期刊
DIAGNOSTICS
卷 13, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics13101798
关键词
HSV-1/2; H. pylori; HNSCC; chronic tonsillitis; PCR
Recent studies have found that viral and bacterial factors, including HSV-1 and H. pylori, may be associated with diseases such as chronic tonsillitis and cancers like head and neck squamous cell carcinoma (HNSCC). By using PCR after DNA isolation, the prevalence of HSV-1/2 and H. pylori was assessed in patients with HNSCC, chronic tonsillitis, and healthy individuals. HSV-1 and H. pylori were found most frequently in the control group.
Recent studies identified viral and bacterial factors, including HSV-1 and H. pylori, as possible factors associated with diseases such as chronic tonsillitis and cancers, including head and neck squamous cell carcinoma (HNSCC). We assessed the prevalence of HSV-1/2 and H. pylori in patients with HNSCC, chronic tonsillitis, and healthy individuals using PCR after DNA isolation. Associations were sought between the presence of HSV-1, H. pylori, and clinicopathological and demographic characteristics and stimulant use. HSV-1 and H. pylori were most frequently identified in controls (HSV-1: 12.5% and H. pylori: 6.3%). There were 7 (7.8%) and 8 (8.6%) patients with positive HSV-1 in HNSCC and chronic tonsillitis patients, respectively, while the prevalence of H. pylori was 0/90 (0%) and 3/93 (3.2%), respectively. More cases of HSV-1 were observed in older individuals in the control group. All positive HSV-1 cases in the HNSCC group were associated with advanced tumor stage (T3/T4). The prevalence of HSV-1 and H. pylori was highest in the controls compared to HNSCC and chronic tonsillitis patients, which indicates that the pathogens were not risk factors. However, since all positive HSV-1 cases in the HNSCC group were observed only in patients with advanced tumor stage, we suggested a possible link between HSV-1 and tumor progression. Further follow-up of the study groups is planned.
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