☆ 4.7 Editorial Material

Routine Prophylactic Esketamine for the Prevention of Maternal Pain During Cesarean Delivery

JAMA NETWORK OPEN (2023)

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Article Psychiatry

The effect of low-dose esketamine on pain and post-partum depression after cesarean section: A prospective, randomized, double-blind clinical trial

Jiahong Shen et al.

Summary: In this study, the effect of a single intravenous injection of low-dose esketamine on post-operative pain and post-partum depression (PPD) in cesarean delivery patients was observed and evaluated. The results showed that the injection did not significantly reduce the incidence of depression at 1, 2, or 4 weeks post-partum but improved pain during exercise at 24 hours post-operatively under the conditions of this clinical trial.

FRONTIERS IN PSYCHIATRY (2023)

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Article Medicine, General & Internal

Efficacy and Safety of Esketamine for Supplemental Analgesia During Elective Cesarean Delivery: A Randomized Clinical Trial

Li-Li Xu et al.

Summary: This study investigated the sedative and analgesic effects of intravenous esketamine administered before childbirth via cesarean delivery with epidural anesthesia. It found that pre-incision administration of esketamine provided transient analgesia and sedation without significant neonatal depression.

JAMA NETWORK OPEN (2023)

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Article Medicine, General & Internal

Effects of esketamine on analgesia and postpartum depression after cesarean section: A randomized, double-blinded controlled trial

Wei Wang et al.

Summary: This study demonstrates that the use of esketamine combined with sufentanil for patient controlled intravenous analgesia after elective cesarean section can reduce the consumption of sufentanil, improve postoperative analgesia, and decrease the incidence of postpartum depression and postoperative nausea and vomiting.

MEDICINE (2022)

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Article Obstetrics & Gynecology

Optimum dose of spinal ropivacaine with or without single intravenous bolus of S-ketamine during elective cesarean delivery: a randomized, double-blind, sequential dose-finding study

Xiaoyu Zhang et al.

Summary: This study aimed to determine the optimal dose of spinal ropivacaine for caesarean section and observe the rates of hypotension with the addition of intravenous S-ketamine. Results showed that the hypotension rates and associated symptoms were significantly lower in the S-ketamine group compared to the ropivacaine only group.

BMC PREGNANCY AND CHILDBIRTH (2021)

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