期刊
BIOACTIVE MATERIALS
卷 21, 期 -, 页码 20-31出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.07.029
关键词
Myocardial infarction; Sponge; Hydrogel patch; Wet adhesive; Autophagy
Hydrogel patch-based stem cell transplantation and microenvironment-regulating drug delivery strategy shows promise for treating myocardial infarction (MI). However, the low retention of cells and drugs limits their effectiveness. Researchers propose a strategy using a prefixed sponge carpet to enhance the retention of therapeutic drugs and cells in the heart, leading to improved cardiac microenvironment, reduced apoptosis, and enhanced survival of transplanted stem cells for promoting cardiac repair.
Hydrogel patch-based stem cell transplantation and microenvironment-regulating drug delivery strategy is promising for the treatment of myocardial infarction (MI). However, the low retention of cells and drugs limits their therapeutic efficacies. Here, we propose a prefixed sponge carpet strategy, that is, aldehyde-dextran sponge (ODS) loading anti-oxidative/autophagy-regulating molecular capsules of 2-hydroxy-beta-cyclodextrin@resveratrol (HP-beta-CD@Res) is first bonded to the rat's heart via capillary removal of interfacial water from the tissue surface, and the subsequent Schiff base reaction between the aldehyde groups on ODS and amino groups on myocardium tissue. Then, an aqueous biocompatible hydrazided hyaluronic acid (HHA) solution encapsulating mesenchymal stem cells (MSCs) is impregnated into the anchored carpet to form HHA@ODS@HP-beta-CD@Res hydrogel in situ via click reaction, thus prolonging the in vivo retention time of therapeutic drug and cells. Importantly, the HHA added to outer surface consumes the remaining aldehydes to contribute to nonsticky top surface, avoiding adhesion to other tissues. The embedded HP-beta-CD@Res molecular capsules with antioxidant and autophagy regulation bioactivities can considerably improve cardiac microenvironment, reduce cardiomyocyte apoptosis, and enhance the survival of transplanted MSCs, thereby promoting cardiac repair by facilitating angiogenesis and reducing cardiac fibrosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据