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Health Care Sciences & Services
Giulia Giacomucci et al.
Summary: The study aimed to assess empathy deficit and neuronal correlates in patients with logopenic primary progressive aphasia (lv-PPA) and compare it with amnesic Alzheimer's disease (AD). The findings showed that both lv-PPA and AD patients had decreased cognitive empathy and increased personal distress over time. The study also found that specific brain regions with metabolic dysfunction were associated with empathy deficits.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
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Harriet Rydell et al.
Summary: In patients with muscle-invasive bladder cancer undergoing neoadjuvant chemotherapy, there is an association between chemotherapy and thromboembolic events, with a significant portion of patients experiencing decreased renal function, making them potentially less suitable for LMWH prophylaxis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
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Health Care Sciences & Services
Dominik Rak et al.
Summary: This study compared the difference in knee function after TKA between patients who received inpatient rehabilitation (IR) and outpatient rehabilitation (specifically, fast-track rehabilitation or FTR). The findings suggest that IR does not provide significant long-term benefits to patient recovery after primary uncomplicated TKA.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
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Health Care Sciences & Services
Karyn G. Robinson et al.
Summary: This study examined the DNA methylation differences in myoblasts and myotubes derived from satellite cells in patients with spastic cerebral palsy (CP). The results showed significant DNA methylation differences in these cells, suggesting potential new targets for studying the mechanisms contributing to muscle dysregulation in spastic CP.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
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Health Care Sciences & Services
Katarina Hubcikova et al.
Summary: Huntington's disease (HD) often receives less attention in standard medical practice due to its rarity and lack of causal treatment options. However, this study highlights the need for improved genetic counseling, social and health care, and awareness of the disease in the general health community. Additionally, more information on ongoing clinical trials is necessary.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
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Health Care Sciences & Services
Medi Kori et al.
Summary: Cancer hallmark genes and proteins play important roles in regulating and driving carcinogenesis. This study analyzed transcriptome data from 12 common cancers and identified differentially interacting hallmarks of cancer proteins (DIHCP) and DIHCP-centric modules. These modules showed significant changes in interaction patterns between tumor and control phenotypes, and some of them had diagnostic and prognostic capabilities. The study also investigated the druggability of the identified DIHCPs. Overall, the study presents candidate system biomarkers that could enhance understanding of tumorigenesis and improve personalized treatment strategies for various cancers, focusing on their ten hallmark characteristics.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Ishika Mahajan et al.
Summary: COVID-19, mucormycosis, and cancer are major healthcare threats worldwide, and there are interactions and interplay among them. Understanding the relationships between them is crucial for effective management and reducing overall morbidity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
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Health Care Sciences & Services
Sang-Cheol Im et al.
Summary: This study found that lumbar belts with different extensibilities have a positive effect on motor control in patients with nonspecific low back pain. Therefore, these belts can be useful in the sit-to-stand motion for these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Valerio Nardone et al.
Summary: Despite being mainly used in oncological patients, radiotherapy can also be an effective treatment for non-malignant disorders. Recent interest has shed light on this approach, and further investigation and clinical application are needed.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Heh-Shiang Sheu et al.
Summary: This study investigated the correlation between TPMT polymorphisms and AZA-related hepatotoxicity in Asian patients. The results showed that the non-normal metabolizer genotype of TPMT was associated with hepatotoxicity. The incidence of hepatotoxicity was higher in the non-normal metabolizer group compared to the normal metabolizer group, and increased over time.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Anne-Marie Caminade
Summary: This review focuses on the clinical trials conducted with dendrimers, assessing their safety and efficacy. It highlights the poor clinical translation of dendrimers thus far.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Anna Russo et al.
Summary: Musculoskeletal ultrasound is a research method that focuses on superficial targets, particularly in the hands, wrists, and feet. Its high spatial resolution and superb image quality have the potential to bring innovation to diagnostic imaging.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Simon Reider et al.
Summary: The study focused on the prebiotic properties of a purified extract from European black elderberries for microbiota modulation. The ELDERGUT trial involved a 9-week longitudinal intervention with promising results in terms of individualized microbiome trajectories and significant changes in diversity indices. Associations with participant metadata were also identified.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Seung-Su Ha et al.
Summary: The study proposes an ultra-short-term analysis method to assess the balance of autonomic nervous system (ANS) activity in patients with obstructive sleep apnea (OSA). The results show that this method is more effective in revealing the association between sympathetic overactivity and OSA severity, and it exhibits higher consistency compared to the traditional short-term analysis method.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Victoria Eriksson et al.
Summary: A high pre-treatment De Ritis ratio is associated with increased mortality and decreased overall survival in patients with muscle-invasive bladder cancer (MIBC), but is not predictive of downstaging.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Kostas Archontogeorgis et al.
Summary: This study found that patients with OVS had lower Vit D levels compared to OSA patients and non-apneic controls, indicating an increased risk of hypovitaminosis D in this population which might be associated with disease severity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Viviana Nociti et al.
Summary: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with broad heterogeneity and different prognoses. Autoimmune comorbidities play a crucial role in MS, affecting its pathogenesis, diagnostic delay, disease activity, disability progression, brain atrophy, and treatment choices. However, the impact of autoimmune comorbidities on MS is not fully understood.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Minji Kim et al.
Summary: This study utilized preoperative simulation and 3D titanium printing to fabricate and place customized BAMP devices precisely for treating skeletal Class III malocclusion. The growth modification effect was successful, with decreased ANB difference and Wits appraisal after 2 years, indicating accurate placement of the devices at planned locations.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Keh-Sen Liu et al.
Summary: This study identified risk factors of 30-day all-cause mortality in patients with CRKP BSI, including microbiologic eradication > 7 days, lower platelet count, and a higher Pitt bacteremia score. These findings provide new insights into the clinical landscape of CRKP BSI.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Arisa Djurian et al.
Summary: The study of anticancer drug transactions revealed the significance of immune checkpoint blockade in interorganizational collaborations, with drugs like pembrolizumab and nivolumab continuously expanding their approved indications. This suggests that immune checkpoint blockade is a prominent paradigm for cancer treatment, driven by strategic partnerships and continual indication expansion.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
