Nanodrug enhances post-ablation immunotherapy of hepatocellular carcinoma via promoting dendritic cell maturation and antigen presentation

Article Chemistry, Multidisciplinary

Self-Blockade of PD-L1 with Bacteria-Derived Outer-Membrane Vesicle for Enhanced Cancer Immunotherapy

Jingmei Pan et al.

Summary: A nanocarrier that achieves self-blockade of PD-L1 in tumor cells and a detection kit to quantitatively measure the binding rate of PD-1/PD-L1 have been developed, improving the efficacy of PD-1/PD-L1 self-blocking therapy.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Development of a Localized Drug Delivery System with a Step-by-Step Cell Internalization Capacity for Cancer Immunotherapy

Xilin Li et al.

Summary: In this study, a localized drug delivery system based on a hierarchical-structured fiber device was developed to precisely reprogram tumor-associated macrophages (TAMs) and combine them with immunogenic cell death (ICD), aiming to enhance the antitumor immunotherapeutic effect.

ACS NANO (2022)

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Review Immunology

Metabolic programming in dendritic cells tailors immune responses and homeostasis

Sofie Hedlund Moller et al.

Summary: Immune cells rely on specific metabolic traits to function, while the extracellular environment can influence cell metabolism and vice versa. Dendritic cell subsets modulate their stimulatory abilities based on unique metabolic programming in diverse environments. The metabolic requirements of dendritic cells are intertwined with their functions.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Surgical Tumor-Derived Photothermal Nanovaccine for Personalized Cancer Therapy and Prevention

Tan Li et al.

Summary: Recent breakthroughs in cell membrane-fabricated nanovaccine have provided innovative therapeutic options for preventing tumor metastasis and recurrence. However, the immunosuppressive tumor microenvironment makes personalized treatment of solid tumors challenging. In this study, a personalized photothermal nanovaccine was developed based on surgical-loaded mesoporous polydopamine nanoparticles, which showed outstanding imaging-guided photothermal immunotherapy efficacy and inhibited metastasis tumors by inducing antitumor immunities, especially in combination with aPD-L1 therapy. Prophylactic testing results confirmed that the photothermal nanovaccine can prevent rechallenge of 4T1 cells by 100% in a postsurgical tumor model. This work demonstrates the potential of personalized photothermal nanovaccine for tumor-specific treatment and prevention of postoperative tumor recurrence.

NANO LETTERS (2022)

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Article Immunology

Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells

Muxin Yu et al.

Summary: Microwave ablation (MWA) of primary breast cancer activates NK cells, inhibiting lung metastasis and improving survival. NK cells exhibit enhanced cytotoxic functions post-MWA, playing a pivotal role in this process.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Mannose-Derived Carbon Dots Amplify Microwave Ablation-Induced Antitumor Immune Responses by Capturing and Transferring Danger Signals to Dendritic Cells

Qunfang Zhou et al.

Summary: Man-CD nanoparticles effectively capture danger signals after MWA and deliver them to dendritic cells, enhancing tumor-specific immune response and suppressing both primary and distant tumors. These nanoparticles serve as effective adjuvants to improve MWA therapy.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Bacteria-Based Cancer Immunotherapy

Xuehui Huang et al.

Summary: Bacteria-based cancer immunotherapy has garnered significant attention in the past decade due to its unique mechanism and diverse applications. Bacteria are capable of targeting and colonizing tumor core areas, enhancing immune cell activation in the tumor microenvironment, and promoting specific immune recognition and elimination of tumor cells. The field also benefits from advancements in synthetic biology, allowing for creative immunotherapy paradigms using genetically modified bacteria and the combination of bacteria with nanomaterials for multifunctional cancer immunotherapy.

ADVANCED SCIENCE (2021)

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Review Gastroenterology & Hepatology

Advances in immunotherapy for hepatocellular carcinoma

Bruno Sangro et al.

Summary: Immunotherapeutic interventions have shown effectiveness in the treatment of hepatocellular carcinoma. Checkpoint inhibitors have demonstrated strong anti-tumor activity, but other immune strategies have not yet shown consistent clinical activity. Advancing treatment to earlier stages, discovering predictive biomarkers, and exploring effective combinatorial approaches are key challenges in HCC immunotherapy.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells

Xiaona Liu et al.

Summary: The arginine methylation of METTL14 stabilizes the binding of the m(6)A methyltransferase complex to its substrate RNA, thereby promoting global m(6)A modification and mESC endoderm differentiation. The crosstalk between protein methylation and RNA methylation in gene expression is highlighted. The interaction of METTL3/METTL14 with WTAP and substrate RNA is enhanced by arginine methylation of METTL14 at R255 by PRMT1, promoting m(6)A methylation activity of the complex.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

Vijayashree Mysore et al.

Summary: Research shows that stimulating Fc gamma Rs on neutrophils can transform them into antigen-presenting cells with functions comparable to dendritic cells. These converted neutrophils can activate T cells, induce anti-tumor immune responses, and their frequency correlates with disease in lupus patients. This conversion of neutrophils may represent a possible immunotherapy for cancer and infectious diseases.

NATURE COMMUNICATIONS (2021)

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Review Biotechnology & Applied Microbiology

RNA N6-methyladenosine modification in solid tumors: new therapeutic frontiers

Laleh Melstrom et al.

CANCER GENE THERAPY (2020)

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Article Multidisciplinary Sciences

Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy

Zecong Xiao et al.

SCIENCE ADVANCES (2020)

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Article Genetics & Heredity

Dendritic cells with METTL3 gene knockdown exhibit immature properties and prolong allograft survival

Hongbing Wu et al.

GENES AND IMMUNITY (2020)

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Article Chemistry, Multidisciplinary

Programmable Delivery of Immune Adjuvant to Tumor-Infiltrating Dendritic Cells for Cancer Immunotherapy

Jing Liu et al.

NANO LETTERS (2020)

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Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Chemistry, Multidisciplinary

NIR-Triggered Phototherapy and Immunotherapy via an Antigen-Capturing Nanoplatform for Metastatic Cancer Treatment

Meng Wang et al.

ADVANCED SCIENCE (2019)

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Article Multidisciplinary Sciences

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Huamin Wang et al.

NATURE COMMUNICATIONS (2019)

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Article Nanoscience & Nanotechnology

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

Joao Conniot et al.

NATURE NANOTECHNOLOGY (2019)

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Review Gastroenterology & Hepatology

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Multidisciplinary Sciences

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

Liangrong Shi et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Properties of immature and mature dendritic cells: phenotype, morphology, phagocytosis, and migration

Min Kyung Kim et al.

RSC ADVANCES (2019)

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Review Oncology

Defective HLA class I antigen processing machinery in cancer

Lei Cai et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

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Review Cell Biology

RNA N-6-methyladenosine modification in cancers: current status and perspectives

Xiaolan Deng et al.

CELL RESEARCH (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Enhanced antitumor efficacy through microwave ablation in combination with immune checkpoints blockade in breast cancer: A pre-clinical study in a murine model

J. Zhu et al.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2018)

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Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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Review Oncology

Immuno-Oncology: Emerging Targets and Combination Therapies

Henry T. Marshall et al.

FRONTIERS IN ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

Molecular mechanisms involved in dendritic cell dysfunction in cancer

Michael Tang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

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Review Oncology

Tumor-derived factors modulating dendritic cell function

Jinbao Zong et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)

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Article Oncology

PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor

Liangrong Shi et al.

CLINICAL CANCER RESEARCH (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Hepatic Radiofrequency Ablation-induced Stimulation of Distant Tumor Growth Is Suppressed by c-Met Inhibition

Muneeb Ahmed et al.

RADIOLOGY (2016)

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Article Oncology

Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model

Shihao Chen et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Review Genetics & Heredity

Gene expression regulation mediated through reversible m6A RNA methylation

Ye Fu et al.

NATURE REVIEWS GENETICS (2014)

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Article Oncology

Treatment of osteosarcoma with microwave thermal ablation to induce immunogenic cell death

Zhe Yu et al.

ONCOTARGET (2014)

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Review Oncology

Thermal ablation of tumours: biological mechanisms and advances in therapy

Katrina F. Chu et al.

NATURE REVIEWS CANCER (2014)

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Article Hematology

Glucocorticoid receptor translational isoforms underlie maturational stage-specific glucocorticoid sensitivities of dendritic cells in mice and humans

Yun Cao et al.

BLOOD (2013)

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Article Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2012)

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Review Oncology

Cancer immunotherapy via dendritic cells

Karolina Palucka et al.

NATURE REVIEWS CANCER (2012)

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Review Genetics & Heredity

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

Julie A. Law et al.

NATURE REVIEWS GENETICS (2010)

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Review Biology

Cryo-immunology: A review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses

Michael S. Sabel

CRYOBIOLOGY (2009)

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Review Immunology

Drinking a lot is good for dendritic cells

CC Norbury

IMMUNOLOGY (2006)

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Article Radiology, Nuclear Medicine & Medical Imaging

Prognostic factors for survival in patients with hepatocellular carcinoma after percutaneous microwave ablation

P Liang et al.

RADIOLOGY (2005)

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Article Oncology

In situ tumor ablation creates an antigen source for the generation of antitumor immunity

MHMGM den Brok et al.

CANCER RESEARCH (2004)

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Nanodrug enhances post-ablation immunotherapy of hepatocellular carcinoma via promoting dendritic cell maturation and antigen presentation

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