4.6 Article

A Rat Model of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism Shows Attenuated Motivation for Alcohol Self-Administration and Diminished Propensity for Cue-Induced Relapse in Females

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Psychiatry

Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory

Emily J. Jaehne et al.

Summary: The BDNF Val66Met polymorphism, associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD, was found to impair fear memory in rats. This impairment was not dependent on animal sex or observed during adolescence, and there were no genotype differences in other types of memory.

TRANSLATIONAL PSYCHIATRY (2022)

Article Biochemistry & Molecular Biology

Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome

David W. Greening et al.

Summary: Studies have shown that chronic Meth abuse can lead to psychotic episodes resembling schizophrenia, with Brain-derived neurotrophic factor (BDNF) playing a crucial role in this process. Research on transgenic mice revealed that BDNF genetic variation significantly influences the long-term brain changes induced by Meth, indicating that drug-induced psychosis may be modulated at the molecular level by a single genetic locus.

MOLECULAR PSYCHIATRY (2021)

Article Neurosciences

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

Natosha M. Mercado et al.

Summary: The study found that rats with the rs6265 SNP showed enhanced transplant efficacy and neurite outgrowth, but also experienced transplant-induced dyskinesias. This suggests that this common genetic mutation can affect transplant therapeutic efficacy and side effects development.

NEUROBIOLOGY OF DISEASE (2021)

Article Behavioral Sciences

Brain-Derived neurotrophic factor Va166Met induces female-specific changes in impulsive behaviour and alcohol self-administration in mice

Natasha L. Hogan et al.

Summary: Impulsivity may be a potential predictor of addiction risk, while the BDNFVal66Met polymorphism may sex-specifically alter aspects of impulsive behavior and addiction propensity.

BEHAVIOURAL BRAIN RESEARCH (2021)

Article Neurosciences

Brain-derived Neurotropic Factor val66met is a Strong Predictor of Decision Making and Attention Performance on the CONVIRT Virtual Reality Cognitive Battery

Michelle Corrone et al.

Summary: This study investigated the impact of the val66met gene on decision making and attention, revealing that carriers of the Val/met genotype performed better in these aspects. They also exhibited higher levels of perceived chronic stress and increased sympathetic activity.

NEUROSCIENCE (2021)

Review Neurosciences

Alcohol and the brain: from genes to circuits

Gabor Egervari et al.

Summary: Alcohol use has diverse effects on the central nervous system, influencing gene expression, signaling mechanisms, and neuronal circuit activity. These mechanisms result in long-lasting cellular adaptations in the brain, which may drive the development and maintenance of alcohol use disorder.

TRENDS IN NEUROSCIENCES (2021)

Article Medicine, Research & Experimental

Growth Factors and Alcohol Use Disorder

Mirit Liran et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)

Article Neurosciences

7,8-Dihydroxyflavone Enhances Cue-Conditioned Alcohol Reinstatement in Rats

Samuel J. Hogarth et al.

BRAIN SCIENCES (2020)

Review Psychiatry

Alcohol use disorder relapse factors: A systematic review

Wilco Sliedrecht et al.

PSYCHIATRY RESEARCH (2019)

Article Behavioral Sciences

Brain-derived neurotrophic factor (BDNF) determines a sex difference in cue-conditioned alcohol seeking in rats

Samuel J. Hogarth et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

Review Neurosciences

Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders

Shih-Jen Tsai

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Article Clinical Neurology

Does genetic BDNF deficiency in rats interact with neurotransmitter control of prepulse inhibition? Implications for schizophrenia

Maarten van den Buuse et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2017)

Review Substance Abuse

Remission from substance use disorders: A systematic review and meta-analysis

M. -J. Fleury et al.

DRUG AND ALCOHOL DEPENDENCE (2016)

Review Pharmacology & Pharmacy

Sex Differences in Animal Models: Focus on Addiction

Jill B. Becker et al.

PHARMACOLOGICAL REVIEWS (2016)

Article Neurosciences

Corticostriatal BDNF and alcohol addiction

Marian L. Logrip et al.

BRAIN RESEARCH (2015)

Article Neurosciences

microRNA-206 in Rat Medial Prefrontal Cortex Regulates BDNF Expression and Alcohol Drinking

Jenica D. Tapocik et al.

JOURNAL OF NEUROSCIENCE (2014)

Review Pharmacology & Pharmacy

BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis

Batoul Sadat Haerian

PHARMACOGENOMICS (2013)

Article Clinical Neurology

Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related phenotypes

Gordana Nedic et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

Article Behavioral Sciences

Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF

Sheketha R. Hauser et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2011)

Review Biochemistry & Molecular Biology

Neuroscience of alcoholism: molecular and cellular mechanisms

Sachin Moonat et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Biochemistry & Molecular Biology

Population genetic study of the brain-derived neurotrophic factor (BDNF) gene

T. L. Petryshen et al.

MOLECULAR PSYCHIATRY (2010)

Review Immunology

Cautionary insights on knockout mouse studies: The gene or not the gene?

Amy F. Eisener-Dorman et al.

BRAIN BEHAVIOR AND IMMUNITY (2009)

Article Neurosciences

Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking

Jerome Jeanblanc et al.

JOURNAL OF NEUROSCIENCE (2009)

Review Pharmacology & Pharmacy

Ethanol-BDNF interactions: Still more questions than answers

Margaret I. Davis

PHARMACOLOGY & THERAPEUTICS (2008)

Review Neurosciences

The role of impulsive behavior in drug abuse

Jennifer L. Perry et al.

PSYCHOPHARMACOLOGY (2008)

Article Geriatrics & Gerontology

Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression

Warren D. Taylor et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2007)

Article Biochemistry & Molecular Biology

Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo

Luxiang Cao et al.

CURRENT BIOLOGY (2007)

Article Multidisciplinary Sciences

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

Zhe-Yu Chen et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF ( plus /-) mice

JG Hensler et al.

JOURNAL OF NEUROCHEMISTRY (2003)