SYT7 regulates the progression of chronic lymphocytic leukemia through interacting and regulating KNTC1

Article Multidisciplinary Sciences

Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter's transformation

Zachary A. Hing et al.

Summary: PRMT5 plays an important role in the progression of CLL to Richter transformation, and the PRMT5 inhibitor PRT382 shows potential therapeutic value.

NATURE COMMUNICATIONS (2023)

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Article Oncology

KNTC1 as a putative tumor oncogene in pancreatic cancer

Ling Liu et al.

Summary: This study reveals the significant upregulation of KNTC1 in pancreatic cancer and its correlation with pathological grade and clinical prognosis. Inhibition of KNTC1 can suppress cell growth and promote cell apoptosis, and it is associated with the cell cycle, mitosis, and STAT3 signaling pathways.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

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Article Cell Biology

Silencing of KNTC1 inhibits hepatocellular carcinoma cells progression via suppressing PI3K/Akt pathway

Hui Tong et al.

Summary: This study demonstrates the significant role of KNTC1 in hepatocellular carcinoma (HCC) development and its correlation with poor prognosis. KNTC1 affects the biological activity of HCC cells through the PI3K/Akt signaling pathway.

CELLULAR SIGNALLING (2023)

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Article Oncology

SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination

Shuai Dong et al.

Summary: This study found that the expressions of SYT7 and HMGB3 were significantly upregulated in thyroid cancer tissues and cells. SYT7 could regulate the ubiquitination of HMGB3 through its interaction with BRCA1, thereby affecting the progression of thyroid cancer.

ENDOCRINE-RELATED CANCER (2022)

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Article Biochemistry & Molecular Biology

Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia

Alejandro M. Hortal et al.

Summary: The overexpression of wild type RRAS2 is found to be associated with the development of CLL. A single nucleotide polymorphism (rs8570) in the 3'UTR of RRAS2 mRNA is linked to higher expression of RRAS2 and more aggressive disease in CLL. Overexpression of wild type RRAS2 in mice provokes the development of CLL, accompanied by strong convergent selection of somatic mutations. The R-RAS2 protein physically binds to the BCR and mediates BCR signals in CLL.

MOLECULAR CANCER (2022)

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Article Biotechnology & Applied Microbiology

Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9

Caimei Wang et al.

Summary: This study reveals the important role of KNTC1 in the development of cervical cancer and identifies the mechanism by which KNTC1 promotes cervical cancer through MMP9 and MMP2-mediated reduction in tumor cell invasion and migration abilities.

BIOENGINEERED (2022)

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Article Cell Biology

shRNA-mediated knockdown of KNTC1 inhibits non-small-cell lung cancer through regulating PSMB8

Ruijun Liu et al.

Summary: This study demonstrates the significance of KNTC1 in non-small-cell lung cancer by participating in the regulation of cell proliferation, migration, and invasion through the segregation of sister chromatids. The findings also suggest a positive association between KNTC1 depletion and PSMB8 expression. These findings indicate that KNTC1 may serve as a novel therapeutic target for non-small-cell lung cancer.

CELL DEATH & DISEASE (2022)

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Review Hematology

Targeting the tumor microenvironment in chronic lymphocytic leukemia

Rebecka Svanberg et al.

Summary: The tumor microenvironment plays a crucial role in the development and survival of malignant B-cell clones in chronic lymphocytic leukemia. Therapeutic strategies targeting the interactions within the microenvironment may significantly impact clinical efficacy. Understanding the effects of current therapeutic agents on microenvironmental cells and interactions can guide and improve CLL treatment strategies.

HAEMATOLOGICA (2021)

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Review Oncology

Current and future treatment strategies in chronic lymphocytic leukemia

Krish Patel et al.

Summary: Treatment decisions for patients with chronic lymphocytic leukemia (CLL) are based on symptoms and risk classifications. New therapies targeting specific genetic aberrations have shown promising results, improving outcomes and prolonging progression-free survival. Novel targeted oral therapies have largely replaced chemoimmunotherapy in the treatment of CLL.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Medicine, General & Internal

Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations-NOTCH1, SF3B1, MYD88, BIRC3

Maciej Putowski et al.

Summary: CLL is highly heterogeneous and may be treated with personalized therapy through targeting new mutations with drugs. Potential neurogenic locus notch homolog protein 1 (NOTCH1) signaling targeting mechanisms include secretase inhibitors and specific antibodies to block NOTCH ligand/receptor interactions. Studies have shown that newly discovered mutations and their signaling pathways play key roles in the course of the disease.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Oncology

Proteomics and Drug Repurposing in CLL towards Precision Medicine

Dimitra Mavridou et al.

Summary: Despite ongoing efforts, the understanding of CLL molecular pathobiology, diagnosis, prognosis, and treatment remains unclear. Proteomics combined with advanced bioinformatics and drug repurposing show promise in unraveling the complex proteome heterogeneity of CLL patients. The goal is to explore individual molecular characteristics, utilize proteomics for effective therapeutic options, and integrate drug repurposing in precision medicine for better treatment outcomes.

CANCERS (2021)

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Article Oncology

Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis

Feiyang Ji et al.

Summary: The study revealed an increase in ubiquitinated sites with shorter chains during the progression of HCC metastasis, and high expression of E3 ubiquitin-protein ligase SYVN1 was found to be associated with tumor metastasis.

CANCER COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology