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Bone/cartilage targeted hydrogel: Strategies and applications

BIOACTIVE MATERIALS (2023)

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Summary: The study implemented novel intra-articular nanoreservoirs using different cartilage targeting approaches to improve the bioavailability of a chondroprotective drug in cartilage. Active targeting approach via chondroitin sulfate functionalization showed superior efficacy in improving cartilage repair compared to passive targeting.

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Summary: This review highlights the importance of osteons in bone mechanics and turnover, emphasizing the crucial role of osteon structure in cortical bone regeneration. It provides insights into the hierarchical structure and critical functions of osteons, as well as the modeling and remodeling processes at a cellular level. The review also introduces bioengineering approaches developed to mimic the osteon structure, aiming to attract attention in the orthopedic community for future cortical bone regeneration research.

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Organoids as an in vitro model of human development and disease

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Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk

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Review Rheumatology

Ageing and the pathogenesis of osteoarthritis

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NEW ENGLAND JOURNAL OF MEDICINE (2016)

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NUCLEAR MEDICINE AND BIOLOGY (2016)

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Review Nanoscience & Nanotechnology

Designing hydrogels for controlled drug delivery

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NATURE REVIEWS MATERIALS (2016)

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Review Cell & Tissue Engineering

Bone-cartilage crosstalk: a conversation for understanding osteoarthritis

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BONE RESEARCH (2016)

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Review Pharmacology & Pharmacy

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

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ADVANCED DRUG DELIVERY REVIEWS (2015)

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Review Pharmacology & Pharmacy

Bisphosphonate-modified biomaterials for drug delivery and bone tissue engineering

Dmitri A. Ossipov

EXPERT OPINION ON DRUG DELIVERY (2015)

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Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Biophysics

Transport of Neutral Solute Across Articular Cartilage: The Role of Zonal Diffusivities

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JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2015)

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Supramolecular synergy in the boundary lubrication of synovial joints

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NATURE COMMUNICATIONS (2015)

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Glutamine-chitosan modified calcium phosphate nanoparticles for efficient siRNA delivery and osteogenic differentiation

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JOURNAL OF MATERIALS CHEMISTRY B (2015)

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Review Endocrinology & Metabolism

Articular Cartilage: Structural and Developmental Intricacies and Questions

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CURRENT OSTEOPOROSIS REPORTS (2015)

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Review Biophysics

Biomechanics and Mechanobiology of Trabecular Bone: A Review

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JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2015)

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Fracture healing: mechanisms and interventions

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NATURE REVIEWS RHEUMATOLOGY (2015)

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Article Engineering, Biomedical

The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel

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BIOMATERIALS (2014)

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Article Nanoscience & Nanotechnology

Targeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in rats

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Review Endocrinology & Metabolism

Fracture mortality: associations with epidemiology and osteoporosis treatment

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NATURE REVIEWS ENDOCRINOLOGY (2014)

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Review Sport Sciences

Bone Quality: The Determinants of Bone Strength and Fragility

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SPORTS MEDICINE (2014)

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Article Materials Science, Biomaterials

Development of a bioactive composite of nano fluorapatite and poly(butylene succinate) for bone tissue regeneration

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JOURNAL OF MATERIALS CHEMISTRY B (2014)

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Article Nanoscience & Nanotechnology

Hyaluronic acid-coated bovine serum albumin nanoparticles loaded with brucine as selective nanovectors for intra-articular injection

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)

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Article Cell & Tissue Engineering

Enhancing Osteoconductivity of Fibrin Gels with Apatite-Coated Polymer Microspheres

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TISSUE ENGINEERING PART A (2013)

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PLASTIC AND RECONSTRUCTIVE SURGERY (2012)

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Effects of pH on transport properties of articular cartilages

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BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2010)

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The basic science of the subchondral bone

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KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2010)

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Article Sport Sciences

The Basic Science of Articular Cartilage: Structure, Composition, and Function

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SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH (2009)

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Normal Bone Anatomy and Physiology

Bart Clarke

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)

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Extracellular pH regulates bone cell function

Timothy R. Arnett

JOURNAL OF NUTRITION (2008)

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Article Orthopedics

Histomorphometric analysis of an adolescent distal tibial physis prior to growth plate closure

Jeremy Russell White et al.

JOURNAL OF CHILDRENS ORTHOPAEDICS (2008)

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Article Biochemistry & Molecular Biology

Hyaluronate-covered nanoparticles for the therapeutic targeting of cartilage

Hamed Laroui et al.

BIOMACROMOLECULES (2007)

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Article Orthopedics

An anatomical study of tibial metaphyseal/diaphyseal mismatch during revision total knee arthroplasty

Roy Abraham et al.

JOURNAL OF ARTHROPLASTY (2007)

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A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tract

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ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2000)

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