期刊
LIVER INTERNATIONAL
卷 37, 期 1, 页码 19-31出版社
WILEY
DOI: 10.1111/liv.13237
关键词
global burden; hepatitis E; outbreaks
资金
- Endowment Fund for Education (LPDP)
- Dutch Digestive Foundation (MLDS) [CDG 1304]
- Daniel den Hoed Foundation
- Erasmus MC Mrace grant
- China Scholarship Council [201303250056]
Hepatitis E virus (HEV) is responsible for repeated water-borne outbreaks since the past century, representing an emerging issue in public health. However, the global burden of HEV outbreak has not been comprehensively described. We performed a systematic review of confirmed HEV outbreaks based on published literatures. HEV outbreaks have mainly been reported from Asian and African countries, and only a few from European and American countries. India represents a country with the highest number of reported HEV outbreaks. HEV genotypes 1 and 2 were responsible for most of the large outbreaks in developing countries. During the outbreaks in developing countries, a significantly higher case fatality rate was observed in pregnant women. In fact, outbreaks have occurred both in open and closed populations. The control measures mainly depend upon improvement of sanitation and hygiene. This study highlights that HEV outbreak is not new, yet it is a continuous global health problem.
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