based blood flow imaging in human skin of the hands and feet: a spectral filtering approach

A. A. Sagaidachnyi et al.

PHYSIOLOGICAL MEASUREMENT (2017)

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Review Biophysics

Infrared thermal imaging in medicine

E. F. J. Ring et al.

PHYSIOLOGICAL MEASUREMENT (2012)

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Article Cardiac & Cardiovascular Systems

Increased muscle sympathetic nerve activity predicts mortality in heart failure patients

Antonio C. P. Barretto et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2009)

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Review Cardiac & Cardiovascular Systems

Basic notions of heart rate variability and its clinical applicability

Luiz Carlos Marques Vanderlei et al.

REVISTA BRASILEIRA DE CIRURGIA CARDIOVASCULAR (2009)

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Review Medicine, General & Internal

Skin blood flow in adult human thermoregulation: How it works, when it does not, and why

N Charkoudian

MAYO CLINIC PROCEEDINGS (2003)

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Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID

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