4.7 Article

Racial Disparities in Pathological Complete Response Among Patients Receiving Neoadjuvant Chemotherapy for Early-Stage Breast Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Response to Treatment, Racial and Ethnic Disparity, and Survival in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy in the US

Sarah Shubeck et al.

Summary: This study aimed to examine racial and ethnic differences in pathologic complete response (pCR) rate following neoadjuvant chemotherapy (NACT) for breast cancer patients in the US. The results showed significant differences in pCR rates among different racial and ethnic groups, which varied by molecular subtype and were associated with survival.

JAMA NETWORK OPEN (2023)

Article Oncology

Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies

Denise M. Wolf et al.

Summary: By incorporating gene expression, protein/phosphoprotein, and clinical data, we have created new breast cancer subtypes that can better predict drug responses. The best performing subtypes include Immune, DNA repair, and HER2/Luminal phenotypes. Treatment allocation based on these subtypes significantly increases the overall pathologic complete response rate. This study is important for guiding future breast cancer treatment.

CANCER CELL (2022)

Article Oncology

Characterizing Clinicopathologic Features of Estrogen Receptor-Positive/Progesterone Receptor-Negative Breast Cancers

Fei Fei et al.

Summary: Approximately 12% of breast cancers have an estrogen receptor-positive/progesterone receptor-negative phenotype. These tumors have different clinicopathologic features compared to other types of breast cancers and are generally associated with a worse prognosis.

CLINICAL BREAST CANCER (2022)

Article Multidisciplinary Sciences

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

Naser Ansari-Pour et al.

Summary: Research reveals higher genomic instability and intra-tumoral heterogeneity in Nigerian breast cancer patients, as well as early clonal GATA3 mutations and a unique INDEL signature associated with African ancestry. Characterizing tumors for homologous recombination deficiency is shown to have significant clinical relevance, underscoring the importance of including diverse populations in biomedical research. This study sheds light on the unknown breast cancer heterogeneity and tumour evolutionary trajectories among women of African ancestry.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

HER2+breast cancers evade anti-HER2 therapy via a switch in driver pathway

Alison E. Smith et al.

Summary: Resistance to HER2 inhibition in HER2-amplified breast cancer is common in the metastatic setting, with genetic activation of MAPK identified as a recurrent mechanism of resistance. MEK/ERK inhibitors may effectively combat this resistance by targeting the driver pathway switch to CDK2 activation.

NATURE COMMUNICATIONS (2021)

Article Oncology

Case Report: Significant Response to Immune Checkpoint Inhibitor Camrelizumab in a Heavily Pretreated Advanced ER+/HER2-Breast Cancer Patient With High Tumor Mutational Burden

Rong Wang et al.

Summary: TMB may serve as a potential biomarker in immunotherapy selection, especially for ER+ mBC patients.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Impact of estrogen receptor levels on outcome in non-metastatic triple negative breast cancer patients treated with neoadjuvant/adjuvant chemotherapy

Maria Vittoria Dieci et al.

Summary: In this study of non-metastatic triple-negative breast cancer patients, it was found that ER expression levels of 1-9% showed similar clinical behavior to ER levels of 1%, supporting the use of a 10% cut-off to define triple-negative breast cancer.

NPJ BREAST CANCER (2021)

Review Biochemistry & Molecular Biology

Targeting PI3K/Akt signal transduction for cancer therapy

Yan He et al.

Summary: The PI3K/Akt signaling pathway plays a crucial role in cancer, and targeting inhibitors against it may aid in drug discovery. Additionally, combining pathway inhibitors with other cancer treatment strategies could be an effective approach to solving therapeutic dilemmas.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Medicine, General & Internal

Global breast cancer incidence and mortality trends by region, age-groups, and fertility patterns

Sarah M. Lima et al.

Summary: The incidence and mortality rates of breast cancer are increasing globally, with significant rises seen across all age groups and in most regions. Despite declining fertility rates, the upward trend in breast cancer incidence persists.

ECLINICALMEDICINE (2021)

Article Oncology

Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients

Lihua Shang et al.

Summary: This study evaluated weight change patterns and survival outcomes in Black and White breast cancer patients. The results showed that BMI loss is a strong predictor of worse breast cancer outcomes, while BMI gain is also associated with poorer survival, although to a lesser extent. The study emphasizes the importance of monitoring weight changes post-diagnosis for improved survival in breast cancer patients.

BREAST CANCER RESEARCH (2021)

Article Oncology

Racial disparities in survival outcomes among breast cancer patients by molecular subtypes

Fangyuan Zhao et al.

Summary: The study confirmed the racial disparity in survival and recurrence between White and Black breast cancer patients, with the largest difference observed among HR-/HER2+ and HR+/HER2- patients.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Review Biochemistry & Molecular Biology

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

Shannon Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

FGF/FGFR signaling in health and disease

Yangli Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Oncology

Loss of HER2 after HER2-targeted treatment

Tanja Ignatov et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

Article Biochemistry & Molecular Biology

Comprehensive Characterization of Cancer Driver Genes and Mutations

Matthew H. Bailey et al.

Article Biochemistry & Molecular Biology

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Francisco Sanchez-Vega et al.

Article Oncology

Time to Surgery and Breast Cancer Survival in the United States

Richard J. Bleicher et al.

JAMA ONCOLOGY (2016)

Article Oncology

Delayed Initiation of Adjuvant Chemotherapy Among Patients With Breast Cancer

Mariana Chavez-MacGregor et al.

JAMA ONCOLOGY (2016)

Article Oncology

Race, response to chemotherapy, and outcome within clinical breast cancer subtypes

J. R. Tichy et al.

BREAST CANCER RESEARCH AND TREATMENT (2015)

Article

Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge

Katarzyna Tomczak et al.

Wspolczesna Onkologia-Contemporary Oncology (2015)

Article Oncology

Neoadjuvant versus adjuvant systemic treatment in breast cancer: A meta-analysis

D Mauri et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)