☆ 4.6 Review

Electrochemical imaging for cell analysis in microphysiological systems

CURRENT OPINION IN ELECTROCHEMISTRY (2023)

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Review Chemistry, Multidisciplinary

Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces

Hanie Kavand et al.

Summary: Advanced in vitro cell culture systems and microphysiological systems (MPSs) are breakthrough technologies in biomedicine that replicate features of human tissues. The use of advanced functional materials and devices could enable better reproduction of in vivo-like functionality and real-time monitoring of tissue function, leading to more accurate mimicry of human physiology.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Nano-scale physical properties characteristic to metastatic intestinal cancer cells identified by high-speed scanning ion conductance microscope

Dong Wang et al.

Summary: This study used a high-speed scanning ion conductance microscope to observe tumor cells with different gene mutations and found a link between the physical properties of tumor cells and gene alterations. Furthermore, they identified a novel diagnostic strategy for predicting the metastatic ability of cancer cells.

BIOMATERIALS (2022)

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Article Biophysics

Confined electrochemiluminescence imaging microarray for high-throughput biosensing of single cell-released dopamine

Ningning Wang et al.

Summary: In this work, a CEIM chip was designed for high-throughput quantification of cell-secreted dopamine. The chip was able to recognize the target DA secretion from cells and emit an ECL signal without the need for additional coreactants.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Electrochemistry

Electrochemiluminescence imaging of cellular adhesion in vascular endothelial cells during tube formation on hydrogel scaffolds

Kosuke Ino et al.

Summary: This study presents a method for electrochemiluminescence (ECL) imaging to visualize cellular adhesion on hydrogel scaffolds. By culturing human umbilical vein endothelial cells on a Matrigel-coated indium tin oxide (ITO) electrode and using an ECL solution and specific voltage, ECL signals were generated, allowing for imaging of cellular adhesion.

ELECTROCHIMICA ACTA (2022)

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Review Biochemistry & Molecular Biology

Emerging Bioelectronics for Brain Organoid Electrophysiology

Kazi Tasnim et al.

Summary: Human brain organoids generated from human stem cells can partially replicate the development and complexity of the human brain. Understanding their electrophysiological properties requires advanced electrophysiological measurement technologies. This review provides an overview of the development, generation, and applications of human brain organoids, discusses conventional methods for characterizing their properties, and highlights the need for minimally invasive electrophysiological characterization. The review also presents recent advances in electrophysiological measurement technologies and their applications in brain organoid research, as well as the emerging tool of cyborg organoids for high spatiotemporal resolution characterization. The future perspectives of achieving high-throughput, multimodal characterizations from the same brain organoids are also discussed.

JOURNAL OF MOLECULAR BIOLOGY (2022)

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Article Biochemical Research Methods

Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array

Jeffrey Abbott et al.

Summary: Electrode-based impedance and electrochemical measurements can provide non-invasive, label-free cell-biology information, overcoming limitations of optical imaging. However, existing electrode-based techniques have noisy results due to the limited number of electrodes per well. New field-based impedance mapping and electrochemical mapping/patterning techniques using CMOS-MEA expand the possibilities of cell-biology applications, with single-cell spatial resolution.

LAB ON A CHIP (2022)

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Article Chemistry, Analytical

Electrochemiluminescence Microscopy of Cells: Essential Role of Surface Regeneration

Dongni Han et al.

Summary: Electrochemiluminescence (ECL) microscopy is successfully used for imaging cells, micro-/nano-objects, and electrochemical processes. The decrease of ECL signal during successive image recordings is a key limitation for ECL microscopy development. An electrochemical approach involving cathodic regenerative treatment can restore the ECL signal intensity, allowing for continuous image recording without signal loss.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Bio-Coreactant-Enhanced Electrochemiluminescence Microscopy of Intracellular Structure and Transport

Cheng Ma et al.

Summary: The bio-coreactant-enhanced electrochemiluminescence (ECL) microscopy allows for ECL imaging of intracellular structure and dynamic transport by using Ru(bpy)(3)(2+) and intracellular biomolecules. The research reveals the universal edge effect of cellular electroporation, as well as the dynamic transport of Ru(bpy)(3)(3+) in different cellular compartments and its correlation with the actin cytoskeleton.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Neurosciences

Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements

Austin P. Passaro et al.

Summary: Brain organoids serve as a crucial tool for studying the human brain, bridging the gap between different dimensional cell cultures and animal models, facilitating development and disease modeling. Despite advancements in the characterization of brain organoids, there is a need to improve electrophysiological analysis to fully realize their potential.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Chemistry, Analytical

Micropipet-Based Navigation in a Microvascular Model for Imaging Endothelial Cell Topography Using Scanning Ion Conductance Microscopy

Noriko Taira et al.

Summary: The study used SICM to successfully image cell surfaces in hydrogels, providing a new method and approach for studying the mechanisms of intravascular diseases.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Spatially Selective Imaging of Cell-Matrix and Cell-Cell Junctions by Electrochemiluminescence

Hao Ding et al.

Summary: A novel method for spatially selective imaging of cell junctions by regulating the thickness of the electrochemiluminescence (ECL) layer through control of luminophore and co-reactant concentrations has been reported. Low luminophore concentration reveals cell-matrix adhesions, while high concentration allows sequential imaging of cell-matrix and cell-cell junctions. This strategy not only provides new insights into ECL mechanisms but also expands the potential applications of ECL microscopy in bioimaging.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Single Biomolecule Imaging by Electrochemiluminescence

Yujie Liu et al.

Summary: This study successfully imaged single biomolecules using RuDSNs/AuNPs as ECL nanoemitters, demonstrating the visualization of single protein molecules and single membrane proteins in cells, overcoming the challenges in ultrasensitive ECL analysis and providing valuable information for cellular biology research.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Engineering, Biomedical

Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications

Monize Caiado Decarli et al.

Summary: Three-dimensional (3D) cell culture, especially using spheroids, is a powerful tool for mimicking the in vivo structure and microenvironment of healthy tissues and solid tumors. Engineering processes to obtain uniform 3D cell spheroids, considering mass transfer and shear stress, as well as computational and mathematical modeling, are important for developing large tissues and complex organs. Challenges in analyzing morphological parameters, cell quantification, viability, gene expression profiles, metabolic behavior, and high-content analysis need to be addressed to maximize the potential applications of spheroids in various research fields.

BIOFABRICATION (2021)

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Review Chemistry, Physical

Light-addressable potentiometric sensors for cell monitoring and biosensing

Tatsuo Yoshinobu et al.

Summary: The light-addressable potentiometric sensor (LAPS) is a versatile platform for chemical and biosensing, with the ability to divide its flat sensor surface into separate areas or pixels for independent sensing. It has been widely applied to cells and biological samples, with recent trends and applications focusing on advancements in technology and biomaterials.

CURRENT OPINION IN ELECTROCHEMISTRY (2021)

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Article Chemistry, Analytical

Ion Conductance-Based Perfusability Assay of Vascular Vessel Models in Microfluidic Devices

Rise Akasaka et al.

Summary: A novel methodology based on ion conductance was proposed to evaluate the perfusability of vascular vessels in microfluidic devices without microscopic imaging. By analyzing the ion current changes, the perfusability of vessels could be determined, serving as an important tool for drug screening using organs-on-a-chip.

MICROMACHINES (2021)

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Article Chemistry, Multidisciplinary

Electrochemical Imaging of Endothelial Permeability Using a Large-Scale Integration-Based Device

Kosuke Ino et al.

Summary: A novel electrochemical imaging method was introduced to evaluate endothelial permeability by monitoring the diffusion of tracers through a monolayer of HUVECs. The method demonstrated its potential in studying the effects of histamine on endothelial monolayers and evaluating the metastasis of cancer spheroids. The developed device provides spatial information and allows for monitoring the interaction between monolayers and spheroids, showing promise for organs-on-a-chip and in vitro drug screening applications.

ACS OMEGA (2021)

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Review Chemistry, Physical

Scanning electrochemical microscopy for biosurface imaging

Yuanshu Zhou et al.

Summary: Scanning electrochemical microscopy (SECM) is a powerful technique that provides chemical identity, quantification, and spatiotemporal information on biosurfaces. It is valuable for studying cell phenotypes and functions, with applications in measuring biomarkers, membrane permeability, neurotransmitters, and intracellular activities.

CURRENT OPINION IN ELECTROCHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Shadow Electrochemiluminescence Microscopy of Single Mitochondria

Yumeng Ma et al.

Summary: This study introduces a label-free shadow electrochemiluminescence (ECL) microscopy technique to image single living mitochondria deposited on electrode surface. By utilizing negative optical contrast and local diffusional hindrance, this approach visualizes individual mitochondria and validates their functionality with classical fluorescent biomarkers. The versatility and extreme sensitivity of this method make it promising for imaging subcellular structures while alleviating photobleaching and phototoxicity issues associated with conventional microscopy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Biophysics

Electrochemiluminescence imaging of respiratory activity of cellular spheroids using sequential potential steps

Kaoru Hiramoto et al.

Summary: This study demonstrates the electrochemiluminescence (ECL) imaging of spheroid respiratory activity for the first time, providing visualization of O2 distribution and enabling time-lapse imaging for studying cellular dynamics in spheroids with promising high-throughput imaging strategy.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Engineering, Biomedical

Topography and Permeability Analyses of Vasculature-on-a-Chip Using Scanning Probe Microscopies

Yuji Nashimoto et al.

Summary: This study evaluates the role of scanning probe microscopy (SPM) as an analytical tool for microphysiological systems (MPS), providing a new solution for real-time high spatial resolution imaging. A simple vascular model was used for permeability and topographical analysis, paving the way for the application of SPM technology in MPS.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Toxicology

Microphysiological systems in early stage drug development: Perspectives on current applications and future impact

Anna K. Kopec et al.

Summary: MPS have the potential to improve drug development and reduce the use of animals in research, but face challenges in adoption and require collaboration between organizations and regulators to address limitations and establish reproducibility.

JOURNAL OF TOXICOLOGICAL SCIENCES (2021)

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Review Toxicology

Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project

Seiichi Ishida

Summary: Microphysiological systems (MPS) have been actively developed as a new technology for in vitro toxicity testing platforms, with the potential to become next-generation in vitro toxicity assessment systems. MPS involve culture techniques to reconstruct specific organ or tissue functions in a limited space, creating miniaturized human test systems.

FRONTIERS IN TOXICOLOGY (2021)

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Article Chemistry, Multidisciplinary

Imaging Cell-Matrix Adhesions and Collective Migration of Living Cells by Electrochemiluminescence Microscopy

Hao Ding et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Biophysics

Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model

Jeremy F. Wong et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Chemistry, Multidisciplinary

Closed Bipolar Electrode Array for On-Chip Analysis of Cellular Respiration by Cell Aggregates

Kosuke Ino et al.

ACS SENSORS (2020)

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Article Electrochemistry

Electrochemical measurement of respiratory activity for evaluation of fibroblast spheroids containing endothelial cell networks

Kaoru Hiramoto et al.

ELECTROCHIMICA ACTA (2020)

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Development of a tunable method to generate various three-dimensional microstructures by replenishing macromolecules such as extracellular matrix components and polysaccharides

Fumiya Tao et al.

SCIENTIFIC REPORTS (2020)

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Review Chemistry, Multidisciplinary

Electrochemiluminescence Single-Cell Analysis: Intensity- and Imaging-Based Methods

Hao Ding et al.

CHEMPLUSCHEM (2020)

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Review Chemistry, Physical

Recent advances of scanning electrochemical microscopy and scanning ion conductance microscopy for single-cell analysis

Junjie Zhang et al.

CURRENT OPINION IN ELECTROCHEMISTRY (2020)

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Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

Xinyue Yuan et al.

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Article Cell & Tissue Engineering

Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development

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Review Polymer Science

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

JunJie Yu et al.

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Article Electrochemistry

Scanning electrochemical microscopy for the investigation of redox potential of human myocardium-derived mesenchymal stem cells grown at 2D and 3D conditions

Jurate Petroniene et al.

ELECTROCHIMICA ACTA (2020)

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Article Electrochemistry

In situ electrochemical analysis of alkaline phosphatase activity in 3D cell cultures

Claudia Caviglia et al.

ELECTROCHIMICA ACTA (2020)

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Oxygen consumption rate of tumour spheroids during necrotic-like core formation

Rei Mukomoto et al.

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Nanocage-confined electrochemiluminescence for the detection of dopamine released from living cells

Hao Ding et al.

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A flexible 3-dimensional microelectrode array for in vitro brain models

David A. Soscia et al.

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Article Materials Science, Biomaterials

Biofabrication Using Electrochemical Devices and Systems

Kosuke Ino et al.

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Article Chemistry, Analytical

Electrochemical Imaging of Cell Activity in Hydrogels Embedded in Grid-shaped Polycaprolactone Scaffolds Using a Large-scale Integration-based Amperometric Device

Kosuke Ino et al.

ANALYTICAL SCIENCES (2019)

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Article Chemistry, Analytical

Systematic Analysis of Different Cell Spheroids with a Microfluidic Device Using Scanning Electrochemical Microscopy and Gene Expression Profiling

Liang Zhao et al.

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Review Chemistry, Multidisciplinary

Optical Imaging Approaches to Monitor Static and Dynamic Cell-on-Chip Platforms: A Tutorial Review

Alireza Arandian et al.

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Bo Zhou et al.

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Steady-State Electrochemiluminescence at Single Senniconductive Titanium Dioxide Nanoparticles for Local Sensing of Single Cells

Chen Cui et al.

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Jeremy F. Wong et al.

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Direct Electrochemiluminescence Imaging of a Single Cell on a Chitosan Film Modified Electrode

Gen Liu et al.

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Electrochemical biosensor system using a CMOS microelectrode array provides high spatially and temporally resolved images

William Tedjo et al.

BIOSENSORS & BIOELECTRONICS (2018)

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Review Pharmacology & Pharmacy

Organ/body-on-a-chip based on microfluidic technology for drug discovery

Hiroshi Kimura et al.

DRUG METABOLISM AND PHARMACOKINETICS (2018)

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Article Electrochemistry

Electrochemicolor imaging of endogenous alkaline phosphatase and respiratory activities of mesenchymal stem cell aggregates in early-stage osteodifferentiation

Kosuke Ino et al.

ELECTROCHIMICA ACTA (2018)

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Tzu-En Lin et al.

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Single Cell Electrochemiluminescence Imaging: From the Proof-of-Concept to Disposable Device-Based Analysis

Giovanni Valenti et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

Olivier Y. F. Henry et al.

LAB ON A CHIP (2017)

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Label-Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes

Su Ryon Shin et al.

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Electrochemicolor Imaging Using an LSI-Based Device for Multiplexed Cell Assays

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Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers

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NATURE CELL BIOLOGY (2016)

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Molecular electrochemical switching element based on diffusive molecular competition for multipoint electrochemical detection of respiration activity of cell aggregates

Kosuke Ino et al.

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Densified Electrochemical Sensors Based on Local Redox Cycling between Vertically Separated Electrodes in Substrate Generation/Chip Collection and Extended Feedback Modes

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ANALYTICAL CHEMISTRY (2014)

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John P. Wikswo

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Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11

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