A Safe-by-Design Approach for the Synthesis of a Novel Cross-Linked Hyaluronic Acid with Improved Biological and Physical Properties

Review Chemistry, Multidisciplinary

Chemical Modification of Hyaluronan and Their Biomedical Applications

Vera Hintze et al.

Summary: This review provides an overview of different synthesis strategies for modulating the biological and material properties of hyaluronan, and discusses the current advances, challenges, and consequences of chemical modifications.

FRONTIERS IN CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

The Degradation of Hyaluronan in the Skin

Petra Zadnikova et al.

Summary: This study characterizes the distribution and activity of hyaluronidases and other proteins involved in the degradation of hyaluronan (HA) in healthy human skin. It also identifies a novel hyaluronidase TMEM2 and a protein CEMIP involved in HA degradation, which were localized in the human epidermis and dermis.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Functionalized injectable hyaluronic acid hydrogel with antioxidative and photothermal antibacterial activity for infected wound healing

Yikun Ren et al.

Summary: An injectable hyaluronic acid hydrogel with antioxidative and photothermal antibacterial activity has been developed as a functional dressing for infected wounds. This hydrogel demonstrates good stability, biocompatibility, and effective prevention of early infection and acceleration of wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biotechnology & Applied Microbiology

Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long-term treatment of inflammatory arthritis

Yongsheng Gao et al.

Summary: Antiproliferative chemotherapeutic agents show promise for treating inflammatory arthritis, but face limitations in clinical application due to high systemic toxicity and low joint bioavailability. A new intra-articular drug delivery system combining hyaluronic acid hydrogels and drug nanocrystals offers a potential solution for localized and sustained delivery of camptothecin, with positive results shown in rat models of collagen-induced arthritis.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

A Safe-by-Design Approach to Reef Safe Sunscreens Based on ZnO and Organic UV Filters

Mattia Battistin et al.

Summary: Research indicates that sunscreen formulations containing ZnO combined with organic filters deemed safe for coral reefs exhibit lower photocatalytic oxidation, highlighting their safety for use.

ANTIOXIDANTS (2022)

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Review Biotechnology & Applied Microbiology

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections

Reza Alipoor et al.

Summary: Bacterial contamination of medical devices is a significant concern for public health and hospital-acquired infections. Hyaluronic acid (HA) has bactericidal effects and nanotechnology has been used to improve its clinical utility. Combining HA with other bactericidal molecules can enhance the antibacterial effects and improve the management of hard-to-heal wound infections.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Polymer Science

The Effect of Crosslinking Degree of Hydrogels on Hydrogel Adhesion

Zhangkang Li et al.

Summary: The development of adhesive hydrogel materials has significantly advanced biomedical engineering. This study explores the effect of internal crosslinking degree on hydrogel adhesion and proposes two strategies to improve it.

GELS (2022)

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Article Polymer Science

Synthesis of Novel Hyaluronic Acid Sulfonated Hydrogels Using Safe Reactants: A Chemical and Biological Characterization

Elisa Sturabotti et al.

Summary: In this study, a one-pot procedure for the preparation of sulfonated hydrogels was presented. The hydrogels showed improved mechanical properties, stability, and biocompatibility compared to non-sulfonated samples.

GELS (2022)

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Article Biochemistry & Molecular Biology

Effect of crosslinking strategy on the biological, antibacterial and physicochemical performance of hyaluronic acid and e-polylysine based hydrogels

Kristine Salma-Ancane et al.

Summary: Hydrogels based on hyaluronic acid and ε-polylysine with antibacterial and cell attractive properties were designed using physical and chemical crosslinking methods. Both types of crosslinked hydrogels showed fast swelling behavior and long-term stability, with physically crosslinked hydrogels demonstrating better inhibition of Gram-negative E. coli.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Biochemistry & Molecular Biology

A guide to the composition and functions of the extracellular matrix

Nikos K. Karamanos et al.

Summary: Extracellular matrix (ECM) is a dynamic 3-dimensional network of macromolecules providing structural support for cells and tissues. It plays key regulatory roles in cell signaling, functions, and morphology. Different ECM components affect cell processes such as proliferation, migration, differentiation, angiogenesis, and immunity regulation, with structural alterations associated with disease progression.

FEBS JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Bioactivity reinforced surface patch bound collagen-pectin hydrogel

Himansh Goel et al.

Summary: The CPBG hydrogel forms a hybrid crosslinked network through surface patch interactions, with BG particles acting as pseudo crosslink junctions. In vitro bioactivity tests show bone-like hydroxyapatite microcrystals on its surface, and drug release kinetics follow the Fiddan mechanism.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Design, Synthesis, Characterization, and In Vitro Evaluation of a New Cross-Linked Hyaluronic Acid for Pharmaceutical and Cosmetic Applications

Sabrina Sciabica et al.

Summary: By modifying native HA through cross-linking reactions with Ornithine, the half-life and performance of the new product (HA-Orn) were improved. The gel-like profile of HA-Orn showed improved resistance against enzymatic digestion, and in vitro cytotoxicity studies demonstrated no cytotoxicity on lung cell lines.

PHARMACEUTICS (2021)

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Review Biochemistry & Molecular Biology

Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation

Andreia Marinho et al.

Summary: Hyaluronic acid is a natural polymer with unique physicochemical and biological properties, widely studied for applications in inflammatory diseases. While exogenous HA may not fully replace the properties of endogenous HA, it can still provide satisfactory pain relief.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Thermal Properties and Structural Features of Multilayer Films Based on Chitosan and Anionic Polysaccharides

Galina N. Gubanova et al.

Summary: This study investigated the thermal and structural properties of multilayer composites based on chitosan and different polyanions. The results showed that the type of polyanion used influenced the thermal degradation and crystallization behavior of the composite materials. Strong acid salts as counterions to chitosan led to strong interactions between layers, while weak polyacid salts resulted in weaker PEC formation.

BIOMOLECULES (2021)

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Article Physiology

Therapeutic effects of high molecular weight hyaluronic acid in severe Pseudomonas aeruginosa pneumonia in ex vivo perfused human lungs

Xiwen Zhang et al.

Summary: This study found that high molecular weight hyaluronic acid (HMW HA) can improve alveolar fluid clearance in ex vivo perfused human lungs injured with Pseudomonas aeruginosa (PA)103 bacterial pneumonia, while decreasing protein permeability and alveolar inflammation, but had no effect on bacterial counts. HMW HA also improved bacterial phagocytosis by human monocytes and neutrophils, and suppressed the inflammatory properties of EVs released during pneumonia on monocytes.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

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Article Ophthalmology

Clinical improvement of ocular surface parameters in dry eye patients following treatment with urea/crosslinked-hyaluronate eyedrops correlates with the secretion of MUC-4

Rosa Longo et al.

Summary: Treatment with U-HACL tear substitute resulted in significant improvement of ocular surface status in dry eye patients, as evidenced by improvements in symptoms, tear film parameters, and corneal/conjunctival damage scores.

EXPERT REVIEW OF OPHTHALMOLOGY (2021)

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Article Materials Science, Biomaterials

Hyaluronic acid/corn silk extract based injectable nanocomposite: A biomimetic antibacterial scaffold for bone tissue regeneration

Pooyan Makvandi et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Engineering, Environmental

Multifunctional injectable protein -based hydrogel for bone regeneration

Wenjuan Liu et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Oxidative Degradation of High-Molar-Mass Hyaluronan: Effects of Some Indole Derivatives to Hyaluronan Decay

Katarina Valachova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Arginine and Endothelial Function

Jessica Gambardella et al.

BIOMEDICINES (2020)

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Review Surgery

Hyaluronidase: An overview of its properties, applications, and side effects

Hyunwook Jung

ARCHIVES OF PLASTIC SURGERY-APS (2020)

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Article Chemistry, Applied

Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

Timothy E. L. Douglas et al.

CARBOHYDRATE POLYMERS (2019)

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Article Biochemistry & Molecular Biology

Various methods to combine hyaluronic acid and antimicrobial peptides coatings and evaluation of their antibacterial behaviour

Jean-Baptiste Paris et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Applied

Biosynthesis and characterization of antibacterial thermosensitive hydrogels based on corn silk extract, hyaluronic acid and nanosilver for potential wound healing

Pooyan Makvandi et al.

CARBOHYDRATE POLYMERS (2019)

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Article Nanoscience & Nanotechnology

Anti-Inflammation and Joint Lubrication Dual Effects of a Novel Hyaluronic Acid/Curcumin Nanomicelle Improve the Efficacy of Rheumatoid Arthritis Therapy

Zengjie Fan et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Medicine, Research & Experimental

Arginine: Challenges and opportunities of this two-faced molecule in cancer therapy

Mozhgan Jahani et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Polymer Science

Hyaluronic Acid in the Third Millennium

Arianna Fallacara et al.

POLYMERS (2018)

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Article Chemistry, Applied

Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects

Syed Nasir Abbas Bukhari et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Polymer Science

Hyaluronic Acid-Based Nanomaterials for Cancer Therapy

Jin Hong Kim et al.

POLYMERS (2018)

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Article Pharmacology & Pharmacy

Formulation and Characterization of Native and Crosslinked Hyaluronic Acid Microspheres for Dermal Delivery of Sodium Ascorbyl Phosphate: A Comparative Study

Arianna Fallacara et al.

PHARMACEUTICS (2018)

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Article Medicine, Research & Experimental

Standardized in vitro analysis of the degradability of hyaluronic acid fillers by hyaluronidase

Bettina Alexandra Buhren et al.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2018)

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Article Chemistry, Applied

Design, synthesis and characterization of linear unnatural amino acids for skin moisturization

N. R. Arezki et al.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2017)

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Article Biochemistry & Molecular Biology

Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study

Arianna Fallacara et al.

MOLECULES (2017)

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Article Microbiology

The Skin Bacterium Propionibacterium acnes Employs Two Variants of Hyaluronate Lyase with Distinct Properties

Seven Nazipi et al.

MICROORGANISMS (2017)

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Review Engineering, Biomedical

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation

Helena Knopf-Marques et al.

ADVANCED HEALTHCARE MATERIALS (2016)

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Article Chemistry, Applied

Relationship between structure and cytocompatibility of divinyl sulfone cross-linked hyaluronic acid

Jui-Yang Lai

CARBOHYDRATE POLYMERS (2014)

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Review Dermatology

A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether-Crosslinked Hyaluronic Acid Dermal Fillers

Koenraad De Boulle et al.

DERMATOLOGIC SURGERY (2013)

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Article Food Science & Technology

Glass Transition and Water Dynamics in Hyaluronic Acid Hydrogels

Anna Panagopoulou et al.

FOOD BIOPHYSICS (2013)

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Review Chemistry, Applied

Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications

Carole E. Schante et al.

CARBOHYDRATE POLYMERS (2011)

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Article Biochemistry & Molecular Biology

Hyaluronic acid derivatives prepared in aqueous media by triazine-activated amidation

Kristoffer Bergman et al.

BIOMACROMOLECULES (2007)

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Review Medicine, Research & Experimental

The magic glue hyaluronan and its eraser hyaluronidase: A biological overview

K. S. Girish et al.

LIFE SCIENCES (2007)

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Review Biotechnology & Applied Microbiology

Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications

Grigorij Kogan et al.

BIOTECHNOLOGY LETTERS (2007)

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Article Engineering, Biomedical

Effects of cross-linking molecular weights in a hyaluronic acid - poly(ethylene oxide) hydrogel network on its properties

Insup Noh et al.

BIOMEDICAL MATERIALS (2006)

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Article Medicine, Research & Experimental

Inhibition of Naja naja venom hyaluronidase:: Role in the management of poisonous bite

KS Girish et al.

LIFE SCIENCES (2006)

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Article Multidisciplinary Sciences

Identification of a hyaluronidase, HyaI5, involved in penetration of mouse sperm through cumulus mass

E Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Polymer Science

Morphology and water affinity of superabsorbent hydrogels composed of methacrylated cashew gum and acrylamide with good mechanical properties

MR Guilherme et al.

POLYMER (2005)

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Article Biochemistry & Molecular Biology

Rheological characterization of in situ cross-linkable hyaluronan hydrogels

K Ghosh et al.

BIOMACROMOLECULES (2005)

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Article Biochemical Research Methods

Enzymatic degradation of liposome-grafted poly(hydroxyethyl L-glutamine)

B Romberg et al.

BIOCONJUGATE CHEMISTRY (2005)

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Article Biochemistry & Molecular Biology

Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

MD Rees et al.

BIOCHEMICAL JOURNAL (2004)

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Article Chemistry, Physical

Application of rheology for assessment and prediction of the long-term physical stability of emulsions

T Tadros

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2004)

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Article Biochemistry & Molecular Biology

Regulation of hyaluronidase activity by alternative mRNA splicing

VB Lokeshwar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

Mechanism of hyaluronan binding and degradation:: Structure of Streptococcus pneumoniae hyaluronate lyase in complex with hyaluronic acid disaccharide at 1.7 Å resolution

K Ponnuraj et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

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A Safe-by-Design Approach for the Synthesis of a Novel Cross-Linked Hyaluronic Acid with Improved Biological and Physical Properties

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