☆ 4.6 Article

Early Cytokine Signatures of Hospitalized Mild and Severe COVID-19 Patients: A Prospective Observational Study

JOURNAL OF INFLAMMATION RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Levels of Vascular Endothelial Growth Factor and Its Association with Pulmonary Embolism in COVID-19

Jazmin A. Guerra-Lopez et al.

Summary: This study aimed to investigate whether vascular endothelial growth factor (VEGF) levels in COVID-19 patients at hospital admission can predict the occurrence of pulmonary embolism. The study found that VEGF levels were elevated in COVID-19 patients and correlated with inflammatory markers. However, VEGF levels were unable to predict the appearance of pulmonary embolism during hospitalization.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Specialized interferon action in COVID-19

Matthew D. Galbraith et al.

Summary: The impacts of IFN signaling on COVID-19 pathology are diverse, with both protective and harmful effects. Different types of IFNs are associated with specific biosignatures and have unique metabolic signatures. They also show differential relationships with clinical markers of prognosis and disease severity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cytokine Storm Signature in Patients with Moderate and Severe COVID-19

Olga Kalinina et al.

Summary: This study investigated the levels of cytokines in patients with moderate and severe COVID-19 and found elevated levels of pro-inflammatory factors, chemokines, anti-inflammatory factors, and growth factors. Patients with severe disease had higher levels of FGF-2/FGF-basic, IL-1 beta, and IL-7 compared to healthy donors. Pneumonia lung injury was positively correlated with levels of EGF, IP-10, and MCP-3, and negatively correlated with IL-12 p40. Pro-inflammatory factors were negatively correlated with the frequency of circulating Th17-like cells and follicular Th cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comprehensive Cytokine Profiling of Patients with COVID-19 Receiving Tocilizumab Therapy

Anna Lebedeva et al.

Summary: COVID-19 patients with cytokine storm syndrome (CSS) and those without formed distinct clusters based on their cytokine concentrations. However, the administration of tocilizumab therapy did not fully correspond to these CSS clusters. IL-1RA was found to be prognostically significant in both groups and may be useful in defining the onset of a cytokine storm and indicating anti-cytokine therapy in COVID-19.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows

Antonio Giovanni Solimando et al.

Summary: Endothelial activation plays a crucial role in understanding infectious diseases, including COVID-19, and predicting their outcomes and future treatments. Research has shown that endothelial cells have important regulatory functions in viral infections, and studying their phenotypic changes may provide valuable insights for managing COVID-19 and other infections. Endothelial cell injury in COVID-19 is associated with thrombosis and increased vessel contraction, and a novel phenomenon of intussusceptive microvascular growth has been discovered, offering potential for new therapeutic approaches.

BIOMEDICINES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cytokine profile and disease severity in patients with COVID-19

Ali Ghazavi et al.

Summary: Cytokine dysregulation is proposed as the mechanism for COVID-19. This study evaluated serum cytokines levels in COVID-19 patients, finding elevated levels of IFN-gamma, TGF-beta, IL-17, and IL-8 compared to the control group, with significant differences in TGF-beta levels between mild and severe groups, and no significant differences in IL-5 and IL-9 levels.

CYTOKINE (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels at initial hospital presentation in COVID-19 patients are associated with an increased risk of venous thromboembolism, acute kidney injury, critical illness, and mortality. There is a dose-response relationship between CRP concentration and adverse outcomes, with patients with high levels of both CRP and D-dimer showing the greatest risk of adverse outcomes. Systemic inflammation, as measured by CRP, plays a significant role in predicting clinical outcomes in COVID-19.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Editorial Material Immunology

A Potential Role of Interleukin 10 in COVID-19 Pathogenesis

Ligong Lu et al.

Summary: One unique feature of the cytokine storm in COVID-19 is the significant elevation of IL-10, which was initially believed to be a negative feedback mechanism to suppress inflammation. However, clinical evidence suggests that early proinflammatory IL-10 elevation may actually play a pathological role in the severity of COVID-19.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Sex differences in the immune response to acute COVID-19 respiratory tract infection

Shaohua Qi et al.

Summary: Sex differences in immune responses to COVID-19 were studied in hospitalized patients, showing that males exhibit exacerbated inflammatory responses and stronger innate immunity, while females demonstrate stronger adaptive immunity.

BIOLOGY OF SEX DIFFERENCES (2021)

添加到收藏夹

Article Immunology

Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases

Javier Castillo-Olivares et al.

Summary: During the COVID-19 pandemic, precise monitoring of antibody responses has become increasingly important, especially with the large-scale vaccine rollout and the emergence of SARS-CoV-2 variants. Identifying Correlates of Protection (CoP) for SARS-CoV-2 infection and COVID-19 disease is crucial, with virus neutralising antibodies and specific binding antibodies being identified as potential CoP candidates. Results from this study show higher levels of neutralising antibodies in severe COVID-19 patients compared to seropositive healthcare workers with mild or asymptomatic infections. The study aims to identify biomarkers that could differentiate between severe and mild/asymptomatic SARS-CoV-2 infections, with potential implications for future serological studies.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Allergy

Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines

Karim Dorgham et al.

Summary: Anaphylactic reactions to the novel mRNA lipid nanoparticle vaccines have raised significant public concern due to their unexpected occurrence, particularly among atopic individuals. Various potential contributors to these reactions have been considered, yet the clinical utility of available testing methods remains unclear. Further research and clinical trials are needed to address these concerns and ensure safety during public health emergencies.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Cytokines: From Clinical Significance to Quantification

Chao Liu et al.

Summary: Cytokines play a critical role in regulating immune and inflammatory responses, serving as biomarkers for many diseases. Quantification of cytokines provides valuable insights into physiological and pathological processes for diagnosis and treatment in both clinical medicine and biology. Advances in in vitro and in vivo assays, biosensors, and quantification platforms aim to achieve real-time multiplex cytokine analysis for biomedical research and clinical practice.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Clinical characteristics and risk factors of patients with severe COVID-19 in Riyadh, Saudi Arabia: A retrospective study

Fadilah S. Aleanizy et al.

Summary: This study aimed to describe clinical and demographic features of COVID-19 patients, and found that old age, fever, and comorbidities involving diabetes mellitus, asthma, and smoking were significantly associated with infection severity.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels upon hospital admission in COVID-19 patients are associated with increased risks of VTE, AKI, critical illness, and mortality, suggesting a crucial role of systemic inflammation in the clinical course of COVID-19.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

添加到收藏夹

Letter Virology

Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19

Nurshad Ali

JOURNAL OF MEDICAL VIROLOGY (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Gender Differences in Patients With COVID-19: Focus on Severity and Mortality

Jian-Min Jin et al.

FRONTIERS IN PUBLIC HEALTH (2020)

添加到收藏夹

Review Medical Laboratory Technology

Biomarkers associated with COVID-19 disease progression

Giovanni Ponti et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

Victor J. Costela-Ruiz et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

添加到收藏夹

Review Immunology

The COVID-19 Cytokine Storm; What We Know So Far

Dina Ragab et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Cell Biology

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts

Jin Wang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

添加到收藏夹

Review Virology

Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection

Synat Keam et al.

REVIEWS IN MEDICAL VIROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19

Marthe Jontvedt Jorgensen et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Cell Biology

Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients

Roberta Angioni et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Review Immunology

The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis

Kaviyarasi Renu et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2020)

添加到收藏夹

Article Virology

IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection

Ana Carolina Gadotti et al.

VIRUS RESEARCH (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19

Yu Chen et al.

MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Immunology

Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19

Julika Neumann et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

添加到收藏夹

Article Cell Biology

Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells

James P. Maloney et al.

MEDIATORS OF INFLAMMATION (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

VEGF-VEGFR Signals in Health and Disease

Masabumi Shibuya

BIOMOLECULES & THERAPEUTICS (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

Masabumi Shibuya

JOURNAL OF BIOCHEMISTRY (2013)

添加到收藏夹

Article Virology

Interferon-γ and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells

Anna de Lang et al.

VIROLOGY (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.