4.7 Article

Association of Adverse Childhood Experiences With Accelerated Epigenetic Aging in Midlife

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biology

DunedinPACE, a DNA methylation biomarker of the pace of aging

Daniel W. Belsky et al.

Summary: This study reports a novel blood biomarker of aging called DunedinPACE, which was validated in five datasets. Results showed that DunedinPACE is associated with morbidity, disability, and mortality, and provides incremental prediction beyond the GrimAge clock. This finding is significant for gerontology and geroscience research.
Article Psychology, Developmental

Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model

Steven R. H. Beach et al.

Summary: This study builds upon prior research on the impact of childhood stressors and harsh environments on risky behavior and physical health, by adding measures of accelerated aging based on DNA methylation. The findings suggest that harsh childhood environments influence accelerated DNA aging through risky cognition and substance use pathways, as well as through the danger/FKBP5 pathway involving early exposure to threats and enhanced pro-inflammatory tendencies.

DEVELOPMENT AND PSYCHOPATHOLOGY (2022)

Article Endocrinology & Metabolism

Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks

Cathal McCrory et al.

Summary: This study explores the association between childhood adversity and epigenetic age acceleration in mid-life and older ages. It finds that childhood poverty is significantly associated with accelerated biological aging, and that lifetime smoking explains a substantial portion of the increased risk of age acceleration in individuals who experienced childhood poverty.

PSYCHONEUROENDOCRINOLOGY (2022)

Article Public, Environmental & Occupational Health

Accelerated epigenetic aging mediates link between adverse childhood experiences and depressive symptoms in older adults: Results from the Health and Retirement Study

Eric T. Klopack et al.

Summary: Adverse childhood experiences (ACEs) are associated with a higher risk of depression, and this study finds that accelerated epigenetic aging may partially explain this link. By measuring three different types of epigenetic aging, the researchers discovered that ACEs are associated with older age and faster aging, which in turn are associated with more depressive symptoms. Socioeconomic and lifestyle factors such as obesity and substance use play a role in these associations. The findings suggest that epigenetic aging may be a physiological mechanism underlying the connection between early life adversity and adult depression.

SSM-POPULATION HEALTH (2022)

Article Environmental Sciences

Adverse Childhood Experiences and Cardiovascular Risk among Young Adults: Findings from the 2019 Behavioral Risk Factor Surveillance System

Dylan B. Jackson et al.

Summary: This study examines the association between adverse childhood experiences (ACEs) and cardiovascular health among young adults in the United States using data from the 2019 Behavioral Risk Factor Surveillance System (BRFSS). The findings suggest that young adults with a greater number of ACEs have a higher likelihood of having moderate to high cardiovascular risk. Poor mental health and cumulative disadvantage play a significant role in explaining this association. These findings highlight the importance of prevention efforts targeting cardiovascular risk in young adulthood.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Cell Biology

DNA methylation GrimAge version 2

Ake T. Lu et al.

Aging-US (2022)

Article Medicine, General & Internal

Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study

Xingqi Cao et al.

Summary: This study evaluated the impact of life course circumstances on aging disparities and found that disadvantaged subpopulations are more likely to experience accelerated aging. The findings emphasize the importance of promoting health among disadvantaged subpopulations and reducing health disparities with advantaged counterparts.

ECLINICALMEDICINE (2022)

Article Geriatrics & Gerontology

GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality

Cathal McCrory et al.

Summary: The study indicates that the GrimAge clock is a significant improvement in predicting age-related decline in various clinical phenotypes compared to other epigenetic clocks, showing better predictive utility and promising to advance precision medicine.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

Review Cardiac & Cardiovascular Systems

Association of Adverse Childhood Experiences With Cardiovascular Disease Later in Life A Review

Lucas C. Godoy et al.

Summary: ACEs, which encompass abuse, household dysfunction, and neglect, chronically activate the stress response system and lead to dysfunction in autonomic, neuroendocrine, and inflammatory pathways. Adults with 4 or more ACEs have over a 2-fold higher risk of developing CVD and almost 2-fold higher risk of premature mortality. Strategies for CVD prevention through ACE management in adults lack sufficient evidence, highlighting the need for better approaches to mitigate the health consequences of ACEs.

JAMA CARDIOLOGY (2021)

Article Psychiatry

Psychological and biological resilience modulates the effects of stress on epigenetic aging

Zachary M. Harvanek et al.

Summary: The study shows that cumulative stress is associated with epigenetic aging, and this association is modified by psychological resilience factors such as emotion regulation and self-control.

TRANSLATIONAL PSYCHIATRY (2021)

Article Public, Environmental & Occupational Health

Maternal adverse childhood experiences and pregnancy intentions

Alexander Testa et al.

Summary: The study found an association between maternal adverse childhood experiences (ACEs) and unwanted pregnancies, but no association with mistimed pregnancies. It suggests the importance of allocating more resources to prevent adverse childhood experiences and unintended pregnancies.

ANNALS OF EPIDEMIOLOGY (2021)

Article Endocrinology & Metabolism

Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children

Sandro Marini et al.

PSYCHONEUROENDOCRINOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Association of Childhood Psychosocial Environment With 30-Year Cardiovascular Disease Incidence and Mortality in Middle Age

Jacob B. Pierce et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

Review Genetics & Heredity

Epigenetic mechanisms activated by childhood adversity

Bernardo J. Krause et al.

EPIGENOMICS (2020)

Article Cell Biology

Untitled

Aging-US (2018)

Review Genetics & Heredity

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Steve Horvath et al.

NATURE REVIEWS GENETICS (2018)

Article Behavioral Sciences

Untitled

GENES BRAIN AND BEHAVIOR (2017)

Article Family Studies

Adverse childhood experiences and life opportunities: Shifting the narrative

Marilyn Metzler et al.

CHILDREN AND YOUTH SERVICES REVIEW (2017)

Review Chemistry, Medicinal

Epigenetic modifications of gene expression by lifestyle and environment

Qudeer Ahmed Abdul et al.

ARCHIVES OF PHARMACAL RESEARCH (2017)

Article Psychology, Developmental

Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults

Audrey R. Tyrka et al.

DEVELOPMENT AND PSYCHOPATHOLOGY (2016)

Article Psychiatry

The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length

Josine E. Verhoeven et al.

PSYCHOSOMATIC MEDICINE (2015)

Article Clinical Neurology

Methylation of BDNF in women with bulimic eating syndromes: Associations with childhood abuse and borderline personality disorder

Lea Thaler et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2014)

Review Pediatrics

Toxic Stress: Effects, Prevention and Treatment

Hillary A. Franke

CHILDREN-BASEL (2014)

Article Biochemistry & Molecular Biology

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

Gregory Hannum et al.

MOLECULAR CELL (2013)

Article Neurosciences

Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions

Torsten Klengel et al.

NATURE NEUROSCIENCE (2013)

Article Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types

Steve Horvath

GENOME BIOLOGY (2013)

Article Biochemical Research Methods

DNA methylation arrays as surrogate measures of cell mixture distribution

Eugene Andres Houseman et al.

BMC BIOINFORMATICS (2012)

Review Behavioral Sciences

Epigenetic modifications of brain and behavior: Theory and practice

David Crews

HORMONES AND BEHAVIOR (2011)

Review Behavioral Sciences

The Adaptive Calibration Model of stress responsivity

Marco Del Giudice et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2011)

Article Psychiatry

Cumulative Childhood Stress and Autoimmune Diseases in Adults

Shanta R. Dube et al.

PSYCHOSOMATIC MEDICINE (2009)