Recent advances in nickel catalyzed Suzuki-Miyaura cross coupling reaction via C-O& C-N bond activation

Research on transition metal catalysis is advancing day by day. Unlike the conventional precious metal based catalysis, the researchers are now focussing on exploring the applicability of earthabundant first row transition elements as catalysts for C-C coupling reactions. Among them, the Suzuki-Miyaura coupling reaction greatly impacts the industrial catalytic processes. Nickel catalyzed Suzuki-Miyaura coupling is a great topic of interest for organic chemists over the last few decades. But, the mitigation of halogen waste is the major environmental concern associated with the traditional Suzuki coupling reaction. In this concern, various abundant and cheap electrophiles such as carboxylic acid derivatives, phenol derivatives, and amides have a remarkable priority in replacing the organic halides. In this strategy, the core C-O and C-N bonds were activated to form the C-C coupling products. Based on the advantages of Ni-catalysis, the research is directed towards exploring the various Ni-based catalytic systems for the successful Suzuki coupling reaction by activating C-O and C-N bonds. The recent reports are highly motivated toward green metrics. In the current review, we would like to summarize the recent advances in the Nicatalyzed Suzuki coupling via C-O and C-N bond activation.

Automated summary

Research on transition metal catalysis, specifically exploring the applications of abundant first row transition elements for C-C coupling reactions, is rapidly advancing. The Suzuki-Miyaura coupling reaction, particularly catalyzed by nickel, has attracted significant interest from organic chemists in recent decades. However, the environmental concern of halogen waste has prompted the exploration of alternative electrophiles, such as carboxylic acid derivatives, phenol derivatives, and amides, to replace organic halides in traditional Suzuki coupling reactions. This strategy involves activating C-O and C-N bonds to form C-C coupling products. The current focus is on developing various Ni-based catalytic systems that activate C-O and C-N bonds to achieve successful Suzuki coupling reactions, with a recent emphasis on green metrics.