☆ 4.6 Review

Clinical and Dermoscopic Characteristics of Cutaneous Sarcomas: A Literature Review

DIAGNOSTICS (2023)

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Article Dermatology

Cutaneous Mesenchymal Sarcomas

Frances Walocko et al.

Summary: Cutaneous mesenchymal sarcomas are rare diseases with limited guidelines. A summary of management is provided to assist clinicians. Surgical excision may lead to higher rates of local recurrence compared to common forms of nonmelanoma skin cancer. Patients with certain types of sarcomas are at higher risk of metastatic disease. Collecting data in large databases might help standardize the management of these rare carcinomas.

DERMATOLOGIC CLINICS (2023)

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Article Dermatology

Atypical fibroxanthoma and pleomorphic dermal sarcoma - gene expression analysis compared with undifferentiated cutaneous squamous cell carcinoma

Iris Marie Anders et al.

Summary: This study investigates the histogenetic origin of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Through clinical, histomorphological, and immunohistochemical evaluations, similarities between AFX/PDS and undifferentiated cutaneous squamous cell carcinoma (cSCC) were discovered. RNA transcriptome analysis showed that AFX/PDS and differentiated cSCC formed their own clusters, while undifferentiated cSCCs fell in between. Differential gene expression analysis identified undifferentiated cSCC cases that were more likely to be AFX/PDS based on their expression profile. These findings provide evidence for molecular similarities and a common histogenetic origin between AFX/PDS and undifferentiated cSCC.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2023)

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Review Oncology

Surgical management of dermatofibrosarcoma protuberans

Dylan J. Rust et al.

Summary: Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin malignancy. The primary treatment is complete resection, but the optimal method is debated. Mohs micrographic surgery is now recommended as the preferred approach according to National Comprehensive Cancer Network guidelines, replacing wide local excision. Medical therapy with imatinib can be used in advanced or unresectable cases. This review focuses on the current management of DFSP, with an emphasis on optimal surgical approach.

JOURNAL OF SURGICAL ONCOLOGY (2023)

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Article Virology

Kaposi's Sarcoma-Associated Herpesvirus Immediate Early Proteins Trigger FOXQ1 Expression in Oral Epithelial Cells, Engaging in a Novel Lytic Cycle-Sustaining Positive Feedback Loop

Natalie Atyeo et al.

Summary: The oral cavity is an important site for virus entry and transmission. KSHV, an oncogenic gammaherpesvirus, can replicate in oral epithelial cells and promote viral transmission via saliva. FOXQ1, a host transcription factor, is induced by KSHV infection and plays a role in sustaining the viral lytic cycle in oral epithelial cells. Immediate early proteins ORF45 and RTA are involved in inducing FOXQ1 expression, and ORF45 uses a shared mechanism to induce both host and viral genes for lytic infection.

JOURNAL OF VIROLOGY (2023)

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Article Medicine, General & Internal

Weekly paclitaxel treatment in the first-line therapy of classic Kaposi sarcoma: A real-life study

Nail Paksoy et al.

Summary: The study aimed to evaluate the efficacy and safety of weekly paclitaxel therapy in the first-line treatment of Kaposi sarcoma. The results showed that paclitaxel is an effective therapy option with an acceptable safety profile for patients with advanced Kaposi sarcoma.

MEDICINE (2023)

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Editorial Material Medicine, General & Internal

Gastrointestinal Kaposi's Sarcoma

Deniz E. Tekcan E. Sanli et al.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Article Oncology

Atypical Fibroxanthoma: Outcomes from a Large Single Institution Series

Erin McClure et al.

Summary: This retrospective study provides clinical, pathologic, and treatment characteristics, as well as oncologic outcomes of AFX patients. The majority of AFX occurred in elderly, immunocompetent, Caucasian men, with most tumors located on the head and neck. Resection margins of 1 cm achieved excellent local control, with a recurrence rate close to 99% and 100% disease-specific survival.

CANCER CONTROL (2023)

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Article Surgery

Utility of Multimodal Treatment Protocols in the Management of Scalp Cutaneous Angiosarcoma

Adel Alharbi et al.

Summary: This study retrospectively reviewed cases of scalp cutaneous angiosarcoma diagnosed between 2005 and 2021. The analysis focused on resectability, defect reconstruction, and survival outcomes. The results showed that multimodal therapy combined with surgery had significantly better overall survival compared to surgery alone. Defect coverage was successfully achieved using various flap techniques. Further research is needed to explore advanced treatment modalities for this aggressive tumor.

PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN (2023)

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Article Dermatology

A description of Kaposi sarcoma risk factors and outcomes in HIV-positive and HIV-negative patients at a tertiary care medical center from 2005 to 2020

Karissa Libson et al.

Summary: Kaposi sarcoma (KS) is a vascular malignancy caused by human herpesvirus-8 (HHV-8). This study examined KS patients in Ohio, USA, and identified a fifth subtype called Unclassified-KS-Type. HIV-positive and HIV-negative patients were categorized, and the Unclassified-KS-Type patients were found to match the characteristics of the emerging non-epidemic subtype. This report provides updated information on KS risk factors and outcomes for improved detection and treatment in dermatology.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2023)

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Review Oncology

Cutaneous Angiosarcoma of the Head and Neck-A Retrospective Analysis of 47 Patients

Neeraj Ramakrishnan et al.

Summary: This study retrospectively evaluated the clinical characteristics and treatment outcomes of 47 patients with cutaneous angiosarcoma (CAS) of the head and neck. The study found that surgery significantly improved overall survival (OS) in patients, while chemotherapy, radiotherapy, and immunotherapy did not have a significant impact on OS.

CANCERS (2022)

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Review Oncology

Epidemiology of Kaposi's Sarcoma

Sophie Grabar et al.

Summary: An air mattress is a non-breathable sleeping aid commonly used for camping or guests' accommodation.

CANCERS (2021)

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Review Oncology

Uncommon and peculiar soft tissue sarcomas: Multidisciplinary review and practical recommendations for diagnosis and treatment. Spanish group for Sarcoma research (GEIS - GROUP). Part I

Javier Martinez-Trufero et al.

CANCER TREATMENT REVIEWS (2021)

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Letter Dermatology

Arborizing Telangiectasias May Also Be a Dermoscopic Vascular Pattern of Cutaneous Leiomyosarcoma

Gabriela F. Escobar et al.

DERMATOLOGIC SURGERY (2021)

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Review Pathology

The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives

Marta Sbaraglia et al.

Summary: Mesenchymal tumors, especially those in challenging diagnostic pathology, are greatly impacted by the refinement of classification schemes as it improves the quality of pathologic diagnosis and therapeutic options. The recent 2020 WHO classification of Soft Tissue Tumours and Bone, open to expert clinicians, has stimulated a debate on the importance of pathologic diagnosis and precision oncology. Pathologic diagnosis, integrating morphologic, immunohistochemical and molecular characteristics, plays a crucial role in clinical decision making and the WHO classification serves as a key instrument in promoting multidisciplinary efforts for more effective treatments.

PATHOLOGICA (2021)

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Article Dermatology

Paediatric melanoma of the nail unit with rapid progression: a case report with dermatoscopic follow-up and intraoperative dermatoscopic images

Bengu Nisa Akay et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2020)

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Review Dermatology

Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature

Meagan Chambers et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2020)

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Letter Dermatology

Purpuric Plaques-Dermoscopic and Histopathological Correlation of Cutaneous Angiosarcoma

Daniel W. Cole et al.

DERMATOLOGY PRACTICAL & CONCEPTUAL (2020)

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Review Oncology

The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes

Vicky Soomers et al.

ESMO OPEN (2020)

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Article Dermatology

Dermoscopy of cutaneous smooth muscle neoplasms: a morphological study of 136 cases

P. Zaballos et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

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Article Dermatology

Dermoscopy of Dermatofibrosarcoma Protuberans: What Do We Know?

Gabriela F. Escobar et al.

DERMATOLOGY PRACTICAL & CONCEPTUAL (2019)

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Article Dermatology

Dermoscopy features of atypical fibroxanthoma: A multicenter study of the International Dermoscopy Society

Elvira Moscarella et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2018)

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Review Oncology

Current and Future Directions for Angiosarcoma Therapy

Vaia Florou et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2018)

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Review Dermatology

Guidelines for Diagnosis and Treatment of Cutaneous Sarcomas: Dermatofibrosarcoma Protuberans

B. Llombart et al.

ACTAS DERMO-SIFILIOGRAFICAS (2018)

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Letter Dermatology

Dermoscopy of uncommon variants of dermatofibrosarcoma protuberans

C. Costa et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

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Article Dermatology

Cutaneous Angiosarcorna: Clinical and Pathoogy Study of 16 Cases

C. Requena et al.

ACTAS DERMO-SIFILIOGRAFICAS (2017)

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Editorial Material Dermatology

Pigmented Dermatofibrosarcoma Protuberans and Blue Naevi with Similar Dermoscopy: A Case Report

Yuko Ehara et al.

ACTA DERMATO-VENEREOLOGICA (2016)

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Editorial Material Dermatology

Maculonodular Lesion on the Back of a 66-year-old Man

F. Hartmann et al.

HAUTARZT (2016)

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Editorial Material Dermatology

Dermoscopy of dermatofibrosarcoma protuberans on black skin

Vincenzo Piccolo et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

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Editorial Material Dermatology

In vivo characterization of recurrent dermatofibrosarcoma protuberans by dermoscopy and reflectance confocal microscopy

Marina Venturini et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

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Article Otorhinolaryngology

Angiosarcoma of the Scalp and Face The Mayo Clinic Experience

Samir H. Patel et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2015)

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Article Dermatology

Dermoscopic features of dermatofibrosarcoma protuberans

Jose Antonio Aviles-Izquierdo et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2014)

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Letter Dermatology

Atrophic dermatofibrosarcoma protuberans: are there specific dermatoscopic features?

Sule Gungor et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2014)

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Article Dermatology

Clinical, dermoscopic and histopathological features of spontaneous scalp or face and radiotherapy-induced angiosarcoma

Iris Zalaudek et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2013)

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Article Dermatology

Dermoscopy of dermatofibrosarcoma protuberans: a study of 15 cases

J. Bernard et al.

BRITISH JOURNAL OF DERMATOLOGY (2013)

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Letter Dermatology

Dermoscopic Rainbow Pattern in Kaposi's Sarcoma Lesions: Our Experience

Rosanna Satta et al.

ARCHIVES OF DERMATOLOGY (2012)

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Article Pathology

Atypical Intradermal Smooth Muscle Neoplasms: Clinicopathologic Analysis of 84 Cases and a Reappraisal of Cutaneous Leiomyosarcoma

Stefan Kraft et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2011)

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Article Cell Biology

Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases

Daniela Massi et al.

HISTOPATHOLOGY (2010)

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Review Oncology

Angiosarcoma

Robin J. Young et al.

LANCET ONCOLOGY (2010)

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Letter Dermatology

Dermoscopic rainbow pattern in non-Kaposi sarcoma lesions

F. Vazquez-Lopez et al.

BRITISH JOURNAL OF DERMATOLOGY (2009)

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Article Dermatology

Rainbow pattern in Kaposi's sarcoma under polarized dermoscopy: a dermoscopic pathological study

S-T. Cheng et al.

BRITISH JOURNAL OF DERMATOLOGY (2009)

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Article Dermatology

Dermoscopy of Kaposi's sarcoma: Areas exhibiting the multicoloured 'rainbow pattern'

S. C-S Hu et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2009)

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