Risk of cerebrovascular disease after cancer diagnosis in the United States

The risk of subsequent cerebrovascular disease among cancer patients of multiple cancers in the US is not well understood. A total of 3,843,261 cancer patients diagnosed from 1975 to 2018, were included from the surveillance, epidemiology, and end results (SEER) database. Standardized mortality ratios (SMRs) and absolute excess risks (AERs) were estimated. The overall cerebrovascular disease SMR was 1.04 (95% CI, 1.03-1.04), and the AER per 10,000 person-years at risk was 0.89. When compared with the US general population, greater cerebrovascular disease risk was correlated with certain cancer sites, American Indian/Alaska Native race, Asian or Pacific Islander race, unmarried marital status, distant metastasis, younger age, and an earlier time of cancer diagnosis. Clinically, more precision and proactive strategies for cerebrovascular disease prevention are required to subgroup of cancer patients with a greater risk of cerebrovascular disease, especially within the first two months.

Automated summary

The risk of subsequent cerebrovascular disease among cancer patients of multiple cancers in the US is not well understood. Certain cancer sites, race, marital status, metastasis, age, and time of cancer diagnosis are associated with an increased risk of cerebrovascular disease. More precise and proactive strategies for cerebrovascular disease prevention are needed for cancer patients with a higher risk, especially within the first two months.