相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Hepatocellular carcinoma
Josep M. Llovet et al.
NATURE REVIEWS DISEASE PRIMERS (2021)
Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance
Yanhua Zhang et al.
BIOMATERIALS (2021)
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Qian Li et al.
NATURE MEDICINE (2021)
Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics
Annadurai Thangaraj et al.
AUTOPHAGY (2020)
NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter
Dong-Eun Lee et al.
CELL DEATH & DISEASE (2020)
Targeting apoptosis in cancer therapy
Benedito A. Carneiro et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2020)
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
Lorenzo Galluzzi et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2020)
Inhibitors of BRAF dimers using an allosteric site
Xiomaris M. Cotto-Rios et al.
NATURE COMMUNICATIONS (2020)
Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer
Zhefang Wang et al.
THERANOSTICS (2020)
PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
Alexander W. Fischer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells
Weidong Li et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence
Jean-Luc Raoul et al.
CANCER TREATMENT REVIEWS (2019)
AASLD guidelines for the treatment of hepatocellular carcinoma
Julie K. Heimbach et al.
HEPATOLOGY (2018)
PID1 in adipocytes modulates whole-body glucose homeostasis
Ling Chen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2018)
Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling
Ming Luo et al.
CELL METABOLISM (2018)
An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
Christian Baumgartner et al.
CELL STEM CELL (2018)
Sorafenib paradoxically activates the RAS/RAF/ERK pathway in polyclonal human NK cells during expansion and thereby enhances effector functions in a dose- and time-dependent manner
J. Lohmeyer et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)
PDK1: At the crossroad of cancer signaling pathways
Paolo Armando Gagliardi et al.
SEMINARS IN CANCER BIOLOGY (2018)
Molecular therapies and precision medicine for hepatocellular carcinoma
Josep M. Llovet et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins
Alexander W. Fischer et al.
MOLECULAR METABOLISM (2018)
Cytoprotective effect of neuropeptides on cancer stem cells: vasoactive intestinal peptide-induced antiapoptotic signaling
Konduru S. Sastry et al.
CELL DEATH & DISEASE (2017)
PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB
Jingying Xu et al.
SCIENTIFIC REPORTS (2017)
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer
Wei-Jun Wei et al.
THERANOSTICS (2017)
RAS Proteins and Their Regulators in Human Disease
Dhirendra K. Simanshu et al.
CELL (2017)
ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α
Fu-Quan Wu et al.
JOURNAL OF HEPATOLOGY (2016)
Hepatocellular carcinoma
Josep M. Llovet et al.
NATURE REVIEWS DISEASE PRIMERS (2016)
The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update
Waseem Ahmad Siddiqui et al.
ARCHIVES OF TOXICOLOGY (2015)
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
Yoshihiko Ichikawa et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE
Dmitry B. Zorov et al.
PHYSIOLOGICAL REVIEWS (2014)
MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance
Katarina Zmajkovicova et al.
MOLECULAR CELL (2013)
Cancer drug resistance: an evolving paradigm
Caitriona Holohan et al.
NATURE REVIEWS CANCER (2013)
NYGGF4 (PID1) effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes
Jie Qiu et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)
Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death
A. Teresa Alberobello et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
Hung Huynh et al.
JOURNAL OF HEPATOLOGY (2010)
Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt
Chun-mei Zhang et al.
ACTA PHARMACOLOGICA SINICA (2009)
Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin
S. Bafna et al.
BRITISH JOURNAL OF CANCER (2009)
AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer
Shu Yang et al.
MOLECULAR CANCER THERAPEUTICS (2009)
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal
Federica Catalanotti et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity
Guo-Chang Fan et al.
CIRCULATION RESEARCH (2008)
Characterization of Ser338 Phosphorylation for Raf-1 Activation
Mengwei Zang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Mechanisms of cell death in oxidative stress
Stefan W. Ryter et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation
Bin Wang et al.
GENE (2006)
Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
F Fiory et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
p21-Activated kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association
SH Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
SM Wilhelm et al.
CANCER RESEARCH (2004)
Bax, reactive oxygen, and cytochrome c release in neuronal apoptosis
RA Kirkland et al.
ANTIOXIDANTS & REDOX SIGNALING (2003)
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
NN Danial et al.
NATURE (2003)
The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2
M Adachi et al.
CELL DEATH AND DIFFERENTIATION (2002)
Regulation of Raf-1 activation and signalling by dephosphorylation
AS Dhillon et al.
EMBO JOURNAL (2002)
BAY 43-9006: Preclinical data
S Wilhelm et al.
CURRENT PHARMACEUTICAL DESIGN (2002)
Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity
J Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)