☆ 4.6 Review

Elastography of the Liver in Wilson's Disease

DIAGNOSTICS (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Application of attenuation coefficient in the assessment of hepatic involvement in children and adolescents with Wilson's disease

Jiajia Wang et al.

Summary: This study aimed to investigate the use of the attenuation coefficient (ATT) as a noninvasive index to assess liver involvement in children and adolescents with Wilson's disease (WD). The results showed that ATT can be used as a noninvasive index for evaluating liver steatosis in WD patients, and the combination of ATT with APRI, FIB-4, and SWM may improve diagnostic efficacy.

BMC MEDICAL IMAGING (2023)

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Review Radiology, Nuclear Medicine & Medical Imaging

Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies

Jong Keon Jang et al.

Summary: Accurate detection and quantification of hepatic steatosis are crucial for managing nonalcoholic fatty liver disease. In this study, we conducted a systematic review and meta-analysis to assess the accuracy of ultrasound-measured attenuation coefficient (AC) in evaluating hepatic steatosis. The results showed that AC has good diagnostic performance for assessing hepatic steatosis. However, the interpretation of results should take into account factors such as body mass index (BMI) and the prevalence of steatosis or significant fibrosis.

ULTRASONOGRAPHY (2022)

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Article Medicine, General & Internal

Clinical relevance of shear wave elastography compared with transient elastography and other markers of liver fibrosis

Oyekoya T. Ayonrinde et al.

Summary: This study compares the application of SWE, TE, and clinical markers in patients with various liver diseases and finds that SWE is at least comparable to TE and other non-invasive tests for liver fibrosis. SWE is highly accurate in predicting liver-related portal hypertension.

INTERNAL MEDICINE JOURNAL (2022)

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Article Gastroenterology & Hepatology

Baveno VII - Renewing consensus in portal hypertension

Roberto de Franchis et al.

Summary: The Baveno VII workshop focused on personalized care for portal hypertension in patients with compensated cirrhosis or cACLD, discussing various aspects including diagnosis, treatment, and prevention measures in 9 main topics, resulting in a series of consensus recommendations.

JOURNAL OF HEPATOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Liver fibrosis assessment: MR and US elastography

Arinc Ozturk et al.

Summary: Elastography has become a preferred non-invasive imaging technique for clinical assessment of liver fibrosis, providing liver stiffness measurement as a surrogate biomarker for fibrosis burden. Both ultrasound and MRI-based elastography methods have shown to be accurate in detecting liver diseases.

ABDOMINAL RADIOLOGY (2022)

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Article Acoustics

Correlation Between QElaXto Techniques and Supersonic Imagine for Liver Stiffness Quantification in Chronic Liver Disease

Matteo Garcovich et al.

Summary: The study investigated the agreement between different equipment for liver stiffness quantification, showing a very good correlation between QElaXto techniques and SSI in LS measurements. Cut-off thresholds for fibrosis staging in non-HBV-related CLD were identified using two QElaXto techniques for the first time.

JOURNAL OF ULTRASOUND IN MEDICINE (2022)

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Article Multidisciplinary Sciences

Simplification of 2D shear wave elastography by enlarged SWE box and multiple regions of interest in one acquisition

Moritz Weiher et al.

Summary: This study improves and compares the method of using Two-dimensional Shear Wave Elastography (SWE) to evaluate liver stiffness. The results show that there is good reliability between one acquisition with increased size of the SWE-box and ten different ROI measurements and ten separate acquisitions with a single ROI measurement, if the mean shear-wave-speed is below 1.6m/s (7.7kPa).

PLOS ONE (2022)

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Article Gastroenterology & Hepatology

Evaluation of the Liver and Pancreas by 2D Shear Wave Elastography in Pediatric Wilson's Disease

Sibel Yavuz et al.

Summary: The study aimed to investigate parenchymal changes in the liver and pancreas related to copper accumulation in pediatric patients with Wilson's disease and explore the effectiveness of two-dimensional shear wave elastography in diagnosing organ involvement. The results showed increased liver tissue stiffness and decreased pancreatic tissue stiffness in Wilson's disease patients compared to healthy controls. Two-dimensional shear wave elastography is an easy to use, non-invasive, and promising method for objectively monitoring the early changes in tissue stiffness in Wilson's disease patients.

TURKISH JOURNAL OF GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Evaluation of liver fibrosis in patients with Wilson's disease

Adam Przybylkowski et al.

Summary: CPA is correlated with Ishak score, while transient elastography results are highly correlated with SWE measurements. However, transient elastography or SWE did not show significant correlation with Ishak score or CPA.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Fibroscan® probe selection for lean adults

Vanessa Stadlbauer et al.

Summary: The study aimed to compare liver stiffness assessments using Fibroscan (R) S+ and M+ probes, as well as controlled attenuation parameter (only available for M+ probe), in healthy volunteers with a thoracic circumference <= 75 cm and >75 cm. Results showed that intake of a light meal had no relevant influence on liver stiffness or CAP measurements in both groups, indicating that lean adults with a thoracic circumference below 75 cm can be assessed with either probe and may eat before assessment.

JGH OPEN (2021)

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Article Gastroenterology & Hepatology

Long-term outcome of Wilson's disease complicated by liver disease

Satoko Arai et al.

Summary: This study observed the long-term liver disease status of Wilson's disease patients and found that continuous treatment could effectively prolong survival, prevent liver function deterioration, and reduce the risk of hepatocellular carcinoma. Treatment interruption should be avoided to achieve better prognosis.

JGH OPEN (2021)

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Article Pharmacology & Pharmacy

HR-MS Based Untargeted Lipidomics Reveals Characteristic Lipid Signatures of Wilson's Disease

Yixiao Zhi et al.

Summary: The study found that in Wilson's disease patients, the levels of saturated triglycerides increase while other unsaturated lipids decrease. Some serum lipid species may be used as biomarkers for Wilson's disease. Additionally, a similar lipid profile was also found in relatives, suggesting that these changes may be related to mutations in the ATP7B gene.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Gastroenterology & Hepatology

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

Emmanuel Anandraj Selvaraj et al.

Summary: Non-invasive tests measuring liver stiffness or using MRI have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these tests cannot be fully assessed due to lack of intention-to-diagnose analyses and validation of pre-specified thresholds.

JOURNAL OF HEPATOLOGY (2021)

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Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update

Annalisa Berzigotti et al.

Summary: The article provides the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for assessing liver disease severity and prognosis, with a focus on topics with relevant evidence published in the last 5 years.

JOURNAL OF HEPATOLOGY (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Attenuation coefficient (ATT) measurement for liver fat quantification in chronic liver disease

Nobuharu Tamaki et al.

Summary: ATT measurement is a noninvasive and quantitative method for liver fat measurement, with high accuracy associated with histological steatosis grade and high interobserver reproducibility. It can measure the exact location of the region of interest on a B-mode image and is suitable for point-of-care and screening applications.

JOURNAL OF MEDICAL ULTRASONICS (2021)

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Review Medicine, General & Internal

Systematic Review with Meta-Analyses: Diagnostic Accuracy of FibroMeter Tests in Patients with Non-Alcoholic Fatty Liver Disease

Anne-Marieke van Dijk et al.

Summary: In this study, FibroMeter versions were systematically reviewed for their performance in detecting different levels of fibrosis in patients with NAFLD. The findings indicated that FibroMeter VCTE had the highest diagnostic accuracy in detecting advanced fibrosis, followed by FibroMeter V2G and FibroMeter NAFLD, with no significant differences between the different versions. Head-to-head comparison studies are needed to further evaluate the performance of these tests.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

Association of shear-wave elastography with clinical outcomes post-liver transplantation

Tom Boeken et al.

Summary: In this study, liver-stiffness values on 2D-SWE were found to be significantly higher in liver transplant patients without complications during the first 90 days post-transplantation compared to after 1 year. Patients with biliary complications had significantly higher liver-stiffness values on 2D-SWE compared to those without complications.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Advances in non-invasive assessment of hepatic fibrosis

Rohit Loomba et al.

GUT (2020)

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Article Gastroenterology & Hepatology

Non-invasive diagnosis of cirrhosis and long-term disease monitoring by transient elastography in patients with Wilson disease

Rafael Paternostro et al.

LIVER INTERNATIONAL (2020)

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Article Gastroenterology & Hepatology

Guidelines on the use of liver biopsy in clinical practice from the British Society of Gastroenterology, the Royal College of Radiologists and the Royal College of Pathology

James Neuberger et al.

GUT (2020)

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Article Acoustics

Diagnostic Performance of Ultrasound Elastography and Serologic Fibrosis Indices for Evaluation of Hepatic Involvement in Wilson Disease

Jisun Hwang et al.

JOURNAL OF ULTRASOUND IN MEDICINE (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

MR elastography of liver: current status and future perspectives

Ilkay S. Idilman et al.

ABDOMINAL RADIOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Advances in Magnetic Resonance Elastography of Liver

Jiahui Li et al.

MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Update to the Society of Radiologists in Ultrasound Liver Elastography Consensus Statement

Richard G. Barr et al.

RADIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Liver Stiffness Reflecting Right-Sided Filling Pressure Can Predict Adverse Outcomes in Patients With Heart Failure

Tatsunori Taniguchi et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Gastroenterology & Hepatology

Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Peter J. Eddowes et al.

GASTROENTEROLOGY (2019)

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Review Gastroenterology & Hepatology

Non-invasive assessment of liver fibrosis and prognosis: an update on serum and elastography markers

Uchenna Agbim et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Acute Liver Failure due to Wilson Disease: Eight Years of the National Liver Transplant Program in Uruguay

Victoria Mainardi et al.

ANNALS OF HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Acoustic Radiation Force Impulse (ARFI) Elastography in Autoimmune and Cholestatic Liver Diseases

Ruediger S. Goertz et al.

ANNALS OF HEPATOLOGY (2019)

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Review Biochemistry & Molecular Biology

Liver pathology in Wilson's disease: From copper overload to cirrhosis

C. Gerosa et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2019)

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Article Acoustics

Propagation Imaging in the Demonstration of Common Shear Wave Artifacts

Theodore J. Dubinsky et al.

JOURNAL OF ULTRASOUND IN MEDICINE (2019)

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Article Acoustics

Ultrasonic Adaptive Sound Speed Estimation for the Diagnosis and Quantification of Hepatic Steatosis: A Pilot Study

Marco Dioguardi Burgio et al.

ULTRASCHALL IN DER MEDIZIN (2019)

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Article Engineering, Biomedical

An initial study of complete 2D shear wave dispersion images using a reverberant shear wave field

Juvenal Ormachea et al.

PHYSICS IN MEDICINE AND BIOLOGY (2019)

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Article Gastroenterology & Hepatology

Non-invasive evaluation of portal hypertension using shearwave elastography: analysis of two algorithms combining liver and spleen stiffness in 191 patients with cirrhosis

L. Elkrief et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2018)

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Review Gastroenterology & Hepatology

Noninvasive imaging biomarker assessment of liver fibrosis by elastography in NAFLD

Elliot B. Tapper et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Review Acoustics

LIVER ULTRASOUND ELASTOGRAPHY: AN UPDATE TO THE WORLD FEDERATION FOR ULTRASOUND IN MEDICINE AND BIOLOGY GUIDELINES AND RECOMMENDATIONS

Giovanna Ferraioli et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2018)

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Article Gastroenterology & Hepatology

Direct-Acting Antiviral Therapy for Chronic HCV Infection Results in Liver Stiffness Regression Over 12 Months Post-treatment

Justin Chan et al.

DIGESTIVE DISEASES AND SCIENCES (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Changes in Liver Congestion in Patients with Budd-Chiari Syndrome following Endovascular Interventions: Assessment with Transient Elastography

Amar Mukund et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2017)

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Article Acoustics

EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version)

Christoph F. Dietrich et al.

ULTRASCHALL IN DER MEDIZIN (2017)

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Article Acoustics

Transient Elastography of the Liver in Children with Wilson's Disease: Preliminary Results

Ana Cristina Stefanescu et al.

JOURNAL OF CLINICAL ULTRASOUND (2016)

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Article Gastroenterology & Hepatology

Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?

Behairy El-Sayed Behairy et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Article Biochemistry & Molecular Biology

Matrix metalloproteinases in liver injury, repair and fibrosis

Sergio Duarte et al.

MATRIX BIOLOGY (2015)

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WFUMB GUIDELINES AND RECOMMENDATIONS FOR CLINICAL USE OF ULTRASOUND ELASTOGRAPHY: PART 3: LIVER

Giovanna Ferraioli et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2015)

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Article Gastroenterology & Hepatology

Histologic evolution and long-term outcome of Wilson's disease: results of a single-center experience

Margherita Sini et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Ultrasound elastography in liver

N. Frulio et al.

Diagnostic and Interventional Imaging (2013)

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Article Hematology

Longitudinal changes in serum ferritin levels correlate with measures of hepatic stiffness in transfusion-independent patients with β-thalassemia intermedia

Khaled M. Musallam et al.

BLOOD CELLS MOLECULES AND DISEASES (2012)

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Article Gastroenterology & Hepatology

Non-invasive assessment of hepatic fibrosis in a series of patients with Wilson's Disease

Margherita Sini et al.

DIGESTIVE AND LIVER DISEASE (2012)

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Article Gastroenterology & Hepatology

Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores

Thomas Karlas et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2012)

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Article Biochemistry & Molecular Biology

Alterations of lipid metabolism in Wilson disease

Jessica Seessle et al.

LIPIDS IN HEALTH AND DISEASE (2011)

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Article Gastroenterology & Hepatology

Non-invasive evaluation of liver fibrosis using transient elastography

Laurent Castera et al.

JOURNAL OF HEPATOLOGY (2008)

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