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Article
Endocrinology & Metabolism
Benchao Li et al.
Summary: This study found that serum uric acid (SUA) level is associated with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes. Higher SUA levels are associated with increased risks of all-cause and CVD mortality. Interventional studies are needed to evaluate the health effect of treatments to lower SUA levels in clinical practice.
Review
Pharmacology & Pharmacy
Rodrigo Damian Garcia et al.
Summary: Cardiovascular diseases pose a significant burden on health and economy, with inactivity, hypertension, obesity, diabetes, and smoking being the main risk factors. Vascular remodeling is an adaptive response to these risk factors, leading to thickening of arterial walls and increased risk of cerebrovascular and coronary events. Antiplatelet, lipid-lowering, and antihypertensive therapies have been effective in preventing cardiovascular events, and there is growing evidence suggesting the role of inflammation in the pathogenesis of these diseases.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Digne Tembely et al.
Summary: The incidence of cardiovascular diseases is increasing due to the aging population, which has a major influence on the vascular tree. Aging leads to changes in the morphology and function of the arterial wall, as well as remodeling of the vascular extracellular matrix. The release of elastin-derived peptides (EDPs) from elastin degradation products is a characteristic feature of aged conduit arteries. These EDPs not only affect the mechanical properties of arteries but also modulate the development and progression of various vascular and metabolic diseases. The elastin receptor complex (ERC), which contains elastin-binding protein, protective protein/cathepsin A, and neuraminidase-1 (NEU1), plays a crucial role in mediating the biological effects of these peptides. This review provides an overview of the consequences of aging on the vasculature and the release of EDPs, discusses the composition and signaling pathways of the ERC, and explores the pharmacological strategies targeting ERC activation. Additionally, it highlights the emerging regulatory functions of the ERC through desialylation of membrane glycoproteins by NEU1 and its potential implication in receptor transactivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Linh Ho et al.
Summary: Pulmonary arterial hypertension (PAH) is a disease that leads to right-ventricular failure and death. Epigenetic modifications play an important role in the pathology of PAH. Dysregulation of epigenetic mechanisms is strongly associated with the pathological vascular remodeling during PAH development. Targeting these epigenetic regulators offers potential candidates for drug discovery and treatment of PAH.
Article
Cardiac & Cardiovascular Systems
Max J. van Hout et al.
Summary: This study calculated estimated-PWV (ePWV) based on clinical and anthropometric measures, determining PWV <6.7 m/s as the optimal discriminative value. Linear ridge regression and Deep Neural Network (DNN) models showed similar performance, with the expanded ridge regression model performing best in external validation.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Peripheral Vascular Disease
Sae Young Jae et al.
Summary: High pulse wave velocity (PWV) and low socioeconomic status (SES) are independently associated with increased risk of stroke. Elevated PWV is a risk factor for stroke regardless of SES.
JOURNAL OF HYPERTENSION
(2022)
Review
Physiology
Paul B. Dieffenbach et al.
Summary: Aging is associated with declining lung function and increased susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by evidence, but the underlying mechanisms are still unclear.
Editorial Material
Cardiac & Cardiovascular Systems
Pierre Boutouyrie
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Esben Laugesen et al.
Summary: This study found that in patients with stable angina, ePWV is associated with increased all-cause mortality and incidence of myocardial infarction, beyond traditional risk factors. However, the addition of ePWV to prediction models did not significantly improve the accuracy of mortality prediction in a clinically relevant manner.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Haishan Huang et al.
Summary: This study investigated the association of fat distribution, arterial stiffness, left ventricular (LV) structure and diastolic function in T2DM patients. The results indicated that visceral fat might impact LV remodeling through changes in arterial stiffness, thus influencing diastolic function in T2DM patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jordana B. Cohen et al.
Summary: In this study, we used prospective cohort data and Mendelian randomization analyses to show that greater large artery stiffness (LAS) is associated with an increased risk of developing type 2 diabetes. LAS may play an important role in glucose homeostasis and could serve as a useful marker for future diabetes risk.
CIRCULATION RESEARCH
(2022)
Article
Nutrition & Dietetics
Victor L. Fulgoni et al.
Summary: This study found that the use of low-calorie sweeteners (LCS) is associated with higher socioeconomic status, lower smoking prevalence, and higher-quality diets, but not with cancer mortality.
Article
Neurosciences
Kevin S. Heffernan et al.
Summary: This study examined the association of arterial stiffness with cognitive function in a bi-racial sample of older adults. The results showed an inverse association between arterial stiffness and cognitive function, suggesting that arterial stiffness may be related to cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lina AlQobaly et al.
Summary: This study aimed to assess the association between e-cigarettes and self-reported periodontal disease, and whether smoking status explains this association. The results showed that e-cigarette use is associated with self-reported periodontal disease, but smoking status appears to explain the relationship.
JOURNAL OF DENTISTRY
(2022)
Review
Peripheral Vascular Disease
Andrew O. Agbaje
Summary: Arterial stiffness is a strong predictor of cardiovascular events and all-cause mortality in middle-aged and old adults. However, it has been limited to being an intermediate marker of atherosclerotic cardiovascular events in adolescents and young adult studies. The lack of normative longitudinal data and repeated gold-standard assessments in the young population has led to a significant knowledge gap in its clinical utility. This review summarizes recent evidence in a large adolescent population, supporting the value of arterial stiffness as a novel risk factor for hypertension, overweight/obesity, and insulin resistance, and provides suggestions for incorporating arterial stiffness measures into routine pediatric and young adult clinical practice.
JOURNAL OF HYPERTENSION
(2022)
Review
Biochemistry & Molecular Biology
Li Zhang et al.
Summary: This manuscript aims to summarize the literature on the preventive role of Tetrahydrocurcumin (THC) on vascular dysfunction and the development of hypertension by exploring its effects on hemodynamic status, aortic elasticity, oxidative stress, and mitochondrial dysfunction. The studies suggest that THC can be used as a dietary supplement to protect against cardiovascular changes caused by various factors and improve mitochondrial dysfunction in cerebral vasculature during ischemic stroke through epigenetic mechanisms.
Editorial Material
Cardiac & Cardiovascular Systems
Lorenzo Loffredo et al.
CIRCULATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Yasuhiro Mukai et al.
Summary: This study found that aortic root size and estimated pulse wave velocity (ePWV) are independently associated with unfavorable left ventricular (LV) remodeling in individuals without overt cardiac disease.
JOURNAL OF HYPERTENSION
(2022)
Article
Medicine, General & Internal
Carla Serra et al.
Summary: According to this study, alterations in heart rate variability (HRV) are associated with arterial aging. Lower sympathetic and parasympathetic activity in women are significantly associated with arterial stiffening, while there is no significant association in men.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Vladiana-Romina Turi et al.
Summary: Cardio-renal and metabolic modifications during gestation have significant implications for fetal and maternal health, particularly in the prevention of conditions such as hypertension, preeclampsia, eclampsia, and diabetes in pregnant women through early arterial function assessment and individualized measures.
Article
Cardiac & Cardiovascular Systems
Alessandro Gentilin et al.
Summary: The incidence of cardiovascular events is higher in the morning than in the evening, with differences between sexes. However, this study found that aortic stiffness is lower in the morning compared to the evening in all groups, and there are differences in stiffness between sexes, ages, and diabetes statuses.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Li-Da Wu et al.
Summary: This study investigated the association between novel anthropometric indices and hypertension risk in a large population in the United States. The results showed that anthropometric measurements were positively and independently associated with hypertension risk. In addition, some novel anthropometric indices had better discriminatory power for screening hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Jun Ma et al.
Summary: Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases and the leading cause of premature death worldwide. The pathogenesis of essential hypertension, especially, is complex and requires further studies. Recent findings in the field have the potential to provide important theoretical bases and therapeutic tools to overcome the existing limitations of essential hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Haojia Chen et al.
Summary: This study assessed the predictive value of estimated pulse wave velocity (ePWV) for the risk of new-onset atrial fibrillation (AF). The results showed that increased ePWV is associated with higher incidence of new-onset AF, with a higher predictive value in the female population. These findings may promote more aggressive primary prevention strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hantong Zhao et al.
Summary: The study revealed an association between metal exposures and Charlson comorbidity index, with cadmium and manganese potentially increasing mortality, while selenium and lead having possible positive effects on health. These findings could be crucial in disease prevention and improving quality of life.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Endocrinology & Metabolism
Mira M. Sachdeva
Summary: Diabetic retinal neurodegeneration may occur before the onset of retinal vascular changes, serving as an independent target for intervention. Research suggests that diabetes may directly affect retinal neural and glial tissue, indicating potentially relevant molecular pathways. As understanding increases, there may be advancements in treatment options and the clinical definition of DR.
CURRENT DIABETES REPORTS
(2021)
Article
Peripheral Vascular Disease
Bernhard Hametner et al.
Summary: Aortic pulse wave velocity (PWV) is directly related to arterial stiffness. This prospective study evaluated the prognostic value of PWV in high-risk patients with suspected coronary artery disease and compared 3 different methods for assessing PWV. The study found that all 3 methods for determining PWV were able to predict cardiovascular events and mortality in patients with suspected coronary artery disease.
Article
Multidisciplinary Sciences
Kimon Stamatelopoulos et al.
Summary: Accurate risk stratification is crucial in guiding therapeutic strategies for COVID-19 patients. This study found that estimated pulse wave velocity (ePWV), a marker of arterial stiffness, provided additional prognostic value beyond established risk factors and scores in risk stratification of hospitalized COVID-19 patients. The optimal prognostic ePWV value was 13.0 m/s, suggesting its potential as a clinical tool for refining risk stratification in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Xinyu Zhang et al.
Summary: Rb1 has shown promising results in alleviating arterial stiffness induced by diabetes, improving aortic compliance and endothelium-dependent vasodilation. Additionally, Rb1 can ameliorate aortic remodeling in diabetes by influencing MMP2, MMP9, and TGF beta 1/Smad2/3 pathways. It is also suggested that Rb1 may inhibit oxidative stress and enhance AMPK phosphorylation as potential mechanisms for improving arterial stiffness in diabetes.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Julija G. Voicehovska et al.
Summary: Chronic kidney disease is closely related to cardiovascular disease, with cardiovascular events being the leading cause of death in these patients. The interplay between cardiovascular disease and declining renal function leads to increased arterial stiffness, accelerating the development of cardiac pathology.
HEART LUNG AND CIRCULATION
(2021)
Article
Peripheral Vascular Disease
Haojia Chen et al.
Summary: This study evaluated the association between estimated pulse wave velocity (ePWV) and the incidence of hypertension, finding a positive correlation with both systolic and diastolic blood pressure. An increase in ePWV was associated with an increase in the incidence of hypertension.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Kevin S. Heffernan et al.
Summary: The study found that for every 1 m/s increase in ePWV, there was a 17% increased risk of residual-specific mortality. Those with an elevated ePWV above 10 m/s had a 57% increased risk of residual-specific mortality.
JOURNAL OF HYPERTENSION
(2021)
Article
Physiology
Zhen-Ye Zhang et al.
JOURNAL OF VASCULAR RESEARCH
(2020)
Letter
Cardiac & Cardiovascular Systems
Kevin S. Heffernan et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Peripheral Vascular Disease
Julie K. K. Vishram-Nielsen et al.
Review
Nutrition & Dietetics
Carroll A. Reider et al.
Article
Peripheral Vascular Disease
Chunpeng Ji et al.
INTERNATIONAL JOURNAL CARDIOLOGY HYPERTENSION
(2020)
Article
Medicine, General & Internal
Charalambos Vlachopoulos et al.
Review
Cardiac & Cardiovascular Systems
Bryan Williams et al.
EUROPEAN HEART JOURNAL
(2018)
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Peripheral Vascular Disease
Sara V. Greve et al.
JOURNAL OF HYPERTENSION
(2016)
Review
Peripheral Vascular Disease
Sara V. Greve et al.
Review
Cardiac & Cardiovascular Systems
Silvia Visentin et al.
Article
Peripheral Vascular Disease
Bryan Williams
JOURNAL OF HYPERTENSION
(2012)
Article
Cardiac & Cardiovascular Systems
Francesco U. S. Mattace-Raso et al.
EUROPEAN HEART JOURNAL
(2010)
