Supplementing a specific synbiotic suppressed the incidence of AOM/DSS-induced colorectal cancer in mice

In this study, we evaluated the effect of a specific synbiotic on CAC (AOM/DSS-induced colitis-associated cancer). We confirmed that the synbiotic intervention was able to protect the intestinal barrier and inhibit CAC occurrence via upregulating tight junction proteins and anti-inflammatory cytokines, and downregulating pro-inflammatory cytokines. Moreover, the synbiotic significantly improved the disorder of the colonic microbiota of CAC mice, promoted the formation of SCFAs and the production of secondary bile acids, and alleviated the accumulation of primary bile acids in the CAC mice. Meanwhile, the synbiotic could significantly inhibit the abnormal activation of the intestinal Wnt/beta-catenin signaling pathway significantly related to IL-23. In a word, the synbiotic can inhibit the occurrence and development of colorectal tumors and it may be a functional food to prevent inflammation-related colon tumors, and the research also provided a theoretical basis for improving the intestinal microecological environment through diet therapy.

Automated summary

This study found that a specific synbiotic intervention can protect the intestinal barrier, inhibit the occurrence of colitis-associated cancer (CAC), and improve the intestinal microecological environment. The synbiotic upregulates tight junction proteins and anti-inflammatory cytokines, while downregulating pro-inflammatory cytokines. It also improves the disorder of the colonic microbiota, promotes the formation of SCFAs and the production of secondary bile acids, and alleviates the accumulation of primary bile acids in CAC mice. Additionally, it inhibits the abnormal activation of the intestinal Wnt/β-catenin signaling pathway related to IL-23.