Supramolecular Assembly of Tetramethylcucurbit[6]uril and 2-Picolylamine

The supramolecular assembly of symmetrical tetramethylcucurbit[6]uril (TMeQ[6]) and 2-picolylamine (AMPy) has been investigated via various techniques, including ultraviolet-visible (UV-vis) and nuclear magnetic resonance spectroscopy, isothermal titration calorimetry (ITC), and X-ray crystallography. The results indicated that TMeQ[6] could encapsulate the AMPy guest molecule to form a stable inclusion complex. The rotational restriction of the guest in the cavity of TMeQ[6] resulted in a large negative value of entropy. The X-ray crystal structure of the 1:1 inclusion complex between TMeQ[6] and AMPy revealed that AMPy exists in the elliptical cavity of TMeQ[6].

Automated summary

The supramolecular assembly of symmetrical tetramethylcucurbit[6]uril (TMeQ[6]) and 2-picolylamine (AMPy) was studied using various techniques, including UV-vis spectroscopy, NMR spectroscopy, ITC, and X-ray crystallography. The results showed that TMeQ[6] could form a stable inclusion complex with AMPy. The rotational restriction of AMPy in the cavity of TMeQ[6] resulted in a large negative entropy value. The X-ray crystal structure revealed that AMPy was located in the elliptical cavity of TMeQ[6].