Step-Economic Total Synthesis of Melosatin A from Eugenol

Article Chemistry, Multidisciplinary

Lactone Backbone Density in Rigid Electron-Deficient Semiconducting Polymers Enabling High n-type Organic Thermoelectric Performance

Maryam Alsufyani et al.

Summary: Increasing the benzene content to increase the lactone group density can enhance the electron affinity, favoring the doping process, and significantly increasing the electrical conductivity.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Oncology

In-vitro Evaluation of Isatin Derivatives as Potent Anti-Breast Cancer Agents against MCF-7, MDA MB 231, MDA-MB 435 and MDA-MB 468 Breast Cancers Cell Lines: A Review

Garima Chauhan et al.

Summary: Breast cancer is a common malignancy with chemotherapy as the main treatment. However, there are challenges in differentiating between cancer cells and normal cells and severe side effects. Therefore, there is a need for more effective and specific anti-BC agents. This review focuses on the anti-BC activities of IST derivatives and identifies 33 compounds with good activity.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Organic

Total Synthesis of Aqabamycin G, a Nitrophenyl Indolylmaleimide Marine Alkaloid from Vibrio sp. WMBA

Didier F. Vargas et al.

Summary: The first total synthesis of marine alkaloid aqabamycin G was disclosed, involving addition to maleimide of an indole motif and a substituted diazo-benzenoid unit derived from acetaminophen. An alternative strategy using a protected phenol was also reported.

JOURNAL OF ORGANIC CHEMISTRY (2022)

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Article Materials Science, Multidisciplinary

Synthesis of asymmetric indolonaphthyridines with enhanced excited state charge-transfer character

Michael Purdy et al.

Summary: In this study, a new class of asymmetric indolonaphthyridines (IND) derived using a novel high yielding methodology was presented. The absorption properties and excited state charge-transfer character of these novel asymmetric INDs were compared with symmetric INDs. The results showed that the asymmetry of INDs increased the change in dipole moment and excited state charge-transfer character, which was attributed to the increased spatial separation between excited state electron and hole wavefunctions for the asymmetric INDs. The structure-property relationships introduced in this work provide invaluable design principles for the generation of high performance materials.

JOURNAL OF MATERIALS CHEMISTRY C (2022)

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Article Chemistry, Multidisciplinary

Copper(i)-catalyzed synthesis of natural alkaloid tryptanthrin and its derivatives

Jiankai Hong et al.

Summary: This study describes a mild method for preparing tryptanthrin and its derivatives using copper catalyst with two identical isatins and KHCO3 as a base. More complex tryptanthrin derivatives were also obtained in two steps using two different isatins in one pot. The research highlights the use of readily available starting materials, mild reaction conditions, simple operation, good functional group tolerance, and high yields and selectivity. This transformation not only provides a new method for accessing tryptanthrin and its derivatives but also enriches the chemistry of isatins and copper catalysis.

NEW JOURNAL OF CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Acene Ring Size Optimization in Fused Lactam Polymers Enabling High n-Type Organic Thermoelectric Performance

Hu Chen et al.

Summary: In this study, three n-type fused lactam semiconducting polymers were synthesized via a transition-metal free aldol polycondensation method, showing progressively larger electron affinities as the central acene core size decreases. The N-N and A-N polymers exhibited the highest charge carrier mobilities and power factors among the three polymers, representing promising candidates for high-performance n-type materials in thermoelectric applications. The results highlight the effectiveness of modulating the size of the central acene ring as a molecular design strategy to optimize the electronic and thermoelectric performance of conjugated polymers.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Chemistry, Medicinal

Isatin: A Scaffold with Immense Biodiversity

Priyobrata Nath et al.

Summary: Isatin is an important fused heterocyclic compound with diverse biological effects, including antimicrobial, antitubercular, anticonvulsant, and anticancer properties. Its derivatives have synthetic significance and can be utilized for the synthesis of various chemical entities, some of which have emerged as drugs. Studies suggest that electron-withdrawing groups, halogens, nitro groups, and alkoxy groups at specific positions of isatin play a crucial role in alleviating clinical conditions.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

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Article Materials Science, Multidisciplinary

Investigating the backbone conformation and configuration effects for donor-acceptor conjugated polymers with ladder-type structures synthesized through Aldol polycondensation

Yen-Wen Huang et al.

Summary: Aldol reaction is a green approach for developing conjugated polymers with ladder-type structures. Copolymerization of electron-deficient bis-isoindigo with electron-rich spacers through Aldol polycondensation results in donor-acceptor CPs with varied conformational flexibility and aggregation behavior. The configurational differences between axisymmetric and centrosymmetric spacers deeply affect the surface morphology and film ductility of the polymers, while their regularity in both conformation and configuration impacts the hole mobility.

JOURNAL OF MATERIALS CHEMISTRY C (2021)

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Review Chemistry, Medicinal

Recent Advancement of Synthesis of Isatins as a Versatile Pharmacophore: A review

Gajendra Kumar et al.

Summary: Isatin and its derivatives are versatile compounds acting as precursors for various pharmacologically active substances. They exhibit a variety of biological activities, including antimicrobial, anticonvulsant, anti-inflammatory, analgesic, and antitubercular activities.

DRUG RESEARCH (2021)

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Article Chemistry, Organic

Ruthenium-Catalyzed Asymmetric Allylic Alkylation of Isatins

Barry M. Trost et al.

ORGANIC LETTERS (2020)

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Article Chemistry, Organic

Convergent First Total Synthesis of Melovinone: A Densely Substituted 3-Methoxy-4-quinolone Isolated from Melochia tomentosa L.

Abel A. Arroyo Aguilar et al.

SYNTHESIS-STUTTGART (2019)

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Review Biochemistry & Molecular Biology

Isatin and its derivatives: a survey of recent syntheses, reactions, and applications

Varun et al.

MEDCHEMCOMM (2019)

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Article Chemistry, Multidisciplinary

First total synthesis of ampullosine, a unique isoquinoline alkaloid isolated from Sepedonium ampullosporum, and of the related permethylampullosine

Didier F. Vargas et al.

RSC ADVANCES (2019)

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Article Chemistry, Organic

Angular-Shaped Naphthalene Bis(1,5-diamide-2,6-diylidene)malononitrile for High-Performance, Air-Stable N-Type Organic Field-Effect Transistors

Attrimuni P. Dhondge et al.

ORGANIC LETTERS (2018)

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Article Chemistry, Organic

Advances in the Synthesis of Isatins: A Survey of the Last Decade

Andrei V. Bogdanov et al.

SYNTHESIS-STUTTGART (2018)

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Article Chemistry, Organic

A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication

Adel A. Rashad et al.

TETRAHEDRON (2018)

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Article Chemistry, Organic

Total Synthesis of Waltherione F, a Nonrutaceous 3-Methoxy-4-quinolone, Isolated from Waltheria indica L. F.

Abel A. Arroyo Aguilar et al.

ORGANIC LETTERS (2018)

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Article Chemistry, Multidisciplinary

Practical Singly and Doubly Electrophilic Aminating Agents: A New, More Sustainable Platform for Carbon-Nitrogen Bond Formation

Padmanabha V. Kattamuri et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Biochemistry & Molecular Biology

Effect of Structure on Charge Distribution in the Isatin Anions in Aprotic Environment: Spectral Study

Pavol Tisovsky et al.

MOLECULES (2017)

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Review Chemistry, Physical

Recent Advancements in Stereoselective Olefin Metathesis Using Ruthenium Catalysts

T. Patrick Montgomery et al.

CATALYSTS (2017)

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Article Chemistry, Organic

A Straightforward Synthesis of 5-Methylaaptamine from Eugenol, Employing a 6π-Electrocyclization Reaction of a 1-Azatriene

Daniel A. Heredia et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2016)

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Article Chemistry, Physical

Bisisoindigo: using a ring-fusion approach to extend the conjugation length of isoindigo

Nicholas M. Randell et al.

JOURNAL OF MATERIALS CHEMISTRY A (2016)

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Article Chemistry, Multidisciplinary

An Efficient Method on Nitration of Eugenol Using NH4NO3 and KHSO4

I. M. Sudarma et al.

ASIAN JOURNAL OF CHEMISTRY (2014)

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Article Chemistry, Medicinal

6-Bromoisatin Found in Muricid Mollusc Extracts Inhibits Colon Cancer Cell Proliferation and Induces Apoptosis, Preventing Early Stage Tumor Formation in a Colorectal Cancer Rodent Model

Babak Esmaeelian et al.

MARINE DRUGS (2014)

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Article Chemistry, Organic

Ylide mediated carbonyl homologations for the preparation of isatin derivatives

Christina T. Lollar et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

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Article Chemistry, Organic

Recent Developments in the Synthesis and Applications of Isatins

Yu-Chao Liu et al.

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL (2014)

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Article Chemistry, Organic

Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate

Akhil Sivan et al.

TETRAHEDRON LETTERS (2014)

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Article Chemistry, Organic

Synthesis of substituted isatins

Larry L. Klein et al.

TETRAHEDRON LETTERS (2013)

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Article Biochemistry & Molecular Biology

Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues

Clarina I. Manley-King et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

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Review Oncology

Cytotoxic and Anticancer Activities of Isatin and Its Derivatives: A Comprehensive Review from 2000-2008

K. L. Vine et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2009)

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Article Chemistry, Medicinal

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6

Hongliang Duan et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

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Article Chemistry, Organic

Pd-C-induced catalytic transfer hydrogenation with triethylsilane

Pijus K. Mandal et al.

JOURNAL OF ORGANIC CHEMISTRY (2007)

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Article Chemistry, Medicinal

Syntheses and antiproliferative evaluation of oxyphenisatin derivatives

Muhammed K. Uddin et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

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Article Chemistry, Medicinal

Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties

M Kawai et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

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Article Chemistry, Medicinal

Combinatorial optimization of isatin-β-thiosemicarbazones as anti-poxvirus agents

MC Pirrung et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

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Article Chemistry, Multidisciplinary

A general model for selectivity in olefin cross metathesis

AK Chatterjee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

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Article Chemistry, Medicinal

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis

HN Bramson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2001)

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Review Chemistry, Multidisciplinary

The chemistry of isatins: a review from 1975 to 1999

JFM da Silva et al.

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY (2001)

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Article Chemistry, Applied

Synthesis and evaluation of organic pigments. 4. New monoarylide and diarylide pigments

M Nakpathom et al.

DYES AND PIGMENTS (2001)

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Article Chemistry, Multidisciplinary

The synthesis of ventilone A

MJ Piggott et al.

AUSTRALIAN JOURNAL OF CHEMISTRY (2000)

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Step-Economic Total Synthesis of Melosatin A from Eugenol

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