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Mitochondrial Oxidative Metabolism: An Emerging Therapeutic Target to Improve CKD Outcomes

BIOMEDICINES (2023)

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Review Cell Biology

Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease

Hsin-Jung Ho et al.

Summary: The kidney contains mitochondria that produce ATP for cellular processes, but impaired mitochondria can cause oxidative stress injury. There is increasing evidence linking oxidative stress to kidney diseases and providing insights into mitochondria-targeted therapeutics. This review integrates recent studies on oxidative stress and mitochondrial function in kidney diseases, focusing on chronic kidney disease, and identifies potential drugs that modulate mitochondrial function for clinical therapeutics.

CELLS (2023)

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Article Cardiac & Cardiovascular Systems

NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease

Manovriti Thakur et al.

Summary: Arterial and venous thrombosis are significant causes of morbidity and mortality worldwide. The association between thrombotic complications and cardiovascular and chronic inflammatory diseases is well-established. Inflammation and immunothrombosis, the initiation of thrombotic events, are gaining attention, but still not fully understood. However, the clinical relevance of aberrant immunothrombosis, known as thromboinflammation, is evident by the increased risk of thrombosis and cardiovascular events in patients with inflammatory or infectious diseases. This review focuses on the interrelationships and functions between NETs and other mediators in cardiovascular disease, as well as neutrophil phenotype, function, and NET formation in chronic kidney disease. Therapeutic targeting of NETs-induced immunothrombosis is also discussed as a potential intervention beyond current treatment options.

CIRCULATION RESEARCH (2023)

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Article Biochemistry & Molecular Biology

Avasopasem manganese (GC4419) protects against cisplatin-induced chronic kidney disease: An exploratory analysis of renal metrics from a randomized phase 2b clinical trial in head and neck cancer patients

K. A. Mapuskar et al.

Summary: Patients with head and neck squamous cell carcinoma (HNSCC) treated with high-dose cisplatin and radiotherapy commonly experience kidney injury, leading to acute and chronic kidney disease (AKD and CKD). In a clinical trial, treatment with 90 mg avasopasem manganese (AVA) prevented a significant reduction in estimated glomerular filtration rate (eGFR) compared to lower doses of AVA and placebo. Additionally, AVA treatment promoted renal recovery and showed an increase in plasma iron homeostasis proteins. These findings suggest that treatment with 90 mg AVA can mitigate cisplatin-induced CKD and promote kidney repair.

REDOX BIOLOGY (2023)

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Article Biochemistry & Molecular Biology

Nrf2 Protein Serum Concentration in Human CKD Shows a Biphasic Behavior

Marianne Rasmussen et al.

Summary: Oxidative stress plays a role in the progression of CKD and related mortality. Nrf2, an important regulator of cellular redox status, is being evaluated for its therapeutic potential in CKD. In this study, Nrf2 protein concentrations were analyzed in CKD patients at different stages and in healthy subjects. The results showed that Nrf2 protein was upregulated in mild to moderate kidney function impairment, but reduced in severe impairment. These findings suggest the need to explore the efficacy of Nrf2 therapies in specific populations of CKD patients.

ANTIOXIDANTS (2023)

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Article Chemistry, Physical

Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment

Qingsi Wu et al.

Summary: The etiology of chronic kidney disease is complex, leading to outcomes such as glomerular sclerosis, endothelial dysfunction, and chronic inflammation. Traditional Chinese herb tripterygium wilfordii has shown efficacy in kidney disease treatment, with active ingredient celastrol being toxic. Targeted delivery systems like peptides coupled CLT-phospholipid lipid nanoparticles offer efficient drug delivery to alleviate inflammation and endothelial damage in CKD.

NANO RESEARCH (2022)

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Review Urology & Nephrology

A systematic review for the efficacy of coenzyme Q10 in patients with chronic kidney disease

Yongxing Xu et al.

Summary: The systematic review found inconsistent cardiovascular outcomes for CKD patients with CoQ10 supplementation, but beneficial effects on oxidative stress, inflammation, and glucose metabolism.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2022)

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Review Multidisciplinary Sciences

Mitochondria-targeted drugs for diabetic kidney disease

Akira Mima

Summary: Diabetic kidney disease (DKD) is a common cause of chronic kidney disease (CKD) in the United States, with chronic hyperglycemia believed to be the primary cause. Recent research has highlighted the potential of targeting mitochondrial function as a novel therapeutic approach for DKD, such as improving mitochondrial dynamics to provide renal protection.

HELIYON (2022)

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Review Biochemistry & Molecular Biology

Mitochondrial Pathophysiology on Chronic Kidney Disease

Patricia C. Braga et al.

Summary: This article discusses the role of interstitial fibroblasts in maintaining kidney architecture and their involvement in chronic kidney diseases (CKD). It also explores the potential of antioxidant targeted therapies and pharmacologic agents in delaying the progression of kidney disease. Furthermore, it highlights the importance of mitochondrial integrity in early detection of CKD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Urology & Nephrology

Role of abnormal energy metabolism in the progression of chronic kidney disease and drug intervention

Xuyan Liu et al.

Summary: Energy metabolism disorders play an important role in chronic kidney disease (CKD), and regulating energy metabolism may be a promising strategy to delay the progression of the disease.

RENAL FAILURE (2022)

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Review Cell Biology

The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development

Tomohito Doke et al.

Summary: Mitochondrial dysfunction plays a crucial role in the development of kidney disease, leading to epithelial atrophy, inflammation, or cell death.

TRENDS IN CELL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Roles of Fatty Acids and Apolipoproteins in the Kidneys

Xiaoyue Pan

Summary: The kidneys are metabolically active organs with a similar energy requirement to the heart. They play an important role in regulating lipid function in the body and their lipid metabolism affects the rest of the body and the kidneys. Apolipoproteins in the kidneys have multiple functions in lipid transport and metabolism, and are important for normal physiological function. They are also associated with renal diseases and their gene expression is regulated under different conditions.

METABOLITES (2022)

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Article Biochemistry & Molecular Biology

Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage

Monica Locatelli et al.

Summary: This study found that Sirt3 deficiency makes mice more susceptible to damage from high-fat diets, resulting in more severe kidney diseases. This suggests that protecting mitochondria may be a method to prevent high-fat diet-induced renal injury.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Endocrinology & Metabolism

Sirtuin 1 in Chronic Kidney Disease and Therapeutic Potential of Targeting Sirtuin 1

Jiayi Yan et al.

Summary: The incidence and prevalence of chronic kidney disease (CKD) are increasing worldwide and pose a significant public health burden. SIRT1, a NAD+-dependent deacetylase, has protective effects on the kidney by regulating fibrosis, apoptosis, senescence, oxidative stress, inflammation, and aging. This narrative review provides an overview of the recent progress on the role of SIRT1 and its downstream pathways in CKD and discusses potential therapeutic approaches by activating the SIRT1-related pathway in CKD patients.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Health Care Sciences & Services

Prevalence, outcomes, and cost of chronic kidney disease in a contemporary population of 2.4 million patients from 11 countries: The CaReMe CKD study

Johan Sundstrom et al.

Summary: The CaReMe CKD study aimed to estimate the prevalence, adverse outcomes, and costs of chronic kidney disease (CKD) across 11 countries. The study found that the prevalence of CKD is underestimated when relying solely on diagnostic codes, and there is considerable potential in diagnosing and treating CKD to improve public health. CKD patients experience significant adverse events and costs, with renal events and heart failure being more costly than atherosclerotic events.

LANCET REGIONAL HEALTH-EUROPE (2022)

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Article Multidisciplinary Sciences

Tissue inhibitor metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) best predicts the development of acute kidney injury

Samuel Asamoah Sakyi et al.

Summary: This study assessed AKI among hospitalized patients using cell cycle arrest biomarkers and NGAL, with TIMP-2 and IGFBP7 showing the best predictive ability for AKI development. These biomarkers can be used for early diagnosis of AKI in high risk patients.

HELIYON (2021)

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Article Cell Biology

Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway

Xiaoyu Liu et al.

Summary: This study demonstrates for the first time that spermidine alleviates vascular calcification in CKD by upregulating SIRT1 and inhibiting ER stress, providing a promising therapeutic treatment to ameliorate vascular calcification in CKD.

AGING CELL (2021)

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Review Cell Biology

Mitochondria in Diabetic Kidney Disease

Amna Ayesha Ahmad et al.

Summary: Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA, with a multifactorial pathogenesis involving activation of multiple signaling pathways that lead to various pathological changes, mainly driven by alterations in mitochondrial bioenergetics. Understanding the role of bioenergetics in the progression of DKD may offer novel therapeutic approaches to delay progression to ESRD.

CELLS (2021)

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Review Medicine, General & Internal

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Lu Wen et al.

Summary: The kidneys play a crucial role in glucose homeostasis and abnormal glucose metabolism is associated with kidney diseases such as acute kidney injury. This review discusses the regulation of glucose homeostasis in kidneys and the impact of glucose metabolism on different types of AKI. Further research on glucose metabolism in kidney injury and repair could lead to the discovery of new therapeutic targets for kidney diseases.

FRONTIERS IN MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Mitochondrial Dysfunction and Alterations in Mitochondrial Permeability Transition Pore (mPTP) Contribute to Apoptosis Resistance in Idiopathic Pulmonary Fibrosis Fibroblasts

Erika Rubi Luis-Garcia et al.

Summary: IPF fibroblasts exhibit resistance to apoptosis induced by mitomycin C, potentially due to inhibition of mPTP and mitochondrial dysfunction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Mitoquinone Protects Podocytes from Angiotensin II-Induced Mitochondrial Dysfunction and Injury via the Keap1-Nrf2 Signaling Pathway

Zijing Zhu et al.

Summary: The study demonstrates that MitoQ exerts a protective effect in Ang II-induced mitochondrial injury in podocytes by mitigating mitochondrial fission and ROS production via the Keap1-Nrf2 signaling pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Cell Biology

Mitochondrial DNA-Mediated Inflammation in Acute Kidney Injury and Chronic Kidney Disease

Lini Jin et al.

Summary: The integrity and function of mitochondria are essential for normal kidney physiology. Abnormalities in mitochondrial DNA (mtDNA) can lead to disruption of cellular function. Aberrant mtDNA copy number is associated with kidney diseases, and mtDNA may trigger inflammatory responses through various mechanisms, highlighting a potential therapeutic target for kidney diseases.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Ana Karina Aranda-Rivera et al.

Summary: Mitochondria play essential roles in cell physiology and kidney diseases by generating cellular energy and producing reactive oxygen species (ROS). However, overproduction of ROS in kidney diseases can lead to oxidative stress, disrupting mitochondrial function and altering cell signaling pathways, ultimately causing inflammation and cell apoptosis. Studies on the dysregulation of redox-sensitive signaling pathways in mitochondria could provide insights into potential therapeutic targets for kidney diseases.

BIOMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury

Kranti A. Mapuskar et al.

Summary: Cisplatin is a widely used chemotherapy agent with potent anti-tumor activity, but it can cause renal injuries, leading to the need for intervention strategies to reduce kidney damage. In addition to DNA cross-linking, cisplatin affects mitochondrial metabolism, resulting in reactive oxygen species production and renal damage. Mitochondrial superoxide dismutase mimetics show potential in preventing platinum-associated nephrotoxicity.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

The Role of Mitochondria in Acute Kidney Injury and Chronic Kidney Disease and Its Therapeutic Potential

Xiaoqin Zhang et al.

Summary: Mitochondrial dysfunction plays a critical role in the pathogenesis of kidney diseases such as AKI and CKD, leading to renal microvascular loss, oxidative stress, and apoptosis. Understanding the molecular events governing mitochondrial functions in these diseases is crucial for developing novel therapeutic strategies. Targeting mitochondrial dysfunction may offer potential therapeutic options to ameliorate renal injury and delay disease progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Urology & Nephrology

Risk Factors for CKD Progression Overview of Findings from the CRIC Study

Mary Hannan et al.

Summary: The CRIC Study is an ongoing longitudinal study involving nearly 5500 adults with CKD in the United States, making significant contributions to understanding factors associated with CKD progression over the past 10 years. Findings from the study were grouped into six thematic categories, highlighting areas for future research and opportunities for interdisciplinary collaboration.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology

Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

Tamara Isakova et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

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Review Chemistry, Medicinal

Triphenylphosphonium (TPP)-Based Antioxidants: A New Perspective on Antioxidant Design

Jiayao Y. Wang et al.

CHEMMEDCHEM (2020)

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Article Medicine, General & Internal

Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Boris Bikbov et al.

LANCET (2020)

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Review Cell Biology

Mitophagy in Acute Kidney Injury and Kidney Repair

Ying Wang et al.

CELLS (2020)

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Article Endocrinology & Metabolism

Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study

Kare Birkeland et al.

DIABETES OBESITY & METABOLISM (2020)

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Article Physiology

MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men

Toan Pham et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2020)

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Review Urology & Nephrology

Mitochondrial Metabolism in Acute Kidney Injury

Amanda J. Clark et al.

SEMINARS IN NEPHROLOGY (2020)

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Review Physiology

Glucose transporters in the kidney in health and disease

Volker Vallon

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2020)

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Potential mechanisms of uremic muscle wasting and the protective role of the mitochondria-targeted antioxidant Mito-TEMPO

Yuqing Liu et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2020)

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Review Physiology

Mitochondrial dysfunction and the AKI-to-CKD transition

Mingzhu Jiang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

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Review Urology & Nephrology

Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches

Divya Bhatia et al.

KIDNEY RESEARCH AND CLINICAL PRACTICE (2020)

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Review Biochemistry & Molecular Biology

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

Florian Juszczak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Regulation of the mitochondrial permeability transition pore and its effects on aging

Damiano Pellegrino-Coppola

MICROBIAL CELL (2020)

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Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

Jin Zhang et al.

THERANOSTICS (2020)

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Association of Urinary Oxalate Excretion With the Risk of Chronic Kidney Disease Progression

Sushrut S. Waikar et al.

JAMA INTERNAL MEDICINE (2019)

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Article Endocrinology & Metabolism

SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy

Weixia Han et al.

JOURNAL OF ENDOCRINOLOGY (2019)

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Review Medicine, General & Internal

Efficacy of coenzyme Q10 in patients with chronic kidney disease: protocol for a systematic review

Yongxing Xu et al.

BMJ OPEN (2019)

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Article Biochemistry & Molecular Biology

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease

Kranti A. Mapuskar et al.

REDOX BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice

Matthew D. Campbell et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Mitochondria-Targeted Drugs

Roman A. Zinovkin et al.

CURRENT MOLECULAR PHARMACOLOGY (2019)

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Review Urology & Nephrology

Chronic kidney disease and acquired mitochondrial myopathy

Madhumathi Rao et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2018)

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Review Endocrinology & Metabolism

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2

Chiara Ghezzi et al.

DIABETOLOGIA (2018)

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Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI

Ali C. M. Johnson et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Renal tubule injury: a driving force toward chronic kidney disease

Bi-Cheng Liu et al.

KIDNEY INTERNATIONAL (2018)

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Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress

Yuqing Liu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Biochemistry & Molecular Biology

The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease

Anne E. Barden et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2018)

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Review Urology & Nephrology

Mitochondrial Dysfunction and Signaling in Diabetic Kidney Disease: Oxidative Stress and Beyond

Nicole Bernadette Flemming et al.

SEMINARS IN NEPHROLOGY (2018)

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Review Immunology

Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome

Simona E. Mihai et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

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Article Physiology

Kidney outer medulla mitochondria are more efficient compared with cortex mitochondria as a strategy to sustain ATP production in a suboptimal environment

Tomas A. Schiffer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Review Physiology

Endothelial colony-forming cells and pro-angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury

D. P. Basile et al.

ACTA PHYSIOLOGICA (2018)

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Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility

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DIABETES (2017)

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Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD

Hazel H. Szeto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Role of mitochondrial dysfunction in renal fibrosis promoted by hypochlorite-modified albumin in a remnant kidney model and protective effects of antioxidant peptide SS-31

Hao Zhao et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

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The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress

Yunzhuo Ren et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

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The hallmarks of mitochondrial dysfunction in chronic kidney disease

Daniel L. Galvan et al.

KIDNEY INTERNATIONAL (2017)

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Mitochondrial energetics in the kidney

Pallavi Bhargava et al.

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Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?

Anila Duni et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Marcel Morgenstern et al.

CELL REPORTS (2017)

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The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

Li Xiao et al.

REDOX BIOLOGY (2017)

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Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury

Wei-gang Wang et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2017)

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Role of Immune Cells in Acute Kidney Injury and Repair

Sul A. Lee et al.

NEPHRON (2017)

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Mazen Alsahli et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2017)

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Roshan Rajani et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2017)

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Editorial Material Urology & Nephrology

Vascular Endothelial Growth Factor Therapy for the Kidney: Are We There Yet?

Alejandro R. Chade

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Article Biochemistry & Molecular Biology

Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation

Yujiro Kida et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

Hyun-Eui Kim et al.

CELL (2016)

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Article Urology & Nephrology

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

Rongpei Lan et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Risk Factors for Development and Progression of Chronic Kidney Disease A Systematic Review and Exploratory Meta-Analysis

Wan-Chuan Tsai et al.

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Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis

Nathan R. Hill et al.

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Article Physiology

Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy

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Macrophage Phenotype Controls Long-Term AKI Outcomes-Kidney Regeneration versus Atrophy

Maciej Lech et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Urology & Nephrology

Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence

Radovan Vasko et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Review Cell Biology

Cellular mechanisms and physiological consequences of redox-dependent signalling

Kira M. Holmstroem et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Review Cell Biology

Mitochondrial dynamics and inheritance during cell division, development and disease

Prashant Mishra et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Physiology

Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury

Naeem K. Patil et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

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Article Cell Biology

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

Michael P. Siegel et al.

AGING CELL (2013)

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Review Pharmacology & Pharmacy

Role of Nrf2 in Oxidative Stress and Toxicity

Qiang Ma

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)

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Review Oncology

The myofibroblast matrix: implications for tissue repair and fibrosis

Franco Klingberg et al.

JOURNAL OF PATHOLOGY (2013)

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Article Urology & Nephrology

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

Alexander V. Birk et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

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Article Cell Biology

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

Petra Simic et al.

CELL REPORTS (2013)

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Review Biochemistry & Molecular Biology

Renoprotective effect of the antioxidant curcumin: Recent findings

Joyce Trujillo et al.

REDOX BIOLOGY (2013)

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Article Urology & Nephrology

Risk factors for chronic kidney disease: an update

Rumeyza Kazancioglu

KIDNEY INTERNATIONAL SUPPLEMENTS (2013)

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Article Pharmacology & Pharmacy

AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney

J. Lempiainen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Editorial Material Biochemistry & Molecular Biology

Controlling Radicals in the Powerhouse: Development of MitoSOD

Tanecia Mitchell et al.

CHEMISTRY & BIOLOGY (2012)

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Article Biochemistry & Molecular Biology

A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic

Geoffrey F. Kelso et al.

CHEMISTRY & BIOLOGY (2012)

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Review Medicine, Research & Experimental

AMP-activated protein kinase, stress responses and cardiovascular diseases

Shaobin Wang et al.

CLINICAL SCIENCE (2012)

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Article Peripheral Vascular Disease

Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type 1 receptor among chronic kidney disease patients in a Chinese population

Sui-Lung Su et al.

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2012)

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Article Physiology

Prevalence, Awareness, Treatment and Control of Hypertension in Adults with Chronic Kidney Disease in Turkey: Results from the CREDIT Study

Bulent Altun et al.

KIDNEY & BLOOD PRESSURE RESEARCH (2012)

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Article Urology & Nephrology

Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury

Jianchun Chen et al.

KIDNEY INTERNATIONAL (2012)

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Article Cardiac & Cardiovascular Systems

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

Dao-Fu Dai et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

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Article Urology & Nephrology

AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet

Anne-Emilie Decleves et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

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Article Urology & Nephrology

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

Hazel H. Szeto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

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Article Cardiac & Cardiovascular Systems

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Anna E. Dikalova et al.

CIRCULATION RESEARCH (2010)

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Review Urology & Nephrology

Renal lipid metabolism and lipotoxicity

Ion Alexandru Bobulescu

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2010)

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Review Endocrinology & Metabolism

Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications

J. E. Gerich

DIABETIC MEDICINE (2010)

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Article Urology & Nephrology

Effect of Community Characteristics on Familial Clustering of End-Stage Renal Disease

Eun-Young Song et al.

AMERICAN JOURNAL OF NEPHROLOGY (2009)

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Review Genetics & Heredity

The Role of Mitochondria in Apoptosis

Chunxin Wang et al.

ANNUAL REVIEW OF GENETICS (2009)

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Review Biochemistry & Molecular Biology

Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

David F. Stowe et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

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Article Medicine, Research & Experimental

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

Craig Brooks et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

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Article Genetics & Heredity

Multiple loci associated with indices of renal function and chronic kidney disease

Anna Koettgen et al.

NATURE GENETICS (2009)

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Editorial Material Urology & Nephrology

The challenge of discovering patient-level cardiovascular risk factors in chronic kidney disease

R. Agarwal

KIDNEY INTERNATIONAL (2008)

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Article Physiology

A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction

Yasunori Mizuguchi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)

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Article Urology & Nephrology

Regulatory mechanisms of Na+/glucose cotransporters in renal proximal tubule cells

Y. J. Lee et al.

KIDNEY INTERNATIONAL (2007)

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Review Urology & Nephrology

The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function

D. P. Basile

KIDNEY INTERNATIONAL (2007)

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Review Endocrinology & Metabolism

Vascular calcification in chronic kidney disease

S Jono et al.

JOURNAL OF BONE AND MINERAL METABOLISM (2006)

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Article Endocrinology & Metabolism

The pathobiology of diabetic complications - A unifying mechanism

M Brownlee

DIABETES (2005)

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Article Biochemistry & Molecular Biology

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

A Vaquero et al.

MOLECULAR CELL (2004)

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Article Multidisciplinary Sciences

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

HL Cheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Nutrition & Dietetics

Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

IS Wood et al.

BRITISH JOURNAL OF NUTRITION (2003)

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Article Pharmacology & Pharmacy

A role for superoxide in gentamicin-mediated nephropathy in rats

S Cuzzocrea et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2002)

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Article Urology & Nephrology

Peritubular capillary regression during the progression of experimental obstructive nephropathy

R Ohashi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)

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Article Biochemistry & Molecular Biology

Selective targeting of a redox-active ubiquinone to mitochondria within cells - Antioxidant and antiapoptotic properties

GF Kelso et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Physiology

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

JM Weinberg et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2000)

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