期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2023.1128834
关键词
acute coronary sydrome; body mass index; dual antiplatelet therapy; ticagrelor; drug eluting stent
This study aimed to evaluate the BMI-dependent effect of ticagrelor monotherapy after 3-month DAPT compared with 12-month DAPT on clinical outcomes in patients with ACS. The results showed consistent effects of ticagrelor monotherapy after 3-month DAPT on major clinical outcomes, regardless of BMI.
Background: Although ticagrelor monotherapy after 3-month dual antiplatelet therapy (DAPT) results in a significantly greater net clinical benefit over that with ticagrelor-based 12-month DAPT in patients with acute coronary syndrome (ACS), it remains uncertain whether this effect is dependent on body mass index (BMI). We aimed to evaluate the BMI-dependent effect of these treatment strategies on clinical outcomes. Methods: This was a pre-specified subgroup analysis from the TICO trial (Ticagrelor Monotherapy After 3 Months in Patients Treated With New Generation Sirolimus-eluting Stent for Acute Coronary Syndrome), evaluating the interaction between BMI and treatment strategies for the primary outcome [composite of major bleeding and adverse cardiac and cerebrovascular events (MACCE): death, myocardial infarction, stent thrombosis, stroke, or target-vessel revascularization]. The secondary outcomes were major bleeding and MACCE. Results: Based on a pre-specified BMI threshold of 25 kg/m(2), 3,056 patients were stratified. Patients with BMI <25 kg/m(2) had a higher risk of primary and secondary outcomes than those with BMI >= 25 kg/m(2). Regardless of the BMI subgroup, the effects of ticagrelor monotherapy after 3-month DAPT on the primary outcome ( p(int)= 0.61), major bleeding ( p(int)= 0.76), and MACCE ( p(int)= 0.80) were consistent without significant interaction compared with ticagrelor-based 12month DAPT. The treatment effects according to the BMI quartiles and age, sex, and diabetic status were also consistent without significant interaction. Conclusion: The BMI-dependent impact of ticagrelor monotherapy after 3-month DAPT compared with 12-month DAPT on clinical outcomes was not heterogeneous in patients with ACS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据