期刊
BIOACTIVE MATERIALS
卷 21, 期 -, 页码 157-174出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.08.011
关键词
Antibacterial photodynamic therapy; Polymers; Photosensitizers; Conjugation; Hydrogels; Biomaterials
This review assesses recent advancements in polymer-photosensitizer hybrid materials developed for antibacterial photodynamic therapy (APDT) applications. The review discusses the integration and functionalization of photosensitizers with polymers, the use of photosensitizer coatings to eliminate healthcare-associated infections, and the application of photosensitizers in films, scaffolds, and hydrogels for regenerative medicine.
Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain a most severe concern due to the prevalence and emergence of multi-drug resistance (MDR) and limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is a potential therapeutic modality that involves the systematic administration of photosensitizers (PSs), light, and molecular oxygen (O2) for coping with bacterial infections. Although the existing porphyrin and non-porphyrin PSs were effective in APDT, the poor solubility, limited efficacy against Gram-negative bacteria, and non-specific distribution hinder their clinical applications. Accordingly, to promote the efficiency of conventional PSs, various polymer-driven modification and functionalization strategies have been adopted to engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements and state-of-the-art research in polymer-PSs hybrid materials developed for APDT applications. Further, the key research findings of the following aspects are considered in-depth with constructive discussions: i) PSs-integrated/functionalized polymeric composites through various molecular interactions; ii) PSs-deposited coatings on different substrates and devices to eliminate healthcare-associated infections; and iii) PSs-embedded films, scaffolds, and hydrogels for regenerative medicine applications.
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