ABO Blood Group and the Risk and Prognosis of Lymphoma

ABO blood group antigens exhibit alternative phenotypes and genetically derived structures that are located on the red cell surface. The role of ABO blood group in cancer biology has been intensely reported by several studies, and it is now widely recognized that ABO antigens are associated with the risk and prognosis of several types of tumors, namely gastric cancer and pancreatic cancer. However, there have been contentious limited issues with the association between the ABO blood group and lymphoma. In this narrative review, based on literature data, we discuss the role of ABO blood group in the risk and prognosis of lymphoma and summarize the current knowledge of the underlying pathogenic mechanisms of the association. The possible association of ABO blood group with racial disparities and pathological classification in lymphoma patients is also discussed.

Automated summary

ABO blood group antigens exhibit diverse phenotypes and genetically derived structures on the red cell surface. While the association between ABO antigens and the risk and prognosis of various tumors, particularly gastric and pancreatic cancers, is well-established, the relationship between ABO blood group and lymphoma remains controversial. This narrative review examines the role of ABO blood group in the risk and prognosis of lymphoma, providing insights into the underlying pathogenic mechanisms and discussing its potential association with racial disparities and pathological classification in lymphoma patients.