期刊
BIOACTIVE MATERIALS
卷 21, 期 -, 页码 547-565出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.09.011
关键词
Ionizing radiation; Osteoporosis; Nanozyme; Cerium oxide; Bone strength; Bone resorption
The disability, mortality, and costs caused by ionizing radiation-induced osteoporotic bone fractures are substantial. However, there is currently no effective therapy available. This study demonstrates that engineered artificial nanozymes composed of cerium oxide can mitigate the bone loss caused by ionizing radiation and protect against DNA damage, cellular senescence, and elevated osteoclastic activity. The nanozymes also promote new bone formation and regulate osteoclast formation, making them a promising approach for preventing radiation-induced bone loss.
The disability, mortality and costs due to ionizing radiation (IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy exists. Ionizing radiation increases cellular oxidative damage, causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing osteoclast. We demonstrate that rats exposed to sublethal levels of IR develop fragile, osteoporotic bone. At reactive surface sites, cerium ions have the ability to easily undergo redox cycling: drastically adjusting their electronic con-figurations and versatile catalytic activities. These properties make cerium oxide nanomaterials fascinating. We show that an engineered artificial nanozyme composed of cerium oxide, and designed to possess a higher fraction of trivalent (Ce3+) surface sites, mitigates the IR-induced loss in bone area, bone architecture, and strength. These investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species, protecting the rats against IR-induced DNA damage, cellular senescence, and elevated osteoclastic activity in vitro and in vivo. Further, we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells, favoring new bone formation despite its exposure to harmful levels of IR in vitro. These findings open a new approach for the specific prevention of IR-induced bone loss using synthesis -mediated designer multifunctional nanomaterials.
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