Chronic bronchial infection in stable COPD: To treat or not to treat

Article Respiratory System

[Translated article] Spanish COPD guidelines (GesEPOC) 2021: Updated pharmacological treatment of stable COPD

Marc Miravitlles et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2022)

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Editorial Material Respiratory System

Pseudomonas aeruginosa Colonization and COPD: The Chicken or the Egg?

Rajesh Kunadharaju et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2022)

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Article Respiratory System

Spanish COPD Guidelines (GesEPOC) 2021 Update Diagnosis and Treatment of COPD Exacerbation Syndrome

Juan Jose Soler-Cataluna et al.

Summary: This article provides detailed recommendations on the diagnosis and treatment of COPD exacerbation syndrome (CES). The guidelines propose a syndromic approach, a new severity classification, and the recognition of different treatable traits (TT), aiming to personalize medicine. The diagnostic process includes four stages, and the treatment varies depending on severity and specific traits.

ARCHIVOS DE BRONCONEUMOLOGIA (2022)

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Article Respiratory System

Effectiveness and Safety of Inhaled Antibiotics in Patients With Chronic Obstructive Pulmonary Disease. A Multicentre Observational Study

David De la Rosa Carrillo et al.

Summary: Inhaled antibiotics appear to be an effective and safe treatment for chronic obstructive pulmonary disease (COPD) patients, especially those with multiple exacerbations and/or chronic bronchial infection. This treatment can significantly reduce exacerbation frequency, hospital admissions, and hospitalization days, as well as decrease sputum production and eradicate potentially pathogenic microorganisms.

ARCHIVOS DE BRONCONEUMOLOGIA (2022)

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Review Respiratory System

Long-Term Risk of Mortality Associated with Isolation of Pseudomonas aeruginosa in COPD: A Systematic Review and Meta-Analysis

Miguel Angel Martinez-Garcia et al.

Summary: Isolation of Pseudomonas aeruginosa (PA) in sputum is associated with an increased risk of death, readmission, and hospitalization in patients with chronic obstructive pulmonary disease (COPD).

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2022)

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Article Respiratory System

The Impact of Chronic Bronchial Infection in COPD: A Proposal for Management

Miguel Angel Martinez-Garcia et al.

Summary: Up to 50% of stable state chronic obstructive pulmonary disease (COPD) patients may carry potentially pathogenic microorganisms (PPMs) in their airways, which are associated with increased symptoms, exacerbations, decline in lung function, and impaired quality of life. Currently, there is a lack of evidence-based recommendations for evaluating and treating the presence of PPMs in COPD, but defining chronic bronchial infection (CBI) as the isolation of the same PPM in three sputum samples separated by at least one month and recommending antibiotic treatment based on specific criteria may help manage these challenging patients.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2022)

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Article Respiratory System

Chronic Bronchial Infection Is Associated with More Rapid Lung Function Decline in Chronic Obstructive Pulmonary Disease

Miguel Angel Martinez-Garcia et al.

Summary: The presence of chronic bronchial infection (CBI) and isolation of Pseudomonas aeruginosa (PA) are independently associated with forced expiratory volume in 1 second (FEV1) decline in patients with COPD.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2022)

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Article Immunology

Bronchial Infection and Temporal Evolution of Bronchiectasis in Patients With Chronic Obstructive Pulmonary Disease

Miguel Angel Martinez-Garcia et al.

Summary: This study aimed to assess the temporal evolution of bronchiectasis in patients with COPD. Results indicated that the presence of chronic purulent sputum production, number of pathogenic microorganism isolations in sputum, and number of hospitalizations due to exacerbations of COPD were independent risk factors for the progression or development of BE.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Respiratory System

Prevalence and Determinants of COPD in Spain: EPISCAN II

Joan B. Soriano et al.

Summary: The EPISCAN II study aimed to estimate the prevalence of COPD in the general population aged 40 years or older in all 17 regions of Spain, revealing a high prevalence of COPD in Spain and frequent underdiagnosis of the condition.

ARCHIVOS DE BRONCONEUMOLOGIA (2021)

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Article Respiratory System

Risk Factors and Relation with Mortality of a New Acquisition and Persistence of Pseudomonas aeruginosa in COPD Patients

Miguel Angel Martinez-Garcia et al.

Summary: The isolation of Pseudomonas aeruginosa (PA) in patients with chronic obstructive pulmonary disease (COPD) is associated with increased mortality. Risk factors for first PA isolation and PA persistence are different in clinically stable COPD patients, with the latter associated with increased all-cause mortality.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2021)

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Article Public, Environmental & Occupational Health

Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade

Davies Adeloye et al.

Summary: The global prevalence of COPD has been increasing, emphasizing the need for defining research priorities in respiratory medicine. Through the CHNRI methodology, new effective strategies for smoking cessation and feasible pulmonary rehabilitation delivery were identified as key research priorities. Additional priorities include improved screening and accurate diagnosis methods for COPD in low-resource settings.

JOURNAL OF GLOBAL HEALTH (2021)

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Article Respiratory System

Chronic bronchial infection and incident cardiovascular events in chronic obstructive pulmonary disease patients: A long-term observational study

Miguel Angel Martinez-Garcia et al.

Summary: This study investigated the relationship between chronic bronchial infection (CBI), systemic inflammation, and incident cardiovascular (CV) events in COPD patients. It found that CBI, especially by Pseudomonas aeruginosa (PA), is associated with sustained inflammation and a higher risk of CV events, particularly coronary events. Further research is needed to explore the potential benefits of treating CBI in reducing systemic inflammation and CV events in COPD.

RESPIROLOGY (2021)

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Article Respiratory System

Actualización 2021 de la Guía Española de la EPOC (GesEPOC). Tratamiento no farmacológico

Borja G. Cosío et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2021)

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Letter Respiratory System

Forum COPD Working Group Consensus on the Diagnosis, Treatment and Follow-Up of COPD

Jose Luis Lopez-Campos et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2021)

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Article Respiratory System

Burden of Disease Among Exacerbating Patients with COPD Treated with Triple Therapy in Spain

Bernardino Alcazar-Navarrete et al.

Summary: This study aimed to describe the disease burden of COPD patients in Spain receiving triple therapy, and found that patients with low blood eosinophil levels had a larger impact among exacerbating patients.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2021)

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Review Respiratory System

Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD

Marc Miravitlles et al.

Summary: The long-term use of ICSs in patients with COPD may increase the risk of pneumonia, tuberculosis, and mycobacterial disease, while also potentially leading to local disorders such as oral candidiasis and dysphonia.

EUROPEAN RESPIRATORY REVIEW (2021)

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Article Critical Care Medicine