The Role of Pericytes in Regulation of Innate and Adaptive Immunity

Review Cell & Tissue Engineering

Blood Vessel Resident Human Stem Cells in Health and Disease

David J. Craig et al.

Summary: This article discusses the current knowledge on vessel wall-associated tissue remodeling cells, including their functional diversity in health and disease, and their potential therapeutic value.

STEM CELLS TRANSLATIONAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme

Maria Teresa Pallotta et al.

Summary: IDO1 plays a crucial role in pregnancy and autoimmune diseases by catalyzing tryptophan degradation and reprogramming the expression profile of immune cells towards a highly immunoregulatory phenotype. In addition to its enzymic function, IDO1 also exhibits a peculiar conformational plasticity.

FEBS JOURNAL (2022)

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Review Cell Biology

Central Nervous System Pericytes Contribute to Health and Disease

Francesco Girolamo et al.

Summary: Understanding pericyte (PC) signaling is crucial for the function and modified cell-cell interactions of the neurovascular unit (NVU). PCs play a crucial role in controlling the functions and blood-brain barrier stability of endothelial, astrocyte, and oligodendrocyte precursor cells. Dysfunctional PC signaling could also serve as a potential biomarker for NVU pathology.

CELLS (2022)

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Article Cell Biology

Chaperone-Mediated Autophagy Ablation in Pericytes Reveals New Glioblastoma Prognostic Markers and Efficient Treatment Against Tumor Progression

Maria Luisa Molina et al.

Summary: The study demonstrates the crucial role of chaperone-mediated autophagy (CMA) in the progression of glioblastoma (GB). The ablation of CMA in pericytes (PC) is identified as a key target mechanism for successful GB treatment. Additionally, new target markers related to tumor immune responses are identified.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Single Cell Transcriptomic Analysis Reveals Organ Specific Pericyte Markers and Identities

Seung-Han Baek et al.

Summary: By analyzing single-cell RNA sequencing data, we have identified specific pericyte markers among lung, heart, kidney, and bladder, and revealed differentially expressed genes and functional relationships between mural cells.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Multidisciplinary Sciences

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A

Regis Joulia et al.

Summary: This study reveals that perivascular mast cells regulate the final steps of neutrophil diapedesis through the outer pericyte layer via IL-17A production, potentially providing insights for inflammatory disorders driven by increased neutrophil diapedesis.

NATURE COMMUNICATIONS (2022)

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Article Immunology

Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier

Eliza Gil et al.

Summary: Excessive neutrophil extravasation can lead to immunopathology, but the mechanisms that amplify this process are not well understood. This study shows that human brain vascular pericytes (HBVP) contribute to neutrophil extravasation by enhancing endothelial barrier formation and promoting neutrophil transmigration. This process is mediated by paracrine signaling from monocyte derived macrophages, which upregulates the production of neutrophil chemokines by pericytes. Understanding the role of pericytes in amplifying neutrophil extravasation may provide new therapeutic targets for reducing neutrophil mediated pathology in pyogenic meningitis.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy

Yu Fujiwara et al.

Summary: Strategies to overcome immunosuppression in the tumor microenvironment, such as IDO1 inhibition, have been explored to address resistance to immune checkpoint blockade. These strategies have shown promising results in preclinical studies and early-phase clinical trials. However, some clinical trials have yielded disappointing results, dampening enthusiasm for IDO inhibitors. Additional potential targets, such as the aryl hydrocarbon receptor and tryptophan 2,3-dioxygenase, have been proposed to enhance clinical effectiveness. The expression level of IDO1 varies among tumors and patients, highlighting the importance of patient selection based on IDO1 expression levels in clinical trials.

CANCER TREATMENT REVIEWS (2022)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms Underlying Pathological and Therapeutic Roles of Pericytes in Atherosclerosis

Siarhei A. Dabravolski et al.

Summary: Pericytes play a key role in the pathogenesis and development of atherosclerosis, being involved in plaque formation and vulnerability. They can also be targeted as a therapeutic approach to promote vessel maturity and stability, reducing plaque vulnerability.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, General & Internal

The CRTh2 polymorphism rs533116 G > A associates with asthma severity in older females

Nami Shrestha Palikhe et al.

Summary: The polymorphism CRTh2 rs533116 G > A is associated with severe asthma and type 2 inflammation in older females.

FRONTIERS IN MEDICINE (2022)

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Review Medicine, Research & Experimental

Emerging role of pericytes in therapy of cardiovascular diseases

Siarhei A. Dabravolski et al.

Summary: Pericytes play crucial roles in the formation, maintenance, and regulation of blood vessels in cardiovascular diseases. They have been studied for their potential application in cell therapy and as pharmacological targets for novel drugs and techniques.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Physiology

Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells

Ranjit K. Sahu et al.

Summary: This study demonstrates the pathogenic role of increased expression of the complement receptor on macrophages using novel floxed green fluorescent protein C5a receptor 1 mice and the model of folic acid-induced kidney fibrosis.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2022)

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Review Cell & Tissue Engineering

Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair

Sipin Zhu et al.

Summary: Vascular regeneration and bone development rely on the important role of pericytes, but distinguishing different subtypes of pericytes remains a challenge. This review discusses the biology, markers, and differentiation capacity of pericytes, with a focus on their potential applications in the treatment of spinal cord injury and bone diseases in orthopedics.

BONE RESEARCH (2022)

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Article Respiratory System

Periostin: contributor to abnormal airway epithelial function in asthma?

Janette K. Burgess et al.

Summary: POSTN may serve as a biomarker for Type-2 mediated eosinophilic airway inflammation in asthma. IL-13 increases POSTN expression in bronchial epithelial cells and is higher in bronchial biopsies from asthma patients.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Pericytes cross-talks within the tumor microenvironment

Caroline C. Picoli et al.

Summary: Cancer cells interact dynamically with components of the tumor microenvironment during tumor progression, and recent studies have shown that pericytes communicate with cancer cells using advanced technologies. Understanding the cross-talk within the tumor microenvironment is crucial for developing new therapies against cancer.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Hematology

Mesenchymal stromal cells: Getting ready for clinical primetime

Holly Wobma et al.

Summary: Mesenchymal stromal cells (MSC) are multipotent precursor cells that have generated interest as cell therapies for their immune regulatory function. Despite a good safety record, they are currently only approved for use in a few countries due to a lack of consistent efficacy data.

TRANSFUSION AND APHERESIS SCIENCE (2021)

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Article Cell Biology

Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes

Seley Gharanei et al.

Summary: The study reveals that pericytes in the midluteal human endometrium express VAP-1, and its knockdown affects their biophysical properties and interactions with uterine natural killer cells. This suggests a potential role for VAP-1 as a biomarker for pregnancy pathologies related to compromised perivascular environment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Pericytes regulate vascular immune homeostasis in the CNS

Orsolya Toeroek et al.

Summary: Pericytes regulate leukocyte infiltration in the adult central nervous system and play a role in neuroinflammation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Anatomy & Morphology

Digital Imaging Analysis Reveals Reduced Alveolar α-Smooth Muscle Actin Expression in Severe Asthma

Jacob A. Jerome et al.

Summary: This study found a significant decrease in alpha-SMA expression in the alveolated parenchyma of individuals with severe asthma, suggesting a potential role of changes in myofibroblast alpha-SMA expression or cell number. Further research is needed to fully evaluate the mechanisms and consequences of this phenomenon.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2021)

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Review Biochemistry & Molecular Biology

Microvascular cells: A special focus on heterogeneity of pericytes in diabetes associated complications

Sharmila Rajendran et al.

Summary: Pericytes are microvascular mural cells that regulate vascular development, stabilization, maturation, and remodeling. In diabetic retinopathy and diabetic nephropathy, apoptotic loss and migration of pericytes lead to microvascular instability, exacerbating the disease progression. Specific biomarkers are needed for early stabilization of pericytes in these diabetes-associated complications.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

Maria Michelle Papamichael et al.

Summary: Pediatric asthma is a major public health challenge, affecting 5-20% of children in Europe and attributed to genetic susceptibility and environmental factors. Metabolomics, as an emerging approach, can provide deeper insight into the pathophysiological mechanisms of asthma, facilitate the discovery of early diagnostic markers and personalized therapies. Analyzing intermediate metabolites in clinical practice may have a positive impact on pediatric asthma management.

METABOLITES (2021)

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Review Endocrinology & Metabolism

Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity

Daniel Tome

Summary: The defense mechanisms against pathogens in mammals involve interactions between immune functions and metabolic pathways to control inflammation and pathogen replication, protecting the host's health.

NUTRITION & DIABETES (2021)

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Review Neurosciences

Pericytes for Therapeutic Approaches to Ischemic Stroke

Lu Cao et al.

Summary: Pericytes are multipotent cells located on capillaries and play a crucial role in maintaining the blood-brain barrier and regulating the neurovascular system. Dysfunction of pericytes can lead to diseases such as stroke. Recent studies suggest that pericytes can be a therapeutic target for ischemic stroke.

FRONTIERS IN NEUROSCIENCE (2021)

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Review Immunology

Periostin in Allergy and Inflammation

Eva Sonnenberg-Riethmacher et al.

Summary: Periostin, a matricellular protein, plays important roles in allergic and inflammatory reactions by influencing crosstalk between cells, promoting the development of diseases, and having differential expression in various allergic conditions and inflammatory diseases. It also contributes to tissue remodelling, fibrosis, regeneration, and repair, and has been linked to chronic inflammation and cancer.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

The Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer

Domenico Ribatti et al.

Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.

CANCERS (2021)

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Article Allergy

Matricellular Protein Periostin Promotes Pericyte Migration in Fibrotic Airways

Rebecca E. Bignold et al.

Summary: The study revealed abundant periostin expression in pericytes, with increased levels following TGF-beta treatment. Pericytes treated with periostin showed enhanced migratory capabilities, suggesting a key role for periostin in inducing pericyte migration during airway remodeling.

FRONTIERS IN ALLERGY (2021)

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Article Physiology

Renal NG2-expressing cells have a macrophage-like phenotype and facilitate renal recovery after ischemic injury

Wararat Kittikulsuth et al.

Summary: This study reveals that NG2(+) cells in injured kidneys show macrophage-like activities, express anti-inflammatory cytokine genes, and play a crucial role in facilitating the recovery process after renal injury.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Chemistry, Medicinal

Targeting B7-1 in immunotherapy

Rui Chen et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Review Endocrinology & Metabolism

Pros and Cons of Chaperone-Mediated Autophagy in Cancer Biology

Esperanza Arias et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

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Review Medicine, General & Internal

Combining Immune Checkpoint Inhibitors with Anti-Angiogenic Agents

Paola Ciciola et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Oncology

Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma

Maria L. Molina et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

Pericyte-myofibroblast transition in the human lung

Miki Yamaguchi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Oncology

Clinical and histopathological analyses of VEGF receptors peptide vaccine in patients with primary glioblastoma-a case series

Ryota Tamura et al.

BMC CANCER (2020)

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Article Biochemistry & Molecular Biology

C/EBPγ is a critical negative regulator of LPS-/IgG immune complex-induced acute lung injury through the downregulation of C/EBPβ-/C/EBPδ-dependent C/EBP transcription activation

Chunguang Yan et al.

FASEB JOURNAL (2020)

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Review Cell Biology

Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis

Peter Ping Lin

CELLS (2020)

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Review Medicine, General & Internal

Airway Remodeling in Asthma

Kenneth P. Hough et al.

FRONTIERS IN MEDICINE (2020)

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Article Hematology

Improving the antitumor activity of R-CHOP with NGR-hTNF in primary CNS lymphoma: final results of a phase 2 trial

Andres J. M. Ferreri et al.

BLOOD ADVANCES (2020)

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Article Cardiac & Cardiovascular Systems

COPD is deleterious for pericytes: implications during training-induced angiogenesis in skeletal muscle

Leo Blervaque et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Article Cell Biology

Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature

Bilal N. Sheikh et al.

NATURE CELL BIOLOGY (2020)

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Article Oncology

Integration of Antiangiogenic Therapy with Cisplatin and Gemcitabine Chemotherapy in Patients with Nasopharyngeal Carcinoma

Wan Qin Chong et al.

CLINICAL CANCER RESEARCH (2020)

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Review Cell Biology

Principles of Leukocyte Migration Strategies

Petra Kameritsch et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Endocrinology & Metabolism

PDGFR-β restores blood-brain barrier functions in a mouse model of focal cerebral ischemia

Jie Shen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)

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Article Neurosciences

Cocaine Mediated Neuroinflammation: Role of Dysregulated Autophagy in Pericytes

Susmita Sil et al.

MOLECULAR NEUROBIOLOGY (2019)

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Article Dermatology

Eight autopsy cases of melanoma brain metastases showing angiotropism and pericytic mimicry. Implications for extravascular migratory metastasis

Ann-Katrin Rodewald et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2019)

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Article Medicine, General & Internal

Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study

Damir Hudetz et al.

CROATIAN MEDICAL JOURNAL (2019)

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Review Surgery

T-cell receptor and B-cell receptor repertoire profiling in adaptive immunity

Anastasia Minervina et al.

TRANSPLANT INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

Philipp Kirchner et al.

PLOS BIOLOGY (2019)

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Article Multidisciplinary Sciences

Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy

Rut Valdor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Multidisciplinary Sciences

C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress

Sudip Banerjee et al.

SCIENTIFIC REPORTS (2019)

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Article Cell Biology

Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS

Fang Niu et al.

JOURNAL OF CELL BIOLOGY (2019)

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Article Respiratory System

Impaired training-induced angiogenesis process with loss of pericyte-endothelium interactions is associated with an abnormal capillary remodelling in the skeletal muscle of COPD patients

Leo Blervaque et al.

RESPIRATORY RESEARCH (2019)

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Review Immunology

TLRs/NLRs: Shaping the landscape of host immunity

Komal Dolasia et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2018)

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Article Endocrinology & Metabolism

Pericytes secrete pro-regenerative molecules in response to platelet-derived growth factor-BB

Abderahim Gaceb et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

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Article Biochemistry & Molecular Biology

Nerve/glial antigen (NG) 2 is a crucial regulator of intercellular adhesion molecule (ICAM)-1 expression

Beate M. Schmitt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Markers for human brain pericytes and smooth muscle cells

Leon C. D. Smyth et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2018)

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Article Developmental Biology

Human predecidual stromal cells have distinctive characteristics of pericytes: Cell contractility, chemotactic activity, and expression of pericyte markers and angiogenic factors

Raquel Munoz-Fernandez et al.

PLACENTA (2018)

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Article Biology

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

Luis Alarcon-Martinez et al.

ELIFE (2018)

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Review Oncology

Glioblastoma-activated pericytes support tumor growth via immunosuppression

Isadora F. G. Sena et al.

CANCER MEDICINE (2018)

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Article Immunology

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

Tamara Girbl et al.

IMMUNITY (2018)

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Article Medicine, Research & Experimental

Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1

Rebecca Liu et al.

JCI INSIGHT (2018)

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Article Pharmacology & Pharmacy

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel CRTH2 Antagonist BI 1021958 at Single Oral Doses in Healthy Men and Multiple Oral Doses in Men and Women With Well-Controlled Asthma

Andy Fowler et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2017)

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Article Multidisciplinary Sciences

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

Martin Teichert et al.

NATURE COMMUNICATIONS (2017)

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Article

Glioblastoma progression is assisted by induction of immunosuppressive function of pericytes through interaction with tumor cells

Rut Valdor et al.

Oncotarget (2017)

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Article

Inflammatory responses and inflammation-associated diseases in organs

Linlin Chen et al.

Oncotarget (2017)

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Article Cell Biology

Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature

Tomoko Yamazaki et al.

CELL REPORTS (2017)

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Review Immunology

Antigen Presentation by vascular Cells

Jordan S. Pober et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

Seiji Yamamoto et al.

SCIENTIFIC REPORTS (2017)

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Article Pathology

Tumor Necrosis Factor-α and IL-17A Activation Induces Pericyte-Mediated Basement Membrane Remodeling in Human Neutrophilic Dermatoses

Holly M. Lauridsen et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

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Article Immunology

Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes

Adam Nyul-Toth et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

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Article Allergy

A randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthma

David Miller et al.

ALLERGY AND ASTHMA PROCEEDINGS (2017)

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Article Physiology

Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis

Sandhya Xavier et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

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Article Physiology

Lung pericyte-like cells are functional interstitial immune sentinel cells

Chi F. Hung et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

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Article Immunology

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot et al.

JOURNAL OF IMMUNOLOGY (2017)

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Review Pharmacology & Pharmacy

Intraplaque neovascularization as a novel therapeutic target in advanced atherosclerosis

Bieke Van der Veken et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

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Article Cell Biology

Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation

Rocio Navarro et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)

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Article Immunology

IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium

Rebecca Liu et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Immunology

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

Justin Rustenhoven et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Toxicology

Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa

Kathila S. Rajapaksa et al.

TOXICOLOGICAL SCIENCES (2016)

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Review Neurosciences

Brain and Retinal Pericytes: Origin, Function and Role

Andrea Trost et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2016)

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Article Multidisciplinary Sciences

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

Jeffrey J. Wallin et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

Yunlong Yang et al.

NATURE COMMUNICATIONS (2016)

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Article Multidisciplinary Sciences

Cultured pericytes from human brain show phenotypic and functional differences associated with differential CD90 expression

Thomas I-H. Park et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype

Shingo Sato et al.

CELL REPORTS (2016)

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Article Physiology

Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma

Jill R. Johnson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

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Article Oncology

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

JongWook Hong et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Article Oncology

Immunosuppressive mechanisms in glioblastoma

Edjah K. Nduom et al.

NEURO-ONCOLOGY (2015)

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Article Multidisciplinary Sciences

An anti-inflammatory role for C/EBPδ in human brain pericytes

Justin Rustenhoven et al.

SCIENTIFIC REPORTS (2015)

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Article Oncology

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

JongWook Hong et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Review Cell & Tissue Engineering

Combined Effects of Pericytes in the Tumor Microenvironment

Aline Lopes Ribeiro et al.

STEM CELLS INTERNATIONAL (2015)

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Article Oncology

Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma

Xian-De Liu et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Article Neurosciences

Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro

Christian Pieper et al.

BRAIN RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Lipopolysaccharide Activates Toll-like Receptor 4 (TLR4)-mediated NF-κB Signaling Pathway and Proinflammatory Response in Human Pericytes

Irene Guijarro-Munoz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Cell & Tissue Engineering

Immunoevasive Pericytes From Human Pluripotent Stem Cells Preferentially Modulate Induction of Allogeneic Regulatory T Cells

Hagit Domev et al.

STEM CELLS TRANSLATIONAL MEDICINE (2014)

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Review Urology & Nephrology

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