☆ 4.6 Review

Microalgae as a Nutraceutical Tool to Antagonize the Impairment of Redox Status Induced by SNPs: Implications on Insulin Resistance

BIOLOGY-BASEL (2023)

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Review Nutrition & Dietetics

Bioactivity and Digestibility of Microalgae Tetraselmis sp. and Nannochloropsis sp. as Basis of Their Potential as Novel Functional Foods

Samuel Paterson et al.

Summary: It is estimated that the world's population will exceed 10 billion people by 2050, leading to a decline in global food security. To address this issue, the FAO and WHO have recommended dietary changes to reduce animal calorie intake and increase the consumption of sustainable and nutrient-rich products. Microalgae, such as Tetraselmis and Nannochloropsis, have gained attention as potential sources of functional foods due to their high-value compounds with potential health benefits. However, their use is limited by challenges related to species diversity, cultivation factors, extraction procedures, and limited evidence on safety and bioavailability of microalgae bioactives.

NUTRIENTS (2023)

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Review Biochemistry & Molecular Biology

Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection

Ignacio Moratilla-Rivera et al.

Summary: Neurodegenerative diseases (NDs) are common diseases affecting the West due to increased life expectancy. Cells accumulate oxidative damage, triggering neurodegeneration. The transcription factor Nrf2 regulates endogenous antioxidant systems and induces the transcription of genes containing ARE in response to prooxidant conditions. Natural products such as quercetin, curcumin, and terpenoids can positively modulate Nrf2, reducing oxidative damage to the nervous system. This review aims to update knowledge on the potential treatments for NDs by activating the Nrf2 pathway with secondary metabolites of health interest.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Food Science & Technology

The anti-obesity and anti-diabetic effects of the edible seaweed Gloiopeltis furcata (Postels et Ruprecht) J. Agardh in mice fed a high-fat diet

Shigeru Murakami et al.

Summary: This study found that the polysaccharides from Gloiopeltis furcata can alleviate obesity, diabetes, and metabolic diseases by inhibiting intestinal fat absorption and reducing inflammation and oxidative stress.

FOOD SCIENCE & NUTRITION (2023)

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Review Biochemistry & Molecular Biology

Effects of Microalgae on Metabolic Syndrome

Kartthigeen Tamel Selvan et al.

Summary: Metabolic syndrome (MetS) is a collection of metabolic disturbances, and microalgae has shown potential in alleviating its symptoms through its bioactive compounds. However, there is a lack of comprehensive reviews on this topic. This review discusses the effects of microalgae on MetS, the underlying mechanisms, and the future perspectives of its development as a health supplement.

ANTIOXIDANTS (2023)

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Article Medicine, General & Internal

Polymorphisms of Antioxidant Enzymes SOD2 (rs4880) and GPX1 (rs1050450) Are Associated with Bladder Cancer Risk or Its Aggressiveness

Predrag Nikic et al.

Summary: This study investigated the association of GPX1 (rs1050450) and SOD2 (rs4880) genetic variants with the risk of urothelial bladder cancer (UBC) independently and in combination with smoking. The results showed that carrying at least one variant SOD2 Val allele significantly increased the risk of UBC, especially in smokers. Furthermore, GPX1 genetic polymorphism was associated with the aggressiveness of the disease.

MEDICINA-LITHUANIA (2023)

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Article Medicine, Research & Experimental

Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy

R. Dhanya

Summary: Quercetin, a bioflavonoid, shows promising potential in managing Type 2 diabetes and its complications. Further studies are needed to establish optimal dosing regimen and improve bioavailability.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Pharmacology & Pharmacy

Obesity and insulin resistance: Pathophysiology and treatment

Yue Tong et al.

Summary: The prevalence of obesity is a major cause of chronic metabolic disorders. This review discusses the mechanisms of insulin resistance and current therapeutic strategies for obesity.

DRUG DISCOVERY TODAY (2022)

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Review Cell Biology

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Sajad Fakhri et al.

Summary: Despite progress in understanding the pathophysiological mechanisms of neurodegenerative diseases and spinal cord injury, effective treatments are still lacking. Oxidative stress and inflammatory pathways are major factors in the dysregulated pathways following spinal cord injury. Polyphenols have the potential to be alternative therapeutic agents, regulating neuronal oxidative stress, neuroinflammation, and axonal regeneration. Combination therapy of polyphenols and stem cells shows promise in improving post-spinal cord injury complications.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Green & Sustainable Science & Technology

Recent advances in lutein production from microalgae

Heshan Zheng et al.

Summary: This review summarizes recent research progress in lutein production from microalgae, including the selection of competitive microalgal strains, cultivation systems, and subsequent biomass treatment technologies. By selecting high yielding strains and optimizing photobioreactor design, maximal lutein production from microalgae can be economically viable.

RENEWABLE & SUSTAINABLE ENERGY REVIEWS (2022)

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Article Nutrition & Dietetics

Dietary Carotenoids in Head and Neck Cancer-Molecular and Clinical Implications

Katarzyna Starska-Kowarska

Summary: Head and neck cancer is one of the most common cancers worldwide and remains a leading cause of death. A diet rich in carotenoids has been found to be associated with a reduced risk of head and neck cancer. This review examines the potential anticancer effects of dietary carotenoids and summarizes the limited clinical and preclinical research in this field.

NUTRIENTS (2022)

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Article Biochemistry & Molecular Biology

Relationships between Skin Carotenoid Levels and Metabolic Syndrome

Yuji Takayanagi et al.

Summary: This study found that the antioxidant capacity of carotenoids plays an important role in metabolic syndrome, and non-invasive measurement of skin carotenoid levels using reflection spectroscopy is a useful method to detect participants at risk of developing metabolic syndrome in a large population.

ANTIOXIDANTS (2022)

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Article Food Science & Technology

The Extraction of β-Carotene from Microalgae for Testing Their Health Benefits

Jing Wang et al.

Summary: Beta-carotene, an important carotenoid, can be extracted from microalgae and has been found to have biological activities such as promoting lifespan and reducing oxidative stress. However, further studies are needed to explore the health benefits and functional mechanisms of beta-carotene in microalgae extracts.

FOODS (2022)

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Article Chemistry, Medicinal

Antioxidant effects of astaxanthin and metformin combined therapy in type 2 diabetes mellitus patients: a randomized double-blind controlled clinical trial

Nikoo Roustaei Rad et al.

Summary: The study demonstrates that AST supplementation in combination with metformin has a synergistic effect in controlling oxidative stress in T2DM patients. This combination therapy improves antioxidant capacity by inducing Nrf2 transcription factor and activating SOD and catalase. Consequently, AST and metformin together may be beneficial in modifying oxidative stress and preventing T2DM complications.

RESEARCH IN PHARMACEUTICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling

Bhuvaneshwari R. Gehi et al.

Summary: This study investigated the presence of intrinsic disorder in proteins of the oxidative stress-induced JNK signaling cascade. It was found that most proteins in this pathway contain disordered regions, with scaffold proteins and transcription factors having the highest levels of intrinsic disorder. Additionally, the study characterized the molecular recognition features, posttranslational modification sites, and short linear motifs associated with the predicted disordered regions in these proteins.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Review Peripheral Vascular Disease

Controversies in the Use of Omega-3 Fatty Acids to Prevent Atherosclerosis

Renato Quispe et al.

Summary: This article discusses the controversies surrounding the clinical use of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and examines the discrepancies between recent trials. Recent evidence suggests that high-purity EPA can reduce the risk of cardiovascular events in individuals with high triglycerides, while trials of mixed EPA/DHA products have consistently failed to improve cardiovascular outcomes. The differences in results may be attributed to variations in omega-3 FA products, dosing, study populations, and study designs.

CURRENT ATHEROSCLEROSIS REPORTS (2022)

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Review Biotechnology & Applied Microbiology

Sustainable production of eicosapentaenoic acid-rich oil from microalgae: Towards an algal biorefinery

Rohith Sivakumar et al.

Summary: Utilization of sustainable natural resources such as microalgae for the production of high-value products like biofuels, aquaculture feed, and bioactives is of great importance. EPA-rich microalgae oil is a promising resource that can be maximized through multi-product biorefinery for various applications. This approach is seen as a sustainable and economically feasible possibility for large-scale production of microalgae for biodiesel, jet fuel, nutraceuticals, animal and aquaculture feed, etc.

JOURNAL OF APPLIED MICROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling

Jeppe Nielsen et al.

Summary: Insulin regulates glucose homeostasis by binding and activating the insulin receptor in an asymmetric manner. This study reveals how insulin binds at two distinct sites and disrupts the autoinhibited state, stabilizing the active state of the receptor.

JOURNAL OF MOLECULAR BIOLOGY (2022)

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Review Genetics & Heredity

The genetics of obesity: from discovery to biology

Ruth J. F. Loos et al.

Summary: In this review, Loos and Yeo summarize our current understanding of the genetic underpinnings of monogenic and polygenic obesity, highlighting shared genetic and biological underpinnings between the two forms of obesity. Genome-wide association studies with increasing sample sizes have driven recent discoveries, with post-GWAS collaborations facilitating translation of genetic loci into meaningful biology and new treatment avenues.

NATURE REVIEWS GENETICS (2022)

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Review Chemistry, Medicinal

Fucoxanthin from Algae to Human, an Extraordinary Bioresource: Insights and Advances in up and Downstream Processes

Anne Pajot et al.

Summary: This review presents the biological functions, chemical structure, and functional activities of fucoxanthin in human health. The production methods and extraction technologies are discussed, along with an analysis of the market and future prospects.

MARINE DRUGS (2022)

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Article Biochemistry & Molecular Biology

SOD2 rs4880 and GPX1 rs1050450 polymorphisms do not confer risk of COVID-19, but influence inflammation or coagulation parameters in Serbian cohort

Djurdja Jerotic et al.

Summary: The distribution of antioxidant genetic polymorphisms in COVID-19 patients and controls was assessed, and their association with laboratory biochemical parameters was investigated. The GSTP1 haplotype was found to be associated with COVID-19 risk. Polymorphisms of SOD2 and GPX1 influenced laboratory biochemical profile in COVID-19 patients.

REDOX REPORT (2022)

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Article Endocrinology & Metabolism

Association of genetic variants in the Sirt1 and Nrf2 genes with the risk of metabolic syndrome in a Chinese Han population

T. T. Tao et al.

Summary: The Sirt1 rs7895833 SNP contributes to the susceptibility of MetS as well as glycemic and metabolic traits in a Chinese population.

BMC ENDOCRINE DISORDERS (2022)

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Review Biotechnology & Applied Microbiology

An overview of microalgae biomass as a sustainable aquaculture feed ingredient: food security and circular economy

Ashfaq Ahmad et al.

Summary: Sustainable management of natural resources is critical to food security, particularly for the expansion of the shrimp feed and fishery sector. Microalgal biomass has the potential to serve as an environmentally friendly and nutrient-rich alternative to fish feed ingredients. Fish and microalgae have similar nutritional profiles, and highly digestible feed can reduce production costs, feed waste, and the risk of pollution.

BIOENGINEERED (2022)

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Review Pharmacology & Pharmacy

Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

Akansha Chauhan et al.

Summary: Nuclear factor kappa B (NF-κB) is a crucial regulator of signalome and plays a pivotal role in cell functions and cancer progression. Various phytochemicals have been found to modulate NF-κB signaling pathways, providing new insights for cancer-directed interventions.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2022)

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Article Biochemistry & Molecular Biology

Genetic Variations on Redox Control in Cardiometabolic Diseases: The Role of Nrf2

Cecilia Zazueta et al.

Summary: The polymorphisms of Nrf2-related genes are associated with cardiometabolic diseases and have an impact on cardiovascular health. Further research on the implications of Nrf2 polymorphisms on cardiometabolic disease progression and prevalence is essential for developing more accurate protective strategies.

ANTIOXIDANTS (2022)

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Article Nutrition & Dietetics

Dietary Acid Load but Not Mediterranean Diet Adherence Score Is Associated With Metabolic and Cardiovascular Health State: A Population Observational Study From Northern Italy

Juana Maria Sanz et al.

Summary: Diet plays a crucial role in the development of chronic diseases. The Mediterranean diet has been shown to be beneficial for cardiometabolic health, while the Western diet has detrimental effects. This study found that dietary acid load is associated with metabolic and cardiovascular prognosis, and that assessing DAL using 24-hour dietary recalls may be a better predictor of cardiometabolic health compared to MDA evaluated using food frequency questionnaires.

FRONTIERS IN NUTRITION (2022)

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Article Nutrition & Dietetics

Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study

Jung-Piao Tsao et al.

Summary: The study showed that 7-day oral quercetin supplementation enhanced high-intensity cycling time to exhaustion, possibly due to increased whole-body insulin-stimulated glucose uptake and attenuation of exercise-induced oxygen stress and pro-inflammation.

FRONTIERS IN NUTRITION (2022)

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Article Chemistry, Multidisciplinary

Optimization of extraction process parameters of caffeic acid from microalgae by supercritical carbon dioxide green technology

Smritikana Pyne et al.

Summary: In this study, the optimization of extraction process parameters of caffeic acid from Spirulina platensis using supercritical green technology was performed. The supercritical carbon dioxide (SC-CO2) extraction parameters were optimized using Box-Behnken design and response surface methodology. The extracted caffeic acid content reached its highest level at the optimized extraction conditions, along with high total phenolic content and antioxidant properties. Additionally, the extract exhibited antimicrobial activity.

BMC CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

The Effect of beta-Carotene, Tocopherols and Ascorbic Acid as Anti-Oxidant Molecules on Human and Animal In Vitro/In Vivo Studies: A Review of Research Design and Analytical Techniques Used

Krystian Miazek et al.

Summary: This review presents the antioxidant properties of beta-carotene, tocopherols and ascorbic acid based on in vitro, in vivo and populational studies. The mechanisms of oxidative stress occurrence and antioxidant defense are discussed, as well as the effectiveness of beta-carotene, tocopherols and ascorbic acid as antioxidants. The detection methods of oxidative stress biomarkers and the potential use of Raman spectroscopy and imaging in studying the effects of antioxidants on cell structure and metabolism are also presented.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model

Nancy Nabil Shahin et al.

Summary: The study prepared a CAPE-loaded nanoliposomal formulation which significantly improved the efficacy of CAPE for acute pancreatitis management, displaying superior antioxidant, anti-inflammatory, and anti-apoptotic effects.

ANTIOXIDANTS (2022)

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Review Food Science & Technology

Microalgae: Bioactive Composition, Health Benefits, Safety and Prospects as Potential High-Value Ingredients for the Functional Food Industry

Josephine Ampofo et al.

Summary: The global population is estimated to reach 9.22 billion by 2075. Microalgae, an aquatic microorganism, have diverse bioactive compounds with positive health effects such as lowering blood pressure, anti-obesity, antioxidative, anticancer, and cardiovascular protection. Despite facing challenges in species diversity, biomass, and cultivation factors, there are still great opportunities to develop functional foods using microalgae.

FOODS (2022)

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Article

Antioxidative Responses of Chlorella vulgaris Under Different Growth Phases

Norhayati Yusuf et al.

Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology (2022)

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Review Chemistry, Medicinal

Fucoxanthin Production of Microalgae under Different Culture Factors: A Systematic Review

Yam Sim Khaw et al.

Summary: This study systematically reviews the production of fucoxanthin in microalgae under different conditions. Microalgae are found to be a more reliable source of fucoxanthin compared to macroalgae, with higher fucoxanthin content achievable by adjusting the light intensity. The findings and recommendations from this study provide insights into the feasibility of commercial fucoxanthin production.

MARINE DRUGS (2022)

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Review Biochemistry & Molecular Biology

Carotenoids in Drug Discovery and Medicine: Pathways and Molecular Targets Implicated in Human Diseases

Damilohun Samuel Metibemu et al.

Summary: This review focuses on the biosynthesis and extraction of carotenoids, their roles in human health, metabolism, and their potential as drugs and supplements.

MOLECULES (2022)

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Article Food Science & Technology

Bioactive compounds in microalgae and their potential health benefits

Linhui Zhou et al.

Summary: Driven by concerns about food security, microalgae have gained attention for their resource-efficient production and high nutritional value. They contain various bioactive compounds with health-promoting effects such as anti-oxidative, anti-inflammatory, anti-cancer, and antimicrobial properties. While microalgae are being applied in the food and aquaculture industries, obstacles to commercial application remain due to technological immaturity and high production costs.

FOOD BIOSCIENCE (2022)

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Review Biochemistry & Molecular Biology

Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid

Agnieszka Gegotek et al.

Summary: This review highlights the importance of ascorbate as a strong antioxidant and its various mechanisms of action. It also emphasizes the interaction of ascorbate with other antioxidants and its role in promoting antioxidant proteins and transcription factors.

ANTIOXIDANTS (2022)

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Article Food Science & Technology

Microalgae-based products: Food and public health

Ana Paula Ferreira de Oliveira et al.

Summary: Microalgae biomass offers beneficial compounds for human nutrition, and microalgae-based foods present opportunities for research and development. These foods could be sold as supplements and innovative products, contributing to global food security. However, the presence of residues and contaminants in microalgae biomass could pose risks to human health, emphasizing the need for monitoring and control.

FUTURE FOODS (2022)

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Article Biochemistry & Molecular Biology

Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer's Disease

Vasileios Siokas et al.

Summary: In this study, no association was found between SOD2 rs4880 and AD in any of the examined genetic models. The results suggest that SOD2 rs4880 may not play a determining role in the risk of developing AD. Larger studies are needed to further elucidate the connection between rs4880 and AD.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Mengwei Li et al.

Summary: The centenary of insulin discovery provides an important opportunity to transform diabetes from a fatal diagnosis to a manageable chronic condition. Insulin resistance, associated with obesity, diabetes, and other abnormalities, is caused by abnormal biological response to insulin stimulation. Recent studies suggest that dysregulated metabolic mediators released by adipose tissue contribute to insulin resistance. Although there is no specific medication for insulin resistance, lifestyle changes and pharmacological interventions have been used to improve insulin sensitivity.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Proceedings Paper Materials Science, Multidisciplinary

Antioxidant property of beta-cryptoxanthin produced by Kocuria marina DAGII

Daiji Brahma et al.

Summary: The study evaluated the antioxidant activity of beta-cryptoxanthin extracted from the gram positive bacteria Kocuria marina DAGII isolated from soil. The results showed significant antioxidant properties of beta-cryptoxanthin, with activity increasing with concentration. Beta-cryptoxanthin can serve as an economical pigment with antioxidant properties.

MATERIALS TODAY-PROCEEDINGS (2022)

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Review Food Science & Technology

The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Domenico Sergi et al.

Summary: AGEs are a group of molecules produced through non-enzymatic reactions, implicated in complications of diabetes and metabolic health, contributing to the development of type 2 diabetes and obesity.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Review Nutrition & Dietetics

From carotenoid intake to carotenoid blood and tissue concentrations - implications for dietary intake recommendations

Volker Boehm et al.

Summary: There is uncertainty in carotenoid intake recommendations, as the effects depend on study type, dosage, and matrix. Interindividual variations in blood/tissue carotenoid concentrations make the relationship with health effects unclear and highly variable.

NUTRITION REVIEWS (2021)

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Review Chemistry, Medicinal

Biological Role of AKT and Regulation of AKT Signaling Pathway by Thymoquinone: Perspectives in Cancer Therapeutics

Md Junaid et al.

Summary: AKT is a crucial enzyme in cancer development, and the natural compound TQ found in black cumin has shown potential anti-cancer activities by inhibiting AKT signaling pathways. Despite the development of numerous drugs targeting AKT, only a few have successfully passed clinical trials.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Association between rs662 (A > G) and rs854560 (A > T) polymorphisms in PON1 gene and the susceptibility for psoriasis in mestizo population of Western Mexico

A. A. Hernandez-Collazo et al.

Summary: The study aimed to determine the association of rs662 (A > G) and rs854560 (A > T) PON1 polymorphisms with psoriasis susceptibility in Western Mexico population. The results showed that the G allele of rs662 (A > G) is associated with risk for psoriasis, while the T allele of rs854560 (A > T) is associated with low susceptibility to psoriasis. It suggests that carriers of G allele of rs662 (A > G) present a greater susceptibility to psoriasis.

MOLECULAR BIOLOGY REPORTS (2021)

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Review Physiology

Ceramides in Metabolism: Key Lipotoxic Players

Bhagirath Chaurasia et al.

Summary: The review discusses the impact of lipid metabolites like ceramides on metabolic diseases and the potential therapeutic approaches to combat them.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 83 (2021)

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Article Chemistry, Medicinal

Carotenoid Production from Microalgae: Biosynthesis, Salinity Responses and Novel Biotechnologies

Yuanyuan Ren et al.

Summary: Microalgae are excellent biological factories for high-value products and biofunctional carotenoids. Carotenoids are natural pigments with high value in production and human health. Astaxanthin, beta-carotene, and lutein are currently the three carotenoids with the largest market share. Other pigments like fucoxanthin and zeaxanthin in microalgae also have great biofunctional potentials.

MARINE DRUGS (2021)

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Editorial Material Biology

Are mitochondria the main contributor of reactive oxygen species in cells?

Yufeng Zhang et al.

Summary: Although mitochondria are considered as the main producers of ROS in cells, data supporting such an assumption are lacking. Mitochondria are one of the significant sources of cellular ROS, but they are not necessarily the main contributors under normal conditions, even under various stressors.

JOURNAL OF EXPERIMENTAL BIOLOGY (2021)

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Review Nutrition & Dietetics

Edible Microalgae and Their Bioactive Compounds in the Prevention and Treatment of Metabolic Alterations

Sara Ramos-Romero et al.

Summary: Microalgae are considered as excellent future foods due to their high-quality protein content and rich bioactive molecules, which have potential activity against modern epidemics of obesity and diabetes. They may contribute beneficial effects against metabolic syndrome through antioxidant, anti-inflammatory, and other bioactive components at different stages.

NUTRIENTS (2021)

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Review Microbiology

Fatty Acids Derivatives From Eukaryotic Microalgae, Pathways and Potential Applications

Martina Blasio et al.

Summary: The exploitation of petrochemical hydrocarbons is harming the environment and human health, leading biotechnological research to focus on sustainable materials from plants and microalgae. Fatty acid derivatives from microalgae have various applications in biofuels, cosmetics, pharmaceuticals, and nutraceuticals, offering potential for increasing the viability of microalgal biotechnologies. Nannochloropsis spp. are particularly promising for biotechnological applications due to their fast growth rates and unique fatty acid and cell wall polymer compositions.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Food Science & Technology

Microalgae Xanthophylls: From Biosynthesis Pathway and Production Techniques to Encapsulation Development

Slim Smaoui et al.

Summary: This review focuses on the importance of xanthophylls from microalgae in scientific and industrial fields, covering their chemical diversity, extraction techniques, biosynthetic pathways, and advancements in encapsulation technologies.

FOODS (2021)

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Article Medicine, General & Internal

Evaluating the role of GSTP1 genetic polymorphism (rs1695, 313A>G) as a predictor in cyclophosphamide-induced toxicities

Jin-Yu Gong et al.

Summary: The study investigated the association between GSTP1 rs1695 polymorphism and cyclophosphamide-induced toxicities, with results showing increased risks of gastrointestinal toxicity and infection in patients with AG and GG genotypes. Significant associations were found in SLE or lupus nephritis syndrome patients, emphasizing the predictive role of GSTP1 rs1695 polymorphism in cyclophosphamide-induced toxicities. More studies are needed to confirm these findings in the future.

MEDICINE (2021)

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Article Multidisciplinary Sciences

Paraoxonase 1 concerning dyslipidaemia, cardiovascular diseases, and mortality in haemodialysis patients

Alicja E. Grzegorzewska et al.

Summary: The study found that polymorphisms of the PON1 gene and serum PON1 activity are associated with the risk of atherosclerosis, ischemic cerebral stroke, and cardiovascular mortality in uremic patients receiving hemodialysis.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Microalgal production of zeaxanthin

Loic Bourdon et al.

Summary: The study found that microalgae could potentially be used for zeaxanthin production, with Synechococcus PCC7002 showing the highest growth rate. By optimizing the process, cell density increased by approximately 13-fold, achieving a zeaxanthin productivity of 0.7 mg L-1 day-1. This approach could also be applied to the production of other compounds.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2021)

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Review Physiology

Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress

Hasna Tirichen et al.

Summary: Mitochondrial reactive oxygen species (mtROS) and oxidative stress (OS) result in oxidative damage to cellular components such as lipids, DNA, and proteins, contributing to kidney damage and the progression of chronic kidney disease (CKD).

FRONTIERS IN PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Reactive oxygen species in exercise and insulin resistance: Working towards personalized antioxidant treatment

Kathryn McKeegan et al.

Summary: This study reviewed the impact of antioxidant treatment on glycemic control in both healthy and diseased individuals, highlighting key factors influencing the effectiveness of antioxidant therapy such as treatment context, endogenous antioxidant deficiencies, antioxidant specificity, and bioavailability. The majority of human research failed to consider these factors, limiting the ability to robustly test the effectiveness of antioxidants for health promotion and disease prevention. It is suggested that a modern redox screening and personalized antioxidant treatment approach is needed to explore redox regulation of human physiology and improve antioxidant therapy efficacy in humans.

REDOX BIOLOGY (2021)

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Article Endocrinology & Metabolism

Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus

Amani M. T. Gusti et al.

Summary: This study found that oxidative stress-related molecular markers, such as GSTT1 rs17856199 and NOS2 rs2297518 variants, were significantly associated with the risk and phenotype of type 2 diabetes in the study population. These genetic variants play a crucial role in the occurrence and development of T2DM, and have different effects on factors such as sex, BMI, hyperglycemia, and/or hyperlipidemia.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

Carotenoids from Cyanobacteria: Biotechnological Potential and Optimization Strategies

Fernando Pagels et al.

Summary: Carotenoids in cyanobacteria play a crucial role in photosynthesis and photoprotection, showing potential in natural antioxidant, anti-inflammatory, and anti-tumoral applications. Although not the primary choice for industrial production, cyanobacteria offer a sustainable and environmentally friendly approach to pigment production with optimized bioprocesses.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study

Amani M. T. Gusti et al.

Summary: The study investigated the association of 12 SNPs related to antioxidants with obesity susceptibility in a Saudi population. Results suggest that genetic determinants related to oxidative stress could significantly associate with obesity risk in the study population.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Insulin Signal Transduction Perturbations in Insulin Resistance

Mariyam Khalid et al.

Summary: Type 2 diabetes mellitus is characterized by high blood glucose and inadequate insulin action, caused by insulin resistance which involves multiple molecular and pathophysiological mechanisms. Although various factors like metabolic disorders, lipotoxicity, and inflammation contribute to insulin resistance, a central underlying mechanism has yet to be identified. This review focuses on defects in insulin signal transduction pathway, emphasizing the importance of the AGE-RAGE-NF-kappa B axis, in providing new insights for future interventions in type 2 diabetes mellitus.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Administration of vitamin E attenuates airway inflammation through restoration of Nrf2 in a mouse model of asthma

Quang Luu Quoc et al.

Summary: Accumulating evidence suggests that ROS is a key mediator in asthma development, and antioxidants may have beneficial effects. In older mice, oxidative stress and inflammation levels are elevated, while vitamin E treatment can restore Nrf2 levels and improve airway hyperresponsiveness.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Chemistry, Medicinal

Microalgae as Sustainable Bio-Factories of Healthy Lipids: Evaluating Fatty Acid Content and Antioxidant Activity

Tiago A. Conde et al.

Summary: The study used gas-chromatography mass-spectrometry to characterize the fatty acid profiles of seven different commercial microalgae, revealing unique compositions among them, especially in terms of omega-3 fatty acids, with species of the same phylum showing similar trends. Additionally, the research found that different lipid extracts exhibited comparable antioxidant activities, further demonstrating the potential of microalgae as sustainable and healthy sources of essential lipids.

MARINE DRUGS (2021)

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Review Nutrition & Dietetics

Mechanistic aspects of carotenoid health benefits - where are we now?

Torsten Bohn et al.

Summary: Intake and tissue levels of carotenoids are associated with reduced risk of chronic diseases, but intervention trials with isolated carotenoid supplements have mostly failed to confirm health benefits. Basic mechanisms include antioxidant actions and activation of nuclear hormone receptor pathways, with potential different mechanisms for different diseases.

NUTRITION RESEARCH REVIEWS (2021)

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Review Nutrition & Dietetics

Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing

Katherina V. Gantenbein et al.

Summary: Healthy nutrition, especially the Mediterranean diet, rich in anti-inflammatory and antioxidant components, helps reduce the incidence of obesity, diabetes, and other non-communicable diseases. The MD not only benefits physical health but also improves reproductive health, reduces the risk of neurodegenerative diseases, and provides protection against mental health issues.

NUTRIENTS (2021)

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Article Biology

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

Alison L. Kearney et al.

Summary: The study reveals that Akt phosphorylates IRS1 and IRS2, engaging in a negative feedback mechanism that limits the synthesis of PIP3 and plasma membrane-associated PI3K. This phosphorylation leads to the depletion of IRS1/2 from the plasma membrane, reducing their interaction with the insulin receptor.

ELIFE (2021)

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Review Food Science & Technology

Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases

Shuai Jiang et al.

Summary: Oxidative stress is an imbalance between oxidants and antioxidants, leading to molecular damage and disruption of redox signaling. A healthy diet can regulate oxidative stress, maintain cellular and tissue homeostasis, and prevent inflammation and chronic metabolic diseases.

FOODS (2021)

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Article Health Care Sciences & Services

Single Nucleotide Polymorphism rs17173608 in the Chemerin Encoding Gene: Is It a Predictor of Insulin Resistance and Severity of Coronary Artery Disease in Non-Obese Type 2 Diabetes?

Sangeetha Perumalsamy et al.

Summary: The study revealed a significant association between the RARRES2 rs17173608 variant and both insulin resistance and the severity of CAD, with significant associations found in both preliminary and secondary analysis. The secondary analysis also indicated correlations between FPG and ACEI with insulin resistance and the severity of CAD.

HEALTHCARE (2021)

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Article Cell Biology

ROS and diseases: role in metabolism and energy supply

Shenshu Yang et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)

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Review Fisheries

Applications of microalga Chlorella vulgaris in aquaculture

Muhammad Talba Ahmad et al.

REVIEWS IN AQUACULTURE (2020)

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Review Food Science & Technology

Lutein as a functional food ingredient: Stability and bioavailability

Mario Ochoa Becerra et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Biochemistry & Molecular Biology

Phenols and Melanoidins as Natural Antioxidants in Beer. Structure, Reactivity and Antioxidant Activity

Alvaro Martinez-Gomez et al.

BIOMOLECULES (2020)

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Article Biotechnology & Applied Microbiology

Monitoring of eicosapentaenoic acid (EPA) production in the microalgae Nannochloropsis oceanica

Marta Sa et al.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2020)

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Article Biotechnology & Applied Microbiology

Development of a Chlorella vulgaris mutant by chemical mutagenesis as a producer for natural violaxanthin

Jongrae Kim et al.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2020)

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Article Nutrition & Dietetics

Cytoprotective Effect of Ascorbic Acid and Rutin against Oxidative Changes in the Proteome of Skin Fibroblasts Cultured in a Three-Dimensional System

Agnieszka Gegotek et al.

NUTRIENTS (2020)

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Article Biochemical Research Methods

Single nucleotide polymorphisms affect RNA-protein interactions at a distance through modulation of RNA secondary structures

Elan Shatoff et al.

PLoS Computational Biology (2020)

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Review Biochemistry & Molecular Biology

Interrelation between ROS and Ca2+ in aging and age-related diseases

Corina T. Madreiter-Sokolowski et al.

REDOX BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Microalgae: A Promising Source of Valuable Bioproducts

Vyacheslav Dolganyuk et al.

BIOMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Microalgae-Derived Pigments: A 10-Year Bibliometric Review and Industry and Market Trend Analysis

Samara C. Silva et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

DHA-enriched fish oil reduces insulin resistance in overweight and obese adults

K. A. Abbott et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2020)

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Article Biochemistry & Molecular Biology

Oxidative Stress and Analysis of Selected SNPs ofACHE(rs 2571598),BCHE(rs 3495),CAT(rs 7943316),SIRT1(rs 10823108),GSTP1(rs 1695), and GeneGSTM1,GSTT1in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan

Leonel Javeres Mbah Ntepe et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Plant Sciences

Canthaxanthin, a Red-Hot Carotenoid: Applications, Synthesis, and Biosynthetic Evolution

Barbara A. Rebelo et al.

PLANTS-BASEL (2020)

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Review Medicine, General & Internal

Ascorbic acid supplementation in type 2 diabetes mellitus A protocol for systematic review and meta-analysis

Lipeng Shi et al.

MEDICINE (2020)

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Review Biotechnology & Applied Microbiology

Challenging microalgal vitamins for human health

Angelo Del Mondo et al.

MICROBIAL CELL FACTORIES (2020)

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Article Oncology

Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma

Shaimaa Gamal Hassan Elofey et al.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2020)

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Article Clinical Neurology

Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population

Ci Yan et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2020)

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Article Biochemistry & Molecular Biology

Glutathione S-Transferase P1 313 (A > G) Ile105Val Polymorphism Contributes to Cancer Susceptibility in Indian Population: A Meta-analysis of 39 Case-Control Studies

Raju K. Mandal et al.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2020)

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Review Oncology

The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism

Gerta Hoxhaj et al.

NATURE REVIEWS CANCER (2020)

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Article Biochemistry & Molecular Biology

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression

Melissa L. Hancock et al.

CELL (2019)

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Review Endocrinology & Metabolism

Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents

Antonino Di Pino et al.

ENDOCRINE REVIEWS (2019)

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Review Physiology

Mitochondrial (Dys) function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

Domenico Sergi et al.

FRONTIERS IN PHYSIOLOGY (2019)

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Article Multidisciplinary Sciences

Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease

Nisa Decharatchakul et al.

PEERJ (2019)

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Review Medicine, General & Internal

Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials

Tracey J. Brown et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Review Pharmacology & Pharmacy

Liver and insulin resistance: New wine in old bottle!!!

Bhoomika M. Patel et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

The Contribution of Carotenoids, Phenolic Compounds, and Flavonoids to the Antioxidative Properties of Marine Microalgae Isolated from Mediterranean Morocco

Imane Haoujar et al.

MOLECULES (2019)

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Review Nutrition & Dietetics

A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia

Marialaura Simonetto et al.

NUTRIENTS (2019)

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Article Multidisciplinary Sciences

Omega-3 fatty acids decrease oxidative stress and inflammation in macrophages from patients with small abdominal aortic aneurysm

Lara T. Meital et al.

SCIENTIFIC REPORTS (2019)

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Article Agriculture, Dairy & Animal Science

β-carotene attenuates lipopolysaccharide-induced inflammation via inhibition of the NF-κB, JAK2/STAT3 and JNK/p38 MAPK signaling pathways in macrophages

Ruonan Li et al.

ANIMAL SCIENCE JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Zeaxanthin: Metabolism, Properties, and Antioxidant Protection of Eyes, Heart, Liver, and Skin

Ana Gabriela Murillo et al.

ANTIOXIDANTS (2019)

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Article Cell Biology

A phenolic amide (LyA) isolated from the fruits of Lycium barbarum protects against cerebral ischemia-reperfusion injury via PKCε/Nrf2/HO-1 pathway

Kai Gao et al.

AGING-US (2019)

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Article Neurosciences

β-carotene provides neuro protection after experimental traumatic brain injury via the Nrf2-ARE pathway

Peiqing Chen et al.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2019)

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Article Agricultural Engineering

Mixotrophic and heterotrophic production of lipids and carbohydrates by a locally isolated microalga using wastewater as a growth medium

Jean Claude Nzayisenga et al.

BIORESOURCE TECHNOLOGY (2018)

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Review Biochemistry & Molecular Biology

Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases

Jia-Qiang Huang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Genetics & Heredity

Association of paraoxonase-1 gene polymorphisms with insulin resistance in South Indian population

Panneerselvam Gomathi et al.

GENE (2018)

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Review Biotechnology & Applied Microbiology

The promising future of microalgae: current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products

Muhammad Imran Khan et al.

MICROBIAL CELL FACTORIES (2018)

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Review Cell Biology

Nrf2 at the heart of oxidative stress and cardiac protection

Qin M. Chen et al.

PHYSIOLOGICAL GENOMICS (2018)

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Article Multidisciplinary Sciences

Integrative analysis of super enhancer SNPs for type 2 diabetes

Weiping Sun et al.

PLOS ONE (2018)

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Review Nutrition & Dietetics

Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

Marcelo Macedo Rogero et al.

NUTRIENTS (2018)

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Review Nutrition & Dietetics

Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress

Marilena Lepretti et al.

NUTRIENTS (2018)

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Article

Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

Carolina Simioni et al.

Oncotarget (2018)

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Review Physiology

OxInflammation: From Subclinical Condition to Pathological Biomarker

Giuseppe Valacchi et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Biotechnology & Applied Microbiology

Enhancement of docosahexaenoic acid (DHA) production from Schizochytrium sp S31 using different growth medium conditions

Deniz Sahin et al.

AMB EXPRESS (2018)

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Article Food Science & Technology

β-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-κB and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents

Kazim Sahin et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

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Article Biochemistry & Molecular Biology

Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer

Nicole M. Fletcher et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Agriculture, Multidisciplinary

Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells

Katja Frede et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

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Article Chemistry, Medicinal

Spirulina platensis Improves Mitochondrial Function Impaired by Elevated Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells (ASCs) and Intestinal Epithelial Cells (IECs), and Enhances Insulin Sensitivity in Equine Metabolic Syndrome (EMS) Horses

Daria Nawrocka et al.

MARINE DRUGS (2017)

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Article Chemistry, Medicinal

Dual Biological Functions of a Cytoprotective Effect and Apoptosis Induction by Bioavailable Marine Carotenoid Fucoxanthinol through Modulation of the Nrf2 Activation in RAW264.7 Macrophage Cells

Junsei Taira et al.

MARINE DRUGS (2017)

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Review Food Science & Technology

Prospects of microalgae proteins in producing peptide-based functional foods for promoting cardiovascular health

Chukwunonso E. C. C. Ejike et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2017)

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Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

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Article Oncology

The Anti-inflammatory Effect of Personalized Omega-3 Fatty Acid Dosing for Reducing Prostaglandin E2 in the Colonic Mucosa Is Attenuated in Obesity

Zora Djuric et al.

CANCER PREVENTION RESEARCH (2017)

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Review Biochemistry & Molecular Biology

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus

Philipp A. Gerber et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

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Article Biochemistry & Molecular Biology

Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin

Janina Dose et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Food Science & Technology

Inhibitory mechanism against oxidative stress of caffeic acid

Farhan Ahmed Khan et al.

JOURNAL OF FOOD AND DRUG ANALYSIS (2016)

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Review Nutrition & Dietetics

Absorption, metabolism, and functions of β-cryptoxanthin

Betty J. Burri et al.

NUTRITION REVIEWS (2016)

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Article Immunology

Plausible anti-inflammatory mechanism of resveratrol and caffeic acid against chronic stress-induced insulin resistance in mice

Suprithi Choudhary et al.

INFLAMMOPHARMACOLOGY (2016)

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Article Medicine, Research & Experimental

Q192R Polymorphism of Paraoxonase 1 Gene Associated with Insulin Resistance in Mexican Children

Jorge Alejandro Alegria-Torres et al.

ARCHIVES OF MEDICAL RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population

Xia Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Chemistry, Medicinal

Carotenoids, Phenolic Compounds and Tocopherols Contribute to the Antioxidative Properties of Some Microalgae Species Grown on Industrial Wastewater

Hamed Safafar et al.

MARINE DRUGS (2015)

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Review Chemistry, Medicinal

Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases

Maria Filomena de Jesus Raposo et al.

MARINE DRUGS (2015)

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Article Chemistry, Medicinal

Astaxanthin from Haematococcus pluvialis Prevents Oxidative Stress on Human Endothelial Cells without Toxicity

Philippe Regnier et al.

MARINE DRUGS (2015)

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Review Chemistry, Medicinal

Anti-Obesity Activity of the Marine Carotenoid Fucoxanthin

Maria Alessandra Gammone et al.

MARINE DRUGS (2015)

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Article Medicine, General & Internal

The Catalase C-262T Gene Polymorphism and Cancer Risk A Systematic Review and Meta-analysis

Yongchun Shen et al.

MEDICINE (2015)

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Article Multidisciplinary Sciences

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

Yinhua Ni et al.

SCIENTIFIC REPORTS (2015)

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Article Neurosciences

Plant polyphenols as inhibitors of NF-κB induced cytokine production a potential anti-inflammatory treatment for Alzheimer's disease?

Niloo Karunaweera et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2015)

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Review Pharmacology & Pharmacy

Antioxidant properties of HDL

Handrean Soran et al.

FRONTIERS IN PHARMACOLOGY (2015)

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Article Endocrinology & Metabolism

High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study

Minoru Sugiura et al.

BMJ OPEN DIABETES RESEARCH & CARE (2015)

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Article Agricultural Engineering

Induction of canthaxanthin production in a Dactylococcus microalga isolated from the Algerian Sahara

Borhane Samir Grama et al.

BIORESOURCE TECHNOLOGY (2014)

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Article Chemistry, Applied

Profiling of carotenoids and antioxidant capacity of microalgae from subtropical coastal and brackish waters

Faruq Ahmed et al.

FOOD CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

Carotenoid derivatives inhibit nuclear factor kappa B activity in bone and cancer cells by targeting key thiol groups

Karin Linnewiel-Hermoni et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

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Review Biochemistry & Molecular Biology

Genetics of Oxidative Stress in Obesity

Azahara I. Ruperez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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Editorial Material Endocrinology & Metabolism

Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention

Shaodong Guo

JOURNAL OF ENDOCRINOLOGY (2014)

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Article Neurosciences

Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1

Meijuan Zhang et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Plant Sciences

Detection of flavonoids in microalgae from different evolutionary lineages

Koen Goiris et al.

JOURNAL OF PHYCOLOGY (2014)

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Review Chemistry, Medicinal

Chlorella zofingiensis as an Alternative Microalgal Producer of Astaxanthin: Biology and Industrial Potential

Jin Liu et al.

MARINE DRUGS (2014)

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Article Cell Biology

Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death

X. Zou et al.

CELL DEATH & DISEASE (2014)

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Review Biochemistry & Molecular Biology

Reactive metabolites and antioxidant gene polymorphisms in Type 2 diabetes mellitus

Monisha Banerjee et al.

REDOX BIOLOGY (2014)

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Article Engineering, Environmental

Light and growth medium effect on Chlorella vulgaris biomass production

Matthew Forrest Blair et al.

JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2014)

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Article Gastroenterology & Hepatology

Catalase gene C-262T polymorphism: Importance in ulcerative colitis

Siamak Khodayari et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Article Biochemistry & Molecular Biology

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

Takafumi Suzuki et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

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Article Food Science & Technology

Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation

Xu-Dan Guo et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2013)

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Article Cardiac & Cardiovascular Systems

Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study

Cecile M. Povel et al.

CARDIOVASCULAR DIABETOLOGY (2012)

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Review Endocrinology & Metabolism

Catalase polymorphisms and metabolic diseases

Marylise Hebert-Schuster et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2012)

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Review Endocrinology & Metabolism

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

K. D. Copps et al.

DIABETOLOGIA (2012)

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Article Biotechnology & Applied Microbiology

Functional genomics based prioritization of potential nsSNPs in EPHX1, GSTT1, GSTM1 and GSTP1 genes for breast cancer susceptibility studies

Tariq Ahmad Masoodi et al.

GENOMICS (2012)

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Article Genetics & Heredity

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P. Morris et al.

NATURE GENETICS (2012)

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Article Toxicology

Genetic Variants in Antioxidant Genes Are Associated With Diisocyanate-Induced Asthma

Berran Yucesoy et al.

TOXICOLOGICAL SCIENCES (2012)

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Article Plant Sciences

Fatty acid profiles and their distribution patterns in microalgae: a comprehensive analysis of more than 2000 strains from the SAG culture collection

Imke Lang et al.

BMC PLANT BIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Influence of glutathione S-transferase polymorphisms on type-2 diabetes mellitus risk

M. A. Amer et al.

GENETICS AND MOLECULAR RESEARCH (2011)

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Article Multidisciplinary Sciences

Paraoxonase 1 (PON1) Polymorphisms, Haplotypes and Activity in Predicting CAD Risk in North-West Indian Punjabis

Nidhi Gupta et al.

PLOS ONE (2011)

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Article Pharmacology & Pharmacy

Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264 7 macrophages

Kil-Nam Kim et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

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Article Medicine, General & Internal

Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population

H. K. Bid et al.

JOURNAL OF POSTGRADUATE MEDICINE (2010)

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Review Medicine, General & Internal

GENOMIC MEDICINE Genomics, Type 2 Diabetes, and Obesity

Mark I. McCarthy

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Article Endocrinology & Metabolism

Genetic Variants of TCF7L2 Are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults

Pi-Hua Liu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

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Article Biochemistry & Molecular Biology

Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury

Jacqui M. Marzec et al.

FASEB JOURNAL (2007)

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Review Biochemistry & Molecular Biology

AKT/PKB signaling: Navigating downstream

Brendan D. Manning et al.

CELL (2007)

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Article Environmental Sciences

Lead exposure is associated with decreased serum paraoxonase 1 (PON1) activity and genotypes

Wan-Fen Li et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2006)

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Article Oncology

Associations between catalase phenotype and genotype: Modification by epidemiologic factors

Jiyoung Ahn et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2006)

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Article Integrative & Complementary Medicine

Reactive oxygen species (ROS): Pathogens or sources of vital energy? Part 2. Bioenergetic and bioinformational functions of ROS

VL Voeikov

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2006)

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Article Biotechnology & Applied Microbiology

The catalase-262C/T promoter polymorphism and diabetic complications in Caucasians with type 2 diabetes

Katia Goncalves dos Santos et al.

DISEASE MARKERS (2006)

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