Pediatric pulmonary valve replacements: Clinical challenges and emerging technologies

Article Cardiac & Cardiovascular Systems

Novel Valve Choices for Pulmonary Valve Replacement

David Kalfa

SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY (2023)

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Article Cardiac & Cardiovascular Systems

Patient-Prosthesis Mismatch Associated With Somatic Growth After Mechanical Mitral Valve Replacement in Small Children: Metrics for Reoperation and Outcomes

Yuji Nakamura et al.

SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY (2023)

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Editorial Material Cardiac & Cardiovascular Systems

Transcatheter Approaches to Pulmonary Valve Replacement in Congenital Heart Disease: Revolutionizing the Management of RVOT Dysfunction?

Ari J. Gartenberg et al.

SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY (2023)

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Article Chemistry, Multidisciplinary

Spatially Heterogeneous Tubular Scaffolds for In Situ Heart Valve Tissue Engineering Using Melt Electrowriting

Navid Toosi Saidy et al.

Summary: Heart valve tissue engineering aims to provide autologous heart valve implants with regenerative capabilities and durability. This study demonstrates the additive manufacturing of bioinspired tubular scaffolds using melt electrowriting, which can meet the mechanical requirements of heart valves and enable cellular infiltration. The scaffolds are then embedded with a microporous hydrogel to enhance cell infiltration and ensure compatibility with blood flow.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association

Connie W. Tsao et al.

Summary: This article introduces the latest statistics on heart disease, stroke, and cardiovascular risk factors published by the American Heart Association in conjunction with the National Institutes of Health. The Statistical Update includes data on a range of clinical heart and circulatory disease conditions and their associated outcomes. It serves as a critical resource for the general public, policymakers, healthcare professionals, researchers, and others seeking the best available data.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Long-Term Outcomes After Melody Transcatheter Pulmonary Valve Replacement in the US Investigational Device Exemption Trial

Thomas K. Jones et al.

Summary: The development of the Melody valve aims to extend the lifespan of previously implanted conduits or valves for patients with complex congenital heart disease. The study shows that Melody TPV replacement provides sustained symptomatic and hemodynamic improvement for the majority of patients during a 10-year follow-up.

CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2022)

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Article Cardiac & Cardiovascular Systems

Reintervention and Survival After Transcatheter Pulmonary Valve Replacement

Doff B. McElhinney et al.

Summary: This study evaluated the mid- and long-term outcomes after transcatheter pulmonary valve replacement (TPVR) and found that survival and freedom from reintervention or surgery after TPVR were generally comparable to outcomes of surgical conduit/valve replacement across a wide age range. Age, prosthetic valve in other positions, and existing transvenous pacemaker/implantable cardioverter-defibrillator were identified as risk factors for death.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Comparison of homografts and bovine jugular vein conduits in the pulmonary position in patients <20 years of age

Supreet P. Marathe et al.

Summary: This study compared the performance of homografts and bovine jugular vein (BJV) conduits in the pulmonary position. The results showed that in patients under the age of 20 with a conduit size larger than 15mm, homografts outperformed BJV conduits and aortic homografts. Small conduits had similar performance across all conduit types.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

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Article Biochemistry & Molecular Biology

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Thomas Senage et al.

Summary: In a large cohort of patients who underwent aortic valve replacement, antibody responses to glycans present in bioprosthetic heart valves, notably galactose-alpha 1,3-galactose and N-glycolylneuraminic acid, were implicated in valve calcification and deterioration. It was found that antibodies against xenoantigens galactose-alpha 1,3-galactose and N-glycolylneuraminic acid could mediate the deterioration of bioprosthetic heart valves through calcification. Results suggest that BHVs manufactured using donor tissues deficient in these antigens may have improved durability.

NATURE MEDICINE (2022)

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Review Microbiology

Tolerance and resistance of microbial biofilms

Oana Ciofu et al.

Summary: Chronic infections caused by microbial biofilms pose a significant clinical challenge due to the resistance of biofilms to antimicrobials and the immune system, leading to persistent and recurrent infections. This Review discusses the current understanding of the mechanisms underlying the tolerance of biofilms to the immune system and to antimicrobials, as well as their role in the development of antimicrobial resistance.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Nationwide Registry-Based Analysis of Infective Endocarditis Risk After Pulmonary Valve Replacement

Clara Stammnitz et al.

Summary: This study aimed to identify specific long-term risk factors for infective endocarditis (IE) in patients with congenital heart disease after pulmonary valve replacements. The study found that bovine jugular vein valves had the highest risk of IE, while Edwards Sapien and mechanical valves were used less frequently and remained without IE.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

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Article Multidisciplinary Sciences

An imidazolium-based zwitterionic polymer for antiviral and antibacterial dual functional coatings

Pengyu Chen et al.

Summary: A zwitterionic polymer was designed and synthesized to achieve contact deactivation of coronavirus in dry ambient conditions and reduce virus adhesion and bacterial biofilm formation in wet conditions. The polymer was produced using a substrate-independent and solvent-free process and can be applied to various substrates.

SCIENCE ADVANCES (2022)

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Article Chemistry, Multidisciplinary

A Readily Scalable, Clinically Demonstrated, Antibiofouling Zwitterionic Surface Treatment for Implantable Medical Devices

Brian McVerry et al.

Summary: A simple surface modification technique has been developed to reduce microbial and protein adhesion on artificial materials, showing promising results in clinical applications. The treated surfaces exhibit strong resistance against adhesion and are non-toxic to cells. Surface-treated catheters have been approved by the FDA and have shown good clinical efficacy in patients.

ADVANCED MATERIALS (2022)

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Article Engineering, Multidisciplinary

3D printed tubular lattice metamaterials for mechanically robust stents

Huan Jiang et al.

Summary: Coronary artery disease (CAD) is a common condition where the coronary arteries become narrow or blocked due to atherosclerosis. This study proposes a new type of tubular lattice metamaterial that shows improved mechanical resilience and bending performance, making it a promising alternative for stent design. The findings demonstrate the potential of this material for developing more robust stents in medical engineering.

COMPOSITES PART B-ENGINEERING (2022)

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Review Cardiac & Cardiovascular Systems

Genomic frontiers in congenital heart disease

Sarah U. Morton et al.

Summary: Next-generation sequencing has provided new insights into the causes and mechanisms of congenital heart disease (CHD) by identifying damaging gene variants and shared pathways in organogenesis. Developmental single-cell transcriptomic data demonstrate the expression of CHD-associated genes in specific cell lineages, while genetic variants may disrupt multicellular interactions crucial for cardiogenesis.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Materials Science, Multidisciplinary

The evolution of polyurethane heart valve replacements: How chemistry translates to the clinic

Matthew Crago et al.

Summary: Polyurethane has the potential to be a promising material for next-generation heart valve replacements due to its unique chemical structure that mimics the characteristics of soft tissues. However, its past clinical failures have limited its application. Recent advancements in polyurethane chemistry have contributed towards overcoming these limitations and progressing towards clinical translation.

MATERIALS TODAY COMMUNICATIONS (2022)

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Review Health Care Sciences & Services

The health digital twin to tackle cardiovascular disease-a review of an emerging interdisciplinary field

Genevieve Coorey et al.

Summary: Precision medicine in cardiovascular disease has the potential to benefit from the concept of digital twins, where virtual representations of patients receive real-time updates on various data variables to predict diseases and optimize treatment selection. Through a systematic literature review, it was found that digital twin research in the field of cardiovascular disease is interdisciplinary and globally established, with numerical simulation models being the main focus. However, implementation challenges include ethical constraints and clinical barriers to the adoption of decision tools based on artificial intelligence systems.

NPJ DIGITAL MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Antiplatelet therapy abrogates platelet-assisted Staphylococcus aureus infectivity of biological heart valve conduits

Bartosz Ditkowski et al.

Summary: The study found that bovine pericardium and BJV wall are more susceptible to Staphylococcus aureus adhesion during pulmonary valve replacement surgeries. Antiplatelet therapy can effectively reduce S aureus adherence to BJV, and dual antiplatelet therapy may be a realistic approach to prevent endocarditis and associated mortality.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Experience and Outcomes of Surgically Implanted Melody Valve in the Pulmonary Position

Eric N. Feins et al.

Summary: The study retrospectively evaluated outcomes in young patients undergoing surgical implantation of a Melody valve in the RVOT, showing acceptable early results with successful valve dilation through transcatheter reintervention to accommodate growth.

ANNALS OF THORACIC SURGERY (2021)

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Review Cardiac & Cardiovascular Systems

The Task Force for the management of adult congenital heart disease of the European Society of Cardiology (ESC)

Helmut Baumgartner et al.

EUROPEAN HEART JOURNAL (2021)

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Review Surgery

Conduits for Right Ventricular Outflow Tract Reconstruction in Infants and Young Children

Tao Qian et al.

Summary: No conduit has proven to have lifelong durability in RVOT position. We are far from the ideal, but we are not in a state of emergency. In-depth clinical research as well as innovation in material science are needed to help improve the durability of the conduits used in infants and young children.

FRONTIERS IN SURGERY (2021)

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Article Surgery

Anisotropic Polytetrafluoroethylene Cardiovascular Conduits Spontaneously Expand in a Growing Lamb Model

Anthony Azakie et al.

Summary: The study evaluated the efficacy of anisotropic conduits in growing lambs and found that compared to conventional conduits, the anisotropic conduits not only had better expansion performance, but also did not cause adverse events in animals, with significantly lower trans-conduit gradients.

JOURNAL OF INVESTIGATIVE SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Reintervention rates after biourosthetic pulmonary valve replacement in patients younger than 30 years of age: A multicenter analysis

Christopher W. Baird et al.

Summary: For patients younger than 30 years undergoing surgical bioprosthetic pulmonary valve replacement, the rate of reintervention is influenced by valve type. Independent risk factors for reintervention, after controlling for age and valve size, mainly include valve type.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2021)

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Review Cardiac & Cardiovascular Systems

Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity

Emanuela S. Fioretta et al.

Summary: Valvular heart disease is a significant cause of morbidity and mortality worldwide, but current clinically adopted heart valve replacement options have limitations. Next-generation tissue-engineered heart valves have the potential to address these limitations and become a promising therapeutic alternative for patients with valvular disease.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Engineering, Biomedical

Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction

Arnat Balabiyev et al.

Summary: The study found that mice with fibrinogen deficiency exhibited reduced macrophage fusion on implanted biomaterials and were protected from the formation of fibrin-containing fibrous capsules, highlighting the key role of fibrin polymer in driving the foreign body reaction.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Chemical bonding of biological valve leaflets with an aminated zwitterionic copolymer for long-term anticoagulation and improved anti-calcification

Kunpeng Liu et al.

Summary: A novel postcrosslinking method using a zwitterionic copolymer was developed on glutaraldehyde cross-linked pericardium, improving issues of thrombus, cytotoxicity, and calcification.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Scalable inter-diffused zwitterionic polyurethanes for durable antibacterial coatings

Zixu Huang et al.

Summary: A novel zwitterionic polyurethane (ZPU) was designed to eliminate bacterial attachment on polyurethane (PU) coatings, achieving long-lasting surface hydrophilicity and improved toughness through inter-diffusion with acrylic polyurethane (APU). The enriched ZPU on the coating surface demonstrated superior antibacterial efficacy even after mechanical abrasion, making it feasible for large-scale application on commercial vinyl tarpaulin. The inter-diffused PU coating showed low batch-to-batch deviation and no delamination, indicating its potential for scalable production from laboratory to practical use.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Biomedical

Design and numerical simulation for the development of an expandable paediatric heart valve

Monica M. Kerr et al.

Summary: The study aims to develop an expandable valve for pediatric valve replacement to avoid the issue of constantly needing revisions as the child grows. Using parametric design modeling and fluid-structure simulation methods, the performance of the valve under loading is analyzed to achieve optimal valve parameter design.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2021)

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Review Cardiac & Cardiovascular Systems

Semilunar Valve Interventions for Congenital Heart Disease

Brian H. Morray et al.

Summary: Transcatheter balloon valvuloplasty is an effective treatment for aortic and pulmonary valve stenosis, reducing valve obstruction and the long-term need for reintervention and valve replacement. Although valve regurgitation may occur in some cases, it does not commonly lead to the need for valve replacement.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Letter Cardiac & Cardiovascular Systems

Preliminary Evaluation of a Novel Polymeric Valve Following Surgical Implantation for Symptomatic Aortic Valve Disease

Dean J. Kereiakes et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2021)

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Review Cardiac & Cardiovascular Systems

Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration

Matteo Marro et al.

Summary: Bioprosthetic heart valves (BHVs) offer an alternative to mechanical valves with reduced long-term anticoagulation needs, but are prone to structural valve degeneration which may require reoperation. This degeneration, often characterized by leaflet calcification, can also occur with minimal mineralization in some cases, posing challenges for treatment. Various factors such as protein infiltration, glycation, oxidative and mechanical stress, and inflammation may play a role in noncalcific mechanisms of BHV structural valve degeneration.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Multidisciplinary Sciences

High-strength and fibrous capsule-resistant zwitterionic elastomers

Dianyu Dong et al.

Summary: This study presents a unique class of materials, called zwitterionic-elastomeric-networked (ZEN) hydrogels, which combine two weak zwitterionic hydrogels into a high-strength pure zwitterionic hydrogel to achieve both high mechanical properties and long-term resistance to fibrous capsule formation. This successful integration provides design principles for durable and fibrous capsule-resistant materials.

SCIENCE ADVANCES (2021)

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Article Biochemistry & Molecular Biology

A Uniform and Robust Bioinspired Zwitterion Coating for Use in Blood-Contacting Catheters with Improved Anti-Inflammatory and Antithrombotic Properties

Yuqi Liu et al.

Summary: This study developed a new biomimetic erythrocyte membrane coating that can effectively reduce inflammation and thrombotic complications of blood-contacting catheters, improving hemocompatibility and anticoagulation properties.

MACROMOLECULAR BIOSCIENCE (2021)

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Article Cardiac & Cardiovascular Systems

Resource Use and Outcomes of Pediatric Congenital Heart Disease Admissions: 2003 to 2016

Jonathan B. Edelson et al.

Summary: Children admitted with congenital heart disease (CHD) have seen an increasing trend in hospital admissions, charges, and mortality rates over the past decade. Despite a decrease in mortality rates among CHD admissions, they are still significantly higher than those without CHD, and CHD patients account for a growing proportion of all pediatric inpatient deaths. Effective resource allocation is essential to improve outcomes for these high-risk patients.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

A Novel Restorative Pulmonary Valve Conduit: Early Outcomes of Two Clinical Trials

David L. Morales et al.

Summary: The study reported on the first use of a biorestorative valved conduit, XPV, in children and compared the performance of two designs at 12 months post-implantation. The results showed promising early clinical outcomes of XPV, with the XPV-2 version appearing to correct issues seen in the XPV-1 version.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Engineering, Biomedical

Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support

Noritsugu Naito et al.

Summary: By comparing the effects of different anticoagulation methods on clot formation and bleeding times during ECLS, this study found that the combination of PCB coating and FXII900 inhibitor significantly reduced clotting and tissue bleeding times, making it a promising anticoagulation method for clinical ECLS.

BIOMATERIALS (2021)

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Article Cell Biology

Pediatric tri-tube valved conduits made from fibroblast-produced extracellular matrix evaluated over 52 weeks in growing lambs

Zeeshan H. Syedain et al.

Summary: The study developed collagenous tubes that can grow with children and successfully implanted them in lambs as pulmonary artery replacements. The tri-tube valved conduits showed better growth and functionality compared to bioprosthetic conduits in two sequential cohorts, with reduced calcification and improved hemodynamic function observed in the lamb models.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Engineering, Biomedical

Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy

B. J. De Kort et al.

Summary: This study provides insights into the inflammatory and regenerative processes of in situ heart valve tissue engineering using resorbable synthetic scaffolds over a period of 24 months in sheep. Using a combination of immunohistochemistry and Raman microspectroscopy, spatial variability in graft resorption and tissue formation, as well as heterogeneity in cellular repopulation, were observed. These findings contribute to the mechanistic understanding of in situ tissue engineering and are essential for the development of improved graft designs for clinical translation.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

A Zwitterionic Polyurethane Nanoporous Device with Low Foreign-Body Response for Islet Encapsulation

Qingsheng Liu et al.

Summary: The ZPU encapsulation device is developed with sulfobetaine groups in the polymer backbone, offering superior properties for cell encapsulation therapies with efficient mass transfer and prevention of cell escape. It has demonstrated therapeutic potential for islet encapsulation and treating diabetes, showing low foreign-body response and high biological compatibility.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Mixed-charge pseudo-zwitterionic copolymer brush as broad spectrum antibiofilm coating

Yang Wu et al.

Summary: This study demonstrates the effectiveness of a novel mixed-charge copolymer brush coating in combating biofilm formation, outperforming traditional zwitterionic polymers. By utilizing oppositely charged monomers, a greater than 99% reduction in biofilm formation was achieved against various bacteria in vitro, with excellent long-term efficacy in murine infection models. These findings suggest the potential of combining readily available singly charged monomers for potent antibiofilm applications.

BIOMATERIALS (2021)

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Article Cardiac & Cardiovascular Systems

Consensus document on optimal management of patients with common arterial trunk

Mark G. Hazekamp et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2021)

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Article Engineering, Biomedical

Tissue response, macrophage phenotype, and intrinsic calcification induced by cardiovascular biomaterials: Can clinical regenerative potential be predicted in a rat subcutaneous implant model?

Madeline Cramer et al.

Summary: The study demonstrates that different biomaterials elicit distinct types of macrophage infiltration and host remodeling responses, suggesting that the rat subcutaneous implantation model can be used to predict in vivo biocompatibility and regenerative potential for cardiovascular biomaterials.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Cardiac & Cardiovascular Systems

Multicenter Study of Endocarditis After Transcatheter Pulmonary Valve Replacement

Doff B. McElhinney et al.

Summary: This study evaluated risk factors for and outcomes of endocarditis after transcatheter pulmonary valve replacement, finding that younger age, a previous history of endocarditis, and a higher residual gradient are risk factors. The incidence of endocarditis remained constant over time, and efforts to mitigate risk are crucial for improving patient management.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Ultralow-Fouling Zwitterionic Polyurethane-Modified Membranes for Rapid Separation of Plasma from Whole Blood

Kun Wang et al.

Summary: This paper introduces a portable, low-cost plasma separation device that can rapidly extract plasma in a simple three-step operation, improving the efficiency of plasma extraction. By using a special membrane material, the device can effectively inhibit surface fouling of blood cells and membrane flux, ensuring the quality of extracted plasma and reducing operation time.

LANGMUIR (2021)

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Article Materials Science, Biomaterials

Zwitterionic hydrogel-coated heart valves with improved endothelialization and anti-calcification properties

Yu Luo et al.

Summary: In this study, modified bioprosthetic heart valves with enhanced endothelial cell affinity were developed to improve biocompatibility and anti-calcification properties. After 30 days of subcutaneous implantation, the improved valves showed reduced immune response and calcification compared to traditional BHVs.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Cardiac & Cardiovascular Systems

Global epidemiology of valvular heart disease

Sean Coffey et al.

Summary: Valvular heart disease (VHD) is a major cause of physical function loss, decreased quality of life, and shortened longevity. Rheumatic heart disease remains the most common manifestation of VHD globally, while calcific aortic stenosis and degenerative mitral valve disease are also significant. Despite improvements in mortality related to rheumatic heart disease, deaths from calcific aortic stenosis have increased over the past 20 years.

NATURE REVIEWS CARDIOLOGY (2021)

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Review Chemistry, Multidisciplinary

Bioinspired dopamine and zwitterionic polymers for non-fouling surface engineering

Anika Benozir Asha et al.

Summary: This review highlights the importance of zwitterionic polymers in surface modification and the use of a dopamine adhesive layer for the immobilization of the zwitterion layer. The conjugation of dopamine and zwitterions is categorized into four different approaches, providing promising pathways for the development of non-fouling surfaces.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Cardiac & Cardiovascular Systems

Outcomes Following Heterotopic Placement of Right Ventricle to Pulmonary Artery Conduits

Akshat Saxena et al.

Summary: The study evaluated outcomes following RV-PA conduit placement in pediatric patients, finding that the majority of conduits placed during the neonatal period required replacement before the age of five. The use of pulmonary homografts was associated with improved reintervention-free survival.

WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Residual immune response towards decellularized homografts may be highly individual

Johannes Ebken et al.

Summary: The study found residual immunogenicity in decellularized homografts despite almost complete cell removal. The established dot blot method allows for a semi-quantitative assessment of individual immune response towards the extracellular components of DHVs.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2021)

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Article Engineering, Biomedical

Assessment of a Siloxane Poly(urethane-urea) Elastomer Designed for Implantable Heart Valve Leaflets

Chris Jenney et al.

Summary: The newly developed siloxane poly(urethane-urea) shows promising biocompatibility and biostability, making it suitable for flexible leaflets in totally synthetic heart valve replacements. Various tests indicate its potential to reduce calcification and thrombus, while improving blood flow and device economics.

ADVANCED NANOBIOMED RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Utilization of hospital inpatient resources by children requiring a right ventricle-to-pulmonary artery conduit in the first 10 years of life

Kim Dalziel et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

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Article Engineering, Biomedical

Biodegradable zwitterionic polymer membrane coating endowing nanoparticles with ultra-long circulation and enhanced tumor photothermal therapy

Shaojun Peng et al.

BIOMATERIALS (2020)

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Article Cardiac & Cardiovascular Systems

Three-Year Outcomes From the Harmony Native Outflow Tract Early Feasibility Study

Lee N. Benson et al.

CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2020)

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Review Cardiac & Cardiovascular Systems

The 'Digital Twin' to enable the vision of precision cardiology

Jorge Corral-Acero et al.

EUROPEAN HEART JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Long-term durability of bioprosthetic valves in pulmonary position: Pericardial versus porcine valves

Jae Gun Kwak et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

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Review Hematology

Coagulation: At the heart of infective endocarditis

Laurens Liesenborghs et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Cell Biology

A geometrically adaptable heart valve replacement

Sophie C. Hofferberth et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4

Gonzalo del Monte-Nieto et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Materials Science, Multidisciplinary

Zwitterionic polymers and hydrogels for antibiofouling applications in implantable devices

Nandanan Erathodiyil et al.

MATERIALS TODAY (2020)

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Article Multidisciplinary Sciences

De novo design of functional zwitterionic biomimetic material for immunomodulation

Bowen Li et al.

SCIENCE ADVANCES (2020)

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Article Engineering, Biomedical

Zwitterionic carboxybetaine polymers extend the shelf-life of human platelets

Xiaojie Lin et al.

ACTA BIOMATERIALIA (2020)

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Review Cardiac & Cardiovascular Systems

Seven decades of valved right ventricular outflow tract reconstruction: The most common heart procedure in children

Jeremy L. Herrmann et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

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Article Multidisciplinary Sciences

Design of robust superhydrophobic surfaces

Dehui Wang et al.

NATURE (2020)

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Article Cardiac & Cardiovascular Systems

Alterra Adaptive Prestent and SAPIEN 3 THV for Congenital Pulmonic Valve Dysfunction An Early Feasibility Study

Shabana Shahanavaz et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2020)

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Review Cardiac & Cardiovascular Systems

Degeneration of Bioprosthetic Heart Valves: Update 2020

Alexander E. Kostyunin et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Multidisciplinary Sciences

Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo

Sarah E. Motta et al.

SCIENTIFIC REPORTS (2020)

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Article Cardiac & Cardiovascular Systems

In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Eiastomeric Tissue-Engineered Heart Valves

Marcelle Uiterwijk et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

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Article Cardiac & Cardiovascular Systems

Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

Emanuela S. Fioretta et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

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Article Cardiac & Cardiovascular Systems

Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves

Antonio Frasca et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

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Review Pharmacology & Pharmacy

NOACs: an emerging class of oral anticoagulants-a review article

Chithra Paul et al.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Materials Science, Biomaterials

Meta-biomaterials

Amir A. Zadpoor

BIOMATERIALS SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Artificial Heart Valves with Balanced Charged Networks Exhibiting Anti-Calcification Properties

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ACS APPLIED BIO MATERIALS (2020)

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Review Cardiac & Cardiovascular Systems

The 'Digital Twin' to enable the vision of precision cardiology

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EUROPEAN HEART JOURNAL (2020)

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Global, regional, and national burden of congenital heart disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

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LANCET CHILD & ADOLESCENT HEALTH (2020)

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Designs of Zwitterionic Interfaces and Membranes

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LANGMUIR (2019)

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Outcomes of Mechanical Mitral Valve Replacement in Children

Chizitam Ibezim et al.

ANNALS OF THORACIC SURGERY (2019)

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Article Cardiac & Cardiovascular Systems

2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Outcomes after mechanical aortic valve replacement in children and young adults with congenital heart disease

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Article Chemistry, Multidisciplinary

Blood-Compatible Surfaces with Phosphorylcholine-Based Polymers for Cardiovascular Medical Devices

Kazuhiko Ishihara

LANGMUIR (2019)

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Infective endocarditis in right ventricular outflow tract conduits: a register-based comparison of homografts, Contegra grafts and Melody transcatheter valves

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Article Cardiac & Cardiovascular Systems

A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data

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EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2019)

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Review Public, Environmental & Occupational Health

Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies

Yingjuan Liu et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2019)

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Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

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NATURE COMMUNICATIONS (2019)

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Article Engineering, Biomedical

Zwitterionic poly-carboxybetaine coating reduces artificial lung thrombosis in sheep and rabbits

Rei Ukita et al.

ACTA BIOMATERIALIA (2019)

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Article Cardiac & Cardiovascular Systems

Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves

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EUROPEAN HEART JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Acute and midterm outcomes of the post-approval MELODY Registry: a multicentre registry of transcatheter pulmonary valve implantation

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EUROPEAN HEART JOURNAL (2019)

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Anatomy, Function, and Dysfunction of the Right Ventricle JACC State-of-the-Art Review

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POLYMERS FOR ADVANCED TECHNOLOGIES (2019)

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3D bioprinting of collagen to rebuild components of the human heart

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SCIENCE (2019)

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Article Multidisciplinary Sciences

Trimethylamine N-oxide-derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials

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SCIENCE ADVANCES (2019)

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Review Engineering, Biomedical

The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions

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ACTA BIOMATERIALIA (2019)

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Review Engineering, Biomedical

The blood compatibility challenge. Part 1: Blood-contacting medical devices: The scope of the problem

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ACTA BIOMATERIALIA (2019)

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Review Engineering, Biomedical

The blood compatibility challenge. Part 3: Material associated activation of blood cascades and cells

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ACTA BIOMATERIALIA (2019)

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The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity

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BIOMATERIALS (2019)

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Association between patient age at implant and outcomes after transcatheter pulmonary valve replacement in the multicenter Melody valve trials

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CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2019)

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Review Immunology

The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1

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SEMINARS IN IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

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NATURE COMMUNICATIONS (2019)

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Article Cardiac & Cardiovascular Systems

What Is the Potential of Tissue-Engineered Pulmonary Valves in Children?

Simone A. Huygens et al.

ANNALS OF THORACIC SURGERY (2019)

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Article Cardiac & Cardiovascular Systems

Morphology and mechanisms of a novel absorbable polymeric conduit in the pulmonary circulation of sheep

Marieke Brugmans et al.

CARDIOVASCULAR PATHOLOGY (2019)

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Article Engineering, Biomedical

Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants

Asiyeh Golabchi et al.

BIOMATERIALS (2019)

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Review Engineering, Biomedical

Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing

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BIOMATERIALS (2019)

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Review Cardiac & Cardiovascular Systems

How Did We Get Here?: A Historical Review and Critical Analysis of Anticoagulation Therapy Following Mechanical Valve Replacement

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CIRCULATION (2019)

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Rapid Coating Process Generates Omniphobic Dentures in Minutes to Reduce C. albicans Biofouling

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Cardiac & Cardiovascular Systems

Long-Term Comparison Between Pulmonary Homograft Versus Bioprosthesis for Pulmonary Valve Replacement in Tetralogy of Fallot

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JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

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Review Chemistry, Multidisciplinary

An introduction to zwitterionic polymer behavior and applications in solution and at surfaces

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CHEMICAL SOCIETY REVIEWS (2019)

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Bioinspired Heart Valve Prosthesis Made by Silicone Additive Manufacturing

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MATTER (2019)

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Article Cardiac & Cardiovascular Systems

State of the Art: Tissue Engineering in Congenital Heart Surgery

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SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY (2019)

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Article Cardiac & Cardiovascular Systems

Morphology, Clinicopathologic Correlations, and Mechanisms in Heart Valve Health and Disease

Frederick J. Schoen

CARDIOVASCULAR ENGINEERING AND TECHNOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Pulmonary Valve Replacement: A Single-Institution Comparison of Surgical and Transcatheter Valves

Vikas Sharma et al.

ANNALS OF THORACIC SURGERY (2018)

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Article Cardiac & Cardiovascular Systems

First human implant of the Alterra Adaptive PrestentTM: A new self-expanding device designed to remodel the right ventricular outflow tract

Evan M. Zahn et al.

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2018)

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Article Cardiac & Cardiovascular Systems

Fresh decellularized versus standard cryopreserved pulmonary allografts for right ventricular outflow tract reconstruction during the Ross procedure: a propensity-matched study

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EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2018)

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Review Cardiac & Cardiovascular Systems

Contemporary management and outcomes in congenitally corrected transposition of the great arteries

Shelby Kutty et al.

HEART (2018)

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Article Engineering, Biomedical

In vitro biomechanical and hydrodynamic characterisation of decellularised human pulmonary and aortic roots

A. Desai et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2018)

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Article Cardiac & Cardiovascular Systems

A novel restorative pulmonary valved conduit in a chronic sheep model: Mid-term hemodynamic function and histologic assessment

Ger Bennink et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2018)

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Review Biochemistry & Molecular Biology

Host Responses to Biomaterials and Anti-Inflammatory Design-a Brief Review

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MACROMOLECULAR BIOSCIENCE (2018)

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Article Cell Biology

Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model

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SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Cardiac & Cardiovascular Systems

Surgical Atrioventricular Valve Replacement With Melody Valve in Infants and Children A Multicenter Study

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CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2018)

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Article Cardiac & Cardiovascular Systems

3-Year Outcomes of the Edwards SAPIEN Transcatheter Heart Valve for Conduit Failure in the Pulmonary Position From the COMPASSION Multicenter Clinical Trial

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JACC-CARDIOVASCULAR INTERVENTIONS (2018)

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Article Cardiac & Cardiovascular Systems

Endocarditis After Transcatheter Pulmonary Valve Replacement

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Ross Procedure in Adults for Cardiologists and Cardiac Surgeons JACC State-of-the-Art Review

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Transcatheter pulmonary valve implantation: will it replace surgical pulmonary valve replacement?

Ahmed Kheiwa et al.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2018)

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Article Engineering, Biomedical

Implantation of a Tissue-Engineered Tubular Heart Valve in Growing Lambs

Jay Reimer et al.

ANNALS OF BIOMEDICAL ENGINEERING (2017)

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Review Engineering, Biomedical

The pathology of the foreign body reaction against biomaterials

R. Klopfleisch et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)

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Article Engineering, Biomedical

Examination of the foreign body response to biomaterials by nonlinear intravital microscopy

Eleonora Dondossola et al.

NATURE BIOMEDICAL ENGINEERING (2017)

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Review Cardiac & Cardiovascular Systems

Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis

Rohan D'Souza et al.

EUROPEAN HEART JOURNAL (2017)

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Article Cardiac & Cardiovascular Systems

Standardized definitions of structural deterioration and valve failure in assessing long-term durability of transcatheter and surgical aortic bioprosthetic valves: a consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) endorsed by the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

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EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2017)

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Article Cardiac & Cardiovascular Systems

Harmony Feasibility Trial Acute and Short-Term Outcomes With a Self-Expanding Transcatheter Pulmonary Valve

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JACC-CARDIOVASCULAR INTERVENTIONS (2017)

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Article Cardiac & Cardiovascular Systems

Nomograms for two-dimensional echocardiography derived valvular and arterial dimensions in Caucasian children

Massimiliano Cantinotti et al.

JOURNAL OF CARDIOLOGY (2017)

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Review Cardiac & Cardiovascular Systems

Bioprosthetic Valve Thrombosis

Rishi Puri et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Surgical reconstruction of semilunar valves in the growing child: Should we mimic the venous valve? A simulation study

Peter E. Hammer et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2017)

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Article Cardiac & Cardiovascular Systems

Translational Challenges in Cardiovascular Tissue Engineering

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JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2017)

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Article Cardiac & Cardiovascular Systems

Calcification and Oxidative Modifications Are Associated With Progressive Bioprosthetic Heart Valve Dysfunction

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JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

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A growth-accommodating implant for paediatric applications

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NATURE BIOMEDICAL ENGINEERING (2017)

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Article Nanoscience & Nanotechnology

A Positively Charged Surface Triggers Coagulation Activation Through Factor VII Activating Protease (FSAP)

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ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Engineering, Biomedical

Plasma mediated protein immobilisation enhances the vascular compatibility of polyurethane with tissue matched mechanical properties

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BIOMEDICAL MATERIALS (2017)

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Article Engineering, Biomedical

In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep

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BIOMATERIALS (2017)

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Article Cardiac & Cardiovascular Systems

Current Interventional and Surgical Management of Congenital Heart Disease Specific Focus on Valvular Disease and Cardiac Arrhythmias

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CIRCULATION RESEARCH (2017)

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Article Cardiac & Cardiovascular Systems

Current Status and Future Potential of Transcatheter Interventions in Congenital Heart Disease

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CIRCULATION RESEARCH (2017)

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Heparin coatings for improving blood compatibility of medical devices

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ADVANCED DRUG DELIVERY REVIEWS (2017)

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Three Decades of Auxetics Research - Materials with Negative Poisson's Ratio: A Review

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ADVANCED ENGINEERING MATERIALS (2016)

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Review Cardiac & Cardiovascular Systems

Mechanical Versus Bioprosthetic Aortic Valve Replacement in Middle-Aged Adults: A Systematic Review and Meta-Analysis

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ANNALS OF THORACIC SURGERY (2016)

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Smaller-Sized Expanded Polytetrafluoroethylene Conduits With a Fan-Shaped Valve and Bulging Sinuses for Right Ventricular Outflow Tract Reconstruction

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ANNALS OF THORACIC SURGERY (2016)

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Review Mechanics

Fluid Mechanics of Heart Valves and Their Replacements

Fotis Sotiropoulos et al.

ANNUAL REVIEW OF FLUID MECHANICS, VOL 48 (2016)

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Review Engineering, Biomedical

Superhydrophobic materials for biomedical applications

Eric J. Falde et al.

BIOMATERIALS (2016)

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Review Hematology

Blood flow and mass transfer regulation of coagulation

Kuldeepsinh Rana et al.

BLOOD REVIEWS (2016)

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Article Immunology

Shear-Resistant Binding to von Willebrand Factor Allows Staphylococcus lugdunensis to Adhere to the Cardiac Valves and Initiate Endocarditis

Laurens Liesenborghs et al.

JOURNAL OF INFECTIOUS DISEASES (2016)

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Article Cardiac & Cardiovascular Systems

Concept of an expandable cardiac valve for surgical implantation in infants and children

Sitaram M. Emani et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2016)

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Review Hematology

The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities

A. H. Schmaier

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2016)

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Review Medicine, General & Internal

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LANCET (2016)

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Complement in disease: a defence system turning offensive

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Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs

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NATURE COMMUNICATIONS (2016)

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Article Medicine, General & Internal

Infective endocarditis

Thomas L. Holland et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

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Article Engineering, Biomedical

Improved Geometry of Decellularized Tissue Engineered Heart Valves to Prevent Leaflet Retraction

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ANNALS OF BIOMEDICAL ENGINEERING (2016)

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Article Physiology

Heart Valve Biomechanics and Underlying Mechanobiology

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COMPREHENSIVE PHYSIOLOGY (2016)

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Article Nanoscience & Nanotechnology

Probing the Surface Hydration of Nonfouling Zwitterionic and PEG Materials in Contact with Proteins

Chuan Leng et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Cardiac & Cardiovascular Systems

Expandable Valve for Pediatric Application Constructed From Human Venous Valved Conduit Within a Stent

Erin G. Roberts et al.

ANNALS OF THORACIC SURGERY (2015)

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Article Cardiac & Cardiovascular Systems

Very Long-Term Outcomes of the Carpentier-Edwards Perimount Valve in Aortic Position

Thierry Bourguignon et al.

ANNALS OF THORACIC SURGERY (2015)

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Article Engineering, Biomedical

6-Month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep

Zeeshan Syedain et al.

BIOMATERIALS (2015)

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Article Engineering, Biomedical

Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes

Jay M. Reimer et al.

BIOMATERIALS (2015)

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Review Biochemistry & Molecular Biology

Complement and platelets: Mutual interference in the immune network

Cornelia Speth et al.

MOLECULAR IMMUNOLOGY (2015)

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Review Polymer Science

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

Sean Lowe et al.

POLYMER CHEMISTRY (2015)

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Article Chemistry, Multidisciplinary

Molecular Understanding and Design of Zwitterionic Materials

Qing Shao et al.

ADVANCED MATERIALS (2015)

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Article Engineering, Biomedical

Surface plasma modification and tropoelastin coating of a polyurethane co-polymer for enhanced cell attachment and reduced thrombogenicity

Daniel V. Bax et al.

BIOMATERIALS (2014)

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Article Biophysics

Biomechanical properties of native and tissue engineered heart valve constructs

Anwarul Hasan et al.

JOURNAL OF BIOMECHANICS (2014)

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Article Chemistry, Physical

Differences in Cationic and Anionic Charge Densities Dictate Zwitterionic Associations and Stimuli Responses

Qing Shao et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2014)

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Article Chemistry, Physical

In Situ Probing of the Surface Hydration of Zwitterionic Polymer Brushes: Structural and Environmental Effects

Chuan Leng et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2014)

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Article Cardiac & Cardiovascular Systems

Antimineralization treatment and patient-prosthesis mismatch are major determinants of the onset and incidence of structural valve degeneration in bioprosthetic heart valves

Willem Flameng et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2014)

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Review Chemistry, Multidisciplinary

Zwitteration: Coating Surfaces with Zwitterionic Functionality to Reduce Nonspecific Adsorption

Joseph B. Schlenoff

LANGMUIR (2014)

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Article Biotechnology & Applied Microbiology

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

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NATURE BIOTECHNOLOGY (2014)

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Review Cardiac & Cardiovascular Systems

Cardiac valve cells and their microenvironment-insights from in vitro studies

Huan Wang et al.

NATURE REVIEWS CARDIOLOGY (2014)

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Article Cell & Tissue Engineering

Implantation of Completely Biological Engineered Grafts Following Decellularization into the Sheep Femoral Artery

Zeeshan H. Syedain et al.

TISSUE ENGINEERING PART A (2014)

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Article Engineering, Biomedical

Tubular Heart Valves from Decellularized Engineered Tissue

Zeeshan H. Syedain et al.

ANNALS OF BIOMEDICAL ENGINEERING (2013)

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Article Engineering, Biomedical

Toward Optimization of a Novel Trileaflet Polymeric Prosthetic Heart Valve via Device Thrombogenicity Emulation

Thomas E. Claiborne et al.

ASAIO JOURNAL (2013)

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Article Biophysics

Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves

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JOURNAL OF BIOMECHANICS (2013)

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Article Materials Science, Coatings & Films

Controlled covalent surface immobilisation of proteins and peptides using plasma methods

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SURFACE & COATINGS TECHNOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Assessment of the Relationship Between Contegra Conduit Size and Early Valvar Insufficiency

Katja M. Gist et al.

ANNALS OF THORACIC SURGERY (2012)

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Review Cardiac & Cardiovascular Systems

Valve replacement in children: A challenge for a whole life

Roland Henaine et al.

ARCHIVES OF CARDIOVASCULAR DISEASES (2012)

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Article Engineering, Biomedical

The antithrombotic and antimicrobial properties of PEG-protected silver nanoparticle coated surfaces

V. M. Ragaseema et al.

BIOMATERIALS (2012)

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Article Biophysics

Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet

Choon Hwai Yap et al.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2012)

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Article Biophysics

Experimental measurement of dynamic fluid shear stress on the aortic surface of the aortic valve leaflet

Choon Hwai Yap et al.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2012)

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Review Physiology

Heart Valve Structure and Function in Development and Disease

Robert B. Hinton et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 73 (2011)

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Article Engineering, Biomedical

Thrombogenic Potential of Innovia Polymer Valves versus Carpentier-Edwards Perimount Magna Aortic Bioprosthetic Valves

Thomas E. Claiborne et al.

ASAIO JOURNAL (2011)

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Article Engineering, Biomedical

Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring

Zeeshan H. Syedain et al.

BIOMATERIALS (2011)

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Article Cardiac & Cardiovascular Systems

Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults Early Report

Serghei Cebotari et al.

CIRCULATION (2011)

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Article Cardiac & Cardiovascular Systems

Percutaneous Implantation of the Edwards SAPIEN Transcatheter Heart Valve for Conduit Failure in the Pulmonary Position Early Phase 1 Results From an International Multicenter Clinical Trial

Damien Kenny et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

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Article Multidisciplinary Sciences

Free radical functionalization of surfaces to prevent adverse responses to biomedical devices

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Cardiac & Cardiovascular Systems

Clinical Performance of Decellularized Cryopreserved Valved Allografts Compared With Standard Allografts in the Right Ventricular Outflow Tract

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