4.6 Review

Idiopathic Pulmonary Hemorrhage in Infancy: A Case Report and Literature Review

期刊

DIAGNOSTICS
卷 13, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/diagnostics13071270

关键词

acute idiopathic pulmonary hemorrhage in infants (AIPHI); sudden infant death syndrome; pulmonary hemorrhage; case report; autopsy; postmortem; forensic; lung histology

向作者/读者索取更多资源

Acute idiopathic pulmonary hemorrhage in infants (AIPHI) is a rare and poorly understood disease with high lethality. We report a case of a 2-day-old male who died suddenly from acute pulmonary hemorrhage. Autopsy and histological analysis revealed alveolar spaces filled with red blood cells and hyaline membranes, supporting the diagnosis of AIPHI. A systematic review of scientific literature showed only 61 reported cases, with symptoms including acute respiratory distress, upper airway bleeding, hemoptysis, epistaxis, and hematemesis. Autopsy findings included lower airway hemorrhages and hemosiderin-laden macrophages. Our findings and literature data are crucial for accurate diagnosis, and we propose autoptic criteria for post-mortem diagnosis of AIPHI.
Acute idiopathic pulmonary hemorrhage in infants (AIPHI) is a rare and quite low-described entity. Nowadays, pathophysiological mechanisms are poorly understood, although the lethality remains high. We present an autopsy case report of a 2-day-old male who developed respiratory distress and blood leakage from the endotracheal tube (ET) and suddenly died because of acute pulmonary hemorrhage. A postmortem examination and histological analysis were performed and are reported in this paper. Alveolar spaces were filled with red blood cells and hyaline membranes in all the examined samples. The absence of other findings led us to select a post-mortem diagnosis of AIPHI. To support our diagnosis, we conducted a systematic review of the updated scientific literature and found that only 61 cases have been reported. Most of them presented acute respiratory distress and bleeding from the upper airways with blood leakage from ET (9.83%), hemoptysis (52.45%), epistaxis (8.2%), and hematemesis (3.27%). The autopsy data revealed hemorrhages of the lower airways and hemosiderin-laden macrophages. The data from the scientific publications and our findings are essential to achieving a correct diagnosis. On these bases, we suggest autoptic criteria to achieve a post-mortem diagnosis of AIPHI.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据