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Article
Multidisciplinary Sciences
Magyar Nora et al.
Summary: The SARS-CoV-2 pandemic has posed significant challenges to the global health care system. Early diagnosis is crucial to limit the spread of the virus, but factors such as availability of laboratory equipment and trained personnel affect the use of time-consuming molecular techniques. To facilitate on-the-spot diagnosis, several SARS-CoV-2 rapid antigen tests have been developed. A study in Hungary evaluated the performance of ten commercially available rapid tests compared to RT-qPCR. The results showed promising sensitivity and specificity for these rapid antigen tests.
Article
Dentistry, Oral Surgery & Medicine
Ludwig Czibere et al.
Summary: This study aimed to combine the speed of lateral flow antigen tests (LFATs) with the reliability of qPCR tests for SARS-CoV-2 detection. The results showed that nucleic acid amplification systems had higher sensitivity compared to LFAT. Amplification using extracted eluates improved sensitivity by 10-100 times. LFAT is recommended for single samples in emergency clinical or dental settings, as well as for smaller and larger population screening due to its low cost and fast detection.
Review
Medicine, General & Internal
Anastasia Tapari et al.
Summary: This article conducts a systematic review and meta-analysis of antigen-based diagnostic tests for COVID-19, comparing different methods and performance. The findings suggest that the performance of tests varies based on sample sources and rapid methods, emphasizing the influence of viral load on test sensitivity.
Article
Biochemistry & Molecular Biology
Karolina Wegrzynska et al.
Summary: This study in Poland conducted rapid identification of SARS-CoV-2 variants, revealing the distribution of Alpha, Delta, Kappa, and Omicron variants changed over time, providing insights into the epidemiological trends of the pandemic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Karin A. Skalina et al.
Summary: This study demonstrates the long-term stability of nasopharyngeal swab specimens for SARS-CoV-2 molecular testing, even after 21 days of refrigeration or ambient storage. These findings are important for increasing testing capacity during the global COVID-19 outbreak.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Virology
Ibrahim T. Hagag et al.
Summary: Rapid antigen tests (RATs) are convenient tools for SARS-CoV-2 testing, but they have lower sensitivity and may misdiagnose samples with low viral loads. This study examined the analytical sensitivities of different RATs and found that certain amino acid substitutions can affect their sensitivity. Therefore, optimizing the antibodies used in lateral flow assays is necessary.
FRONTIERS IN VIROLOGY
(2022)
Article
Medical Laboratory Technology
Tae Hyeon Yi et al.
Summary: The study found that the GenBody COVID-19 antigen test has high sensitivity in samples with high viral loads, making it a fast and convenient method for detecting SARS-CoV-2.
CLINICAL LABORATORY
(2022)
Article
Medical Laboratory Technology
Tae Hyeon Yi et al.
Summary: The study found that the sensitivity of the GenBody COVID-19 antigen assay is inferior to the polymerase chain reaction test, but its relatively fast speed and high sensitivity at low cycle threshold values indicating high viral loads make it a simple and quick measure for detecting SARS-CoV-2 in individuals with high viral loads.
CLINICAL LABORATORY
(2022)
Article
Virology
Marie Tre-Hardy et al.
Summary: The study assessed the performance of two ELISA tests for detecting antibodies against SARS-CoV-2 nucleocapsid protein, showing satisfactory analytical performance and excellent clinical performance for IgG, IgA, and total antibodies, especially with optimized cut-offs.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Ignacio Torres et al.
Summary: The Panbio COVID-19 Ag Rapid Test Device displayed low sensitivity in asymptomatic close contacts of COVID-19 patients, particularly in non-household contacts. However, establishing the optimal timing for upper respiratory tract collection in this group seems imperative to pinpoint test sensitivity.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Multidisciplinary Sciences
Adam Booth et al.
Summary: The study aims to analyze various clinical, demographic, and lifestyle variables associated with specific adverse outcomes in COVID-19 patients; by combining data from 17,860,001 patients across 14 countries, it identified many risk factors related to COVID-19, including age over 75, male sex, severe obesity, and active cancer.
Article
Multidisciplinary Sciences
Juha M. Koskinen et al.
Summary: The global ramp-up of COVID-19 diagnostics in early 2020 focused on detecting viral RNA. The novel mariPOC SARS-CoV-2 test, utilizing optical laser technology, showed high sensitivity and specificity with the ability to detect infectious individuals within 20 minutes.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Thirumalaisamy P. Velavan et al.
Summary: The COVID-19 pandemic caused by SARS-CoV-2 presents a significant challenge, with disease severity influenced by factors such as age, gender, BMI, and pre-existing conditions. Host genetic predisposition is increasingly recognized, with numerous genetic variants associated with susceptibility and severity of COVID-19.
Letter
Infectious Diseases
Satoshi Oguri et al.
JOURNAL OF INFECTION
(2021)
Article
Pathology
Andreas Dzung et al.
Summary: This study shows that viral RNA levels are relatively stable at higher temperatures and after repetitive freeze-thawing, but storage conditions can have an impact on RT-PCR detection results.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Medicine, General & Internal
Magdalena Komiazyk et al.
Summary: This study evaluated two RNA extraction methods and four commercial RT-qPCR assays for detecting SARS-CoV-2 in human upper respiratory tract specimens. The results demonstrated the significant impact of laboratory-selected diagnostic methods on the detection of SARS-CoV-2 with low viral loads in clinical specimens.
Review
Medicine, General & Internal
Linda P. Guaman-Bautista et al.
Summary: This review provides a comprehensive overview of the most relevant diagnostic tools for tracking COVID-19, aiming to develop better diagnostic and surveillance alternatives to slow down virus transmission. It discusses different diagnostic options and their pros and cons, as well as the use of automation strategies and new technologies.
Article
Medicine, General & Internal
Magdalena Komiazyk et al.
Summary: A double-dose vaccinated woman with COVID-19 experienced all stages of infection, but exhibited mild symptoms. The virus identified in her belonged to the UK SARS-CoV-2 lineage B.1.1.7 (Alpha variant).
Article
Virology
Doyeong Kim et al.
Summary: Antigen tests for SARS-CoV-2 offer a simpler and faster alternative to molecular tests, and clinical validation is crucial before widespread use. The GenBody (TM) COVAG025 immunoassay showed high sensitivity and specificity in both retrospective and prospective clinical studies, indicating its potential to assist in accurate diagnosis, isolation, and treatment of COVID-19 patients for better pandemic control.
Article
Medicine, General & Internal
Evangelos Terpos et al.
Summary: The COVID-19 Antigen Detection Kit (Colloidal Gold-CG) showed high sensitivity and specificity when the PCR Ct value was less than 33, making it suitable for early disease screening. Confirmatory PCR is essential in cases where a false negative result is suspected.
Article
Health Care Sciences & Services
Emanuele Amodio et al.
Summary: The study in Sicily analyzed SARS-CoV-2 cases and found that higher male prevalence and presence of immigrants were associated with reduced risk of infection. On the other hand, younger age groups, residents with a university degree, residents with secondary education, urban mobility, presence of rental homes, and presence of multiple homes per building were linked to increased risk of SARS-CoV-2 incidence.
Article
Medicine, General & Internal
Alejandro Fernandez-Montero et al.
Summary: The study suggests that rapid antigen tests are less effective in asymptomatic population compared to RT-PCR. Further research is needed to improve screenings based on rapid antigen tests, such as using clinical questionnaires to select higher-risk participants, confirming negative results with RT-PCR, or utilizing repetitive sequential testing.
Article
Infectious Diseases
Victor M. Corman et al.
Article
Medicine, General & Internal
Chaolin Huang et al.
Article
Medicine, General & Internal
W. Guan et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Editorial Material
Microbiology
Yi-Wei Tang et al.
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Review
Medicine, General & Internal
Tu Haitao et al.
MAYO CLINIC PROCEEDINGS
(2020)
Article
Health Care Sciences & Services
Jennifer C. Goldsack et al.
NPJ DIGITAL MEDICINE
(2020)
Article
Ophthalmology
Rajul Parikh et al.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2008)
