Hypertensive heart disease: risk factors, complications and mechanisms

Letter Cardiac & Cardiovascular Systems

Long-Term Efficacy of Colchicine in Patients With Chronic Coronary Disease: Insights From LoDoCo2

Tjerk S. J. Opstal et al.

CIRCULATION (2022)

Review Cardiac & Cardiovascular Systems

Sex Differences in Heart Failure

Anuradha Lala et al.

Summary: Heart failure shows gender differences in prevalence, risk factors, pathophysiology, presentation, and therapies. More research is needed to fully understand and explore these differences.

JOURNAL OF CARDIAC FAILURE (2022)

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Article Cardiac & Cardiovascular Systems

Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial

G. Michael Felker et al.

Summary: This study evaluated the efficacy and safety of omecamtiv mecarbil for severe heart failure patients. The results suggest that omecamtiv mecarbil therapy may have clinically meaningful benefits for patients with severe heart failure, supporting its potential role in patients with limited treatment options.

JAMA CARDIOLOGY (2022)

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Review Medicine, Research & Experimental

Heart Failure with Preserved Ejection Fraction: Mechanisms and Treatment Strategies

Kazunori Omote et al.

Summary: The prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing rapidly, and it has significant impact on the functional capacity and quality of life of patients. Unlike heart failure with reduced ejection fraction, there are limited effective treatments available for HFpEF. Therefore, improved understanding of its pathophysiologic mechanisms and individualized treatment strategies is crucial.

ANNUAL REVIEW OF MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Use of levosimendan combined with Shenfu injection to treat acute heart failure patients with hypotension: a prospective randomized controlled single-blind study

Miaomiao Li et al.

Summary: Levosimendan plus Shenfu injection (SFI) is superior to levosimendan monotherapy in the treatment of acute decompensated heart failure (ADHF) patients, especially those with hypotension, and it significantly improves hemodynamic parameters.

BMC CARDIOVASCULAR DISORDERS (2022)

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Article Public, Environmental & Occupational Health

Global, regional, and national burden of hypertensive heart disease during 1990-2019: an analysis of the global burden of disease study 2019

Yunyan Lu et al.

Summary: This study analyzed the global burden of hypertensive heart disease (HHD) from 1990 to 2019. The results showed an increase in HHD cases over the years, but a decline in mortality rate. The study suggests that improvements in health, education, and income can help alleviate the disease burden of HHD.

BMC PUBLIC HEALTH (2022)

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Article Cardiac & Cardiovascular Systems

Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial

Stephan Willems et al.

Summary: The EAST-AFNET 4 trial showed that early, systematic rhythm control therapy improves clinical outcomes in both symptomatic and asymptomatic atrial fibrillation patients.

EUROPEAN HEART JOURNAL (2022)

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Review Cardiac & Cardiovascular Systems

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Paul A. Heidenreich et al.

Summary: The 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure is an updated version of the 2013 and 2017 guidelines, aiming to provide patient-centric recommendations for the prevention, diagnosis, and management of heart failure. This guideline is based on contemporary evidence and presents an evidence-based approach to improve quality of care and align with patients' interests.

CIRCULATION (2022)

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Article Dermatology

Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity

Andras Maifeld et al.

Summary: Research shows that patients with psoriasis have higher levels of sodium and water in their skin compared to healthy individuals. This high sodium environment may lead to the expansion of pathogenic T helper 17 cells, exacerbating the condition.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Review Biochemistry & Molecular Biology

Interplay between PI3K/AKT pathway and heart disorders

Soudeh Ghafouri-Fard et al.

Summary: The PI3K/AKT signaling pathway plays a crucial role in regulating physiological functions and contributing to the pathogenesis of various diseases.

MOLECULAR BIOLOGY REPORTS (2022)

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Review Cardiac & Cardiovascular Systems

The effects of high-intensity interval training, Nordic walking and moderate-to-vigorous intensity continuous training on functional capacity, depression and quality of life in patients with coronary artery disease enrolled in cardiac rehabilitation: A randomized controlled trial (CRX study)

Jennifer L. Reed et al.

Summary: This study compared the effects of high-intensity interval training (HIIT), Nordic walking (NW), and moderate-to-vigorous intensity continuous training (MICT) on functional capacity in coronary artery disease (CAD) patients. The results showed that NW was the most effective in improving functional capacity, which is a predictor of future cardiovascular events.

PROGRESS IN CARDIOVASCULAR DISEASES (2022)

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Article Multidisciplinary Sciences

Neuroimmune cardiovascular interfaces control atherosclerosis

Sarajo K. Mohanta et al.

Summary: This study discovered the presence of widespread neuroimmune cardiovascular interfaces (NICIs) in the adventitia of atherosclerosis-diseased arteries, suggesting a direct interaction between the peripheral nervous system and diseased arteries. Through anatomical and functional studies, it was found that NICIs play a crucial role in the formation of an artery-brain circuit (ABC). Therapeutic intervention in the ABC was shown to attenuate atherosclerosis.

NATURE (2022)

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Article Multidisciplinary Sciences

Erythrocyte sodium buffering capacity status correlates with self-reported salt intake in a population from Livingstone, Zambia

Sepiso K. Masenga et al.

Summary: The study found a significant correlation between self-reported high salt intake and erythrocyte sodium sensitivity or vascular sodium buffering capacity, potentially impacting cardiovascular health in middle-aged Zambians.

PLOS ONE (2022)

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Review Cell Biology

Insight into the Role of the PI3K/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart

Bartosz Walkowski et al.

Summary: Cardiovascular diseases, particularly myocardial infarction, continue to be the leading cause of death worldwide. The introduction of molecularly targeted drugs, specifically targeting the components of the PI3K/Akt signaling pathway, holds promise for further reducing the death rate. This pathway plays a crucial role in the growth and survival of cardiomyocytes, and its activation has been shown to alleviate negative post-infarct changes in the myocardium. This article provides insights into the role of the PI3K/Akt pathway in ischemia and subsequent left ventricular remodeling, highlights promising substances for further investigation, and explores the molecular mechanism of its effects on myocardial ischemia and left ventricular remodeling.

CELLS (2022)

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Article Cardiac & Cardiovascular Systems

DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension

Ashley Pitzer et al.

Summary: This study reveals a mechanistic link between ENaC, inflammation, and salt-sensitive hypertension involving NLRP3 inflammasome activation in APCs. Activation of APCs via the NLRP3 inflammasome can serve as a potential diagnostic biomarker for salt sensitivity of blood pressure.

CIRCULATION RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Vericiguat and Health-Related Quality of Life in Patients With Heart Failure With Reduced Ejection Fraction: Insights From the VICTORIA Trial

Javed Butler et al.

Summary: This study investigated the effects of vericiguat compared with placebo on health status outcomes in heart failure patients. The Kansas City Cardiomyopathy Questionnaire was used to measure the outcomes. The results showed that vericiguat did not significantly improve the KCCQ scores compared with placebo. However, vericiguat reduced the risk of cardiovascular death or heart failure hospitalization across the range of baseline health status.

CIRCULATION-HEART FAILURE (2022)

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Review Peripheral Vascular Disease

Inverse Salt Sensitivity of Blood Pressure: Mechanisms and Potential Relevance for Prevention of Cardiovascular Disease

Robin A. Felder et al.

Summary: This article reviews the etiology and mechanisms of inverse salt sensitivity of blood pressure, a condition that affects approximately 15% of the adult population. Genetic polymorphisms and increased renal tubular sodium reabsorption are found to be important factors in this condition.

CURRENT HYPERTENSION REPORTS (2022)

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Article Cardiac & Cardiovascular Systems

Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes

Gerasimos Filippatos et al.

Summary: In patients with heart failure and preserved ejection fraction, empagliflozin significantly reduces the risk of heart failure outcomes, regardless of diabetes status at baseline.

CIRCULATION (2022)

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Review Peripheral Vascular Disease

Immune Cell Activation in Obesity and Cardiovascular Disease

Jamie N. Garcia et al.

Summary: This review focuses on immune cell activation in obesity and cardiovascular disease. It highlights specific immune cell microenvironments present in individuals with atherosclerosis, non-ischemic heart disease, hypertension, and infectious diseases. Obesity and cardiovascular disease are closely linked and often characterized by inflammation and metabolic complications. Changes in the immune cell populations impact an individual's ability to combat illnesses such as influenza and SARS-CoV2.

CURRENT HYPERTENSION REPORTS (2022)

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Article Cardiac & Cardiovascular Systems

Intensive Blood Pressure Lowering in Patients With Malignant Left Ventricular Hypertrophy

Simon B. Ascher et al.

Summary: Intensive systolic blood pressure control can prevent malignant left ventricular hypertrophy and significantly reduce the risk of acute decompensated heart failure (ADHF) events and death among SPRINT participants.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Review Physiology

Pathophysiology and genetics of salt-sensitive hypertension

Dina Maaliki et al.

Summary: Most cases of hypertension are primary and closely related to modifiable risk factors such as salt intake. Studies have shown that even small reductions in salt consumption can lower blood pressure in people of all ages. Salt-sensitivity has been identified as an independent risk factor for cardiovascular events and mortality. However, the pathogenesis of salt-sensitive hypertension is still unclear due to its multifactorial etiology, complex genetic influences, and the lack of a diagnostic tool.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Medicine, General & Internal

Effect of High-Intensity Interval Training in Patients With Atrial Fibrillation A Randomized Clinical Trial

Jennifer L. Reed et al.

Summary: This study compared the effects of 12 weeks of high-intensity interval training (HIIT) and moderate to vigorous intensity continuous training (MICT) on functional capacity and quality of life in patients with atrial fibrillation (AF). The results showed that both HIIT and MICT had similar effects in improving functional capacity, quality of life, resting heart rate, and physical activity levels in patients with persistent and permanent AF.

JAMA NETWORK OPEN (2022)

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Review Cardiac & Cardiovascular Systems

Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment

Anastasia V. Poznyak et al.

Summary: Atherosclerosis, a predecessor of cardiovascular diseases, has a high morbidity and mortality rate. However, the trigger mechanism is not well understood. Hypertension, among the various modifiable risk factors, is considered the most widespread and extensively researched factor for atherosclerosis development.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Peripheral Vascular Disease

Immediate pressor response to oral salt and its assessment in the clinic: a time series clinical trial

Sepiso K. Masenga et al.

Summary: This study found that 62% of normotensive individuals experienced a clinically significant increase in mean arterial pressure after ingesting salt, with the systolic blood pressure at 30 minutes post-salt load being a significant predictor of this response. The findings suggest that salt consumed in single meals may contribute to an increased 24-hour blood pressure load, which is a risk factor for hypertension and target organ damage, emphasizing the importance of including dietary sodium assessment in the diagnosis, prevention, and management of high blood pressure.

CLINICAL HYPERTENSION (2022)

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Article Cardiac & Cardiovascular Systems

Circumferential Pulmonary Vein Isolation Plus Low-Voltage Area Modification in Persistent Atrial Fibrillation

Gang Yang et al.

Summary: The study showed that adjunctive LVA ablation did not improve success rates of CPVI in PeAF patients, half of whom had normal LA substrate. Voltage mapping can help identify patients with PeAF who can achieve excellent rhythm control with CPVI alone.

JACC-CLINICAL ELECTROPHYSIOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Genetic predisposition study of heart failure and its association with cardiomyopathy

Vaishak Kaviarasan et al.

Summary: Heart failure is a clinical condition characterized by structural and functional defects in the myocardium, caused by genetic and environmental factors. Research on the genetic variants associated with cardiomyopathy provides a better understanding of the genetics aspect of heart failure and may contribute to personalized therapeutics in the future.

EGYPTIAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation

Natalia Ruggeri Barbaro et al.

Summary: High salt exposure can activate human monocytes, leading to inflammation and enhancing their ability to activate T cells. The activation capacity of monocytes is correlated with cardiovascular disease risk factors.

CARDIOVASCULAR RESEARCH (2021)

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Article Obstetrics & Gynecology

Patients with chronic hypertension are at increased risk for postpartum cardiovascular disease complications

Emily B. Rosenfeld et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST)

Karl-Heinz Kuck et al.

Summary: The study indicates that radiofrequency ablation is more effective than antiarrhythmic drug therapy in delaying the progression from paroxysmal to persistent atrial fibrillation. Patients aged 65 and above may have an increased risk of progressing to persistent atrial fibrillation.

EUROPACE (2021)

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Review Biochemistry & Molecular Biology

Emerging Role of the Inflammasome and Pyroptosis in Hypertension

Carmen De Miguel et al.

Summary: Inflammasomes and pyroptosis play crucial roles in the development of hypertension, with pharmacological inhibition of inflammasomes leading to reduced blood pressure. This pathway shows potential as a future anti-hypertensive strategy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Public, Environmental & Occupational Health

Study of rs10177833 polymorphism in SLC4A5 gene and salt sensitivity in Bulgarian population

Tz Georgieva et al.

EUROPEAN JOURNAL OF PUBLIC HEALTH (2021)

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Review Cardiac & Cardiovascular Systems

Cellular and molecular pathobiology of heart failure with preserved ejection fraction

Sumita Mishra et al.

Summary: Heart failure with preserved ejection fraction (HFpEF) is a complex multiorgan syndrome involving the heart, lungs, kidneys, skeletal muscle, adipose tissue, vascular system, and immune and inflammatory signaling. It is challenging to model in experimental animals due to its multiorgan involvement, but new animal models and efforts to examine human pathophysiology are revealing potential therapeutic targets. Research is focusing on cellular and molecular pathobiology of HFpEF, with efforts to understand mechanisms relevant to the heart as well as other organ systems, in order to develop more patient-specific therapies and improve clinical outcomes.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Medicine, General & Internal

Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation

Oussama M. Wazni et al.

Summary: In this multicenter trial, cryoballoon ablation as initial therapy was found to be superior to drug therapy in preventing atrial arrhythmia recurrence in patients with paroxysmal atrial fibrillation. Serious procedure-related adverse events were uncommon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure

Biykem Bozkurt et al.

Summary: This document proposes a universal definition of heart failure as a clinical syndrome and revised stages of HF, as well as a new classification based on left ventricular ejection fraction (LVEF) levels. The classification includes HFrEF, HFmrEF, HFpEF, and HFimpEF based on LVEF percentages.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Article Peripheral Vascular Disease

2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement

George S. Stergiou et al.

Summary: The collaborators come from different countries and regions, representing experts in the field of hypertension research, working together to make contributions.

JOURNAL OF HYPERTENSION (2021)

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Review Cardiac & Cardiovascular Systems

Interactions of hypertension, obesity, left ventricular hypertrophy, and heart failure

Adrian daSilva-deAbreu et al.

Summary: Hypertension and obesity are major risk factors for cardiac disease, affecting heart structure and function in complex ways. Weight loss and blood pressure control are crucial for preventing and reversing some of the damage caused by these conditions.

CURRENT OPINION IN CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Cryoballoon ablation vs. antiarrhythmic drugs: first-line therapy for patients with paroxysmal atrial fibrillation

Malte Kuniss et al.

Summary: Cryoballoon catheter ablation was superior to anti-arrhythmic drug therapy in reducing atrial arrhythmia recurrence in treatment naive patients with paroxysmal atrial fibrillation. Additionally, cryoballoon catheter ablation was associated with lower symptom recurrence and a similar rate of serious adverse events compared with anti-arrhythmic drug therapy.

EUROPACE (2021)

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Article Peripheral Vascular Disease

Worldwide Trends in Prevalence, Mortality, and Disability-Adjusted Life Years for Hypertensive Heart Disease From 1990 to 2017

Haijiang Dai et al.

Summary: The prevalence of hypertensive heart disease (HHD) has been increasing globally from 1990 to 2017, while the mortality and disability-adjusted life year rates have shown a decrease. Female gender and older age are associated with higher prevalence rates of HHD, while there is a negative correlation between Sociodemographic index and disability-adjusted life year rates.

HYPERTENSION (2021)

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Article Genetics & Heredity

Candidate Gene Polymorphisms Influence the Susceptibility to Salt Sensitivity of Blood Pressure in a Han Chinese Population: Risk Factors as Mediators

Yunyi Xie et al.

Summary: Genome-wide association studies have identified 11 SNPs in 8 genes associated with salt sensitivity of blood pressure, with 4 SNPs remaining significant after correction. CYBA/rs4673 was significantly associated with SSBP in hypertensive subjects, while CYP4A11/rs1126742 was significantly associated with SSBP in normotensive subjects. These genetic variants may contribute to SSBP susceptibility, with other risk factors acting as potential mediators.

FRONTIERS IN GENETICS (2021)

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Review Biochemistry & Molecular Biology

Role of Rho in Salt-Sensitive Hypertension

Wakako Kawarazaki et al.

Summary: High salt intake can result in increased blood pressure, especially in individuals with impaired renal sodium excretion, leading to salt-sensitive hypertension. Activation of Rho in the central nervous system and vascular smooth muscle cells plays a crucial role in this process, contributing to increased vascular resistance and tone, ultimately impacting blood pressure control.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cardiac & Cardiovascular Systems

Individualized Nutritional Support for Hospitalized Patients With Chronic Heart Failure

Lara Hersberger et al.

Summary: Individualized nutritional support in hospitalized patients with chronic heart failure at high nutritional risk reduces the risk for mortality and major cardiovascular events compared with standard hospital food.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Immunology

Sodium and its manifold impact on our immune system

Katarzyna Jobin et al.

Summary: A high salt diet is believed to stimulate the immune system, affecting autoimmune diseases and infections. However, research also suggests that a high salt diet may exacerbate some infections.

TRENDS IN IMMUNOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction

Michinari Hieda et al.

Summary: The study suggests that high-intensity exercise training can reduce LV myocardial stiffness in patients with LV hypertrophy, thus helping to prevent the development of heart failure.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Theresa A. McDonagh et al.

EUROPEAN HEART JOURNAL (2021)

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Article Medicine, General & Internal

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Bin Zhou et al.

Summary: Global prevalence of hypertension doubled from 1990 to 2019, with significant improvements in detection, treatment, and control rates. In 2019, 59% of women and 49% of men with hypertension were previously diagnosed, while treatment rates were 47% for women and 38% for men, with control rates at 23% for women and 18% for men. Disparities exist across countries, with some middle-income nations now outperforming high-income countries in hypertension management.

LANCET (2021)

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Article Clinical Neurology

Mediterranean Diet Reduces Atherosclerosis Progression in Coronary Heart Disease An Analysis of the CORDIOPREV Randomized Controlled Trial

Jose Jimenez-Torres et al.

Summary: The study compared the effects of a Mediterranean diet and a low-fat diet on cardiovascular disease prevention, finding that the Mediterranean diet could reduce the progression of atherosclerosis, as shown by decreased IMT-CC and carotid plaque height.

STROKE (2021)

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Article Cardiac & Cardiovascular Systems

Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults

Daniel H. Katz et al.

Summary: The study identified novel biological pathways specific to Black adults associated with left ventricular hypertrophy and incident heart failure. While certain biomarkers showed consistent associations in Black and White individuals, others such as LKHA4 and fractalkine were significantly different between the two groups.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2021)

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Article Developmental Biology

Hypertension induces compensatory left ventricular hypertrophy by a mechanism involving gap junction lateralization and overexpression of CD36, PKC and MMP-2

Madalina Dumitrescu et al.

Summary: This study revealed the structural and molecular changes in hypertension-induced left ventricular hypertrophy, indicating that some regulatory mechanisms may help the heart adapt to increased stress.

ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY (2021)

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Article Peripheral Vascular Disease

HIV-positive demonstrate more salt sensitivity and nocturnal non-dipping blood pressure than HIV-negative individuals

Sepiso K. Masenga et al.

Summary: High dietary salt intake exacerbates blood pressure in hypertensive individuals, especially in terms of nocturnal blood pressure dipping. Among HIV-positive individuals, hypertensive patients show greater sensitivity to salt intake and have a more pronounced non-dipping pattern compared to HIV-negative hypertensive individuals.

CLINICAL HYPERTENSION (2021)

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Article Physiology

Pathogenesis of Higher Blood Pressure and Worse Renal Function in Salt-Sensitive Hypertension

Yuguang Chu et al.

Summary: This study found that patients with salt-sensitive hypertension have worse renal function and higher blood pressure. Differences in growth factors and pathways, including activated PI3K-AKT pathway and high MCSFR, may account for this phenomenon. Factors such as EG-VEGF, VEGFR2, VEGFR3, and VEGF-D are also related to elevated blood pressure.

KIDNEY & BLOOD PRESSURE RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Genetic Risk Stratification A Paradigm Shift in Prevention of Coronary Artery Disease

Robert Roberts et al.

Summary: Coronary artery disease is a highly preventable pandemic, and genetic risk score may offer a potential solution to improve primary prevention.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2021)

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Article Respiratory System

Resistin-like molecule β acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

Heshen Tian et al.

Summary: RELMB acts as a cytokine-like growth factor in the development of hypoxia-induced pulmonary hypertension, likely mediated by the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK pathways.

RESPIRATORY RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure

Biykem Bozkurt et al.

Summary: This document proposes a universal definition, revised stages, and new classification of heart failure based on left ventricular ejection fraction. The classification includes HF with reduced, mildly reduced, preserved, and improved ejection fraction, each with specific LVEF thresholds.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Article Nutrition & Dietetics

A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial

Valentina Mercurio et al.

CLINICAL NUTRITION (2020)

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Article Cardiac & Cardiovascular Systems

Effects of carvedilol vs bisoprolol on inflammation and oxidative stress in patients with chronic heart failure

Shigeru Toyoda et al.

JOURNAL OF CARDIOLOGY (2020)

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Review Pharmacology & Pharmacy

Mechanisms for the transition from physiological to pathological cardiac hypertrophy

Christopher J. Oldfield et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Racial Differences in Malignant Left Ventricular Hypertrophy and Incidence of Heart Failure A Multicohort Study

Alana A. Lewis et al.

CIRCULATION (2020)

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Review Cardiac & Cardiovascular Systems

Risk Factors for Heart Failure 20-Year Population-Based Trends by Sex, Socioeconomic Status, and Ethnicity

Claire A. Lawson et al.

CIRCULATION-HEART FAILURE (2020)

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Review Peripheral Vascular Disease

High Blood Pressure and Cardiovascular Disease

Flavio D. Fuchs et al.

HYPERTENSION (2020)

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Article Peripheral Vascular Disease

Blood Pressure Control and the Association With Diabetes Mellitus Incidence Results From SPRINT Randomized Trial

Christianne L. Roumie et al.

HYPERTENSION (2020)

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Article Rheumatology

Tissue sodium content in patients with systemic lupus erythematosus: association with disease activity and markers of inflammation

D. A. Carranza-Leon et al.

LUPUS (2020)

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Review Urology & Nephrology

The global epidemiology of hypertension

Katherine T. Mills et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction

Adam K. McDiarmid et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Cardiac & Cardiovascular Systems

Lifestyle modification in older versus younger patients with coronary artery disease

Patricia Jepma et al.

HEART (2020)

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Review Peripheral Vascular Disease

The WNK signaling pathway and salt-sensitive hypertension

Taisuke Furusho et al.

HYPERTENSION RESEARCH (2020)

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Article Medicine, General & Internal

Acute heart failure

Mattia Arrigo et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Article Peripheral Vascular Disease

2020 International Society of Hypertension Global Hypertension Practice Guidelines

Thomas Unger et al.

HYPERTENSION (2020)

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Article Medicine, General & Internal

Early Rhythm-Control Therapy in Patients with Atrial Fibrillation

Paulus Kirchhof et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Cell & Tissue Engineering

Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging

Sherin Saheera et al.

CELL TRANSPLANTATION (2020)

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Article Hematology

Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromso study

Erin Mathiesen Hald et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

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Review Medicine, General & Internal

Effects of low sodium versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride

Niels Albert Graudal et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2020)

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Article Cardiac & Cardiovascular Systems

Dabigatran dual therapy with ticagrelor or clopidogrel after percutaneous coronary intervention in atrial fibrillation patients with or without acute coronary syndrome: a subgroup analysis from the RE-DUAL PCI trial

Jonas Oldgren et al.

EUROPEAN HEART JOURNAL (2019)

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Review Urology & Nephrology

Immune mechanisms of salt-sensitive hypertension and renal end-organ damage

David L. Mattson

NATURE REVIEWS NEPHROLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Atrial Fibrillation Catheter Ablation Increases the Left Atrial Pressure

Je-Wook Park et al.

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A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial

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EUROPEAN HEART JOURNAL (2019)

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Review Peripheral Vascular Disease

Salt-induced effects on microvascular function: A critical factor in hypertension mediated organ damage

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Rivaroxaban With or Without Aspirin in Patients With Heart Failure and Chronic Coronary or Peripheral Artery Disease The COMPASS Trial

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Patho-immune Mechanisms of Hypertension in HIV: a Systematic and Thematic Review

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CURRENT HYPERTENSION REPORTS (2019)

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Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension

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Plasma protein thiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans

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PLOS ONE (2019)

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Effects of 1 year of exercise training versus combined exercise training and weight loss on body composition, low-grade inflammation and lipids in overweight patients with coronary artery disease: a randomized trial

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AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS (2019)

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Hypertensive Heart Disease and Obesity A Review

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HEART FAILURE CLINICS (2019)

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BIOMEDICINE & PHARMACOTHERAPY (2019)

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Echocardiographic Features of Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction

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ESC HEART FAILURE (2019)

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New American and European Hypertension Guidelines, Reconciling the Differences

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CARDIOLOGY AND THERAPY (2019)

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Regular consumption of green tea improves pulse pressure and induces regression of left ventricular hypertrophy in hypertensive patients

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PHYSIOLOGICAL REPORTS (2019)

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Gender Differences in Atrial Fibrillation: A Review of Epidemiology, Management, and Outcomes

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CURRENT CARDIOLOGY REVIEWS (2019)

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Aneesh Bapat et al.

HEART (2018)

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2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

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JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION (2018)

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Tissue Sodium Content is Elevated in the Skin and Subcutaneous Adipose Tissue in Women with Lipedema

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OBESITY (2018)

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Clinical Benefit of Evolocumab by Severity and Extent of Coronary Artery Disease: Analysis From FOURIER

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CIRCULATION (2018)

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Genetics of atrial fibrillation: an update

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CURRENT OPINION IN CARDIOLOGY (2018)

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Apixaban compared to heparin/vitamin K antagonist in patients with atrial fibrillation scheduled for cardioversion: the EMANATE trial

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EUROPEAN HEART JOURNAL (2018)

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Targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent atrial fibrillation: results of the RACE 3 trial

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EUROPEAN HEART JOURNAL (2018)

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Left ventricular hypertrophy offsets the sex difference in cardiovascular risk (the Campania Salute Network)

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INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

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Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus

Naoto Katakami

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2018)

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Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke

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Malignant Left Ventricular Hypertrophy Identifies Subjects at High Risk for Progression to Asymptomatic Left Ventricular Dysfunction, Heart Failure, and Death: MESA (Multi-Ethnic Study of Atherosclerosis)

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FRONTIERS IN PEDIATRICS (2018)

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Genetic Predisposition to High Blood Pressure and Lifestyle Factors Associations With Midlife Blood Pressure Levels and Cardiovascular Events

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Skin Sodium and Hypertension: a Paradigm Shift?

Viknesh Selvarajah et al.

CURRENT HYPERTENSION REPORTS (2018)

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Impact of left ventricular hypertrophy on long-term clinical outcomes in hypertensive patients who underwent successful percutaneous coronary intervention with drug-eluting stents

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MEDICINE (2018)

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Mechanisms of isolevuglandin-protein adduct formation in inflammation and hypertension

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PROSTAGLANDINS & OTHER LIPID MEDIATORS (2018)

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Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography

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PLOS ONE (2018)

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Anti-Inflammatory Effects of a Vegan Diet Versus the American Heart Association-Recommended Diet in Coronary Artery Disease Trial

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Atrial Fibrillation Mechanisms and Implications for Catheter Ablation

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FRONTIERS IN PHYSIOLOGY (2018)

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Left Ventricular Hypertrophy Predicts Cardiovascular Events in Hypertensive Patients With Coronary Artery Calcifications

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AMERICAN JOURNAL OF HYPERTENSION (2018)

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Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging

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RHEUMATOLOGY (2017)

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Hypertension and cardiac arrhythmias: a consensus document fromthe European Heart RhythmAssociation (EHRA) and ESC Council on Hypertension, endorsed by the Heart RhythmSociety (HRS), Asia-Pacific Heart RhythmSociety (APHRS) and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLEACE)

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EUROPACE (2017)

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Editorial Material Cardiac & Cardiovascular Systems

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EUROPEAN HEART JOURNAL (2017)

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The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study

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EUROPEAN HEART JOURNAL (2017)

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Staging classification of aortic stenosis based on the extent of cardiac damage

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EUROPEAN HEART JOURNAL (2017)

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Salt Sensitivity of Angiogenesis Inhibition-Induced Blood Pressure Rise Role of Interstitial Sodium Accumulation?

Stephanie Lankhorst et al.

HYPERTENSION (2017)

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Low-dose eplerenone decreases left ventricular mass in treatment-resistant hypertension

Andreas Schneider et al.

JOURNAL OF HYPERTENSION (2017)

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Left Ventricular Hypertrophy Regression During Antihypertensive Treatment in an Outpatient Clinic (the Campania Salute Network)

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JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

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The Transition From Hypertension to Heart Failure

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JACC-Heart Failure (2017)

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A new paradigm of sodium regulation in inflammation and hypertension

Annet Kirabo

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2017)

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Electrocardiographic Left Ventricular Hypertrophy Predicts Cardiovascular Morbidity and Mortality in Hypertensive Patients: The ALLHAT Study

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AMERICAN JOURNAL OF HYPERTENSION (2017)

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Sex Differences in the Associations of Hemodynamic Load With Left Ventricular Hypertrophy and Concentric Remodeling

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AMERICAN JOURNAL OF HYPERTENSION (2016)

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Review Transplantation

Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder

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NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

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ARCHIVES OF MEDICAL RESEARCH (2016)

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Hemodynamics and Salt-and-Water Balance Link Sodium Storage and Vascular Dysfunction in Salt-Sensitive Subjects

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HYPERTENSION (2016)

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Salt Sensitivity of Blood Pressure A Scientific Statement From the American Heart Association

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HYPERTENSION (2016)

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Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Genetic Predisposition to Higher Blood Pressure Increases Risk of Incident Hypertension and Cardiovascular Diseases in Chinese

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HYPERTENSION (2015)

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Review Physiology

Myocardial hypertrophy and its role in heart failure with preserved ejection fraction

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Increased Stroke Risk in Atrial Fibrillation Patients With Heart Failure Does Ejection Fraction Matter?

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STROKE (2015)

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Abnormal Stress-Related Measures of Arterial Stiffness in Middle-Aged and Elderly Men and Women With Impaired Fasting Glucose at Risk for a First Episode of Symptomatic Heart Failure

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JOURNAL OF THE AMERICAN HEART ASSOCIATION (2015)

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Brain Gαi2-subunit proteins and the prevention of salt sensitive hypertension

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FRONTIERS IN PHYSIOLOGY (2015)

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Older Adults, Malignant Left Ventricular Hypertrophy, and Associated Cardiac-Specific Biomarker Phenotypes to Identify the Differential Risk of New-Onset Reduced Versus Preserved Ejection Fraction Heart Failure CHS (Cardiovascular Health Study)

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JACC-HEART FAILURE (2015)

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Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines

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EUROPEAN HEART JOURNAL (2015)

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Sodium selective erythrocyte glycocalyx and salt sensitivity in man

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COMPREHENSIVE PHYSIOLOGY (2015)

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Noninvasive Characterization of Vascular Tone by Model-Based System Identification in Healthy and Heart Failure Patients

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ANNALS OF BIOMEDICAL ENGINEERING (2015)

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Review Peripheral Vascular Disease

Left Ventricular Hypertrophy and Obesity: Only a Matter of Fat?

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HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2015)

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Gαi2-Protein-Mediated Signal Transduction Central Nervous System Molecular Mechanism Countering the Development of Sodium-Dependent Hypertension

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HYPERTENSION (2015)

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Stakeholder Discussion to Reduce Population-Wide Sodium Intake and Decrease Sodium in the Food Supply A Conference Report From the American Heart Association Sodium Conference 2013 Planning Group

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CIRCULATION (2014)

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Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation

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CIRCULATION (2014)

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Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis

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CIRCULATION RESEARCH (2014)

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Four-Group Classification of Left Ventricular Hypertrophy Based on Ventricular Concentricity and Dilatation Identifies a Low-Risk Subset of Eccentric Hypertrophy in Hypertensive Patients

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CIRCULATION-CARDIOVASCULAR IMAGING (2014)

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Impact of Azelnidipine and Amlodipine on Left Ventricular Mass and Longitudinal Function in Hypertensive Patients with Left Ventricular Hypertrophy

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ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES (2014)

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EUROPEAN HEART JOURNAL (2014)

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DC isoketal-modified proteins activate T cells and promote hypertension

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Mechanism of Salt-Sensitive Hypertension: Focus on Adrenal and Sympathetic Nervous Systems

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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Infiltrating immune cells in the kidney in salt-sensitive hypertension and renal injury

David L. Mattson

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

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Johan Frostegard

BMC MEDICINE (2013)

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Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk

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HYPERTENSION (2013)

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Immune cells control skin lymphatic electrolyte homeostasis and blood pressure

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JOURNAL OF CLINICAL INVESTIGATION (2013)

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Challenges in sodium intake reduction and meal consumption patterns among participants with metabolic syndrome in a dietary trial

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NUTRITION JOURNAL (2013)

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Review Medicine, General & Internal

Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials

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BMJ-BRITISH MEDICAL JOURNAL (2013)

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Effect of lower sodium intake on health: systematic review and meta-analyses

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BMJ-BRITISH MEDICAL JOURNAL (2013)

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Lack of Reduction of Left Ventricular Mass in Treated Hypertension: The Strong Heart Study

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Renin activates PI3K-Akt-eNOS signalling through the angiotensin AT1 and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii

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BRITISH JOURNAL OF PHARMACOLOGY (2012)

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CIRCULATION (2012)

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Myocardial Ischemia in Women: Lessons From the NHLBI WISE Study

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CLINICAL CARDIOLOGY (2012)

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Left Ventricular Mass and Function With Reduced-Fat or Reduced-Carbohydrate Hypocaloric Diets in Overweight and Obese Subjects

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HYPERTENSION (2012)

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Salt Sensitivity of Blood Pressure Is Associated With Polymorphisms in the Sodium-Bicarbonate Cotransporter

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HYPERTENSION (2012)

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T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology

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IMMUNITY (2012)

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Hypertensive left ventricular hypertrophy: a mechanistic approach to optimizing regression assessed by cardiovascular magnetic resonance

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Atrial Fibrillation Pathophysiology Implications for Management

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CIRCULATION (2011)

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The Progression of Hypertensive Heart Disease

Mark H. Drazner

CIRCULATION (2011)

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The Effects of Simvastatin on Left Ventricular Hypertrophy and Left Ventricular Function in Patients with Essential Hypertension

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CLINICAL AND EXPERIMENTAL HYPERTENSION (2011)

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Genetics of Hypertension and Cardiovascular Disease and Their Interconnected Pathways: Lessons from Large Studies

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CURRENT HYPERTENSION REPORTS (2011)

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Salt-induced renal injury in SHRs is mediated by AT1 receptor activation

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JOURNAL OF HYPERTENSION (2011)

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Molecular mechanisms of left ventricular hypertrophy (LVH) in systemic hypertension (SH)-possible therapeutic perspectives

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JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION (2011)

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NATURE (2011)

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Salt overload damages the glycocalyx sodium barrier of vascular endothelium

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PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2011)

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Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease

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Management of Hypertension among Patients with Coronary Heart Disease

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INTERNATIONAL JOURNAL OF HYPERTENSION (2011)

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Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension

Midori S. Yatabe et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

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Brain tissue sodium concentration in multiple sclerosis: a sodium imaging study at 3 tesla

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BRAIN (2010)

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Angiotensin II revisited: new roles in inflammation, immunology and aging

Ariela Benigni et al.

EMBO MOLECULAR MEDICINE (2010)

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Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy

Kyung Hye Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2010)

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Effect of Modest Salt Reduction on Skin Capillary Rarefaction in White, Black, and Asian Individuals With Mild Hypertension

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HYPERTENSION (2010)

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Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats

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HYPERTENSION (2010)

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Coronary artery disease: Clinical presentation, diagnosis and prognosis in women

C. Leuzzi et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2010)

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Genetic Variants Associated With Cardiac Structure and Function A Meta-analysis and Replication of Genome-wide Association Data

Ramachandran S. Vasan et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

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Women and Ischemic Heart Disease Evolving Knowledge

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)

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Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis

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LABORATORY INVESTIGATION (2009)

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Article Biochemistry & Molecular Biology

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism

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NATURE MEDICINE (2009)

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Clustered metabolic abnormalities blunt regression of hypertensive left ventricular hypertrophy: the LIFE study

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NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2009)

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Change of genetic determinants of left ventricular structure in adolescence: Longitudinal evidence from the Georgia Cardiovascular Twin Study

Gaston K. Kapuku et al.

AMERICAN JOURNAL OF HYPERTENSION (2008)

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Polymorphism in NEDD4L Is Associated with Increased Salt Sensitivity, Reduced Levels of P-renin and Increased Levels of Nt-proANP

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Review Peripheral Vascular Disease

The fuzzy logic of physiological cardiac hypertrophy

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Review Physiology

Decompensation of cardiac hypertrophy: Cellular mechanisms and novel therapeutic targets

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Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging - The multiethnic study of atherosclerosis

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)

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Review Peripheral Vascular Disease

Angiotensin II signal transduction through small GTP-binding proteins - Mechanism and significance in vascular smooth muscle cells

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Review Cardiac & Cardiovascular Systems

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CARDIOVASCULAR RESEARCH (2006)

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Review Cardiac & Cardiovascular Systems

From left ventricular hypertrophy to congestive heart failure: Management of hypertensive heart disease

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PROGRESS IN CARDIOVASCULAR DISEASES (2006)

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Adverse effects of left ventricular hypertrophy in the reduction of endpoints in NIDDM with the angiotensin II antagonist losartan (RENAAL) study

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Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8

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Review Anesthesiology

Hypertension, hypertensive heart disease and perioperative cardiac risk

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Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol -: The Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial

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Article Peripheral Vascular Disease

Differences in left ventricular structure between black and white hypertensive adults - The hypertension genetic epidemiology network study

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A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension

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AMERICAN JOURNAL OF MEDICINE (2003)

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Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials

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Effect of modest salt reduction on blood pressure: a meta-analysis of randomized trials. Implications for public health

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Systematic review of long term effects of advice to reduce dietary salt in adults

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Sibling correlation of left ventricular mass and geometry in hypertensive African Americans and whites: The HyperGEN study

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Development of left ventricular hypertrophy in adults with hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations

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Angiotensin II and the heart - On the intracrine renin-angiotensin system

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