Synthesis of α-CF3 Amides via Palladium-Catalyzed Carbonylation of 2-Bromo-3,3,3-trifluoropropene

Amide compounds are important organic com-pounds, which play an important role in biomedical chemistry, materials science, life science, and other fields. The synthesis of alpha- CF3 amides, especially compounds containing 3-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepine-2-one, has long been a challenge due to the tensile properties and instability of the rings. Here, we report an example of palladium-catalyzed carbonylation of CF3-containing olefin to form alpha-CF3 acrylamide. By controlling the ligands, we can get different amide compounds as products. This method has good substrate adaptability and functional group tolerance.

Automated summary

Amide compounds are important in various fields like biomedical chemistry, materials science, and life science. The synthesis of alpha-CF3 amides, especially compounds with 3-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepine-2-one, has been a challenge due to their tensile properties and instability of the rings. However, by using a palladium-catalyzed carbonylation reaction, we have successfully synthesized alpha-CF3 acrylamide. By controlling the ligands, we can obtain different amide compounds with good substrate adaptability and functional group tolerance.