☆ 4.6 Article

Combination of Bacteriophages and Antibiotics for Prevention of Vascular Graft Infections-An In Vitro Study

PHARMACEUTICALS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Virology

Phage Therapy in Germany-Update 2023

Christian Willy et al.

Summary: Bacteriophage therapy shows promise in addressing global and German antibiotic resistance crises. The current situation in Germany regarding phage therapy and research is outlined. Critical shortcomings include a lack of clinical trials, regulation, and phages for clinical use. Phage therapy is being used on a limited number of patients as individual treatment trials.

VIRUSES-BASEL (2023)

添加到收藏夹

Article Microbiology

Methicillin-Susceptible Staphylococcus aureus Biofilm Formation on Vascular Grafts: an In Vitro Study

Cristina Tello-Diaz et al.

Summary: The aim of this study was to quantify in vitro biofilm formation by methicillin-susceptible Staphylococcus aureus (MSSA) on the surfaces of different types of commonly used vascular grafts. The Dacron silver-triclosan and Omniflow II vascular grafts showed the greatest resistance to in vitro methicillin-susceptible Staphylococcus aureus biofilm formation compared to other vascular grafts.

MICROBIOLOGY SPECTRUM (2023)

添加到收藏夹

Article Chemistry, Medicinal

Synergistic Effects of Phage-Antibiotic Combinations against Citrobacter amalonaticus

Prasanth Manohar et al.

Summary: The study demonstrates the potential of using phage-antibiotic combinations as an effective therapeutic strategy against infections caused by multidrug resistant bacteria.

ACS INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Biology

Phage-Antibiotic Synergy Inhibited by Temperate and Chronic Virus Competition

Kylie J. Landa et al.

Summary: This study investigates the synergistic and competitive effects between antibiotics and viruses (temperate and chronic) on antibiotic treatment for bacterial infections. It finds that the combination of antibiotics and temperate viruses has a synergistic effect, but competition between temperate and chronic viruses inhibits the efficacy of antibiotics.

BULLETIN OF MATHEMATICAL BIOLOGY (2022)

添加到收藏夹

Article Microbiology

The antagonistic interactions between a polyvalent phage SaP7 and 13-lactam antibiotics on combined therapies

Dongxin Ma et al.

Summary: This study identified a polyvalent phage SaP7 that exhibited antagonistic effects on multiple drug-resistant bacteria. It is crucial to fully and cautiously evaluate the interactions between phages and antibiotics to avoid antagonistic impacts and failure of combination therapy.

VETERINARY MICROBIOLOGY (2022)

添加到收藏夹

Article Microbiology

Aminoglycoside Antibiotics Inhibit Phage Infection by Blocking an Early Step of the Infection Cycle

Larissa Kever et al.

Summary: Predation by phages is a major driver of bacterial evolution. This study reveals that aminoglycosides, a type of antibiotics produced by Streptomyces, have potent antiviral properties and can block an early step of phage infection. The supernatants from natural aminoglycoside producers also show broad inhibitory effects on phage propagation. Acetylation of the aminoglycoside antibiotic apramycin abolishes its antibacterial effect but retains its antiviral properties. These findings expand our understanding of aminoglycoside functions and suggest that they may provide protection against phage predation at the community level.

MBIO (2022)

添加到收藏夹

Article Microbiology

Eradication of Biofilm-Mediated Methicillin-Resistant Staphylococcus aureus Infections In Vitro: Bacteriophage-Antibiotic Combination

Razieh Kebriaei et al.

Summary: Bacterial biofilms are difficult to eradicate and can complicate infections. Phage+antibiotic combinations (PAC) may be more effective on biofilms than single agents. Our study demonstrated the effectiveness of phage Sb-1 on MRSA biofilms and suggested PAC regimens as adjuncts to antibiotics.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹

Article Infectious Diseases

Evaluation of Bacteriophage-Antibiotic Combination Therapy for Biofilm-Embedded MDR Enterococcus faecium

Katherine Lev et al.

Summary: This study examined the synergy between lytic bacteriophages and antibiotics in treating multidrug-resistant Enterococcus faecium. The results showed that combinations of bacteriophages with daptomycin and other antibiotics had synergistic and bactericidal effects, while also preventing the emergence of resistance.

ANTIBIOTICS-BASEL (2022)

添加到收藏夹

Article Microbiology

Antibiotic Exposure Leads to Reduced Phage Susceptibility in Vancomycin Intermediate Staphylococcus aureus (VISA)

Shawna McCallin et al.

Summary: In Vancomycin-intermediate Staphylococcus aureus (VISA), exposure to vancomycin may lead to cross-resistance to phage. VISA strains with intermediate levels of vancomycin resistance showed decreased sensitivity to phage. Serial passaging with vancomycin induced reduced vancomycin susceptibility and phage sensitivity. Understanding the interference between antibiotic and phage resistance mechanisms is important for designing effective therapeutic regimens.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

添加到收藏夹

Article Surgery

Treatment of an Infected TEVAR with Extra- and Endovascular Bacteriophage Application

Eberhard Grambow et al.

Summary: This article describes a bacteriophage treatment approach for infected aortic stent grafts, which involves the application of bacteriophage suspension and gel locally. The treatment successfully cured the infection in the patient.

EJVES VASCULAR FORUM (2022)

添加到收藏夹

Article Microbiology

A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model

Willemijn Boot et al.

Summary: The study introduces a clinically relevant large animal model of chronic MRSA ODRI, demonstrating that an injectable, thermoresponsive, hyaluronic acid-based hydrogel loaded with gentamicin and vancomycin outperforms current clinical practice treatment. These results suggest that local antibiotic delivery with an injectable hydrogel can significantly increase treatment success rates beyond current clinical practice in a robust animal model.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

添加到收藏夹

Article Infectious Diseases

Bacteriophages for the Treatment of Graft Infections in Cardiovascular Medicine

Simon Junghans et al.

Summary: Bacterial infections in cardiovascular surgery pose a significant challenge, with antibiotic treatment hindered by various factors. Bacteriophage therapy, discovered a century ago, could potentially serve as an important treatment method, particularly in the face of antimicrobial resistance and personalized medicine. Further research and standardization are needed to fully utilize the potential of phage therapy in combating vascular graft infections.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹

Article Chemistry, Medicinal

Friends or Foes? Rapid Determination of Dissimilar Colistin and Ciprofloxacin Antagonism of Pseudomonas aeruginosa Phages

Katarzyna M. Danis-Wlodarczyk et al.

Summary: Research has shown that colistin significantly interferes with phage activities at its minimum inhibitory concentration, while ciprofloxacin has little impact on phages. Combination therapy with phages and antibiotics is more effective in treating P. aeruginosa, and phage replication is crucial for treatment success. The lysis-profile assays provide a useful, quick, and high-throughput method to assess antibiotic antagonism of phage infection activities.

PHARMACEUTICALS (2021)

添加到收藏夹

Article Biology

Searching for synergy: combining systemic daptomycin treatment with localised phage therapy for the treatment of experimental pneumonia due to MRSA

Luca G. Valente et al.

Summary: The study aimed to investigate the combinatorial effects of systemic daptomycin and nebulised bacteriophages for treating experimental pneumonia caused by MRSA. Results showed that the combination of intravenous daptomycin and nebulised phages did not offer superior benefits in improving survival rates or reducing bacterial burdens in the lungs and spleen, indicating that this combination is not beneficial for patients with MRSA pneumonia.

BMC RESEARCH NOTES (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Aminoglycosides Antagonize Bacteriophage Proliferation, Attenuating Phage Suppression of Bacterial Growth, Biofilm Formation, and Antibiotic Resistance

Pengxiao Zuo et al.

Summary: This study reveals that aminoglycoside antibiotics inhibit the replication of phages and reduce their impact on bacterial growth, biofilm formation, and antibiotic tolerance. It highlights the overlooked antagonistic effect on phage proliferation and its implications for bacterial control and antibiotic resistance propagation.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2021)

添加到收藏夹

Article Virology

A Case of In Situ Phage Therapy against Staphylococcus aureus in a Bone Allograft Polymicrobial Biofilm Infection: Outcomes and Phage-Antibiotic Interactions

Brieuc Van Nieuwenhuyse et al.

Summary: Phage therapy shows potential in managing biofilm infections, but may have limitations in polymicrobial infections. Combination of surgery and antibiotic therapy has a positive impact on improving these infections, but does not completely prevent recurrence.

VIRUSES-BASEL (2021)

添加到收藏夹

Review Multidisciplinary Sciences

The arms race between bacteria and their phage foes

Hannah G. Hampton et al.

NATURE (2020)

添加到收藏夹

Article Infectious Diseases

Bacteriophage Therapy for Critical Infections Related to Cardiothoracic Surgery

Evgenii Rubalskii et al.

ANTIBIOTICS-BASEL (2020)

添加到收藏夹

Article Microbiology

Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry

Carmen Gu Liu et al.

MBIO (2020)

添加到收藏夹

Article Cell & Tissue Engineering

A novel antimicrobial coating to prevent periprosthetic joint infection

R. Ramalhete et al.

BONE & JOINT RESEARCH (2020)

添加到收藏夹

Article Immunology

Polyester Vascular Graft Material and Risk for Intracavitary Thoracic Vascular Graft Infection

Tiziano A. Schweizer et al.

EMERGING INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Fibrin glue as a local drug-delivery system for bacteriophage PA5

Evgenii Rubalskii et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Immunology

Fighting Pathogenic Bacteria on Two Fronts: Phages and Antibiotics as Combined Strategy

Thaysa Leite Tagliaferri et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

添加到收藏夹

Article Microbiology

The Ability of Lytic Staphylococcal Podovirus vB_SauP_phiAGO1.3 to Coexist in Equilibrium With Its Host Facilitates the Selection of Host Mutants of Attenuated Virulence but Does Not Preclude the Phage Antistaphylococcal Activity in a Nematode Infection Model

Aleksandra Glowacka-Rutkowska et al.

FRONTIERS IN MICROBIOLOGY (2019)

添加到收藏夹

Review Infectious Diseases

Phage-Antibiotic Combination Treatments: Antagonistic Impacts of Antibiotics on the Pharmacodynamics of Phage Therapy?

Stephen T. Abedon

ANTIBIOTICS-BASEL (2019)

添加到收藏夹

Review Microbiology

Relationship between the Viable but Nonculturable State and Antibiotic Persister Cells

Mesrop Ayrapetyan et al.

JOURNAL OF BACTERIOLOGY (2018)

添加到收藏夹

Article Evolutionary Biology

Phage treatment of an aortic graft infected with & IT;Pseudomonas aeruginosa & IT;

Benjamin K. Chan et al.

EVOLUTION MEDICINE AND PUBLIC HEALTH (2018)

添加到收藏夹

Article Infectious Diseases

In Vitro Antimicrobial Activity of Fibrin Sealants Containing Antimicrobial Agents

Hidemasa Nakaminami et al.

SURGICAL INFECTIONS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Synergistic Action of Gentamicin and Bacteriophage in a Continuous Culture Population of Staphylococcus aureus

Amy E. Kirby

PLOS ONE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Coexistence of phage and bacteria on the boundary of self-organized refuges

Silja Heilmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Surgery

Prevention of Early Vascular Graft Infection Using Regional Antibiotic Release

Christian Kuehn et al.

JOURNAL OF SURGICAL RESEARCH (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Phage-Antibiotic Synergy (PAS): β-Lactam and Quinolone Antibiotics Stimulate Virulent Phage Growth

Andre M. Comeau et al.

PLOS ONE (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

Maria A. Borovinskaya et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

添加到收藏夹

Review Medicine, General & Internal

Current concepts - Treatment of infections associated with surgical implants

RO Darouiche

NEW ENGLAND JOURNAL OF MEDICINE (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Post-termination complex disassembly by ribosome recycling factor, a functional tRNA mimic

G Hirokawa et al.

EMBO JOURNAL (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.