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Gastrointestinal disorders in Parkinson's disease and other Lewy body diseases

NPJ PARKINSONS DISEASE (2023)

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Article Geriatrics & Gerontology

Sodium butyrate ameliorates gut dysfunction and motor deficits in a mouse model of Parkinson's disease by regulating gut microbiota

Yi Zhang et al.

Summary: It has been found that gut microbiota dysbiosis might be associated with the pathogenesis of Parkinson's disease (PD). Sodium butyrate (NaB) can protect against PD by regulating the gut microbiota-gut-brain axis. This study demonstrated that NaB can improve gut dysfunction and motor deficits in rotenone-induced PD mice by regulating gut microbiota composition and metabolism.

FRONTIERS IN AGING NEUROSCIENCE (2023)

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Article Multidisciplinary Sciences

An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson's disease participants

Deborah A. Hall et al.

Summary: This study found that prebiotic intervention can beneficially change the microbiome, decrease inflammation and a marker of neurodegeneration, with possible clinical effects in Parkinson's disease (PD) patients.

NATURE COMMUNICATIONS (2023)

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Article Multidisciplinary Sciences

Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids

Maria Elisa Caetano-Silva et al.

Summary: Short-chain fatty acids produced by the intestinal microbiota can regulate microglial inflammation indirectly or directly. Feeding mice inulin, which increases SCFAs, reduces microglial inflammation in response to lipopolysaccharide stimulation. SCFAs downregulate histone deacetylase activity and nuclear factor-kappa B nuclear translocation. It is likely that SCFAs regulate microglia through an epigenetic mechanism following diffusion.

SCIENTIFIC REPORTS (2023)

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Article Clinical Neurology

Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Patients With Parkinson Disease

Szu-Ju Chen et al.

Summary: Patients with PD had lower fecal but higher plasma concentrations of SCFAs compared to controls, with specific gut microbiota changes and clinical severity of PD.

NEUROLOGY (2022)

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Article Neurosciences

Alteration of Gut Microbial Metabolites in the Systemic Circulation of Patients with Parkinson's Disease

Szu-Ju Chen et al.

Summary: This study found that PD patients had significantly higher levels of HA, IPA, DCA, and GDCA in plasma, which were positively associated with PD status. Concentrations of these metabolites were not correlated with PD severity, but were associated with the relative abundance of pro-inflammatory gut bacteria.

JOURNAL OF PARKINSONS DISEASE (2022)

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Article Neurosciences

Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease

Hiroshi Nishiwaki et al.

Summary: Random forest models based on gut microbiota can predict the progression of Parkinson's disease in the early stage. Decreases in short-chain fatty acid-producing genera and an increase in mucin-degrading genus are associated with accelerated disease progression. These taxonomic changes are not the consequences of disease progression.

NPJ PARKINSONS DISEASE (2022)

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Article Neurosciences

Gut microbiota in dementia with Lewy bodies

Hiroshi Nishiwaki et al.

Summary: Gut microbiota and fecal bile acids analysis in patients with alpha-synucleinopathies revealed decreased short-chain fatty acids-producing genera in dementia with Lewy bodies (DLB) and increased Ruminococcus torques and Collinsella. Random forest models showed that high Ruminococcus torques, high Collinsella, and low Bifidobacterium were predictive of DLB. In DLB, increased production of ursodeoxycholic acid (UDCA) may mitigate neuroinflammation at the substantia nigra.

NPJ PARKINSONS DISEASE (2022)

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Article Gastroenterology & Hepatology

Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis

Noriaki Gibo et al.

Summary: This study aims to investigate whether there is abnormal aggregation of α-Syn in enteric neurons in UC patients. Immunostaining revealed the presence of abnormal α-Syn aggregates in the enteric neurons of a single UC patient, but not in patients without UC. However, due to the limited number of UC patients, it remains unclear whether abnormal α-Syn aggregation in the colonic neural plexus is increased in UC or not.

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES (2022)

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Article Gastroenterology & Hepatology

Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites

Xiaowu Bai et al.

Summary: Cigarette smoke exposure alters the gut microbiota and related metabolites, leading to an increased risk of colorectal cancer. Mice exposed to cigarette smoke had dysbiosis of the gut microbiota, increased bile acid metabolites, activated oncogenic signaling pathways, and impaired gut barrier function.

GUT (2022)

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Review Immunology

Inflammation and immune dysfunction in Parkinson disease

Malu Gamez Tansey et al.

Summary: This review explores the role of an ageing immune system, host genetics, and exposure to environmental stressors in promoting the development of Parkinson's disease. It discusses the presence of neuroinflammation and alterations in immune cell populations as well as the potential contributions of viral or bacterial exposure, pesticides, and gut microbiota to disease pathogenesis.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Clinical Neurology

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi-Omics

Ai Huey Tan et al.

Summary: The study found significant differences in gut microbiome and metabolome between Parkinson's disease (PD) patients and healthy controls, including changes in bioactive molecules and other compounds. Cognitive impairment, low BMI, and other factors in PD patients were associated with fecal metabolome composition differences.

ANNALS OF NEUROLOGY (2021)

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Article Gastroenterology & Hepatology

Gut microbiota-derived metabolites as central regulators in metabolic disorders

Allison Agus et al.

Summary: Metabolic disorders are closely linked to alterations in the composition and function of the gut microbiota. Specific classes of microbiota-derived metabolites play crucial roles in the pathogenesis of metabolic disorders.

GUT (2021)

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Article Neurosciences

Ursodeoxycholic acid protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis in MPTP/MPP+-induced Parkinson's disease

Huiping Qi et al.

Summary: Neuroprotection targeting mitochondrial dysfunction with ursodeoxycholic acid (UDCA) shows potential therapeutic effects for Parkinson's disease (PD). UDCA improves motor dysfunction, protects dopaminergic neurons, and regulates autophagy and apoptosis through activating the AMPK/mTOR and PINK1/Parkin pathways. The study suggests that UDCA may have pharmacological benefits in treating PD by modulating mitochondrial function.

NEUROSCIENCE LETTERS (2021)

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Article Biochemistry & Molecular Biology

Clinical Phenotypes of Parkinson's Disease Associate with Distinct Gut Microbiota and Metabolome Enterotypes

Sarah Vascellari et al.

Summary: This study investigated the gut microbiota and metabolome composition in Parkinson's disease patients, revealing changes associated with the non-tremor dominant phenotypes. Alterations in specific bacterial families and metabolites were linked to gut inflammatory environment and severity of motor subtypes, suggesting a potential pathophysiological link between gut microbiota/metabolites and PD.

BIOMOLECULES (2021)

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Article Immunology

Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice

Stefan Milde et al.

Summary: Inflammation, particularly induced by lipopolysaccharide/endotoxin (LPS), may lead to neuronal loss in the brain, potentially through microglial phagocytosis regulated by the P2Y(6) receptor. Inhibition or knockout of the P2Y(6) receptor has been shown to prevent inflammatory neuronal loss, suggesting that P2Y(6) receptor antagonists could be a therapeutic strategy for preventing neuronal loss in diseases like Parkinson's.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Immunology

Alterations of gut microbiota and metabolome with Parkinson's disease

Zhenzhen Yan et al.

Summary: This study analyzed stool samples from PD patients and healthy controls, revealing higher abundance of specific bacterial groups and lower concentrations of branched chain amino acids (BCAAs) and aromatic amino acids in PD patients' fecal samples. These findings highlight the important role of gut microbiota and amino acids in the pathology of PD.

MICROBIAL PATHOGENESIS (2021)

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Article Neurosciences

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson's disease

Velma T. E. Aho et al.

Summary: This study found that intestinal inflammatory responses and reductions in fecal SCFAs occur in Parkinson's disease (PD), are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels.

MOLECULAR NEURODEGENERATION (2021)

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Review Biochemistry & Molecular Biology

The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An Overview

Julia Casani-Cubel et al.

Summary: The relationship between gut microbiota and neurodegenerative diseases, particularly ALS, is becoming clearer, with polyphenols showing therapeutic potential. Certain bacteria like Akkermansia muciniphila, Lactobacillus spp., and Bifidobacterium spp. have positive effects on ALS, while others like Escherichia coli show negative impacts. Polyphenols such as EGCG, curcumin, and resveratrol are considered promising therapeutic alternatives for ALS through microbiota changes.

METABOLITES (2021)

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Review Neurosciences

Is LRRK2 the missing link between inflammatory bowel disease and Parkinson's disease?

Mary K. Herrick et al.

Summary: Links between gastrointestinal system and Parkinson's disease have become more common, with similarities to Crohn's disease. Mutations in LRRK2 are strongly associated with PD and CD, suggesting a potential therapeutic target in inflammatory diseases that increase PD risk.

NPJ PARKINSONS DISEASE (2021)

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Article Neurosciences

Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation

Stefano Romano et al.

Summary: Recent studies have shown significant alterations in the gut microbiome of Parkinson's disease patients compared to healthy individuals, which may result in a pro-inflammatory status and impact the symptoms and pathophysiology of the disease.

NPJ PARKINSONS DISEASE (2021)

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Article Gastroenterology & Hepatology

Blue poo: impact of gut transit time on the gut microbiome using a novel marker

Francesco Asnicar et al.

Summary: The study found that the taxonomic composition of the gut microbiome can accurately differentiate between gut transit time classes, with longer transit time being associated with specific microbial species. The blue dye method of measuring gut transit time showed a stronger association with the gut microbiome compared to traditional proxies like stool consistency and frequency.

GUT (2021)

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Review Biochemistry & Molecular Biology

Pesticides and Parkinson's disease: Current and future perspective

Md Shahidul Islam et al.

Summary: Improper use of pesticides can lead to serious health problems, such as neurodegenerative diseases. Parkinson's disease is a progressive motor impairment and neurodegenerative disorder caused by the impact of pesticides on dopaminergic neurons.

JOURNAL OF CHEMICAL NEUROANATOMY (2021)

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Review Endocrinology & Metabolism

Parkinson's Disease and Gut Microbiota

Masaaki Hirayama et al.

Summary: Specific changes in intestinal microbiota in Parkinson's disease patients may increase intestinal permeability, allowing toxins to enter the nervous system, ultimately promoting abnormal aggregation of alpha-synuclein fibrils. Therapeutic interventions targeting these mechanisms may be possible, but further studies are needed to fully understand the direct association between intestinal microbiota and PD.

ANNALS OF NUTRITION AND METABOLISM (2021)

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Review Clinical Neurology

beta-adrenoreceptors and the risk of Parkinson's disease

Franziska Hopfner et al.

LANCET NEUROLOGY (2020)

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Article Clinical Neurology

Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study

Jacob Horsager et al.

BRAIN (2020)

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Article Clinical Neurology

Gut metagenomics-derived genes as potential biomarkers of Parkinson's disease

Yiwei Qian et al.

BRAIN (2020)

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Article Clinical Neurology

Meta-Analysisof Gut Dysbiosis in Parkinson's Disease

Hiroshi Nishiwaki et al.

MOVEMENT DISORDERS (2020)

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Article Microbiology

Gut Microbiota and Metabolome Alterations Associated with Parkinson's Disease

Sarah Vascellari et al.

MSYSTEMS (2020)

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Article Microbiology

Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder

Hiroshi Nishiwaki et al.

MSYSTEMS (2020)

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Review Gastroenterology & Hepatology

The risk of Parkinson's disease in inflammatory bowel disease: A systematic review and meta-analysis

Feng Zhu et al.

DIGESTIVE AND LIVER DISEASE (2019)

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Article Microbiology

Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

John P. Haran et al.

MBIO (2019)

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Article Microbiology

Effects of Bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: a randomised, double-blind, placebo-controlled trial

Y. Kobayashi et al.

BENEFICIAL MICROBES (2019)

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Article Immunology

Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson's disease

Chin-Hsien Lin et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Neurosciences

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Sangjune Kim et al.

NEURON (2019)

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Article Medicine, General & Internal

Gut microbiota in Parkinson's disease: Temporal stability and relations to disease progression

Velma T. E. Aho et al.

EBIOMEDICINE (2019)

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Review Immunology

The gut microbiota perspective for interventions in MS

Magdalena Zoledziewska

AUTOIMMUNITY REVIEWS (2019)

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Article Medicine, General & Internal

Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson's Disease: A South Korean Nationwide Population-Based Study

Seona Park et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Review Neurosciences

Dementia with Lewy bodies: an update and outlook

Tiago Fleming Outeiro et al.

MOLECULAR NEURODEGENERATION (2019)

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Article Clinical Neurology

The Nasal and Gut Microbiome in Parkinson's Disease and Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Anna Heintz-Buschart et al.

MOVEMENT DISORDERS (2018)

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Review Clinical Neurology

A survey of subjective constipation in Parkinson's disease patients in shanghai and literature review

Jing Gan et al.

BMC NEUROLOGY (2018)

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Article Neurosciences

Gut Microbiota is Altered in Patients with Alzheimer's Disease

Zhen-Qian Zhuang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Neurosciences

Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve

Suyan Li et al.

NEUROSCIENCE LETTERS (2018)

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Article Clinical Neurology

Anti-Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease

Inga Peter et al.

JAMA NEUROLOGY (2018)

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Article Medicine, General & Internal

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

Guangxin Chen et al.

EBIOMEDICINE (2018)

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Article Biochemistry & Molecular Biology

A Neural Circuit for Gut-Induced Reward

Wenfei Han et al.

CELL (2018)

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Article Clinical Neurology

Appendectomy and Risk of Parkinson's Disease in Two Large Prospective Cohorts of Men and Women

Natalia Palacios et al.

MOVEMENT DISORDERS (2018)

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Article Clinical Neurology

Gut microbiota in patients with Parkinson's disease in southern China

Aiqun Lin et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Article Multidisciplinary Sciences

A gut-brain neural circuit for nutrient sensory transduction

Melanie Maya Kaelberer et al.

SCIENCE (2018)

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Article Cell Biology

The vermiform appendix impacts the risk of developing Parkinson's disease

Bryan A. Killinger et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Immunology

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

Ethan Stolzenberg et al.

JOURNAL OF INNATE IMMUNITY (2017)

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Review Immunology

Akkermansia muciniphila and its role in regulating host functions

Muriel Derrien et al.

MICROBIAL PATHOGENESIS (2017)

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Article Clinical Neurology

Vagotomy and Parkinson disease A Swedish register-based matched-cohort study

Bojing Liu et al.

NEUROLOGY (2017)

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Review Clinical Neurology

Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium

Ian G. McKeith et al.

NEUROLOGY (2017)

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Article Clinical Neurology

Decreased intestinal acetylcholinesterase in early Parkinson disease

Tatyana D. Fedorova et al.

NEUROLOGY (2017)

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Article Clinical Neurology

Clinical manifestations of nonmotor symptoms in 1021 Japanese Parkinson's disease patients from 35 medical centers

Tetsuya Maeda et al.

PARKINSONISM & RELATED DISORDERS (2017)

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Article Multidisciplinary Sciences

Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study

Tomomi Minato et al.

PLOS ONE (2017)

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Article Genetics & Heredity

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naive Parkinson's disease patients

J. R. Bedarf et al.

GENOME MEDICINE (2017)

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Article Multidisciplinary Sciences

Anti-inflammatory effects of ursodeoxycholic acid by lipopolysaccharide-stimulated inflammatory responses in RAW 264.7 macrophages

Wan-Kyu Ko et al.

PLOS ONE (2017)

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Article Neurosciences

Gut microbiota in Parkinson disease in a northern German cohort

Franziska Hopfner et al.

BRAIN RESEARCH (2017)

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Article Medicine, Research & Experimental

α-Synuclein in gut endocrine cells and its implications for Parkinson's disease

Rashmi Chandra et al.

JCI INSIGHT (2017)

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Review Clinical Neurology

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

Toshiki Uchihara et al.

ACTA NEUROPATHOLOGICA (2016)

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Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

CELL (2016)

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Review Biochemistry & Molecular Biology

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Ara Koh et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

Mahesh S. Desai et al.

CELL (2016)

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Article Clinical Neurology

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

Marcus M. Unger et al.

PARKINSONISM & RELATED DISORDERS (2016)

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Article Genetics & Heredity

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

Jun Chen et al.

GENOME MEDICINE (2016)

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Article Multidisciplinary Sciences

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

Changyoun Kim et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

Shu G. Chen et al.

SCIENTIFIC REPORTS (2016)

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Article Clinical Neurology

Vagotomy and Subsequent Risk of Parkinson's Disease

Elisabeth Svensson et al.

ANNALS OF NEUROLOGY (2015)

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Article Microbiology

Quantitative Imaging of Gut Microbiota Spatial Organization

Kristen A. Earle et al.

CELL HOST & MICROBE (2015)

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Article Neurosciences

Host microbiota constantly control maturation and function of microglia in the CNS

Daniel Erny et al.

NATURE NEUROSCIENCE (2015)

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Article Clinical Neurology

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2G2019S carriers and in vivo

Heather Mortiboys et al.

NEUROLOGY (2015)

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Article Clinical Neurology

Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET

Trine Gjerloff et al.

BRAIN (2015)

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Article Multidisciplinary Sciences

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease

Satoru Hasegawa et al.

PLOS ONE (2015)

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Article Clinical Neurology

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease

David Hilton et al.

ACTA NEUROPATHOLOGICA (2014)

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Article Biochemistry & Molecular Biology

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

Filipe De Vadder et al.

CELL (2014)

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Article Immunology

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

Nagendra Singh et al.

IMMUNITY (2014)

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Article Gastroenterology & Hepatology

Smoking Cessation Alters Intestinal Microbiota: Insights from Quantitative Investigations on Human Fecal Samples Using FISH

Luc Biedermann et al.

INFLAMMATORY BOWEL DISEASES (2014)

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Article Clinical Neurology

Alpha-Synuclein in the Appendiceal Mucosa of Neurologically Intact Subjects

Madison T. Gray et al.

MOVEMENT DISORDERS (2014)

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Article Clinical Neurology

Progression of Intestinal Permeability Changes and Alpha-Synuclein Expression in a Mouse Model of Parkinson's Disease

Leo P. Kelly et al.

MOVEMENT DISORDERS (2014)

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Article Neurosciences

Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats

Rohit Bisht et al.

NEUROTOXICOLOGY (2014)

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Article Multidisciplinary Sciences

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

Gary Frost et al.

NATURE COMMUNICATIONS (2014)

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Review Environmental Sciences

Research on the Premotor Symptoms of Parkinson's Disease: Clinical and Etiological Implications

Honglei Chen et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2013)

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Article Biochemistry & Molecular Biology

Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon

Ja-Young Lee et al.

JOURNAL OF LIPID RESEARCH (2013)

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Article Multidisciplinary Sciences

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Nicholas Arpaia et al.

NATURE (2013)

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Article Multidisciplinary Sciences

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Amandine Everard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Multidisciplinary Sciences

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

Patrick M. Smith et al.

SCIENCE (2013)

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Article Gastroenterology & Hepatology

Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota

Jane L. Benjamin et al.

INFLAMMATORY BOWEL DISEASES (2012)

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Review Clinical Neurology

Nicotine as a potential neuroprotective agent for Parkinson's disease

Maryka Quik et al.

MOVEMENT DISORDERS (2012)

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Article Clinical Neurology

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

Kathleen M. Shannon et al.

MOVEMENT DISORDERS (2012)

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Review Neurosciences

Pathological correlates of gastrointestinal dysfunction in Parkinson's disease

Maria G. Cersosimo et al.

NEUROBIOLOGY OF DISEASE (2012)

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Article Immunology

Anti-inflammatory properties of intestinal Bifidobacterium strains isolated from healthy infants

Ekaterina V. Khokhlova et al.

MICROBIOLOGY AND IMMUNOLOGY (2012)

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Article Gastroenterology & Hepatology

Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins

Hui Wang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

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Article Multidisciplinary Sciences

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

Francisco Pan-Montojo et al.

SCIENTIFIC REPORTS (2012)

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Article Medicine, Research & Experimental

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats

Mikako Ito et al.

MEDICAL GAS RESEARCH (2012)

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Article Environmental Sciences

Rotenone, Paraquat, and Parkinson's Disease

Caroline M. Tanner et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2011)

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Review Public, Environmental & Occupational Health

Epidemiology and etiology of Parkinson's disease: a review of the evidence

Karin Wirdefeldt et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2011)

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Article Multidisciplinary Sciences

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

Christopher B. Forsyth et al.

PLOS ONE (2011)

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Article Clinical Neurology

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

Thomas G. Beach et al.

ACTA NEUROPATHOLOGICA (2010)

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Article Gastroenterology & Hepatology

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

Chin Wen Png et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

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Review Neurosciences

Effects of Caffeine in Parkinson's Disease: From Neuroprotection to the Management of Motor and Non-Motor Symptoms

Rui D. S. Prediger

JOURNAL OF ALZHEIMERS DISEASE (2010)

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Article Genetics & Heredity

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

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NATURE REVIEWS NEUROSCIENCE (2010)

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Clinical availability of skin biopsy in the diagnosis of Parkinson's disease

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NEUROSCIENCE LETTERS (2010)

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Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

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Article Clinical Neurology

Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease

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Intestinal hormones and regulation of satiety: The case for CCK, GLP-1, PYY, and Apo A-IV

David D'Alessio

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2008)

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Review Clinical Neurology

Parkinson's disease: a dual-hit hypothesis

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NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2007)

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Review Clinical Neurology

Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

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Article Nutrition & Dietetics

Dietary intake in relation to self-reported constipation among Japanese women aged 18-20 years

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EUROPEAN JOURNAL OF CLINICAL NUTRITION (2006)

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Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

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ANNALS OF NEUROLOGY (2005)

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Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation

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Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease

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ARCHIVES OF NEUROLOGY (2003)

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Article Neurosciences

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation

TB Sherer et al.

EXPERIMENTAL NEUROLOGY (2003)

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Antioxidant properties of ursodeoxycholic acid

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BIOCHEMICAL PHARMACOLOGY (2002)

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A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease

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ANNALS OF NEUROLOGY (2002)

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Smoking and Parkinson's disease in twins

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NEUROLOGY (2002)

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Frequency of bowel movements and the future risk of Parkinson's disease

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NEUROLOGY (2001)

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Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro

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NEUROSCIENCE LETTERS (2000)

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