4.7 Article

Orai, RyR, and IP3R channels cooperatively regulate calcium signaling in brain mid-capillary pericytes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels

Nicholas R. Klug et al.

Summary: Arteriolar smooth muscle cells and capillary pericytes dynamically regulate blood flow in the central nervous system in response to fluctuating perfusion pressures. This study investigated the involvement of pericytes in pressure-induced changes in blood flow. The results showed that increases in intraluminal pressure induced contraction of both transition zone pericytes and distal pericytes of the capillary bed. The contractile response in pericytes was slower compared to smooth muscle cells. The study also found that the mechanisms and kinetics of Ca2+ elevation, contractility, and blood flow regulation in central nervous system capillary networks differ from neighboring arterioles.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

Review Physiology

Pericyte Control of Blood Flow Across Microvascular Zones in the Central Nervous System

David A. Hartmann et al.

Summary: This review synthesizes current knowledge on the control of blood flow in the brain's microvascular zones, including differences in blood flow between different vascular zones and the role of mural cells in blood flow control. However, many unresolved issues remain.

ANNUAL REVIEW OF PHYSIOLOGY (2022)

Article Multidisciplinary Sciences

A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

Andrew C. Yang et al.

Summary: This study provides a molecular map of vascular and perivascular cell types in the human brain using a method called VINE-seq, revealing their contributions to Alzheimer's disease risk.

NATURE (2022)

Article Biology

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

Amit Jairaman et al.

Summary: The membrane protein TREM2 plays a crucial role in regulating key functions of microglial cells, such as calcium signaling, phagocytosis, and chemotaxis. Loss of TREM2 leads to exaggerated calcium signaling in response to purinergic agonists, resulting in altered cell motility and chemotaxis.
Article Biochemistry & Molecular Biology

Adenosine signaling activates ATP-sensitive K+ channels in endothelial cells and pericytes in CNS capillaries

Maria Sancho et al.

Summary: The presence of K-ATP channels in the capillary endothelial cells and pericytes plays a crucial role in regulating cerebral blood flow.

SCIENCE SIGNALING (2022)

Article Cell Biology

Brain capillary pericytes are metabolic sentinels that control blood flow through a KATP channel-dependent energy switch

Ashwini Hariharan et al.

Summary: This study demonstrates the important role of capillary thin-strand pericytes in regulating brain hemodynamics and responding to local energy deficits. Activation of KATP channels in pericytes leads to hyperpolarization and increased blood flow to prevent energetic shortfalls.

CELL REPORTS (2022)

Article Medicine, Research & Experimental

The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia

Nils Korte et al.

Summary: A small increase in cytoplasmic calcium concentration in pericytes activates chloride efflux through the TMEM16A channel, leading to depolarization of the cell and opening of voltage-gated calcium channels. Inhibition of TMEM16A slows down ischemia-induced increase in calcium concentration, reduces pericyte death, and improves cerebrovascular reperfusion in a rodent stroke model. Altered TMEM16A expression is implicated in poor patient recovery from ischemic stroke, suggesting its potential as a therapeutic target.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Biology

Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex

Ravi L. Rungta et al.

Summary: This study found functional diversity in neuronal activation-triggered vascular events not only between different brain regions but also at the level of different vascular arbours within supragranular layers of the cerebral cortex. The spatial-temporal sequence of vascular events showed significant variability across compartments of different vascular arbours.

COMMUNICATIONS BIOLOGY (2021)

Article Biochemistry & Molecular Biology

A nuclear fluorescent dye identifies pericytes at the neurovascular unit

Sandra P. Mai-Morente et al.

Summary: TO-PRO-3 labeling has been validated as a specific pericyte tracer in the nervous system, providing a reliable tool for bioimaging and quantitative studies of pericytes in the murine neurovascular microvasculature.

JOURNAL OF NEUROCHEMISTRY (2021)

Article Neurosciences

Brain capillary pericytes exert a substantial but slow influence on blood flow

David A. Hartmann et al.

Summary: Capillary pericytes play a role in regulating blood flow by influencing vasoconstriction and dilation. Optogenetic stimulation of these cells leads to decreased luminal diameter and blood flow, affecting the overall modulation of blood flow in the brain.

NATURE NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Brain capillary pericytes and neurovascular coupling

Soren Grubb et al.

Summary: Neurovascular coupling is essential for matching cerebral activity with relevant blood flow, controlled by capillaries and precapillary arterioles. Mural cells, such as pericytes and smooth muscle cells, play a crucial role in determining blood vessel diameter and flow through their tone. The structure of these blood vessels and excitation-contraction coupling of mural cells are important factors to consider.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2021)

Article Multidisciplinary Sciences

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

David O. Dias et al.

Summary: The study reveals that fibrotic scarring is common in mice and humans following central nervous system lesions, deriving from a distinct population of GLAST-expressing perivascular cells.

NATURE COMMUNICATIONS (2021)

Article Biology

Distinct signatures of calcium activity in brain mural cells

Chaim Glueck et al.

Summary: The study found that capillary pericytes exhibited irregular and higher frequency calcium signals, occurring in cellular microdomains, while smooth muscle cells and ensheathing pericytes showed similar calcium dynamics in vivo. Activation of neurons and acute elevation of extracellular potassium can suppress calcium activity in capillary pericytes.
Article Multidisciplinary Sciences

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

Ryan E. Yoast et al.

NATURE COMMUNICATIONS (2020)

Article Geriatrics & Gerontology

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brainin vivo

Amy R. Nelson et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Interpericyte tunnelling nanotubes regulate neurovascular coupling

Luis Alarcon-Martinez et al.

NATURE (2020)

Article Multidisciplinary Sciences

Contractile pericytes determine the direction of blood flow at capillary junctions

Albert L. Gonzales et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Neurosciences

The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes

Ashwini Hariharan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Cell Biology

Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels

Xuexin Zhang et al.

CELL CALCIUM (2020)

Article Endocrinology & Metabolism

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

Roger Grant et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)

Article Multidisciplinary Sciences

A molecular atlas of cell types and zonation in the brain vasculature

Michael Vanlandewijck et al.

NATURE (2018)

Review Pharmacology & Pharmacy

Brain Pericytes As Mediators of Neuroinflammation

Justin Rustenhoven et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Article Medicine, Research & Experimental

IP3 receptors regulate vascular smooth muscle contractility and hypertension

Qingsong Lin et al.

JCI INSIGHT (2016)

Article Multidisciplinary Sciences

Capillary pericytes regulate cerebral blood flow in health and disease

Catherine N. Hall et al.

NATURE (2014)

Article Cardiac & Cardiovascular Systems

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

Brenda R. Chen et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

Article Cardiac & Cardiovascular Systems

Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels

Fabrice Dabertrand et al.

CIRCULATION RESEARCH (2012)

Article Cell Biology

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

Elizabeth Tringham et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Multidisciplinary Sciences

Pericytes regulate the blood-brain barrier

Annika Armulik et al.

NATURE (2010)

Article Multidisciplinary Sciences

Pericytes are required for blood-brain barrier integrity during embryogenesis

Richard Daneman et al.

NATURE (2010)

Article Multidisciplinary Sciences

The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels

Chan Young Park et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels

Youjun Wang et al.

SCIENCE (2010)

Article Ophthalmology

Diabetes-Induced Inhibition of Voltage-Dependent Calcium Channels in the Retinal Microvasculature: Role of Spermine

Kenji Matsushita et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)

Article Neurosciences

TRPC channels function independently of STIM1 and Orai1

Wayne I. DeHaven et al.

JOURNAL OF PHYSIOLOGY-LONDON (2009)

Review Pharmacology & Pharmacy

STIM and Orai: the long-awaited constituents of store-operated calcium entry

Peter Varnai et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Article Biochemical Research Methods

Methods for studying store-operated calcium entry

Gary S. Bird et al.

METHODS (2008)

Article Physiology

Membrane current oscillations in descending vasa recta pericytes

Qingli Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)

Article Biochemistry & Molecular Biology

Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation

S Moosmang et al.

EMBO JOURNAL (2003)

Review Cell Biology

Endothelial-pericyte interactions in angiogenesis

H Gerhardt et al.

CELL AND TISSUE RESEARCH (2003)