期刊
BIOMEDICINES
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines11051412
关键词
adipogenesis; basement membrane; collagen; diabetes; dyslipidemia; extracellular matrix; fibronectin; fibrosis; lipodystrophy; obesity
The increasing prevalence of obesity globally is linked to the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Adipose tissue dysfunction and systemic metabolic dysfunction occur due to excessive adipose tissue, which functions as an active endocrine system. This review summarizes the current understanding of vertebrate collagens and other important extracellular matrix (ECM) components in adipose tissue development and function, with a focus on the role of adipose tissue collagens in metabolic diseases.
The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose tissue (AT) often leads to its malfunction and to a systemic metabolic dysfunction because, in addition to storing lipids, AT is an active endocrine system. Adipocytes are embedded in a unique extracellular matrix (ECM), which provides structural support to the cells as well as participating in the regulation of their functions, such as proliferation and differentiation. Adipocytes have a thin pericellular layer of a specialized ECM, referred to as the basement membrane (BM), which is an important functional unit that lies between cells and tissue stroma. Collagens form a major group of proteins in the ECM, and some of them, especially the BM-associated collagens, support AT functions and participate in the regulation of adipocyte differentiation. In pathological conditions such as obesity, AT often proceeds to fibrosis, characterized by the accumulation of large collagen bundles, which disturbs the natural functions of the AT. In this review, we summarize the current knowledge on the vertebrate collagens that are important for AT development and function and include basic information on some other important ECM components, principally fibronectin, of the AT. We also briefly discuss the function of AT collagens in certain metabolic diseases in which they have been shown to play central roles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据