An Overview of Human Anti-HIV-1 Neutralizing Antibodies against Diverse Epitopes of HIV-1

In this Review, we have addressed some recent developments in the discovery and applications of anti-human immunodeficiency virus type- 1 (HIV-1) broadly neutralizing antibodies (bnAbs) isolated from infected adults and children. The recent developments in human antibody isolation technologies have led to the discovery of several highly potent anti-HIV-1 bnAbs. Herein, we have discussed the characteristics of recently identified bnAbs directed at distinct epitopes of HIV-1, in addition to the existing antibodies, from adults and children and have shed light on the benefits of multispecific HIV-1 bnAbs and their role in the design of polyvalent vaccines.

Automated summary

In this Review, recent developments in the discovery and applications of anti-human immunodeficiency virus type- 1 (HIV-1) broadly neutralizing antibodies (bnAbs) isolated from infected adults and children were addressed. The advancements in human antibody isolation technologies have led to the discovery of highly potent anti-HIV-1 bnAbs. The characteristics of recently identified bnAbs targeted at distinct epitopes of HIV-1, as well as the existing antibodies from adults and children, were discussed, emphasizing the benefits of multispecific HIV-1 bnAbs and their role in the design of polyvalent vaccines.