Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation

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Ageing and rejuvenation of tissue stem cells and their niches

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Summary: Stem cell function declines during ageing, resulting in the loss of tissue integrity and health deterioration. This Review discusses the mechanisms underlying ageing in stem cells and their niches, and potential rejuvenation strategies.

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Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis

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Summary: The association between IGF-1 levels and all-cause mortality is complex, with both low and high levels being associated with increased mortality risk. This meta-analysis found that higher IGF-1 levels were not associated with increased all-cause mortality compared to low levels. However, there was a U-shaped relationship between IGF-1 levels and mortality risk, with both low and high IGF-1 levels increasing the risk compared to middle levels. A specific range of 120-160 ng/ml was associated with the lowest mortality risk.

AGING CELL (2022)

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Review Gastroenterology & Hepatology

Aging of enteric neuromuscular systems in gastrointestinal tract

Vy Truong Thuy Nguyen et al.

Summary: Aging is a complex process that affects the functions of the gastrointestinal tract. Age-related GI motor disorders can negatively impact quality of life and increase the risk of other diseases. However, the mechanisms underlying these disorders and the effect of aging on GI motor functions are still not well understood, necessitating further research.

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Progerin modulates the IGF-1R/Akt signaling involved in aging

Bo Jiang et al.

Summary: Progerin, a result of LMNA mutation, causes nuclear abnormalities and premature aging. Impaired IGF-1R/Akt signaling pathway leads to growth retardation and aging. Progerin mislocalizes outside of nucleus, interacts with IGF-1R, and down-regulates its expression, resulting in inhibited mitochondrial respiration, retarded cell growth, and accelerated senescence. PTEN inhibitor bpV (HOpic) increases Akt activity and improves abnormalities in progeria. These findings provide important insights into the role of Progerin in regulating IGF-1R/Akt signaling and have potential implications in treating LMNA-associated progeroid disorders.

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Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial of Cell of Cajal Depletion During Aging

Yujiro Hayashi et al.

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Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

Kira Young et al.

Summary: As individuals age, the function of hematopoietic stem cells (HSCs) declines, leading to limited health span of the blood and immune systems. Research indicates that the hallmarks of aging in HSCs and hematopoiesis start accumulating by middle age, with decreased levels of the longevity-associated molecule IGF1 in the bone marrow microenvironment playing a key role in causing HSC aging. By directly stimulating middle-aged HSCs with IGF1, molecular and functional hallmarks of aging can be rescued, highlighting the complex relationship between IGF1 levels, longevity, and HSC function.

CELL STEM CELL (2021)

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Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging

Pallab Maity et al.

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Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying

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Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1

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Article Gastroenterology & Hepatology

Stem Cells for Murine Interstitial Cells of Cajal Suppress Cellular Immunity and Colitis Via Prostaglandin E2 Secretion

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The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

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Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

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Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1-and Stem Cell Factor-Activated Pathways

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Changes in interstitial cells of cajal with age in the human stomach and colon

P. J. Gomez-Pinilla et al.

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Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging

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Kitlow Stem Cells Cause Resistance to Kit/Platelet-Derived Growth Factor α Inhibitors in Murine Gastrointestinal Stromal Tumors

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Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice

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Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Klotho and aging

Makoto Kuro-o

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

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CELL (2008)

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Altered mammary gland development in the p53+/m mouse, a model of accelerated aging

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Enteric neuro degeneration in ageing

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Innervation of the gastrointestinal tract: Patterns of aging

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Interstitial cells of Cajal and adaptive relaxation in the mouse stomach

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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

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Reduced stem cell factor links smooth myopathy and loss of interstitial cells of Cajal in murine diabetic gastroparesis

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GASTROENTEROLOGY (2006)

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Reduced insulin and IGF-I signaling, not hyperglycemia, underlies the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach

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Food intake and ageing - the role of the gut

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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NATURE (2003)

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Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation

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