Synergistic mechanism between the endoplasmic reticulum and mitochondria and their crosstalk with other organelles

Organelles are functional areas where eukaryotic cells perform processes necessary for life. Each organelle performs specific functions; however, highly coordinated crosstalk occurs between them. Disorder of organelle networks often occur in various diseases. The endoplasmic reticulum (ER) and mitochondria are crucial organelles in eukaryotic cells as they are the material synthesis and oxidative metabolism centers, respectively. Homeostasis and orchestrated interactions are essential for maintaining the normal activities of cells. However, the mode and mechanism of organelle crosstalk is still a research challenge. Furthermore, the intricate association between organelle dyshomeostasis and the progression of many human diseases remains unclear. This paper systematically summarized the latest research advances in the synergistic mechanism between the endoplasmic reticulum and mitochondria and their crosstalk with other organelles based on recent literature. It also highlights the application potential of organelle homeostasis maintenance as a preventative and treatment strategy for diseases.

Automated summary

Organelles are functional areas in eukaryotic cells that perform vital processes for life, and they interact with each other for coordinated functions. Disorders in organelle networks are often implicated in various diseases. The endoplasmic reticulum and mitochondria are crucial organelles in eukaryotic cells, responsible for material synthesis and oxidative metabolism. Understanding the mode and mechanism of organelle crosstalk remains a challenge, as well as the intricate association between organelle dyshomeostasis and human diseases. This paper provides a systematic summary of the latest research on the synergistic mechanism between the endoplasmic reticulum and mitochondria, their crosstalk with other organelles, and highlights the potential application of maintaining organelle homeostasis as a strategy for disease prevention and treatment.