☆ 4.7 Review

Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes

FRONTIERS IN PUBLIC HEALTH (2023)

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The role of bronchoscopy in patients with SARS-CoV-2 pneumonia

Marisol Arenas-De Larriva et al.

Summary: Bronchoscopy may be indicated in carefully selected COVID-19 patients to rule out superinfection and address complications related to mechanical ventilation. The presence of haematic secretions in the distal bronchial tract is considered a poor prognostic feature in COVID-19, along with older age, mucus plugs as indication for bronchoscopy, and absence of mucosal hyperemia as independent predictors of in-hospital mortality.

ERJ OPEN RESEARCH (2021)

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Article Otorhinolaryngology

Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID-19: a cross-sectional study

Mehtap Koparal et al.

Summary: The study found that nasal mucociliary clearance time was prolonged in COVID-19 patients compared to healthy controls, highlighting the importance of smell and taste as crucial symptoms in suspected cases of COVID-19.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host

Katharine M. Lodge et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Letter Medicine, General & Internal

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

Lirong Zou et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Critical Care Medicine

Bronchoscopy in Patients with COVID-19 with Invasive Mechanical Ventilation: A Single-Center Experience

Alfons Torrego et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Letter Critical Care Medicine

SARS-CoV-2 Viral Load in Clinical Samples from Critically Ill Patients

Yongbo Huang et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Review Pediatrics

Evaluating the Placebo Status of Nebulized Normal Saline in Patients With Acute Viral Bronchiolitis A Systematic Review and Meta-analysis

Samantha A. House et al.

JAMA PEDIATRICS (2020)

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Editorial Material Public, Environmental & Occupational Health

Hypertonic saline nasal irrigation and gargling should be considered as a treatment option for COVID-19

Sandeep Ramalingam et al.

JOURNAL OF GLOBAL HEALTH (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Waradon Sungnak et al.

NATURE MEDICINE (2020)

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Review Physiology

First contact: the role of respiratory cilia in host-pathogen interactions in the airways

Li Eon Kuek et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Article Medicine, General & Internal

New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

Yuan Hou et al.

BMC MEDICINE (2020)

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Editorial Material Otorhinolaryngology

Benefits and Safety of Nasal Saline Irrigations in a Pandemic-Washing COVID-19 Away

Nyssa F. Farrell et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2020)

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Article Dentistry, Oral Surgery & Medicine

Viral Load Dynamics in Sputum and Nasopharyngeal Swab in Patients with COVID-19

R. Liu et al.

JOURNAL OF DENTAL RESEARCH (2020)

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Letter Infectious Diseases

Viral dynamics in mild and severe cases of COVID-19

Yang Liu et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Dentistry, Oral Surgery & Medicine

A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2

Maximilian J. Gottsauner et al.

CLINICAL ORAL INVESTIGATIONS (2020)

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Article Biochemistry & Molecular Biology

Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity

Wakako Sakaguchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Letter Infectious Diseases

Household transmission of COVID-19-a systematic review and meta-analysis

Hao Lei et al.

JOURNAL OF INFECTION (2020)

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Article Multidisciplinary Sciences

Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients

Emel Akgun et al.

PLOS ONE (2020)

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Article Virology

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract

Yichuan Liu et al.

VIRUSES-BASEL (2020)

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Editorial Material Otorhinolaryngology

Interim analysis of an open-label randomized controlled trial evaluating nasal irrigations in non-hospitalized patients with coronavirus disease 2019

Kyle S. Kimura et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2020)

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Article Multidisciplinary Sciences

Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients

Hitoshi Kawasuji et al.

PLOS ONE (2020)

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Review Medicine, General & Internal

Household Transmission of SARS-CoV-2 A Systematic Review and Meta-analysis

Zachary J. Madewell et al.

JAMA NETWORK OPEN (2020)

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Article Cell Biology

Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19

Yuying Liu et al.

CELL RESEARCH (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Jesse Fajnzylber et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia

Andres Pizzorno et al.

CELL REPORTS MEDICINE (2020)

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Article Respiratory System

Position Paper for the State-of-the-Art Application of Respiratory Support in Patients with COVID-19

Michael Pfeifer et al.

RESPIRATION (2020)

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Article Biochemistry & Molecular Biology

Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance

Wu-Chang Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Immunology

Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis

Ajantha Nadesalingam et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels Sandeep Ramalingam

Sandeep Ramalingam et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Universal and reusable virus deactivation system for respiratory protection

Fu-Shi Quan et al.

SCIENTIFIC REPORTS (2017)

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Article Pediatrics

Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis

Silvana Schreiber et al.

ACTA PAEDIATRICA (2016)

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Article Otorhinolaryngology

Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota

Cindy M. Liu et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2015)

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Article Pediatrics

High flow therapy versus hypertonic saline in bronchiolitis: randomised controlled trial

Mercedes Bueno Campana et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2014)

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Article Pharmacology & Pharmacy

Dynamics of aerosol size during inhalation: Hygroscopic growth of commercial nebulizer formulations

Allen E. Haddrell et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Multidisciplinary Sciences

Hypertonic Saline Solution Drives Neutrophil from Bystander Organ to Infectious Site in Polymicrobial Sepsis: A Cecal Ligation and Puncture Model

Mariana Cardillo Theobaldo et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Correction: Salt-Dependent Chemotaxis of Macrophages

Silke MÃ¼ller et al.

PLoS One (2013)

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Review Immunology

Reactive oxidants and myeloperoxidase and their involvement in neutrophil extracellular traps

Heather Parker et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Article Immunology

Hypochlorous acid regulates neutrophil extracellular trap release in humans

L. J. Palmer et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2012)

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Article Cardiac & Cardiovascular Systems

The long term effect of inhaled hypertonic saline 6% in non-cystic fibrosis bronchiectasis

Caroline H. H. Nicolson et al.

RESPIRATORY MEDICINE (2012)

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Article Mechanics

Effect of artificial mucus properties on the characteristics of airborne bioaerosol droplets generated during simulated coughing

M. D. Anwarul Hasan et al.

JOURNAL OF NON-NEWTONIAN FLUID MECHANICS (2010)

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Review Public, Environmental & Occupational Health

Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study

Wei Liu et al.

TROPICAL MEDICINE & INTERNATIONAL HEALTH (2009)

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Article Critical Care Medicine

Sodium chloride inhibits cytokine production by lipopolysaccharide-stimulated human neutrophils and mononuclear cells

Elaine Hatanaka et al.

SHOCK (2007)

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Review Pharmacology & Pharmacy

Airborne infectious disease and the suppression of pulmonary bioaerosols

J Fiegel et al.

DRUG DISCOVERY TODAY (2006)

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Article Otorhinolaryngology

Effect of hypo-, iso- and hypertonic saline irrigation on secretory mucins and morphology of cultured human nasal epithelial cells

CH Kim et al.

ACTA OTO-LARYNGOLOGICA (2005)

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Article Otorhinolaryngology

A daily nasal spray with saline prevents symptoms of rhinitis

L Tano et al.

ACTA OTO-LARYNGOLOGICA (2004)

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