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Editorial Material
Orthopedics
Itaru Kawashima
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Review
Food Science & Technology
Amin Gasmi et al.
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Endocrinology & Metabolism
John P. Bilezikian et al.
Summary: This work reviews and discusses controversial topics regarding vitamin D, SARS-CoV-2 infection, and COVID-19. The International Conferences Controversies in Vitamin D are workshops that started in 2017 and feature international experts and leaders in the field. The fifth annual conference was held in Stresa, Italy, in September 2021.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Shlomi Toussia-Cohen et al.
Summary: This retrospective study examined women diagnosed with bilateral or unilateral transient osteoporosis of the hip during pregnancy or postpartum, and compared the outcomes of normal vaginal delivery and cesarean delivery. The results showed that women with transient osteoporosis of the hip had advanced maternal age, low body mass index, family history of osteoporosis, and a high prevalence of smoking and in-vitro fertilization pregnancies. Transient osteoporosis of the hip was bilateral in 25% of cases and presented postpartum in 50% of cases. There was no significant difference in maternal outcomes between normal vaginal delivery and cesarean delivery. Increased awareness of this potential diagnosis during pregnancy and postpartum may improve patient management and outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Physiology
Diana Athonvarangkul et al.
Summary: A coordinated physiological response occurs during lactation to support increased calcium demands for milk production. This involves the interaction between the hypothalamus, mammary gland, and skeleton, allowing for adequate calcium delivery to milk while protecting maternal skeletal health. Understanding the regulators of bone loss during lactation may provide insights into new therapies for osteoporosis and other diseases of excess bone loss.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Marian Schini et al.
Summary: Bone turnover markers (BTMs) are widely used in research and clinical practice to assess bone metabolism. They can be helpful in diagnosing and managing various diseases, such as osteoporosis and chronic kidney disease-mineral bone disorder. Measurement and interpretation of BTMs have accumulated much experience over the past two decades.
Review
Rheumatology
Maria Chiara Massari et al.
Summary: 'Frailty' is a state of increased vulnerability caused by impairment of homeostasis due to stress. Frail individuals are more likely to experience significant health decline and have a higher risk of adverse outcomes such as osteoporosis, falls, and disability. Frailty is becoming increasingly important due to global population aging. The pathophysiology of frailty involves cumulative molecular and cellular damage and is partially independent of aging but closely related. Uncorrected nutrition and sedentary behavior worsen frailty.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Endocrinology & Metabolism
Sanne Treurniet et al.
Summary: In this report, a 34-year-old woman with severe osteoporosis and multiple vertebral fractures after her first pregnancy was treated with teriparatide and zoledronic acid. Significant improvements in bone mineral density, microarchitecture, and strength were observed at the hip, spine, and distal radius, but remained severely impaired compared to healthy controls at 40 months postpartum.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Yoichi Kaneuchi et al.
Summary: Pregnancy- and lactation-associated osteoporosis (PLO) is a rare type of premenopausal osteoporosis affecting women mainly in the third trimester or after delivery. The exact cause and treatment of PLO are not well understood. This report presents the first case of a patient with PLO treated with romosozumab, following 4 months of teriparatide treatment. After romosozumab treatment for 12 months, the patient experienced significant increases in bone mineral density at the lumbar spine, femoral neck, and total hip, with no subsequent fractures. Romosozumab shows promise as a therapeutic option for improving bone mineral density and reducing fracture risk in patients with PLO.
MEDICINA-LITHUANIA
(2023)
Article
Obstetrics & Gynecology
Tinu Philip et al.
JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA
(2022)
Article
Hematology
Emilie Virot et al.
Summary: Pregnancy in transfused beta-thalassemia women poses challenges due to chronic anemia, hypogonadotropic hypogonadism, and iron chelation. However, rare obstetrical and fetal complications were observed in pregnancies of transfused beta-thalassemia women registered in the French National Registry, with more frequent use of ART and cesarean sections compared to control subjects, and smaller infant weight at birth despite delivery at full term.
ANNALS OF HEMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Adi Cohen et al.
Summary: The study identified likely pathogenic variants or relevant variants of uncertain significance in 8 out of 75 premenopausal women with idiopathic osteoporosis. These variants were consistent with diagnostic evaluations showing evidence of low bone formation rates or increased bone resorption. The majority of patients had no identifiable genetic etiology, indicating that further research is necessary to identify new genetic and non-genetic causes of early-onset osteoporosis.
Review
Obstetrics & Gynecology
R. F. Vasanwala et al.
Summary: The foundation of bone health is established during fetal development and continues throughout childhood and adolescence. Understanding factors that influence peak bone mass is crucial for improving bone health and preventing osteoporosis.
Article
Endocrinology & Metabolism
Suraj Kubihal et al.
Summary: The study comprehensively assessed bone health in women with prior gestational diabetes mellitus and found that women with dysglycemia (diabetes/prediabetes) had lower TBS, higher BMD, and lower serum osteocalcin levels. These factors were associated with the early progression of diabetes in relation to bone health.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Sarah A. Hardcastle
Summary: Pregnancy-associated osteoporosis is a rare condition affecting women in pregnancy or the postpartum period, characterized by skeletal fragility and vertebral fractures. The etiology is poorly understood, and management is challenging due to limited evidence and potential spontaneous improvement in bone density post-pregnancy and lactation.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Genetics & Heredity
Eugenie Koumakis et al.
Summary: The study aimed to investigate fractures occurring during pregnancy and post-partum in OI patients. Results showed that patients with pregnancy or post-partum fractures were older with lower bone mineral density, and most were breastfeeding. OI management during pregnancy and post-partum should focus on controlling modifiable osteoporosis risk factors.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Review
Endocrinology & Metabolism
R. K. Saad et al.
Summary: Bariatric surgery, especially the malabsorptive type, may have a negative impact on bone health. Compared to non-surgical weight loss and obese controls, bariatric surgery, particularly the malabsorptive type, is associated with a higher risk of fractures. However, restrictive surgeries do not seem to increase fracture risk. Further long-term follow-up studies are needed to better assess the fracture risk in patients who have undergone bariatric surgery.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
C. Gaggiano et al.
Summary: Transient osteoporosis of the hip (TOH) is a common self-limiting condition that usually occurs in middle-aged men and pregnant women. This article reports a case of TOH in a child and summarizes previous literature on pediatric cases of TOH. The case presented an unusual complication of TOH with a femoral physis fracture, which was successfully treated with bisphosphonates. Interventional medical treatment should be considered in selected cases of juvenile TOH to prevent irreversible damage to the femoral physis.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Louise Curtin et al.
Summary: Maternal nutrition during pregnancy does not affect offspring bone mineral density at 5 years. Offspring bone mineral density is correlated with offspring body mass index, and is higher in boys than girls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pejman Jabehdar Maralani et al.
Summary: The Canadian Association of Radiologists (CAR) Working Group on MRI in Pregnancy provides evidence-based recommendations for the use of MRI during pregnancy, addressing concerns related to fetal safety.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2022)
Review
Endocrinology & Metabolism
Abraham Yair Lujano-Negrete et al.
Summary: Pregnancy and lactation can alter mineral metabolism and maternal bone status, potentially increasing the risk of fractures. Limited information is available on bone mineral density during pregnancy, and further clinical studies are needed to determine if it is a risk factor for osteoporosis.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Emilie Karense Lykking et al.
Summary: This study found that there was no increased risk of fractures during pregnancy and 12 or 19 months postpartum compared to 12 or 19 months prior to conception.
Review
Endocrinology & Metabolism
Outi Makitie et al.
Summary: Osteoporosis is a skeletal disorder affecting mainly the elderly, characterized by low bone density and fragility fractures. In children and young adults, investigations should explore the possibility of underlying monogenetic bone diseases when fragility fractures occur. Management involves treating secondary factors, optimizing lifestyle factors, and discussing personalized bone-active medication based on severity of osteoporosis and underlying diseases.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Review
Obstetrics & Gynecology
M. Conradie et al.
Summary: Diagnosis of premenopausal osteoporosis should involve a comprehensive evaluation of multiple factors and exclusion of secondary causes. Treatment should include reducing risk factors, advocating a healthy lifestyle, and addressing any secondary causes of bone loss.
Article
Multidisciplinary Sciences
Julie Shlisky et al.
Summary: Dietary calcium deficiency is a global issue, especially in low- and middle-income countries. Recommendations for calcium intake vary across countries, and standard methods for assessing calcium deficiency prevalence and related health consequences are lacking. This study aims to provide a foundation for policy-making and interventions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Editorial Material
Obstetrics & Gynecology
Agata Michalska et al.
Summary: During pregnancy, hormonal and structural changes can lead to temporary musculoskeletal dysfunctions. Pregnancy-related fatigue fractures are a rare cause of persistent or increasing pain in the sacrum region.
GINEKOLOGIA POLSKA
(2022)
Review
Biochemistry & Molecular Biology
Anna Calik-Ksepka et al.
Summary: Lactation is a physiological state characterized by hyperprolactinemia and amenorrhea. Breastfeeding suppresses ovarian function and leads to amenorrhea. The main consequences of lactational amenorrhea are fertility issues and increased bone turnover.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Takaaki Ishida et al.
Summary: This study investigated postpartum bone mineral density (BMD) in patients with systemic lupus erythematosus (SLE) receiving long-term glucocorticoid (GC) therapy, identified risk factors for decreased BMD, and evaluated changes in BMD after postpartum initiation or restarting of osteoporosis drugs. The results showed that low BMI before pregnancy was a risk factor for hip bone loss in postpartum SLE patients. Therefore, preconception care to prevent osteoporosis and regular monitoring of BMD after delivery are necessary.
Article
Nutrition & Dietetics
Roger Bouillon et al.
Summary: Vitamin D deficiency has adverse effects on both skeletal and extra-skeletal health. The optimal level of vitamin D remains a subject of debate. Observational studies suggest a link between low vitamin D levels and increased infection risk and cardiovascular events, but intervention studies have not shown clear benefits on these outcomes. Pregnancy supplementation with vitamin D reduces the risk of certain complications. The role of vitamin D in neurodegenerative diseases is still unclear. Vitamin D supplementation may have a marginal effect on overall mortality risk, particularly in elderly individuals with low vitamin D levels.
Review
Nutrition & Dietetics
Jose Luis Mansur et al.
Summary: Vitamin D deficiency in pregnancy and infants may lead to health issues such as rickets, preeclampsia, and fetal growth restriction; supplementation with Vitamin D can reduce the risk of complications for pregnant women, fetuses, and newborns.
Article
Public, Environmental & Occupational Health
Yimei Yang et al.
Summary: This study found a negative correlation between parity and lumbar spine bone mineral density in postmenopausal women, but no correlation with femoral neck bone mineral density. Additionally, multiple parities were associated with a significantly higher prevalence of lumbar spine osteoporosis.
Editorial Material
Medicine, General & Internal
Yu Ji Kim et al.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Nursing
Susanrachel B. Condon et al.
Summary: Pregnancy-associated osteoporosis is a rare and complex condition with unknown etiology. This study aims to identify key features and experiences of individuals with PAO to assist midwives in early identification and support of patients' recovery.
Article
Obstetrics & Gynecology
Peyman Hadji et al.
Summary: This study aimed to assess the impact of teriparatide on patients with pregnancy- and lactation-associated osteoporosis. The results demonstrated that teriparatide significantly increased bone mineral density at the lumbar spine, femoral neck, and total hip after 24 months of treatment. The increase in bone density was maintained 12 months after cessation of treatment.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2022)
Article
Endocrinology & Metabolism
Mikayo Toba et al.
Summary: The study investigated fracture cases occurring within 2 years of an obstetrics hospitalization. This finding may be useful in selecting preventative measures for patients at risk of fractures within 2 years after obstetric hospitalization, including PLO.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Endocrinology & Metabolism
Stephen J. Woolford et al.
Summary: This study examined the association between the late pregnancy energy-adjusted dietary inflammatory index (E-DII) scores and offspring bone outcomes in childhood. The results showed that higher E-DII scores, indicating a pro-inflammatory diet, were negatively associated with offspring bone measures, suggesting the importance of maternal and childhood diet on longitudinal bone health in offspring.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Olatundun D. Awosanya et al.
Summary: COVID-19 infection may have significant impacts on musculoskeletal health, including bone loss. This review discusses studies on bone loss after infection and explores possible mechanisms, as well as analyzes the effects of COVID-19 treatments on the skeletal system. It also examines the potential consequences of delayed care and limited healthcare accessibility on musculoskeletal patient outcomes.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Endocrinology & Metabolism
Maria Cristina Campopiano et al.
Summary: This study reports a case of a 35-year-old Caucasian woman who experienced multiple vertebral fractures after her second pregnancy. Genetic analysis revealed a heterozygous missense mutation in the WNT1 gene. Treatment with teriparatide for two years resulted in an improvement in bone mineral density. This suggests that teriparatide is an effective therapy for individuals with heterozygous WNT1 mutations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Mariel M. Rickert et al.
Summary: Primary osteoporosis is the most common cause of sacral insufficiency fractures (SIFs), which typically present as lower back or buttock pain after a ground-level fall or without an identified trauma. Diagnosis may be delayed due to nonspecific symptoms, making a high index of suspicion necessary, particularly in high-risk patients. Computed tomography (CT) shows sclerosis of cancellous bone in the sacral ala, while magnetic resonance imaging (MRI) is more sensitive. Treatment options depend on symptom severity, fracture displacement, and pelvic instability.
Review
Biochemistry & Molecular Biology
Agustin Aibar-Almazan et al.
Summary: Osteoporosis, a silent disease of the 21st century, poses a public health risk and mainly affects postmenopausal women and older adults. The disease is characterized by an imbalance between bone resorption and production. Treatments include pharmacological approaches using anti-resorptive drugs as well as non-pharmacological approaches focusing on lifestyle habits such as physical activity and diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
John P. Bilezikian et al.
Summary: The last international guidelines on the evaluation and management of primary hyperparathyroidism (PHPT) were published in 2014. New research since then has led to new insights in epidemiology, pathophysiology, diagnosis, measurements, genetics, outcomes, presentations, new imaging modalities, target and other organ systems, pregnancy, evaluation, and management. An international group of experts reviewed these advances in knowledge and provided evidence-based recommendations and guidelines for the evaluation and management of PHPT.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Rheumatology
Duarte Andre Ferreira et al.
Summary: Pregnancy and lactation-associated osteoporosis is a rare disease that is often seen in late pregnancy or early postpartum, and it is characterized by multiple vertebral fractures. Early diagnosis, cessation of breastfeeding, and targeted therapy are crucial for symptom control, improving the quality of life, and preventing future fractures.
Review
Endocrinology & Metabolism
Fadil M. Hannan et al.
Summary: Lactation is crucial for the health of both infants and mothers, and is regulated by reproductive and metabolic hormones. The development of mammary glands and synthesis of milk are closely related to hormonal functions, which are stimulated by infant suckling. After weaning, there is a large-scale cell loss in the glands leading to involution. The hormonal composition of human milk also has effects on infant health and development. Additionally, endocrine and metabolic diseases, labor interventions, and exposure to endocrine-disrupting chemicals can cause lactation insufficiency.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Caroline A. Crowther et al.
Summary: This study compared the effects of different glycemic criteria for the diagnosis and treatment of gestational diabetes on women and infants. The results showed that using lower glycemic criteria did not reduce the risk of macrosomia, and it led to more labor inductions, use of health services, pharmacologic agents, and neonatal hypoglycemia. For women with glucose test results between the lower and higher criteria, those who received treatment had better maternal and infant health outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Nutrition & Dietetics
James C. Fleet
Summary: Vitamin D plays a critical role in regulating calcium and bone homeostasis, especially in the absorption of calcium in the intestines. The intestinal absorption of calcium is regulated by the hormone 1,25 dihydroxyvitamin D, which activates gene transcription by binding to the intestinal vitamin D receptor. Various physiological and disease states can affect the regulation of intestinal calcium absorption by vitamin D.
Article
Medicine, General & Internal
Caroline A. Crowther et al.
Summary: This study assessed the impact of tighter compared with less tight glycemic control on the morbidity of pregnant women with gestational diabetes mellitus (GDM). The results showed that tighter glycemic control did not reduce the risk of large for gestational age infant, but did reduce serious infant morbidity, while increasing the risk of serious maternal morbidity.
Article
Endocrinology & Metabolism
Jing Liao et al.
Summary: This umbrella review evaluated the association between bariatric surgery and health-related outcomes. The findings suggest that bariatric surgery improves the majority of health-related outcomes, but caution is advised due to the potential risk of adverse mental effects, perinatal problems, and fractures.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Soorya Siva et al.
Summary: The article describes a case of a woman who presented with hip pain after a caesarean section. Further investigation revealed fractures and severe osteoporosis. The article emphasizes the importance of prompt investigation in pregnant patients with disproportionate or persistent hip pain.
Article
Orthopedics
Shai Factor et al.
Summary: Transient osteoporosis of pregnancy (TOP) is a self-limiting condition with unspecified cause that commonly occurs in women during late pregnancy or early postpartum. This case report describes a 38-year-old female with TOP who suffered a femoral neck fracture at 28 weeks of gestation. The patient underwent surgical treatment and had a good recovery postoperatively.
Article
Medicine, General & Internal
Claudiu-Eduard Nistor et al.
Summary: This study compared the diagnosis and treatment of patients with COVID-19 pneumothorax and non-COVID-19 pneumothorax. The results showed that patients with COVID-19 pneumothorax had more severe clinical symptoms and a higher prevalence of respiratory comorbidities. Non-COVID-19 patients underwent surgical treatment to remove the air from the pleural cavity, while COVID-19 patients mainly received systemic treatment.
MEDICINA-LITHUANIA
(2022)
Article
Endocrinology & Metabolism
Matias Vaajala et al.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Elizabeth M. Curtis et al.
Summary: In the Maternal Vitamin D Osteoporosis Study (MAVIDOS) randomized trial, vitamin D supplementation during pregnancy did not have a significant effect on neonatal bone mass overall, but it did increase bone mass among babies born in winter. A follow-up study examined the impact of antenatal vitamin D supplementation on early childhood bone mineralization. The study found that maternal vitamin D supplementation during pregnancy resulted in greater bone mineral density in children at the age of 4.
Review
Toxicology
C. Laldinsangi
Summary: The habitual consumption of tobacco, particularly smokeless tobacco, is a serious global public health issue and has been proven to cause various devastating illnesses. It also adversely affects female reproductive health, pregnancy, and the health of the offspring.
CURRENT RESEARCH IN TOXICOLOGY
(2022)
Article
Obstetrics & Gynecology
Ankita Bhakta
Summary: This is a rare case of transient osteoporosis (TOP) in pregnancy, which poses diagnostic challenges and can result in delays and missed diagnoses. Clinicians should be alert to TOP in pregnant women presenting with hip pain and should initiate early multidisciplinary involvement for diagnosis and management.
CASE REPORTS IN WOMENS HEALTH
(2022)
Article
Obstetrics & Gynecology
Fang-Ping Chen et al.
Summary: The study found no association between P1NP levels and bone strength in postmenopausal women treated with teriparatide. However, early changes in P1NP may offer information regarding subsequent bone mineral density response.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Caroline A. Crowther et al.
Summary: This study compared the impact of diagnosing gestational diabetes using different glycemic criteria on maternal and infant health and found that using lower glycemic criteria did not reduce the risk of overweight infants. Treating gestational diabetes can benefit maternal and infant health.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Cell & Tissue Engineering
Bo Yang et al.
Summary: Pregnancy and lactation-associated osteoporosis (PLO) is a rare and special form of osteoporosis that can lead to vertebral compression fractures and height loss, potentially causing kyphosis of the spine. It is important to consider PLO in the differential diagnosis when a woman experiences severe back pain during or after pregnancy. Further research is needed to better understand the pathophysiology and treatment of PLO.
CURRENT STEM CELL RESEARCH & THERAPY
(2021)
Review
Surgery
Mark E. Mouchantaf et al.
Summary: Although hip avascular necrosis during pregnancy is rare, it is important to differentiate it from common hip pathologies and consider MRI imaging if necessary in order to prevent complications.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Obstetrics & Gynecology
Fernanda Pipitone et al.
Summary: This study conducted a retrospective cohort study of women with persistent postpartum pelvic pain and found that 94.4% of the patients had musculoskeletal abnormalities detected on MRI, which correlated with their clinical symptoms. This highlights the importance of considering pelvic floor imaging in managing unexplained persistent postpartum pelvic pain.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Usa Cain et al.
SEMINARS IN ROENTGENOLOGY
(2021)
Article
Sung Hye Kong et al.
Journal of Bone Metabolism
(2021)
Article
Eunsun Seo et al.
Journal of Preventive Medicine and Public Health
(2021)
Article
Endocrinology & Metabolism
Flavia Di Bari et al.
Summary: Primary hyperparathyroidism in pregnancy is rare but requires early diagnosis and appropriate treatment. In this case, conservative treatment and close monitoring led to a successful pregnancy outcome.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Review
Orthopedics
Ying Qian et al.
Summary: Pregnancy and lactation-related osteoporosis (PLO) with vertebral fractures is a rare clinical condition that mainly affects older and thinner pregnant women, often occurring in the first pregnancy. Patients typically experience back pain in the late stages of pregnancy and early postpartum period, with most vertebral fractures happening at the L2, L1, and T12 levels.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Eri Ito et al.
Summary: In this study, temporary administration of the bisphosphonate alendronate to female mice during pregnancy or lactation was shown to be protective against bone loss without adverse effects on offspring, suggesting a potential strategy to prevent fragility fractures in mothers.
Review
Nutrition & Dietetics
Natalia Wawrzyniak et al.
Summary: This review article discusses the factors affecting calcium bioavailability, including physiological conditions, diseases, hormones, growth factors, intestinal microbiota, etc. Adequate calcium intake can increase bone protection and prevent osteoporosis.
Article
Endocrinology & Metabolism
A. E. Yildiz et al.
Summary: The study found that the MRI prevalence of pregnancy- and lactation-associated vertebral compression fractures (PLVCFs) is approximately 0.5% in females aged 15 to 40 years, showing no distinguishing features from other vertebral insufficiency fractures.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Y. F. Wu et al.
Summary: Sacral stress fractures in the absence of osteoporosis are rare complications of pregnancy that can present with lumbar radiculopathy. Conservative management often produces good clinical outcomes.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Rinonapoli et al.
Summary: Obesity leads to higher bone mineral density, but also an increased risk of fracture due to multiple factors such as metabolic issues and a higher risk of falls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Jung Eun Yoo et al.
Summary: This study found that female reproductive factors are associated with fractures among postmenopausal women in Korea. Late age at menarche (>=17 years) and menopause (>=55 years) were associated with higher risk of any fractures, while longer reproductive span and being a parous woman were associated with lower risk of fractures.
Article
Endocrinology & Metabolism
Sebastian Butscheidt et al.
Summary: Pregnancy and lactation-associated osteoporosis (PLO) may be linked to genetic variants, with some patients showing a correlation between genetic variants and vertebral compression fractures. DXA and HR-pQCT tests revealed decreased bone mass in patients with genetic variants. Patients with genetic variants may benefit from osteo-anabolic medication treatment.
Article
Medicine, General & Internal
Hyeong-Wook Han et al.
Summary: This case report describes a rare occurrence of multiple vertebral fractures associated with post-pregnancy osteoporosis and postpartum thyroiditis in a 25-year-old woman. Proper management with bisphosphate, calcium supplementation, and calcitriol led to pain relief and improved mobility within a month. Awareness of postpartum thyroiditis as a potential contributor to post-pregnancy osteoporosis-related fractures is highlighted.
Article
Obstetrics & Gynecology
Takumi Kurabayashi et al.
Summary: The study examined the low bone mineral density in postpartum women and found that approximately 50% of women had low BMD, with lean women being more susceptible. Regular BMD measurements postpartum, especially for lean women, may help identify individuals at risk for osteoporosis in the future.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Rheumatology
Jan Leipe et al.
Summary: Recommendations for managing glucocorticoid-induced osteoporosis in adult patients on long-term glucocorticoid treatment include supplementation with calcium and vitamin D, using bisphosphonates or denosumab as first-line treatments, and considering teriparatide for high fracture risk patients. Denosumab is recommended in cases of severe renal insufficiency, and specific osteologic treatment should be avoided during pregnancy. Re-evaluation after 3-5 years of treatment or after discontinuation of long-term glucocorticoid treatment is advised.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2021)
Review
Endocrinology & Metabolism
Xiaodong Bai et al.
Summary: Fractures in pregnancy and lactation-associated osteoporosis (PLO) are rare, but should not be ignored by orthopedic doctors. Accurate diagnosis and individualized treatment can improve functional recovery of fractures in perinatal women with PLO. The patient in this case study showed gradual improvement in DEXA and laboratory results over a 12-month follow-up period.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Public, Environmental & Occupational Health
Shahnaz Akil et al.
Summary: This study found that parity affects the BMD of young and middle-aged females compared to nulliparous females. The mean BUA of parous females was significantly higher than nulliparous females, and the prevalence of normal BMD was significantly lower among parous females.
Article
Endocrinology & Metabolism
Mia A. Percival et al.
Summary: Research suggests that maternal 25(OH)D levels at different stages of pregnancy may have gender-specific effects on offspring fracture risk, with higher levels in early gestation associated with lower risk in boys and higher levels in late gestation associated with increased risk in girls.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Public, Environmental & Occupational Health
Shunya Sugai et al.
Summary: Low back pain during pregnancy and postpartum is common and may be a symptom of bone metastases from breast cancer that should be considered in differential diagnosis. Early detection and close monitoring are crucial for timely intervention.
Article
Nutrition & Dietetics
Elizabeth M. Curtis et al.
Summary: This study investigated the changes of maternal bone resorption marker, urinary CTX, across pregnancy, the impact of gestational vitamin D supplementation, and the associations between CTX and maternal postnatal bone outcomes. The results showed that maternal CTX levels increased through pregnancy, with a lesser degree of increase in the cholecalciferol supplementation group, and higher CTX levels at 34 weeks of gestation were associated with lower maternal bone mass postpartum.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Seunghyun Lee et al.
Summary: This retrospective cohort study found that treatment with teriparatide (TPTD) in premenopausal women with pregnancy- and lactation-associated osteoporosis (PLO) can effectively maintain bone mineral density (BMD) without the need for sequential antiresorptive therapy (ART).
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Kalliopi Lampropoulou-Adamidou et al.
Summary: In patients with PLO, treatment with TPTD resulted in significantly greater increases in lumbar spine bone mineral density compared with calcium and vitamin D supplementation at both 12 and 24 months.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Review
Obstetrics & Gynecology
Paola Quaresima et al.
Summary: Pregnancy related transient osteoporosis of the hip (PR-TOH) is a rare condition that typically occurs during the third trimester of pregnancy, characterized by sudden pain in the hip, anterior thigh, and buttocks. It is a benign and self-limiting disease, often becoming a non-obstetric indication for Caesarean delivery, caused by bone marrow edema.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Nelson B. Watts et al.
Summary: Bone mineral density changes throughout life, with rapid increase during adolescence, plateauing in the third decade of life, and age-related decline afterwards. Menopausal women experience accelerated bone loss and increased fracture risk, while between peak bone mass and menopause, BMD remains stable and fracture risk is low. Pregnancy, lactation, and certain medications can temporarily affect BMD, potentially influencing fracture risk in the long term.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Endocrinology & Metabolism
U. Stumpf et al.
Summary: Pregnancy and lactation-associated osteoporosis (PLO) is a rare but severe disease with potential risks. Treatment with denosumab in PLO patients demonstrated significant improvement in bone mineral density and prevention of further fractures, but further research is needed to fully understand its effects.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Francesca Salamanna et al.
Summary: Restrictions during the COVID-19 pandemic impacted the participation of chronic disease patients in osteoporosis screening, highlighting the potential use of blood-related factors as biomarkers for quick screening and monitoring of osteoporosis in both sexes.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Medicine, Research & Experimental
Claudiu Eduard Nistor et al.
Summary: The study demonstrated the effectiveness of the surgical treatment for hyperparathyroidism patients at the Department of Thoracic Surgery of the Central Military Emergency University Hospital 'Dr. Carol Davila' in Romania. Immediate and 30-day postoperative evaluations showed positive results in terms of normalization of blood tests and improvement in clinical and imaging anomalies.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Nutrition & Dietetics
Daria Masztalerz-Kozubek et al.
Summary: Evidence suggests that bone health may be programmed early in life, with factors such as maternal nutrition during the prenatal period influencing offspring's skeletal development and osteoporosis risk. Maternal vitamin D status, diet in pregnancy, anthropometry, and birth weight appear to impact bone mineral density, though additional factors like subsequent growth may play a role. Further well-designed studies are needed to address the ambiguity of current results.
Article
Primary Health Care
Omna Shaki et al.
Summary: This study analyzed the effects of parity and period of lactation on bone density in women from Northeast India, finding a significant negative correlation between parity, prolonged lactation period, and bone density, particularly in lower socioeconomic strata with poor nutritional intake.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2021)
Review
Obstetrics & Gynecology
Alessandra Violi et al.
Summary: Standards and models for osteoporosis have primarily focused on females, but the disease also affects males. Gender aspects in the development and management of osteoporosis are often overlooked, potentially leading to missed opportunities for addressing the issue equitably. Clinical trials predominantly involving female participants limit the generalizability of findings and understanding of the disease across genders.
MINERVA OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Rashmi Rao et al.
Summary: Women with osteogenesis imperfecta are at a significantly higher risk of complications during pregnancy, including diabetes, cesarean delivery, blood transfusion, and antepartum/postpartum fractures. Their neonates also have higher chances of being low or very low birthweight, requiring neonatal intensive care unit admissions, and experiencing higher neonatal mortality at 28 days of life compared to the general population.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Endocrinology & Metabolism
Nekoo Panahi et al.
Summary: The study revealed that postmenopausal women with a history of grand multiparity had significantly lower bone mineral density and trabecular bone score, particularly in the lumbar spine, suggesting deleterious effects of multiple deliveries on bone health.
Article
Medicine, General & Internal
Karim Al-Dourobi et al.
Summary: A 24-year-old woman developed atraumatic lumbosacral pain and was diagnosed with transient osteoporosis of the hip during pregnancy, complicated by a pathological displaced subcapital femur fracture. She underwent total hip arthroplasty and recovered well, highlighting the importance of early diagnosis using MRI to prevent severe fracture complications.
Article
Endocrinology & Metabolism
Maria Florencia Scioscia et al.
Summary: Patients with PLO showed severe deterioration of bone trabecular and cortical microarchitecture compared to healthy lactating women, which may explain the occurrence of multiple fractures in these otherwise healthy young women. Further prospective studies are needed to determine whether bone microarchitecture might be able to be restored in the future.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Rehabilitation
Nurbanu Hindioglu et al.
Summary: Stress fractures are bone injuries caused by overuse, often related to repetitive stress and characterized by tenderness and persistent pain. Persistent pain in the postpartum period may indicate bone lesions such as stress fractures, requiring detailed physical examination and further investigations to detect fractures and risk factors.
TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Medicine, General & Internal
Esther Victoria Wright et al.
Summary: Transient osteoporosis of the hip is a rare cause of pelvic pain in the third trimester of pregnancy and postpartum, with poorly understood etiology. Diagnosis is often missed and clinicians face challenges in both diagnosis and management of this condition.
Review
Rheumatology
Rebecca J. Moon et al.
Summary: Research on the positive effects of prenatal vitamin D supplementation on offspring bone development and the underlying biological mechanisms, can inform clinical care and public health policies.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)
Review
Gastroenterology & Hepatology
Narendra S. Choudhary et al.
Summary: The text mainly discusses the factors leading to long-term survival of liver transplantation recipients, including non-immunological causes of death, as well as health management issues such as osteoporosis, contraception, and pregnancy.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2021)
Review
Sport Sciences
Brad Sifrig et al.
CURRENT SPORTS MEDICINE REPORTS
(2021)
Review
Endocrinology & Metabolism
F. M. F. Grizzo et al.
OSTEOPOROSIS INTERNATIONAL
(2020)
Review
Endocrinology & Metabolism
Pu Jia et al.
ARCHIVES OF OSTEOPOROSIS
(2020)
Review
Endocrinology & Metabolism
Alessro Brancatella et al.
ENDOCRINE CONNECTIONS
(2020)
Article
Endocrinology & Metabolism
Adi Cohen et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Review
Medicine, General & Internal
Gang Wang et al.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2020)
Review
Endocrinology & Metabolism
S. A. Hardcastle et al.
OSTEOPOROSIS INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
D. Scott et al.
OSTEOPOROSIS INTERNATIONAL
(2019)
Review
Endocrinology & Metabolism
X. Sherry Liu et al.
CURRENT OSTEOPOROSIS REPORTS
(2019)
Review
Obstetrics & Gynecology
Roberta Venturella et al.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2018)
Review
Medicine, General & Internal
Min Zhang et al.
Review
Rheumatology
Bente L. Langdahl
CURRENT OPINION IN RHEUMATOLOGY
(2017)
Article
Medicine, General & Internal
Joel G. Ray et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2016)
Article
Orthopedics
Melanie Schorr et al.
SKELETAL RADIOLOGY
(2016)
Article
Endocrinology & Metabolism
Barbara C. Silva et al.
JOURNAL OF CLINICAL DENSITOMETRY
(2015)
Article
Endocrinology & Metabolism
Adi Cohen et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
Article
Rheumatology
Onder Ofluoglu et al.
RHEUMATOLOGY INTERNATIONAL
(2008)
