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Article
Psychology, Biological
Stine Danielsen et al.
Summary: Using longitudinal and repeated cross-sectional data, the study found no increase in the proportion of Danish young adults with self-injury, suicidality, or eating disorder symptoms during the COVID-19 lockdown. The findings indicate a reduction in self-injury, suicide ideation, and symptoms of eating disorders in both men and women, while an increase in suicide attempts was observed in men only. However, no changes were observed in any of the outcomes in the repeated cross-sectional data. The study provides evidence against the notion of worsening mental health in relation to self-injury, suicidality, and eating disorders during the lockdowns.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Multidisciplinary Sciences
Raquel Viana et al.
Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.
Article
Multidisciplinary Sciences
Sezanur Rahman et al.
Summary: This study investigated the rate of SARS-CoV-2 infection and its clinical features among infection-naive, infected, vaccinated, and post-infection-vaccinated individuals. The findings showed that naturally infected populations were less likely to be reinfected by SARS-CoV-2 than individuals who were infection-naive or vaccinated. However, a significant proportion of naturally infected or vaccinated individuals were (re)-infected by the emerging variants.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Miquel Oliu-Barton et al.
Summary: There is growing evidence that elimination strategies have been more effective than mitigation strategies in dealing with the COVID-19 pandemic in terms of public health, economy, and civil liberties. With the availability of highly effective vaccines and increasing vaccination coverage, policymakers are reevaluating their options and considering the feasibility of eliminating SARS-CoV-2. Coordination, equitable vaccine distribution, and addressing concerns about new variants are key factors in achieving this goal.
LANCET GLOBAL HEALTH
(2022)
Editorial Material
Medicine, General & Internal
Helene Vaillant-Roussel et al.
EXERCER-LA REVUE FRANCOPHONE DE MEDECINE GENERALE
(2022)
Letter
Medicine, General & Internal
Jingyou Yu et al.
Summary: Although immunity from two doses of BNT162b2 vaccine diminishes over time, a booster dose significantly enhances the neutralizing antibodies against both the BA.1 and BA.2 variants.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Juliet R. C. Pulliam et al.
Summary: This study provides two methods for monitoring reinfection trends in routine surveillance data. The results suggest immune evasion by the Omicron variant in previously infected individuals in South Africa, and there has been an increase in the risk of having a third infection since mid-November 2021.
Article
Biochemistry & Molecular Biology
Aekkachai Tuekprakhon et al.
Summary: The Omicron variant of SARS-CoV-2 has rapidly spread globally and has evolved into different sublineages, with BA.4 and BA.5 dominating in South Africa. These sublineages show reduced neutralization by vaccine and naturally immune serum, indicating the possibility of repeat Omicron infections.
Article
Multidisciplinary Sciences
Yonatan Woodbridge et al.
Summary: This study demonstrates that recent vaccination reduces Omicron viral load, but its effect wanes rapidly. In contrast, recovered COVID-19 individuals show a significantly slower waning rate. Therefore, a reassessment of future booster campaigns is needed.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
McKenzie Prillaman
Article
Biochemistry & Molecular Biology
Houriiyah Tegally et al.
Summary: The genomic characterization of the SARS-CoV-2 Omicron lineages BA.4 and BA.5, responsible for the fifth wave of the COVID-19 pandemic in South Africa, reveals their continued viral diversification and sheds light on the potential mechanisms that allow these new lineages to outcompete their predecessors. These new lineages, BA.4 and BA.5, share identical spike proteins with BA.2 but have certain differences such as the presence of the 69-70 deletion, L452R, F486V, and the wild-type amino acid at Q493. They can be identified by the S-gene target failure, a proxy marker associated with the 69-70 deletion. BA.4 and BA.5 have rapidly replaced BA.2 and have become the dominant lineages in South Africa.
Article
Multidisciplinary Sciences
Chaitanya Kurhade et al.
Summary: This study found that sera from individuals vaccinated with three doses of BNT162b2 have lower neutralization efficacy against Omicron BA.1, BA.2, and BA.3 compared to the original strain USAWA1/2020. The results have implications for vaccine strategy and understanding the biology of Omicron sublineages.
NATURE COMMUNICATIONS
(2022)
News Item
Medicine, General & Internal
Elisabeth Mahase
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Letter
Medicine, General & Internal
Elias Eythorsson et al.
Summary: This study examines the proportion of individuals who experienced reinfection with SARS-CoV-2 during the Omicron wave in Iceland.
Letter
Medicine, General & Internal
Heba N. Altarawneh et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Sara Carazo et al.
Summary: This study found that individuals who had prior heterologous SARS-CoV-2 infection and received 2 or 3 doses of mRNA vaccine provided the greatest protection against Omicron-associated hospitalization. A third mRNA vaccine dose may offer limited additional protection in twice-vaccinated individuals with prior SARS-CoV-2 infection.
Letter
Medicine, General & Internal
Heba N. Altarawneh et al.
Summary: Prevention of Omicron can be achieved to some extent by previous SARS-CoV-2 infection, with an effectiveness of 35% for preventing reinfection with BA.4 and BA.5 subvariants and 76% for previous omicron infection.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Yair Goldberg et al.
Summary: This study used data from the Israeli Ministry of Health database to compare the rate of infection with the time since immunity-confering events. The results showed that the protection against reinfection decreased over time for individuals who had previously been infected or vaccinated, but it was still higher than the protection conferred after the same time had elapsed since the second dose of vaccine among those who were previously uninfected. A single dose of vaccine after infection reinforced protection against reinfection.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Microbiology
Haibo Wu et al.
Summary: The study found that the co-occurring mutations R203K/G204R on the SARS-CoV-2 nucleocapsid protein contribute to the emergence of high-transmissibility variants with replication advantages. These variants show increased infectivity in human lung cells and hamsters, with a positive association observed between increased COVID-19 severity and sample frequency of these mutations.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Sebastian Weigang et al.
Summary: In a longitudinal case study, researchers demonstrate that SARS-CoV-2 variants with reduced sensitivity to neutralizing antibodies can evolve within persistently infected immunosuppressed patients. The study suggests that immunocompromised patients may serve as a potential source for the emergence of harmful variants, although immune control against these variants can still be achieved in some cases through the generation of neutralizing antibodies upon lowering immunosuppressive treatment.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Carmen Elena Gomez et al.
Summary: SARS-CoV-2 variants with higher transmissibility and mutations in the spike protein have direct implications on infection rates and resistance to antibodies. These variants have significant impacts on medical countermeasures and human health.
Article
Virology
Aine O'Toole et al.
Summary: The global virus genomics community has responded unprecedentedly to the SARS-CoV-2 pandemic, leading to significant advances in 'real-time' generation and sharing of genomic data. The development of new analytical methods, such as pangolin, has been necessary to handle the rapid growth in virus genome data production. Pangolin has processed nearly two million virus genomes, aiding in SARS-CoV-2 genomic epidemiology and providing researchers with valuable information about the pandemic's transmission lineages.
Article
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2020)
Letter
Infectious Diseases
S. Falahi et al.
NEW MICROBES AND NEW INFECTIONS
(2020)
