期刊
CLINICAL PSYCHOLOGICAL SCIENCE
卷 11, 期 5, 页码 942-953出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/21677026221148101
关键词
actigraphy; antidepressant discontinuation; early warning signals; personalized psychiatry; repeated single-subject design
Discontinuation of antidepressants increases the risk of depressive symptoms. This study aimed to determine if transitions in depression were preceded by changes in actigraphy-based early-warning signals (EWSs), circadian-rhythm-based indicators, and mean activity levels. Data from 16 individuals with depression transitions and 9 without transitions were analyzed, showing that transitions were associated with increased EWSs. However, none of the tested risk indicators could confidently predict upcoming transitions in depression.
Antidepressant discontinuation increases the risk of experiencing depressive symptoms. In a repeated single-subject design, we tested whether transitions in depression were preceded by increases in actigraphy-based critical-slowing-down-based early-warning signals (EWSs; variance, kurtosis, autocorrelation), circadian-rhythm-based indicators, and decreases in mean activity levels. Four months of data from 16 individuals with a transition in depression and nine without a transition in depression were analyzed using a moving-window method. As expected, more participants with a transition showed at least one EWS (50% true positives; 22.2% false positives). Increases in circadian rhythm variables (25.0% true positives vs. 44.4% false positives) and decreases in activity levels (37.5% true positives vs. 44.4% false positives) were more common in participants without a transition. None of the tested risk indicators could confidently predict upcoming transitions in depression, but some evidence was found that critical-slowing-down-based EWSs were more common in participants with a transition.
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