☆ 4.6 Review

Precision Medicine for Chronic Endometritis: Computer-Aided Diagnosis Using Deep Learning Model

DIAGNOSTICS (2023)

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Commonalities and Disparities between Endometriosis and Chronic Endometritis: Therapeutic Potential of Novel Antibiotic Treatment Strategy against Ectopic Endometrium

Kotaro Kitaya et al.

Summary: Chronic endometritis (CE) is an inflammatory disorder of the uterine lining characterized by abnormal infiltration of CD138(+) plasmacytes. It is associated with infertility and obstetric/neonatal complications and is believed to be caused by intrauterine infection and local dysbiosis. Antibiotic treatment is effective in eliminating the plasmacytes. Endometriosis is a common reproductive tract disease characterized by ectopic endometrium that can cause chronic pelvic symptoms, infertility, and ovarian cancers. Recent studies have found common characteristics between endometriosis and CE, specifically in immunological, inflammatory, and infectious aspects. This review aims to better understand the immunological and microbial backgrounds of endometriosis and CE and explore the therapeutic potential of novel antibiotic treatment against endometriosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Obstetrics & Gynecology

Accuracy of office hysteroscopy in the diagnosis of chronic endometritis

Mohamed Elmahdy Abdel Moneim et al.

Summary: Office hysteroscopic evaluation is relatively accurate in the diagnosis of chronic endometritis and can be further confirmed by CD138 staining.

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Endometrial Microbiome and Its Impact on Human Conception

Bruno Toson et al.

Summary: Changes in the female genital tract microbiome are related to gynecological and obstetrical pathologies, but the influence of endometrial bacterial communities on human reproduction is still debated. Understanding the impact of microbiome on fertility allows personalized treatment and improves clinical outcomes.

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Article Genetics & Heredity

MUM-1 immunohistochemistry has high accuracy and reliability in the diagnosis of chronic endometritis: a multi-centre comparative study with CD-138 immunostaining

Ettore Cicinelli et al.

Summary: The study indicates that IHC for MUM-1 and CD-138 have similar accuracy in detecting endometrial stromal plasma cells. However, MUM-1 shows higher reliability in the paired comparison of individual samples. Therefore, MUM-1 may be a novel and promising add-on technique for CE diagnosis.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2022)

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Review Obstetrics & Gynecology

Administration of growth hormone improves endometrial function in women undergoing in vitro fertilization: a systematic review and meta-analysis

Yujie Shang et al.

Summary: This meta-analysis evaluated the effects of growth hormone (GH) administration on endometrial function and reproductive outcomes in IVF cycles. The results showed that GH treatment significantly increased endometrial thickness and improved live birth rate and clinical pregnancy rate. Optimal treatment should be offered to the target population based on individual conditions and needs. However, caution should be exercised when interpreting the results due to limited sample sizes and methodological issues.

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Article Genetics & Heredity

Multi-drug-resistant chronic endometritis in infertile women with repeated implantation failure: trend over the decade and pilot study for third-line oral antibiotic treatment

Kotaro Kitaya et al.

Summary: This study evaluated the prevalence and transition of multi-drug resistant chronic endometritis (MDR-CE) in infertile women with repeated implantation failure (RIF) and established a third-line antibiotic treatment regimen for MDR-CE. The study found that MDR-CE increased over the past decade in RIF women, and azithromycin may be a clinically advantageous treatment option.

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The association between chronic deciduitis and preeclampsia

Aina Morimune et al.

Summary: This study investigated the association between chronic deciduitis (CD) and preeclampsia, and found a significant correlation between CD and the incidence of preeclampsia. Patients with CD had earlier gestational age, lower birth weight, and higher rate of low birth weight. Therefore, CD may be a factor associated with poor perinatal outcomes.

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Transient and Prolonged Activation of Wnt Signaling Contribute Oppositely to the Pathogenesis of Asherman's Syndrome

Xiang Xue et al.

Summary: This study investigates the relationship between the Wnt signaling pathway and the progression of Asherman's Syndrome (AS). The study finds that the expression of non-phosphorylated beta-catenin, Wnt5a, and Wnt7a is significantly higher in the endometria with adhesion. Both Wnt5a and Wnt7a promote stem cell proliferation, but only Wnt7a preserves stem cell population by stimulating self-renewal. In a rat model, transient activation of the Wnt/beta-catenin signaling pathway promotes angiogenesis and increases the number of glands. The study suggests that transient Wnt/beta-catenin activation may aid tissue regeneration, while prolonged activation may contribute to fibrosis formation.

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Review Genetics & Heredity

Does antibiotic therapy for chronic endometritis improve clinical outcomes of patients with recurrent implantation failure in subsequent IVF cycles? A systematic review and meta-analysis

Xinghan Cheng et al.

Summary: Antibiotic therapy for chronic endometritis (CE) may improve subsequent IVF outcomes in patients with recurrent implantation failure (RIF) only if the condition of CE is confirmed cured. There is no sufficient evidence of clinical improvements in RIF patients with persistent CE.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2022)

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Review Medicine, General & Internal

Challenges in Clinical Diagnosis and Management of Chronic Endometritis

Tadahiro Yasuo et al.

Summary: Chronic endometritis is a mucosal infectious and inflammatory disorder that is potentially associated with infertility, recurrent pregnancy loss, and other complications. There is a lack of universal diagnostic criteria and management guidelines for this condition, and this review aims to provide insights and summaries to establish clinical guidelines for chronic endometritis in human reproduction.

DIAGNOSTICS (2022)

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Review Medicine, General & Internal

Current Status of Artificial Intelligence-Based Computer-Assisted Diagnosis Systems for Gastric Cancer in Endoscopy

Kentaro Ochiai et al.

Summary: Artificial intelligence (AI) is increasingly being used in various fields, including medicine, particularly in image recognition. In the field of gastrointestinal endoscopy, AI-based computer-assisted detection/diagnosis (CAD) systems have been developed for colorectal polyp detection and diagnosis. However, the implementation of these systems in real-world clinical settings is still limited. The accurate detection and diagnosis of gastric cancer (GC) is a challenge, especially in early stages. The development of CAD systems for GC is challenging due to the need for high-quality GC images.

DIAGNOSTICS (2022)

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The Future Is Coming: Artificial Intelligence in the Treatment of Infertility Could Improve Assisted Reproduction Outcomes-The Value of Regulatory Frameworks

Sanja Medenica et al.

Summary: Infertility is a global health problem that affects men and women of reproductive age. Artificial intelligence (AI) has been increasingly used in infertility diagnosis and assisted reproduction technologies (ART) to improve treatment outcomes. AI applications include ultrasound monitoring, embryo selection, oocyte morphology assessment, and male infertility evaluation. Additionally, AI can help classify and diagnose idiopathic infertility cases. This review summarizes current AI applications and explores the legal, regulatory, and ethical standards for AI in healthcare.

DIAGNOSTICS (2022)

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Investigation of the Relationship between Chronic Endometritis Manifestations under Hysteroscope and CD138 Expression

Shuang Wang et al.

Summary: This study analyzed clinical cases of patients with chronic endometritis (CE) and found that the positiveness of CD138 and the efficacy of antibiotic treatment varied among different manifestations of CE under hysteroscopy. Patients with endometrial micropolyps and endometrial stroma edema and hyperplasia had a high rate of CD138 positivity and better response to antibiotic treatment. However, patients with diffuse endometrial hyperemia had a low rate of CD138 positivity and poor response to antibiotics.

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An Endometrial Thickness < 8 mm Was Associated With a Significantly Increased Risk of EP After Freeze-Thaw Transfer: An Analysis of 5,960 Pregnancy Cycles

Ying Zhao et al.

Summary: This study investigates the endometrial characteristics most likely to induce ectopic pregnancy in frozen-thawed embryo transfers. The risk of ectopic pregnancy significantly increases when the endometrial thickness is less than 8 mm. Thin endometrial thickness may be related to abnormal endometrial peristaltic waves or abnormal endometrial receptivity. Adequate attention should be paid to patients with thin endometrial thickness to prevent ectopic pregnancy or achieve early diagnosis.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Elettra Barberis et al.

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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DIAGNOSTICS (2022)

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Review Medicine, General & Internal

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome-A Systematic Review and Meta-Analysis

Amerigo Vitagliano et al.

Summary: This systematic review and meta-analysis evaluates the impact of chronic endometritis on in vitro fertilization outcomes and finds that antibiotic therapy can improve IVF results. The severity of endometritis has varying effects on IVF outcomes, with mild endometritis having no influence on IVF success.

DIAGNOSTICS (2022)

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Deep-Learning-Based Real-Time and Automatic Target-to-Background Ratio Calculation in Fluorescence Endoscopy for Cancer Detection and Localization

Yang Jiang et al.

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DIAGNOSTICS (2022)

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Article Medicine, Research & Experimental

Deep learning model for classifying endometrial lesions

YunZheng Zhang et al.

Summary: The study developed a convolutional neural network model that can automatically classify endometrial lesions based on hysteroscopic images, with high specificity and sensitivity. The model's accuracy slightly outperformed gynecologists, improving the overall diagnostic accuracy of endometrial lesions.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Correction Engineering, Multidisciplinary

Embedded YOLO: A Real-Time Object Detector for Small Intelligent Trajectory Cars (vol 2021, 6555513, 2021)

WenYu Feng et al.

MATHEMATICAL PROBLEMS IN ENGINEERING (2021)

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Article Obstetrics & Gynecology

Impact of antibiotic therapy on the rate of negative test results for chronic endometritis: a prospective randomized control trial

Dongmei Song et al.

Summary: The study compared the rates of negative test results for chronic endometritis (CE) in patients who received antibiotic treatment and those who did not. The results showed that a 14-day course of broad-spectrum oral antibiotic therapy was effective in treating CE in over 89.8% of cases, but its impact on pregnancy outcomes remains uncertain.

FERTILITY AND STERILITY (2021)

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Antibiotic therapy versus no treatment for chronic endometritis: a case-control study

Ettore Cicinelli et al.

Summary: This study compared the impact of germ oriented antibiotic therapy and no treatment on chronic endometritis (CE), showing that antibiotic therapy significantly improved the cure rate of CE, further confirming the infectious nature of CE.

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Impact of oral antibiotic treatment for chronic endometritis on pregnancy outcomes in the following frozen-thawed embryo transfer cycles of infertile women: a cohort study of 640 embryo transfer cycles

Yujing Xiong et al.

Summary: This study aimed to investigate the therapeutic effect of antibiotic treatment on pregnancy outcomes in infertile women undergoing frozen-thawed embryo transfer cycles. The results showed that CD138+/HPF <4 in the endometrium did not have a negative impact on pregnancy outcomes, while antibiotic treatment was effective in improving reproductive outcomes for women with CD138+/HPF >5. Persistent chronic endometritis was associated with poorer pregnancy outcomes.

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Hysteroscopic detection of chronic endometritis: Evaluating proposed hysteroscopic features suggestive of chronic endometritis

Orestis Tsonis et al.

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Yu Takahashi et al.

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DIAGNOSTIC PATHOLOGY (2020)

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Fani Gkrozou et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2020)

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Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review

Giovanni Buzzaccarini et al.

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Ettore Cicinelli et al.

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Robyn N. Parks et al.

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY (2019)

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